Abstract: A method of analysis of medical signals which uses wavelet transform analysis to decompose cardiac signals. Apparatus for carrying out the method, and cardiac apparatus adapted to employ the method are also described.

Abstract: A method and system is presented for treating moving target regions in a patient's anatomy by creating radiosurgical lesions. The method includes determining a pulsating motion of a patient separately from a determining of a respiratory motion, and directing a radiosurgical beam, from a radiosurgical beam source, to a target in the patient based on the determining of the pulsating motion. Directing the radiosurgical beam to the target may include creating a lesion in the heart to inhibit atrial fibrillation. The method may further include determining the respiratory motion of the patient, and compensating for movement of the target, due to the respiratory motion and the pulsating motion of the patient, in the directing of the radiosurgical beam based on the determining of the respiratory motion and the determining of the pulsating motion.

Abstract: A method of evaluating the surface of a material that has a distinguishable infrared spectrum comprising (a) positioning an infrared fiber optic probe to be in contact with a surface of the sample or material at a region of interest for detecting attenuated total reflectance or within a sufficient distance from the surface of the region for detecting reflection, (b) detecting mid- or near-infrared radiation attenuated total reflectance or reflection off of the surface of the sample or the material, (c) analyzing the infrared radiation from step (b) for at least one of peak height, peak area, frequency and chemometric parameters, and (d) actuating the removal device when a signal from the infrared fiber optic probe is between pre-selected values for at least one of peak height, peak area, frequency and chemometric parameters for the sample of the material.

Abstract: This surgical device uses a laser beam to coagulate tissue. The elongate device carries the beam through an optical fiber that has a chamfered end for deflecting the beam out of a distal end of the device at an angle. Tissue coagulation is monitored using a magnetic resonance imaging system that provides periodic tissue temperature data. A small fluid supply duct provides cooling fluid that expands to a gas near the distal end of the device, thereby cooling the tip.

Abstract: Elastographic images provide visualization in two or three dimensions of RF ablation lesions to guide in the ablation process. Compression may be applied using the RF probe. A similar technique may be applied to in vivo imaging of soft tissue without ablation.

Abstract: In a measuring space of the object (1), an essential measurement region (41, 61, 71, 81, 111, 131) having a center region of the measuring space and a plurality of peripheral measurement regions (42, 62, 63, 72, 82, 112, 132) which do not have any region overlapped with the essential measurement region are set. Then, the essential measurement region is combined with a selected peripheral portion of the plurality of the peripheral measurement regions to measure in a preceding manner a nuclear magnetic resonance signal from the object as data of the measuring space. The essential measurement region is combined with the peripheral measurement region of the plurality of the peripheral measurement regions which has not been selected in the preceding measuring step to measure a nuclear magnetic resonance signal from the object as data of the measuring space.

Abstract: With the beam scanning probe system for surgery, a pointer indicating the observation point of a beam scanning probe is superimposed upon an image of a lesion to be operated on in the head which is obtained via a TV camera or a surgery microscope, and the superimposed image information is registered as such in an image recording device. With the beam scanning probe system for surgery, information of a cytological picture is also registered in the image recording device. With the beam scanning probe system for surgery, the image recording device registers the two image information in a paired fashion. Through this arrangement, the beam scanning probe system for surgery can smoothly locate, for a given cytological picture, a site of a tumor to be treated from which the picture was obtained, which will ease the operation.

Abstract: New or significantly changed skin lesions are detected by providing digital baseline image data of an area of a subject's skin by placing a calibration piece on the area and then positioning a digital camera to frame the area within a field of view of the camera and digitally photographing the area to produce a digital baseline image of the area. The digital baseline image is downloaded from the camera to a computer, which digitally filters the baseline image to produce a partially transparent baseline image scaled to fit over a viewfinder display of the camera. The filtered baseline image is printed on a transparent sheet to produce template. Substantially later, a calibration piece is placed on the area, and the template is placed over the viewfinder display of the camera. The camera is positioned to frame that area within the field of view so as to align a live image of the area with the baseline image on the template. The area is photographed to produce a digital current image thereof.

Abstract: An optical CT scanner for small laboratory animals comprises a housing having a vertical through opening through which a test subject is passed through during a scanning session, the housing including a peripheral slot disposed transversely through the perimeter of the opening; a movable horizontal table disposed through the opening, the table being split with a horizontal slot aligned with the peripheral slot; a scanning head rotatable about the opening, the scanning head including a light beam directed toward the peripheral slot, the scanning head including a plurality of collimators directed toward the peripheral slot, the scanning head including a plurality of main photodetectors to detect the light beam after passing through the test subject and the collimators; a perimeter photodetector adapted to provide perimeter data of the test subject during a scanning session; an electrical circuit to amplify and digitize the output from the photodetectors; and a first computer programmed to reconstruct an image o

Abstract: A portable, hand-holdable Blanching Response Tester apparatus (BRT) pressable against the skin of a human patient to provide an indication of a non-blanchable erythema indicative of an incipient pressure sore includes a housing having in a front end wall thereof an optically transmissive window and within the housing a broad-band light source electrically energizable to emit light including energy in the near infrared (0.8? to 1.5?) outwards through the window. A first, leading photodetector spaced laterally apart from the light source and a second, trailing photodetector spaced equidistant from the light source in an opposite direction have fields of view which include regions of the skin ahead of an behind a central area of the skin illuminated by the light source.

Abstract: An imaging apparatus in which an imaging head having an observation hole for intaking images of an object to be observed formed at a top end is exchangeably mounted to a main body having an imaging device and an illumination light source wherein the imaging head is provided with a plurality of optical fibers for guiding a light from the illumination light source and illuminating the same to the object, light incident ends of respective optical fibers are disposed at positions opposing to emission ends of the illumination light source, and the light emission ends are circularly disposed around the image pick-up optical axis, whereby an appropriate illumination light in accordance with a magnifying ratio can be illuminated without disposing an illumination light source such as of LEDs to an imaging head such as an exchangeable lens unit.

Abstract: Methods and systems for measuring transducer movement are provided. For example, free-hand scanning for three-dimensional imaging is provided. An optical sensor within the transducer measures motion along the skin surface similar to measuring movement of a personal computer mouse with an optical sensor. Alternatively or additionally, the transducer is tilted at an angle other than perpendicular to the skin surface generally towards or away from the direction in which the transducer is translated. The transducer is then translated while maintaining the angle. Motion to or from the transducer is measured, and a component of the motion measured while the transducer is maintained at an angle is parallel to the direction of translation. The component of motion is angle corrected and used to determine a distance of travel.

Abstract: Systems and methods for the orientation of soft tissue such as breast tissue for enhanced accuracy of imaging and/or procedures such as a biopsy or excision are disclosed. The system for orientating and maintaining the orientation of soft tissue generally includes a frame defining an opening, the frame being configured to orient and immobilize an area of soft tissue positioned on one side of the opening, an attachment mechanism to secure the frame to an attachment region defined by the area of soft tissue or by a skin surface overlying the area of soft tissue, to facilitate orienting and immobilizing the area of soft tissue, and an imaging device to image the area of soft tissue. The opening may allow a probe of the imaging device or imaging energy transmitted by the imaging device to be movable therein for image scanning of the soft tissue. The probe, e.g., an ultrasound transducer can be rotated within the frame such that the probe scans at least either of two perpendicular directions within the frame.

Abstract: A portable 3D ultrasound device having an ultrasound transducer. The ultrasound transducer includes a transducer array with a plurality of transducer elements arranged in a plurality of dimensions, the transducer array including an emitter to emit ultrasound energy, a receiver to receive responses generated in accordance with the ultrasound energy, a plurality of sub-array beamformers, a signal processor to convert the generated responses into a 3D ultrasound image and a display unit to display the 3D ultrasound image.

Abstract: A control device and measurement system for a living body applies lights of at least one wavelength in a visible-infrared region to a plurality of incident positions on a surface of the living body, and a light detector detects lights transmitted through the living body at a plurality of detection positions on the surface of the living body. An operation unit determines a type of output signal, based on an intensity of the transmitted light and pre-stored reference data, and outputs a signal indicative thereof as the type of output signal. An external equipment executes a functional operation according to the type of output signal from the operation unit. The incident positions and the detection positions are alternately disposed in square lattice form and middle points between the incident positions and detection positions adjacent to one another are defined as measurement positions.

Abstract: The imaging system can comprise a plurality of elongated rails, a scanhead assembly, and a small animal mount assembly. The scanhead assembly is selectively mounted onto a first rail and is constructed and arranged for movement in a linear bi-directional manner along the longitudinal axis of the first rail. The small-animal mount assembly is selectively mounted onto a second rail and is constructed and arranged for movement in a linear bi-directional manner along the longitudinal axis of the second rail. The second rail being mounted relative to the first rail such that the longitudinal axis of the second rail is at an angle to the longitudinal axis of the first rail. The imaging system can also comprise a needle injection assembly that is selectively mounted onto the third rail and is constructed and arranged for movement in a linear bi-directional manner along the longitudinal axis of the third rail.

Abstract: The present invention relates to a method and a device for transporting a molecule through a mammalian barrier membrane of at least one layer of cells comprising the steps of: ablating said membrane with an electric current from an array of treatment electrodes; and utilizing a driving force to move said molecule through said perforated membrane.

Abstract: Systems and methods are provided for positioning a therapy device, such as an ultrasound transducer, using a tilt sensor carried by the transducer and a positioner coupled to the transducer. The positioner provides roll and pitch control as well as translating the transducer in lateral and longitudinal directions. A processor receives signals from the tilt sensor corresponding to the actual rotational orientation of the transducer and controls the positioner to adjust the orientation of the therapy device until a desired position is achieved.

Abstract: According to the invention, an ultrasonic apparatus for therapeutical use suitable for remedy by the irradiation of an ultrasonic wave low in the degree of convergence using medicine that stays in a disease region, reduces the threshold of cavitation caused by an ultrasonic wave and secondarily generates active oxygen by the acoustic cavitation caused by the ultrasonic wave is provided. The ultrasonic apparatus for therapeutical use is provided with a belt wearable in a position (on the abdomen of a patient) that surrounds a diseased part and unit ultrasonic radiators can be mounted in an arbitrary position of the belt.

Abstract: A method and a system is provided for discriminating between healthy cervical tissue and pathologic cervical tissue based on the fluorescence response of the tissue to laser excitation (LIF) and the backscatter response to illumination by white light (in the spectral range of 360 to 750 nm). Combining LIF and white light responses, as well as evaluating a spatial correlation between proximate cervical tissue sites in conjunction with a statistically significant “distance” algorithm, such as the Mahalanobis distance between data sets, can improve the discrimination between normal and abnormal tissue. The results may be displayed in the form of a map of the cervix representing the suspected pathology.