Patents Examined by Bruce D. Gray
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Patent number: 5077426Abstract: A process for preparing .alpha.-formylamino nitriles of the formula Ia ##STR1## and Ib ##STR2## where R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are identical or different and each is hydrogen or unsubstituted or substituted, with substituents which are inert under the reaction conditions, aliphatic or heteroaliphatic radicals with 1 to 10, cycloaliphatic or heterocycloaliphatic radicals with 3 to 6, araliphatic radicals with 7 to 12, heteroaraliphatic radicals with 4 to 12, aromatic radicals with 6 to 10 or heteroarometic radicals with 3 to 10 carbon atoms, with the priviso that at least one of R.sup.1 and R.sup.2 or R.sup.3 and R.sup.4 is hydrogen, comprises reacting an iminodiacetonitrile of the formula II ##STR3## where R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the abovementioned meanings, with formamide of the formula III ##STR4## in the presence of formic acid or with a compound which provides formic acid, in the presence of acids.Type: GrantFiled: December 13, 1990Date of Patent: December 31, 1991Assignee: BASF AktiengesellschaftInventors: Rolf Fikentscher, Michael Kroener
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Patent number: 4990289Abstract: Neutral lipids are provided characterized by binding to phorboid and ingenoid receptors. These lipids are found in a wide variety of cellular sources as well as milk and may be isolated by specific extraction and chromatographic procedures. Depending upon the source, the glycerides may be mono-or di-glycerides, wherein the total number of carbon atoms of the fatty acids is in the range of 18 to 26, so that the monoglyceride has a fatty acid of at least 18 carbon atoms, while the di-glyceride has a fatty acid of at least 14 carbon atoms.Type: GrantFiled: October 17, 1986Date of Patent: February 5, 1991Assignee: OncogenInventors: Mohammed Shoyab, George J. Todaro
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Patent number: 4957511Abstract: A dispersing agent for solid particles in water, which is a tall oil pitch partially esterified with a polyalkylene glycol mainly composed of ethylene oxide units of a molecular weight of above 600 or a monoester or monoether thereof and optionally also aminated having a residual acid value higher than 3, and a process for preparing said dispersing agent which comprises heating the two reactants at 200.degree.-285.degree. C. for so long that the maximum acid value of the reaction mixture at this temperature is reduced at least 2 units. The dispersing agent can be used to disperse coal particles in water.Type: GrantFiled: March 19, 1984Date of Patent: September 18, 1990Assignee: Bergvik Kemi ABInventor: Helena Ljusberg-Wahren
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Patent number: 4935551Abstract: m-Diisopropylbenzene dihydroperoxide is produced in good yield in a continuous process by the oxidation of diisopropylbenzene, comprised of major amounts of the m-isomer and less than 6% of the o-isomer, under anhydrous, non-alkaline conditions with oxygen or air at about 85.degree. C.-95.degree. C.Type: GrantFiled: December 22, 1987Date of Patent: June 19, 1990Assignee: Indspec Chemical CorporationInventor: Ching-Yong Wu
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Patent number: 4931466Abstract: A compound of the chemical formula (I) ##STR1## in a specific crystalline form, processes for its preparation, and its use for pest control.Type: GrantFiled: February 15, 1989Date of Patent: June 5, 1990Assignee: BASF AktiengesellschaftInventors: Siegfried Kersten, Karl-Friedrich Jaeger, Karl-Heinz Koenig, Albrecht Mueller, Josef B. Pawliczek, Hans-Gert Recker, Wolfgang Rohr, August Wigger
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Patent number: 4931465Abstract: Fungicidally active novel benzaldoxime carbamate derivatives of the formula ##STR1## in which X represents hydrogen or halogen,Y represents halogen or alkyl,Z represents hydrogen, halogen, alkyl, alkoxy or halogenoalkyl, andR represents alkyl, halogenoalkyl, cyanoalkyl, and also phenyl or phenylalkyl, both of which are optionally monosubstituted to polysubstituted by identical or different substituents, or represents tosyl, or cycloalkyl which is optionally monosubstituted to polysubstituted by identical or different substituents,with the exception of those compounds in which X represents 2-chloro, Y represents 6-chloro and Z represents 4-methyl. Many of the benzaldoxime intermediates therefor are also new.Type: GrantFiled: March 8, 1988Date of Patent: June 5, 1990Assignee: Bayer AktiengesellschaftInventors: Christa Fest, Wilhelm Brandes, Stefan Dutzmann, Gerd Hanssler, Karl-Heinz Kuck
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Patent number: 4931088Abstract: A compound of the formula ##STR1## in which each of X and Y represents a halogen atom, R represents a hydrogen atom, a lower alkyl group or an agronomically acceptable soluble salt ion, R.sup.1 represents a lower alkyl group, R.sup.2 represents a hydrogen atom or a lower alkyl group, and Z represents an oxygen or sulfur atom. This compound is useful as herbicide.Type: GrantFiled: August 16, 1988Date of Patent: June 5, 1990Assignee: Mitsubishi Petrochemical Co., Ltd.Inventors: Atsushi Goh, Keiji Endo, Yuri Yamamoto
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Patent number: 4927857Abstract: A process for methanol production includes preparing a hydrogen containing synthesis gas by autothermally reforming a hydrocarbonaceous feed, such as a hydrocarbon feed, with oxygen and steam in an autothermal reformer utilizing a first, monolithic catalyst having a palladium and platinum containing catalyst therein, and a second, platinum group metal steam reforming catalyst. The autothermal reformer provides a relatively simple and compact reactor within which a wide variety of hydrocarbonaceous feeds, from heavy hydrocarbon feedstocks to natural gas, may be utilized for producing methanol synthesis gas, which is advantageously carried out at an elevated pressure. By controlling H.sub.2 O to carbon and O.sub.2 to carbon feed ratios, a given feed can be autothermally reformed to yield a synthesis gas of desired ratio of 1 H.sub.2 to (2CO+3CO.sub.2) for methanol production.Type: GrantFiled: January 18, 1989Date of Patent: May 22, 1990Assignee: Engelhard CorporationInventors: William T. McShea, III, Robert M. Yarrington
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Patent number: 4927928Abstract: An aromatic benzamido compound having the formula ##STR1## wherein R.sub.1 represents --CH.sub.2 OH, --CHOHCH.sub.3 or --COR.sub.5,R.sub.5 represents hydrogen, lower alkyl, or --OR.sub.6 or ##STR2## R.sub.6 represents hydrogen, lower alkyl or mono- or polyhydroxyalkyl, r' and r" represent hydrogen, lower alkyl, mono or polyhydroxyalkyl, aryl or benzyl optionally substituted, the residue of an amino acid or aminated sugar or taken together form a heterocycle,R.sub.2 represents an .alpha.,.alpha.'-disubstituted alkyl having 4-12 carbon atoms or mono or polycyclic cycloalkyl having 5-12 carbon atoms, the linking carbon of which is quaternary,R.sub.3 represents hydrogen or alkyl having 1-10 carbon atoms, andR.sub.4 represents a hydrogen, lower alkyl or hydroxy, andthe salts of this aromatic benzamido compound when R.sub.6 represents hydrogen.Type: GrantFiled: January 21, 1987Date of Patent: May 22, 1990Assignee: Centre International de Recherches Dermatologiques C.I.R.D.Inventors: Braham Shroot, Jacques Eustache, Jean-Michel Bernardon
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Patent number: 4925969Abstract: Ethyl-.beta.-benzoyacrylate is reacted with an alkali metal salt of (S)-alanine or an alkali metal salt of N.sup.6 -trifluoroacetyl-L-lysine to form the corresponding Michael addition product, and not less than an equivalent amount of acid is added after completion of the Michael addition to prevent conversion of the (S,S) form of the product to the (R,S) form.Type: GrantFiled: March 16, 1989Date of Patent: May 15, 1990Assignee: Kanegafuchi Kagaku Kogyo Kabushiki KaishaInventors: Satomi Takahashi, Yasuyoshi Ueda, Kazuhiko Yamada, Yukio Yamada, Takehiko Yamane, Yoshifumi Yanagita, Yoshio Shimada, Kiyoshi Watanabe, Michio Nomura, Takehisa Ohashi, Kenji Inoue
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Patent number: 4925958Abstract: The invention relates to a process for the preparation of compounds of the formula I ##STR1## in which R.sup.1 denotes (substituted) aryl or (substituted) cyclohexyl and R.sup.2 =alkyl, in which a compound of the formula R.sup.1 --NH.sub.2 is reacted with at least twice the molar amount of glyoxylic acid in the presence of water and the resulting acid is then esterified.Type: GrantFiled: June 16, 1988Date of Patent: May 15, 1990Assignee: Hoechst AktiengesellschaftInventors: Roland Schmierer, Rudolf Kunstmann
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Patent number: 4925981Abstract: A method of isolating and recovering methacrylic acid from a methacrylic acid-containing reaction product gas resulting from the vapor-phase catalytic oxidation of isobutylene, tertiary butanol or isobutyraldehyde, which comprises introducing the reaction product gas comprising methacrylic acid and various by-products including high boiling substances at a high temperature of 250.degree. to 300.degree. C. into a cooling zone, rapidly cooling the gas therein to a temperature of not more than 100.degree. C. to condense methacrylic acid and thus isolate methacrylic acid, while also converting the high boiling substances to fumes, thereafter introducing the cooled gas containing said fumes into a venturi scrubber, contacting it therein with an aqueous medium to remove said fumes, finally introducing the treated gas into a methacrylic acid-absorbing zone and absorbing methacrylic acid by absorption into an aqueous medium.Type: GrantFiled: January 16, 1987Date of Patent: May 15, 1990Assignee: Nippon Shokubai Kagaku Kogyo Co., Ltd.Inventors: Noboru Shimizu, Hiroshi Yoshida, Hiromiki Daigo, Shoichi Matsumoto
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Patent number: 4923642Abstract: Quaternary ammonium compounds containing one or two long-chain ester or amide radicals of etherified hydroxycarboxylic acids and, for the remainder, short-chain radicals, which are liquid to pasty substances that may readily be dissolved or dispersed in water or alcohol/water mixtures. They may be used in dilute or concentrated, storable form for softening fabrics without the absorbency of the treated fabrics being adversely affected. The quaternary ammonium compounds are obtained by reaction of epoxyfatty acid esters with amines and subsequent quaternization.Type: GrantFiled: November 16, 1987Date of Patent: May 8, 1990Assignee: Henkel Kommanditgesellschaft auf AktienInventors: Horst Rutzen, Horst Baumann, Bert Gruber
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Patent number: 4923888Abstract: The present invention relates to novel compounds of the general formula (I), ##STR1## wherein R stands for hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-4 alkoxy or C.sub.1-4 acylamino group;R.sub.1 means hydrogen or a carboxyl-protective group; andR.sub.2 represents a --(CH.sub.2).sub.n --CO.sub.2 R.sub.5 group, whereinn is 1, 2, 3 or 4; andR.sub.5 stands for hydrogen or a carboxyl-protective group; orR.sub.2 means a --(CH.sub.2).sub.n --NH.sub.2 group, whereinn is 1, 2, 3 or 4of E and/or Z configurtion as well as their salts.The compounds according to the invention show a cytoprotective effect and promote the healing of the stomach ulcer. Their toxicity is low.Type: GrantFiled: September 26, 1988Date of Patent: May 8, 1990Assignee: Richter Gedeon Vegyeszeti Gyar RTInventors: Tamas Fodor, Laaszlo Dobay, Jaanos Fischer, Bela Stefkoo, Elemeer Ezer, Judit Matuz, Katalin Saghy, Laaszlo Szporny
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Patent number: 4921998Abstract: Antithrombotic, antiatherosclerotic and antiischaemic compounds of the formula ##STR1## in which R.sup.1 is ##STR2## or SO.sub.2 R.sup.4, R.sup.3 is aryl, substituted aryl, heteroaryl, aralkyl or the group ##STR3## R.sup.4 is aryl or substrituted aryl, R.sup.2 is OH, alkoxy, phenoxy, benzoxy or NR.sup.5 R.sup.6, andR.sup.5 and R.sup.6 each independently is hydrogen or alkyl, orone of the radicals R.sup.5 or R.sup.6 is benzyl, and physiologically acceptable salts thereof with mono- and divalent cations.Type: GrantFiled: May 15, 1989Date of Patent: May 1, 1990Assignee: Bayer AktiengesellschaftInventors: Ulrich Niewohner, Franz-Peter Hoever, Bodo Junge, Elisabeth Perzborn, Friedel Seuter, Volker-Bernd Fiedler
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Patent number: 4919844Abstract: A method and apparatus are described for reforming hydrocarbons, particularly natural gas, to form hydrogen wherein the reformation is performed in a reactor in which the heat of reformed products are utilized to reform the hydrocarbons in a catalytic tube reformer. The reformer can be used in conjunction with a traditional steam reformer to produce hydrogen with less energy consumption, lower steam production and less capital cost.Type: GrantFiled: August 16, 1984Date of Patent: April 24, 1990Assignee: Air Products and Chemicals, Inc.Inventor: Shoou-I Wang
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Patent number: 4918216Abstract: .alpha.-L-aspartyl-L-phenylalanine methyl ester or the hydrohalide thereof is prepared by esterifying .alpha.-L-aspartyl-L-phenylalanine or .alpha.-L-aspartyl-L-phenylalanine which has been formed in situ by treating an N-protected-.alpha.-L-aspartyl-L-phenylalanine in an aqueous solution of sulfuric acid or a methanol-containing aqueous solution of sulfuric acid in the presence of an alkali metal halide or alkaline earth metal halide in a medium composed of sulfuric acid, water and methanol, thereby to allow the resulting .alpha.-L-aspartyl-L-phenyl-alanine methyl ester to precipitate as its corresponding hydrohalide, and then isolating the hydrohalide; and when the preparation of the methyl ester is desired, neutralizing the hydrohalide.Type: GrantFiled: May 25, 1989Date of Patent: April 17, 1990Assignee: Mitsui Toatsu Chemicals, IncorporatedInventors: Ryuichi Mita, Toshio Katoh, Chojiro Higuchi, Takeshi Oura, Akihiro Yamaguchi
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Patent number: 4916252Abstract: A process for preparing an optically active alcohol is disclosed, which comprises asymmetrically hydrogenating a 1,3-diketone in the presence of a ruthenium-optically active phosphine complex as a catalyst. The resulting alcohol has high optical purity.Type: GrantFiled: June 16, 1988Date of Patent: April 10, 1990Assignee: Takasago International CorporationInventors: Noboru Sayo, Takao Saito, Hidenori Kumobayashi, Susumu Akutagawa, Ryoji Noyori, Hidemasa Takaya
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Patent number: 4910327Abstract: There are provided novel alkyl esters of substituted 2-methyl-3-quinolinecarboxylic acid and quinoline-2,3-dicarboxylic acid; novel dialkyl 3-(substituted)phenylaminobut-2-ene-dioates, useful as intermediates for the preparation of highly effective 2-(2-imidazolin-2-yl)quinoline herbicidal agents and methods for the preparation thereof.Type: GrantFiled: March 27, 1989Date of Patent: March 20, 1990Assignee: American Cyanamid CompanyInventor: Robert F. Doehner, Jr.
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Patent number: 4908470Abstract: Methyl 4-dimethylamino-3,5-dimethoxybenzoate, an intermediate in the preparation of the antibacterially active aditoprim, is obtained from 4-amino-3,5-dibromobenzoic acid by replacement of the bromine atoms by methoxy groups and subsequent methylation.Type: GrantFiled: November 30, 1988Date of Patent: March 13, 1990Assignee: Hoffman-La Roche Inc.Inventors: Alfredo Guerrato, Martin Karpf, Hanny K. Berger, Ivan Kompis, Markus Schlageter