Abstract: There is disclosed herein improved processes for the preparation of mixtures of alkali metal salts of 1-hydroxy-3-oxa-1,2,4,5-pentane tetracarboxylate and alkali metal salts of 3,6-dioxa-1,2,4,5,7,8-octane hexacarboxylate wherein by-product calcium carbonate produced by the process of making such mixtures is employed in a recycle pattern to prepare additional amounts of mixtures of said compounds.

Abstract: Compounds of the formula: ##STR1## wherein R.sup.1 is a higher alkyl group which may be substituted; R.sup.2 is a hydrogen, a lower alkyl group which may be substituted, a lower alkanoyl group which may be substituted or a lower alkylthiocarbamoyl group; R.sup.3 is a primary to tertiary amino group or a quaternary ammonium group; and n is 2 or 3, and salts thereof, have antitumor activity and platelet activating factor inhibitory activity.

Abstract: A process for producing citric acid or other suitable acids and/or their salts from fermentation solutions. The process comprises removing high molecular weight impurities by means of membrane filtration and/or addition adsorption on a nonionic adsorption resin and removing low molecular weight impurities by anion and cation exchange and/or precipitating a citric acid as a calcium salt.

Abstract: 2-Methallyloxyphenol precursor to 2,3-dihydro-2,2-dimethyl-7-hydroxybenzofuran is prepared selectively and in good yield in the etherification of an alkali metal catecholate by methallyl chloride in an improved process using the same solvent medium for both the precursor and the hydroxybenzofuran, the process characterized by a solvent medium comprising an aromatic hydrocarbon solvent, the medium also containing an amine selected from alkylamines and N-heterocyclic amines. The amine forms a quaternary salt with the methallyl chloride in situ to catalyze the etherification and the aromatic solvent permits rearrangement of the product and Claisen closure to a benzofuran intermediate without solvent exchange.

Abstract: A method for the removal of the formyl group from an ester of an N-formyl peptide or N-formyl aminoacid, in which the ester is reacted with urea in the presence of a polar solvent and a strong acid.

Abstract: Process for preparing alkyl alkoxyalkylidenemalonate. An alkyl malonate is condensed with an orthoester in the presence of a carboxylic acid or its anhydride and a metal compound of the group formed by Cd, Hg, Bi, Mg.

Abstract: N-Hydrocarbyl hydrocarbylenediamine carboxylates, which can be made by the reaction of the appropriate diamine and organic monocarboxylic acid, demonstrate friction reducing properties when formulated into lubricants, particularly lubricating oils, and fuel consumption reduction properties when formulated into such lubricants or into fuels.

Abstract: A process for recrystallization of a brominated aromatic compound under pressure for purifying it from the contamination by bromine and hydrogen bromide, comprising the steps of: placing the brominated aromatic compound in a solvent or a combination of solvents selected from toluene, 1,dibromoethane, m-xylene, benzene, dichloromethane, chloroform, and 1,2-dichloroethane; adding into the resultant mixture a base or a combination of bases selected from pyridine, ethylene diamine, n-butylamine, tert-butylamaine, triethylamine, sodium ethoxide, sodium hydroxide, potassium hydroxide, sodium carbonate, and sodium bicarbonate; and heating the resultant mixture to a temperature above the atmospheric boiling point and at a pressure above the vapor pressure of the resultant material at that temperature.

Abstract: A method and apparatus for carrying out partial oxidation of hydrocarbon feeds to produce hydrogen rich gases suitable for steam reforming, utilizes a monolithic platinum and palladium containing catalyst. The process comprises introducing an oxygen containing oxidant gas (e.g., air), steam and a hydrocarbon feed into a catalytic partial oxidation apparatus comprising an adiabatic reaction vessel. The oxidation catalyst preferably comprises platinum, palladium and optionally rhodium distended upon a stabilized alumina washcoat. At least one half by weight of the hydrocarbon feed is catalytically oxidized in the monolith at a high throughput rate to produce an effluent suitable for further processing, such as steam reforming.

Abstract: Disclosed herein are N-acyl-N-napthoylglycines and methods of their preparation. The N-acyl-N-napthoylglycines are novel aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.

Abstract: An intermediate compound having the structural formula ##STR1## wherein R is halogen, C.sub.1 -C.sub.2 alkyl, C.sub.1 -C.sub.2 alkoxy, nitro; cyano; C.sub.1 -C.sub.2 haloalkyl, or R.sup.a SO.sub.n - wherein n is 0 or 2 and R.sup.a is C.sub.1 -C.sub.2 alkyl; R.sup.1 is hydrogen or C.sub.1 -C.sub.4 alkyl; R.sup.2 is hydrogen or C.sub.1 -C.sub.4 alkyl; or R.sup.1 and R.sup.2 together are alkylene having 2 to 5 carbon atoms; R.sup.3 is hydrogen or C.sub.1 -C.sub.4 alkyl; R.sup.4 is hydrogen or C.sub.1 -C.sub.4 alkyl; or R.sup.3 and R.sup.4 together can be oxo; R.sup.5 is hydrogen or C.sub.1 -C.sub.4 alkyl; R.sup.6 is hydrogen or C.sub.1 -C.sub.4 alkyl; or R.sup.5 and R.sup.6 together are alkylene having 2 to 5 carbon atoms; R.sup.7 and R.sup.8 independently are (1) hydrogen; (2) halogen; (3) C.sub.1 -C.sub.4 alkyl; (4) C.sub. 1 -C.sub.4 alkoxy; (5) trifluoromethoxy; (6) cyano; (7) nitro; (8) C.sub.1 -C.sub.4 haloalkyl; (9) R.sup.b SO.sub.n - wherein n is the integer 0, 1 or 2; and R.sup.b is (a) C.sub.1 -C.sub.

Abstract: A process for producing stable .alpha.-L-aspartyl-L-phenylalanine methyl ester, which comprises heat-treating crystals of .alpha.-L-aspartyl-L-phenylalanine methyl ester having a water content of from 5 to 15% by weight based on wet crystals, at a temperature of higher than 50.degree. C. and lower than 80.degree. for at least 30 minutes.

Abstract: A process for producing dry .alpha.-L-aspartyl-L-phenylalanine methyl ester, which comprises drying wet crystals of .alpha.-L-aspartyl-L-phenylalanine methyl ester by means of an air having an absolute humidity of at least 0.015 kg/kg or at most 0.01 kg/kg.

Abstract: Tertiary butyl esters of anticancer drugs are provided which have the following formula: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and are selected from the group consisting of H, F, Cl, Br, and I and R.sub.2 can also be NH.sub.2 ;R.sub.3, R.sub.4, and R.sub.5 are the same or different and are selected from the group consisting of H, F, Cl, Br, I, and C.sub.1 -C.sub.3 alkyl; wherein alkyl may be substituted with F, Cl, Br, or I, with the proviso that at least two of R.sub.3, R.sub.4, and R.sub.5 are alkyl or substituted alkyl; andn=0-4.The compounds of the present invention can be used in treating cancer by significantly increasing the brain levels of the drugs of the invention and their active metabolites.

Abstract: A process for preparing an alkoxylation catalyst in which the catalyst pre-mix is formed by admixing an alkoxylated alcohol with a calcium containing compound which is dispersible in the alkoxylated alcohol, an inorganic acid and an aluminum trialkoxide, the pre-mix being heated to a temperature and for a time sufficient to effect at least partial exchange reaction betweeen the alkoxide groups of the aluminum alkoxide and the hydroxyl groups of the alkoxylated alcohol. There is also disclosed and claimed an alkoxylation process utilizing the catalysts formed as described above.

Abstract: A method for producing an indan derivative represented by the formula: ##STR1## by condensing an N-(.alpha.-alkoxycarbonylaralkyl)-.alpha.-amino acid with an N-(indan-2-yl)glycine alkyl or aralkyl ester in the presence of a diphenyl phosphorochloridate, and a method for producing another indan derivative having anti-hypertensive activity by using the above intermediate indan derivative are useful for industrial production of the indan derivative having anti-hypertensive activity.

Abstract: 4,4'-dibromodiphenyl ether may be obtained in high yield and purity by the uncatalyzed "neat" bromination of diphenyl oxide, followed by methanol digestion.

Abstract: The explosive 1,3-diamino-2,4,6-trinitrobenzene, commonly known as DATB, is prepred from m-phenylenediamine by making the bis-urethane m-phenylenediamine, nitrating this bis-urethane to the bis-urethane of DATB and removing the urethane groups from the DATB by solvolysis in sulfuric acid.

Abstract: The invention relates to a process for the preparation of aspartylphenylalanine methyl ester from N-formylaspartylalanine methyl ester by treatment with an acid, characterized in that N-formylaspartylalanine methyl ester is treated at 30.degree.-60.degree. C. with at least 0.5 molar equivalent oxalic acid per mole of N-formylaspartylphenylalanine methyl ester in a solvent mixture in which N-formylaspartylphenylalanine methyl ester dissolves well and in which the oxalic acid salt of aspartylphenylalanine methyl ester is poorly soluble, after which the oxalic acid salt of aspartylphenylalanine methyl ester is removed by filtration, dissolved in water subsequently neutralized with the aid of an inorganic base with formation of free aspartylphenylalanine methyl ester.

Abstract: A process for producing dry .alpha.-L-aspartyl-L-phenylalanine methyl ester having an improved solubility by drying wet crystals of .alpha.-L-aspartyl-L-phenylalanine methyl ester, characterized in that the wet crystals of .alpha.-L-aspartyl-L-phenylalanine methyl ester are granulated so that the specific surface area during the drying operation is at least 4 m.sup.2 /g, followed by drying.