Abstract: A disposable high density optically readable polydeoxynucleotide array with integral fluorescence excitation and fluorescence emission channels is described. The compact array size allows integration into several types of interventional devices such as catheters, guidewires, needles, trocars and may be used intraoperatively. Highly sensitive monitoring of the metabolic and disease pathways of cells in vivo under varying chemical, genetic and environmental conditions is afforded.

Abstract: In a magnetic resonance imaging method an echo train is generated of successive magnetic resonance signals from an object to be examined. The magnetic resonance signals are received with a degree of undersampling and by means of a receiver antennae system having a spatial sensitivity profile and the degree of undersampling is set on the basis of an amount of phase evolution due to a magnetic susceptibility distribution of the object to be examined.

Abstract: Disclosed is a method for monitoring early treatment response of a cancer treatment comprising measuring by magnetic resonance spectroscopy (MRS), for example, proton MRS, the amount of Choline present in the cancerous tissue before and after treatment; the treatment comprises administration of a cell surface receptor inhibitor, for example, an EGFR inhibitor, whereby a decrease in the amount of Choline after treatment is indicative of a positive response. The decrease in the amount of Choline represents the decrease in the internal cell membrane as a result of down regulation of the organelles and their secretory granules and their transport vesicles. Disclosed also is a method for determining effectiveness of a cell surface receptor inhibitor in the treatment of cancer.

Abstract: A combined PET/MRI scanner generally includes a magnet for producing a magnetic field suitable for magnetic resonance imaging, a radiofrequency (RF) coil disposed within the magnetic field produced by the magnet and a ring tomograph disposed within the magnetic field produced by the magnet. The ring tomograph includes a scintillator layer for outputting at least one photon in response to an annihilation event, a detection array coupled to the scintillator layer for detecting the at least one photon outputted by the scintillator layer and for outputting a detection signal in response to the detected photon and a front-end electronic array coupled to the detection array for receiving the detection signal, wherein the front-end array has a preamplifier and a shaper network for conditioning the detection signal.

Abstract: A scanning laser polarimetry (SLP) system that measures in vivo retinal nerve fiber layer (RNFL) retardance (?N, ?N) in a single measurement without a variable corneal compensator (VCC). The diagnostic signal is biased so that the detected RNFL retardance orientation angles are sufficiently similar at adjacent pixels in the retinal polarimetric image to permit resolution of the orientation angle ambiguity in a single polarimetric image without repeating the measurement at another signal polarization state. With a simple bias retarder, the effects of anterior segment retardance (?C, ?C) can be removed from a single polarimetric image of the retina without a VCC. Alternatively, from two single polarimetric images obtained at two different bias retarder positions, the anterior segment retardance magnitude ?C and orientation ?C and the RNFL retardance magnitude ?N and orientation ?N can all be determined from the peripapillary RNFL image region alone.

Abstract: The present invention includes a method and apparatus to perform rapid multi-slice MR imaging without ECG gating or requiring breath-holding that is capable of renal profusion analysis and angiographic screening. An ungated interleaved pulse sequence is applied in rapid succession, followed by a delay interval. The ungated interleaved pulse sequence is repeatedly played out with the predefined delay interval between each application of the pulse sequence. The resulting images provide not only a series of temporal phases of contrast-enhanced blood uptake for renal profusion analysis, but also provide enough dynamic range to include angiographic screening of the renal arteries.

Abstract: In a method and system for processing medically relevant data in the framework of an examination of a patient that is to be implemented, a program is installed in a data processing device that selects one or more examination modalities to be implemented for the examination of the patient on the basis of symptom-specific and/or diagnosis-specific information that have been entered and using symptom-based and/or diagnosis-based data bank. The examination modalities are available as an output at a playback device.

Abstract: A CMOS image sensor implementing a low noise active reset operation uses control circuitry outside a pixel sensor array and transistors in a pixel sensor as parts of an amplifier that charges a photodiode node. In one configuration, a reference transistor in the control circuit controls a current mirrored to a column line, and each pixel sensor in the corresponding column contains a transistor that acts as half of a differential pair when the row containing the pixel sensor is selected. A 4-transistor pixel sensor can be implemented using only NMOS transistors with PMOS transistors in the control circuitry used to complete an amplifier circuit.

Abstract: A method for selecting images for coronary analysis using time stamps to correlate cardiovascular images to corresponding physiological or hemodynamic monitoring, e.g., ECG, data. The method uses time stamps that are intrinsic to a distributed network clock synchronization protocol for correlation of images and data. A coronary analysis system is employed to correlate images with physiologic data, e.g., using time stamp data as well as offset data derived using the distributed network clock synchronization protocol.

Abstract: A nuclear magnetic resonance tomography apparatus has gradient coils that superimpose at least one gradient field on a basic magnetic field transversely to a coding direction, with an overall magnetic field in the coding direction having a magnetic field strength with a component that changes quadratically over distance. A support mechanism displaces a subject to be measured by a distance ?w in the coding direction, and a control computer determines an absolute location w of a nuclear magnetic resonance signal in the coding direction from the resulting, quadratically dependent phase differences or resonant frequency differences during the displacement of the subject.

Abstract: A registration pointer for registering points of surfaces of bodily elements in computer-assisted surgery, comprising a handle for being manipulated by a pointer operator. A stem is connected to the handle and has a first and a second tip configurations each having a respective use relating to a registration of points on specified bodily elements. A detectable device is secured to the stem, and is adapted to be tracked in space for position and orientation by a sensing apparatus. A position of the tip configurations with respect to the detectable device is determinable such that a position of the tip configurations is calculable as a function of the position and orientation of the detectable device. The tip configurations are chosen to register points on given bodily elements as a function of the respective use, by recording a position of points of contact between the tip configurations and the given bodily element.

Abstract: A reflector (14) reflects energy emitting from an energy source (16) and focuses and directs it to a target. An aperture stop or suppressor disk (18) is positioned between the energy source (16) and target. The outer periphery of the aperture stop or suppressor disk (18) is an irregular curve (FIGS. 12 and 13). This shape of the periphery prevents diffraction enhancement to the direct wave. In another emobidment, the suppressor disk (18) is replaced by a suppressor member (18?) that is directly mounted on a frame portion of the energy source (16). This energy source (16) includes a spark-gap, or the like, and an open frame (36) that surrounds the spark-gap (52) or the like. This frame (32) includes a pair of laterally spaced apart frame members (42, 44) on the side of the frame (36) that faces the target (F2). The suppressor member (18?) is connected to these frame members (32, 44). It may have longitudinal grooves (48, 50) in its side edges into which the frame members (42, 44) snap-fit.

Abstract: A method of sensory training and testing systems focusing upon the development of pre-attentive and attentive vision for the enhancement of the individual's ability to perform specific functions.

Abstract: In a magnetic resonance apparatus, the transmission coil for generating the radiofrequency excitation field is stationarily arranged. The geometry of the transmission coil is permanently prescribed. For acquiring the magnetic resonance signal, the reception arrangement includes at least one first local coil. This is secured to a movable carrier, so that it can be placed against the person from a remote position. The carrier is secured in a carrier mount arranged stationarily within the examination volume.

Abstract: A device for producing high pressure ultrasound pulses. The device includes an ultrasound source having a piezoelectric transducer provided with electrodes and presenting polarization in a given direction (f1). An electrical voltage is applied to the electrodes to emit an ultrasound wave and to apply an electric field in a direction (f2) opposite to the polarization direction (f1) in order to compress the ultrasound transducer. A transient electric field having the same direction (f3) as the polarization direction (f1) is then applied so as to cause a compression ultrasound wave to be emitted in the coupling medium.

Abstract: A method and system for examining biological tissue includes the steps of radiating a tissue region with a plurality of microwave radiation pulses. The microwave pulses are swept across a range of microwave frequencies. In response to the swept frequency microwave pulses, the tissue region emits a plurality of thermoacoustic signals. At least one image of the tissue region is formed from the plurality of thermoacoustic signals. The signals can be ultrawideband signals.

Abstract: A system for the destruction of adipose tissue utilizing high intensity focused ultrasound (HIFU) within a patient's body. The system comprises a controller for data storage and the operation and control of a plurality of elements. One elements is a means for mapping a human body to establish three dimensional coordinate position data for existing adipose tissue. The controller is able to identify the plurality of adipose tissue locations on said human body and establish a protocol for the destruction of the adipose tissue. A HIFU transducer assembly having one or more piezoelectric element(s) is used along with at least one sensor wherein the sensor provides feed back information to the controller for the safe operation of the piezoelectric element(s). The sensor is electronically coupled to the controller, and the controller provides essential treatment command information to one or more piezoelectric element(s) based on positioning information obtained from the three dimensional coordinate position data.

Abstract: The purpose of the present invention is to provide a corneal-ablation-data determining apparatus and a corneal-ablation-data determining program capable of controlling corneal ablation amount distribution and expanding ablation applicability. In the present invention, the corneal-ablation-data determining apparatus for use in keratorefractive surgery for ablating a corneal surface to correct a refractive error has input means for inputting measurement data on any one of wavefront aberration distribution and refractive power distribution of a patient's eye, decentering means for decentering a reference axis being a calculation reference for a corneal ablation amount, and calculation means for obtaining the corneal ablation amount based on the measurement data and data on eccentricity of the reference axis.

Abstract: The level of a respiration signal obtained from a laser sensor or the like is indicated on a respiration monitor according to an output condition set by synchronizing signal output control device. While the level of the respiration signal is indicated on the respiration monitor, a synchronizing signal output device outputs a synchronizing signal according to the output condition and the respiration signal to an X-ray control device, which controls a high-voltage generating device to energize an X-ray source to apply X-rays to an examinee.

Abstract: The ultrasound puncture system in accordance with the present invention comprises a handpiece which accommodates an ultrasound vibrator, a puncturing probe for transmitting ultrasound waves to a biological wall which is to be punctured, an outer cover tube covering the probe and attached to the handpiece, and an ultrasound power source unit for driving the ultrasound vibrator, wherein the ultrasound power source unit comprises a termination unit for terminating the energy supply to the ultrasound vibrator, an impedance detector for detecting the puncture state of the probe, and a fluid supply unit for supplying a fluid to the distal end opening of the outer cover tube and probe, wherein the penetration of the probe through the biological wall is detected with the detection unit and the supply of energy to the ultrasound vibrator is terminated based on the detection output.