Abstract: A cardiovascular health assessment score, representing a working tissue flow and indicating the dependence on central and peripheral control mechanisms, is generated by the evaluation system and used to support a variety of individualized medicine and health applications. One or more of the individualized medicine and health applications may be implemented as part of the evaluation system and incorporate the cardiovascular health assessment.

Abstract: A method of fixating an implantable heart help device in a human patient is provided. The method comprises the steps of: cutting the skin of said human patient, dissecting an area of the body comprising bone, and fixating said implantable heart help device to said part of the body comprising bone.

Abstract: An apparatus that monitors information associated with an oral cavity is provided, the apparatus comprising: a three-dimensional oral appliance; a data collection device having at least one sensor and/or hydrogel like material configured to sense the information associated with the oral cavity; an interface device cooperatively coupled to the data collection device, the interface device configured to transfer the information from the sensor device to a receiving device external to the oral cavity or the entire device is analyzed.

Abstract: This document discusses, among other things, systems and methods to determine a response between received cardiac electrical information from a subject, such as a time of a P wave, and received cardiac acceleration information of the subject, such as a time of a first heart sound (S1) or a second heart sound (S2), across a set of stimulation signals provided to the subject at different AVD intervals, and determining one or more cardiac resynchronization therapy (CRT) parameters using an inflection point of the determined response.

Abstract: An implantable medical device includes a detecting unit, a control unit and a communication unit. The control unit uses a seizure prediction algorithm to predict epilepsy seizure events in real time based on physiological information detected by the detecting unit, and stores internal data which comprise the detected physiological information and prediction information about the prediction result. The control unit is configured to, in a first communication mode, control its memory unit and communication unit to transmit the internal data to the external monitoring device, and in a second communication mode, control the communication unit to receive an updated seizure prediction algorithm from the external monitoring device and stores the algorithm in the memory unit for predicting seizure events.

Abstract: The present invention relates to a stress analysis method including: acquiring bio-signals from a test subject; calculating a probability of each of a plurality of stress level values by processing the bio-signals using a deep neural network algorithm; estimating a stress level value with the maximum probability of the plurality of stress level values as a stress level value of the test subject; determining usefulness of the estimated stress level value; and outputting the estimated stress level value determined to be useful through the determination of usefulness, as the final stress level.

Abstract: This document discusses, among other things, systems and methods to determine a response curve between received cardiac electrical information from a subject, such as a time of a P wave, and received cardiac acceleration information of the subject, such as a time of a first heart sound (S1) or a second heart sound (S2), to a set of stimulation signals provided to the subject at different AVD intervals. In certain examples, one or more cardiac resynchronization therapy (CRT) parameters can be determined for the subject using the determined response curve.

Abstract: A defibrillation system that includes a first defibrillation device and a second defibrillation device. The first defibrillation device including a therapy module, a communication module, a physiological parameter module and a timing control unit. The second defibrillation device including a therapy module and a communication module. The timing control unit configured to output an instruction to cause the therapy module of the first defibrillator and the therapy module of the second defibrillator to each discharge an energy delivery according to a timing relationship.

Abstract: A method of measuring biological signals of a person including obtaining physiological signals; converting the physiological signals to an energy entropy signal, determining one or more statistical features based on the energy entropy signal, and selecting and combining two or more of the features.

Abstract: A laser therapeutic apparatus includes a laser and a therapeutic optical fiber. The therapeutic optical fiber is configured for being implanted into a body of a patient during surgery to perform a repair treatment on a spinal cord site to-be-treated by irradiation and then being removed from the body of the patient after the surgery. The therapeutic optical fiber includes N number of laser fibers, N?1 number of optical fiber connection components, an optical fiber guiding structure, and an optical fiber controller; the N number of laser fibers are coupled with one another by the N?1 number of optical fiber connection components to form a cascaded optical fiber structure, an end of the cascaded optical fiber structure is coupled to the optical fiber guiding structure, and another end of the cascaded optical fiber structure is coupled to the optical fiber controller.

Abstract: A method includes locating the triangle of Koch region in the right atrium of a patient's heart; securing at least one electrode of an implantable lead or device to cardiac tissue from the triangle of Koch region to deliver ventricle-from-atrium (VfA) cardiac therapy; and testing the location or depth of the at least one electrode to configure VfA cardiac therapy. Locating the target implant region in the triangle of Koch region may include detecting an atrial slow pathway potential (ASP) or atrial pacing output.

Abstract: A brain mapping system and methods that allow to predict and monitor the risk of suicide and provide personalized therapy. The brain mapping system and methods detect if brain dysfunctions (injuries) are located in suicidal hubs that trigger increased suicidal ideation and high risk of suicide. The brain mapping technology is suited for different technologies and allows to monitor the effects of therapy, provide precise therapy to decrease the risk of suicide.

Abstract: A method of predicting physiological alarm frequency by patient monitors includes collecting patient monitoring data of multiple patients in at least a first healthcare environment, and then determining an alarm rate model based on the patient monitoring data, wherein the alarm rate model describes alarm rates at a range of alarm configurations in the first healthcare environment. Initial alarm rate data is collected for a second healthcare environment, wherein the initial alarm rate data includes at least one alarm rate at at least one known alarm configuration within the range of alarm configurations. An alarm rate transform is then calculated for the second healthcare environment comparing the initial alarm rate data for the second healthcare environment to the alarm rate model.

Abstract: In some examples, controlling delivery of CRT includes controlling an implantable medical device to deliver ventricular pacing according to a sequence of different values of a CRT parameter, and acquiring first and second electrograms from respective first and second electrode vectors. For each value of the CRT parameter, a value of a metric of comparison of a first activation interval between occurrences of a first fiducial of a cardiac cycle and a second fiducial of the cardiac cycle detected in the first electrogram to a second activation interval between occurrences of the first fiducial and the second fiducial detected in the second electrogram may be determined. A target value of the metric of comparison may be identified and an updated value of the CRT parameter determined based on the target value. The system then may control the IMD to deliver ventricular pacing at the updated value of the CRT parameter.

Abstract: Provided is an apparatus for estimating bio-information which estimates bio-information from a user. The apparatus for estimating bio-information according to an embodiment of the present disclosure includes: a spectrometer configured to obtain, absorbance from a user; a physiological information obtainer configured to obtain metabolic and physiological information including a concentration of carbon dioxide (CO2); and a processor configured to estimate bio-information based on the absorbance and the metabolic, and physiological information by using a predictive model corresponding to the obtained metabolic and physiological information.

Abstract: In a medical device system, a computer apparatus is configured to receive body surface electrical signals from an electrode apparatus including multiple external electrodes. The computing apparatus generates electrical dyssynchrony data from the body surface electrical signals during delivery of His bundle pacing pulses and identifies effective His bundle capture based on the electrical dyssynchrony data. The computing apparatus generates an indication of His bundle capture in response to identifying the effective His bundle capture.

Abstract: An electroporation device having a battery pack including a plurality of battery cells and at least one lead in electrical communication with a circuit board. The battery pack including a safety switch and a controller for selectively placing the battery cells in electrical communication with the one lead. Where the controller is in operable communication with the safety switch such that when the controller detects one or more operating conditions the controller instructs the safety switch to electrically isolate the lead from the battery cells. The battery pack also includes a manual switch, and where activation of the switch causes the controller to instruct the safety switch to electrically isolate the lead from the battery cells.

Abstract: Based on traditional Chinese medicine and ancient Eight-Trigram theory, a wearable five-color phototherapy device is invented for a unique painless, drug-free, non-invasive, and true green organic therapy by using light energy on some particular areas of a person's skin. There are multiple light-emitting components which is a number of light-emitting elements arranged in each of Eight-Trigram positions are designed on the bottom of this device. These multiple light-emitting components produce color of red or green or white or yellow or black or no color in each of Eight-Trigram positions. A software or App is developed to directly or remotely control and communicate with such device and provide the optimal solution for the five-color phototherapy.

Abstract: The present disclosure relates to a wearable monitor device and methods and systems for using such a device. In certain embodiments, the wearable monitor records cardiac data from a mammal and extracts particular features of interest. These features are then transmitted and used to provide health-related information about the mammal.

Abstract: Apparatus is provided for treating an intervertebral disc of a subject, the apparatus including at least one intra-pulposus exposed electrode surface, which is configured to be implanted in a nucleus pulposus of the intervertebral disc; and one or more extra-pulposus exposed electrode surfaces, which are configured to be implanted outside the nucleus pulposus, in electrical communication with the intervertebral disc. Control circuitry is electrically coupled to the at least one intra-pulposus exposed electrode surface and one or more extra-pulposus exposed electrode surfaces. The control circuitry is configured to treat disc herniation by applying a voltage of less than 1.2 V between the at least one intra-pulposus exposed electrode surface and the one or more extra-pulposus exposed electrode surfaces. Other embodiments are also described.