Patents Examined by C. M. S. Jaisle
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Patent number: 4026905Abstract: Compounds having a cation which is tetrathiafulvalene of 2,5-cyclohexadiene-1,4-diylidene-bis-1,3-dithiole or both, and an anion which is 7,7,8,8-tetracyano-p-quinodimethane or 11,11,12,12-tetracyano-2,6-naphthaquinonedimethane or both, are described. The above compounds are characterized by anions and cations which are both odd-electron species.Type: GrantFiled: December 26, 1972Date of Patent: May 31, 1977Assignee: Monsanto CompanyInventors: Morrel H. Cohen, Malcolm G. Miles, James D. Wilson
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Patent number: 4020168Abstract: Substituted 2,3-dihydro-1,4-oxathiins of the formula ##STR1## display useful plant growth regulant effects including herbicidal effects. Examples are 2,3-dihydro-5,6-diphenyl-1,4-oxathiin, and 2,3-dihydro-5-(4-methylphenyl)-6-phenyl-1,4-oxathiin 4-oxide. The compounds are useful for the selective control of grasses and as dwarfing agents, as well as for inhibition of vegetative and reproductive axillary growth, and for increasing the sugar content of sugar producing species. A number of these are new compounds.Type: GrantFiled: November 6, 1975Date of Patent: April 26, 1977Assignees: Uniroyal Inc., Uniroyal, Ltd.Inventors: Bruce A. Graham, Michael A. Puttock, Ethel E. Felauer, Robert W. Neidermyer
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Patent number: 4012514Abstract: Novel olefinic aryl ketone compounds of the formula: ##STR1## wherein R.sup.1 is hydrogen, halogen, C.sub.1-4 alkyl, or C.sub.1-4 alkoxy, R.sup.2 is hydrogen or halogen, and X is a group of the formula: ##STR2## and their non-toxic salts, which possess various useful pharmacological activities and can be produced by reaction of an acetylenic alcohol of the formula: ##STR3## wherein R.sup.1 and R.sup.2 are each as defined above with formaldehyde and an piperidine compound of the formula: , or its non-toxic salt; reduction of the resultant acetylenic aryl alcohol; and oxidation of the resultant olefinic aryl alcohol.Type: GrantFiled: July 29, 1975Date of Patent: March 15, 1977Assignee: Sumitomo Chemical Company, LimitedInventors: Junki Katsube, Masaru Nakao, Kikuo Sasajima, Isamu Maruyama, Masaharu Takayama, Keiichi Ono, Shigenari Katayama, Yoshihiro Tanaka, Shigeho Inaba, Hisao Yamamoto
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Patent number: 4012515Abstract: Novel olefinic aryl ketone compounds of the formula: ##STR1## wherein R.sup.1 is hydrogen, halogen, C.sub.1.sub.-4 alkyl, or C.sub.1.sub.-4 alkoxy, R.sup.2 is hydrogen or halogen, and R.sup.3 and R.sup.4 are each hydrogen, halogen, C.sub.1.sub.-4 alkyl or trifluoromethyl, and their non-toxic salts, which possess various useful pharmacological activities and can be produced by reaction of an acetylenic alcohol of the formula: ##STR2## wherein R.sup.1 and R.sup.2 are each as defined above, with formaldehyde and an amine of the formula: ##STR3## wherein R.sup.3 and R.sup.4 are each as defined above; reduction of the resultant acetylenic aryl alcohol; and oxidation of the resultant olefinic aryl alcohol.Type: GrantFiled: July 29, 1975Date of Patent: March 15, 1977Assignee: Sumitomo Chemical Company, LimitedInventors: Junki Katsube, Masaru Nakao, Kikuo Sasajima, Isamu Maruyama, Masaharu Takayama, Keiichi Ono, Shigenari Katayama, Yoshihiro Tanaka, Shigeho Inaba, Hisao Yamamoto
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Patent number: 4011235Abstract: The polyglycidyl compounds according to the invention can be manufactured by reacting epihalogenohydrin with compounds of the formula IV ##STR1## or the formula V ##STR2## in which 1. N DENOTES 2, 3 OR 4,2. A represents a 2-valent, 3-valent or 4-valent organic radical which either contains a N-heterocyclic or cycloaliphatic ring or 2 N-heterocyclic rings or 2-phenylene rings,3. either B denotes the --CH.sub.2.O.CO-- radical and m denotes the number 1, or B denotes the radical ##STR3## and m denotes O, and 4. R.sup.1 represents a divalent radical, which contains at least one hydrantoin ring or uracil ring.During the reaction hydrogen halide splits off. From curable mixtures containing polyglycidyl compounds according to the invention and a curing agent such as hexahydrophthalic anhydride or phthalic anhydride are obtained products with good mechanical and electrical properties.Type: GrantFiled: July 7, 1975Date of Patent: March 8, 1977Assignee: Ciba-Geigy CorporationInventors: Jurgen Habermeier, Hans Batzer, Daniel Porret
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Patent number: 4011240Abstract: This invention relates to a new group of substituted cysteines having the general formula: ##STR1## in which: Ar is an aromatic or heteromonocyclic group, such as 2-thienyl or phenyl, which may be substituted by a halogen atom or by a lower alkyl or alkoxy group, and R is a hydrogen atom or a lower alkyl group.These compounds are of use in human therapeutics as liquifiers for bronchal secretions in complaints of the respiratory passage and, in particular, in chronic bronchitis.The invention also relates to a method of preparing these compounds and to the application of these compounds, particularly in human therapeutics.Type: GrantFiled: October 12, 1972Date of Patent: March 8, 1977Assignee: Centre Europeen de Recherches Mauvernay (CERM)Inventors: Roland-Yves Mauvernay, Andre Monteil, Jacques Simond, Jacques Moleyre, Norbert Busch
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Patent number: 4011326Abstract: Oxazolo[4,5-b]pyridine substituted in the 2-position with a polyhydrobicycloaryl group are topical anti-inflammatory agents. They are prepared by condensing a 2-amino-3-hydroxypyridine with the appropriate carboxylic compound.Type: GrantFiled: July 29, 1975Date of Patent: March 8, 1977Assignee: Merck & Co., Inc.Inventor: Norman P. Jensen
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Patent number: 4010170Abstract: Compounds containing the butenolide ring have a wide variety of chemical uses. The invention is a method of synthesizing .beta.-halobutenolides which are valuable intermediates in preparing a variety of butenolide ring containing compounds. The method comprises reacting an acetylenic alcohol with a mercuric halide to provide a vinylmercuric halide and carbonylating the vinylmercuric halide to provide a .beta.-halobutenolide.Type: GrantFiled: September 24, 1975Date of Patent: March 1, 1977Assignee: Iowa State University Research Foundation, Inc.Inventor: Richard Craig Larock
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Patent number: 4010169Abstract: Preparation and the antilipogenic utility of (E)-4-hydroxy-11,15-dioxoprosta-8(12),13-dien-1-oic acid .gamma.-lactones are disclosed.Type: GrantFiled: March 10, 1976Date of Patent: March 1, 1977Assignee: G. D. Searle & Co.Inventors: Leland J. Chinn, Karlene W. Salamon
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Patent number: 4009275Abstract: Phenoxypropylamine derivatives of the formula: ##STR1## (in which R.sub.2 is a halogen atom or a trifluoromethyl group) and R.sub.1 is a halogen atom or a C.sub.1 -C.sub.4 alkyl or C.sub.2 -C.sub.4 alkenyl group, and their pharmaceutically acceptable salts, which are useful as neuroleptic agents and can be prepared by reacting a compound of the formula: ##STR2## wherein X is a halogen atom and R.sub.1 is as defined above with a compound of the formula:H-Ywherein Y is as defined above.Type: GrantFiled: February 28, 1975Date of Patent: February 22, 1977Assignee: Sumitomo Chemical Company, LimitedInventors: Isamu Maruyama, Masaru Nakao, Kikuo Sasajima, Shigeho Inaba, Hisao Yamamoto
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Patent number: 4007279Abstract: A fungicidal compound having a general structure corresponding to a member selected from the group of 2,3-dicyano-5,6-dihydro-p-dithiin and its 5-alkyl derivatives, as expressed by the following general formula: ##STR1## wherein R stands for H or an alkyl radical of C.sub.1 - C.sub.6.Type: GrantFiled: January 28, 1975Date of Patent: February 8, 1977Assignee: Kureha Kagaku Kogyo Kabushiki KaishaInventors: Takaaki Ohtsuka, Keigo Satake, Shiro Yamazaki, Takeo Watanabe
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Patent number: 4007199Abstract: The polyglycidyl compounds according to the invention can be manufactured by reacting epihalogenohydrin with compounds of the formula IV ##STR1## or the formula V ##STR2## in which 1.) n denotes 2, 3 or 4, 2.) A represents a 2-valent, 3-valent or 4-valent organic radical which either contains a N-heterocyclic or cycloaliphatic ring or 2 N-heterocyclic rings or 2 phenylene rings, 3.) either B denotes the --CH.sub.2.O.CO-- radical and m denotes the number 1, or B denotes the radical ##STR3## and m denotes 0, and 4.) R.sup.1 represents a divalent radical, which contains at least one hydrantoin ring or uracil ring. During the reaction hydrogen halide splits off. From curable mixtures containing polyglycidyl compounds according to the invention and a curing agent such as hexahydrophthalic anhydride or phthalic anhydride are obtained products with good mechanical and electrical properties.Type: GrantFiled: July 7, 1975Date of Patent: February 8, 1977Assignee: Ciba-Geigy CorporationInventors: Jurgen Habermeier, Hans Batzer, Daniel Porret
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Patent number: 4006165Abstract: A process for converting maleic anhydride to .gamma.-butyrolactone by treating the anhydride with hydrogen in the presence of co-catalysts comprising palladium and nickel-copper chromite at elevated pressures and temperatures.Type: GrantFiled: August 4, 1975Date of Patent: February 1, 1977Assignee: Deutsche Texaco AktiengesellschaftInventors: Georg Michalczyk, Karl-Heinz Gluzek
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Patent number: 4005108Abstract: There are provided novel diterpenoid triepoxides, derived from Tripterygium wilfordii Hook F. which possess high and surprising antileukemic activity at dosage levels of micrograms/kilogram body weight.Type: GrantFiled: April 3, 1973Date of Patent: January 25, 1977Assignee: Research CorporationInventors: S. Morris Kupchan, William A. Court
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Patent number: 4005104Abstract: Selected novel vic-dialkoxyperfluoroalkyl-vic-diol cyclic sulfates, e.g., 2,3-dimethoxyhexafluorobutane-2,3-diol cyclic sulfate, useful for preparing the corresponding perfluoro-.alpha.-diketones, e.g., hexafluorobiacetyl (known), are synthesized by reacting SO.sub.3 with a vic-dialkoxypolyfluoroalkene, e.g., 2,3-dimethoxyhexafluorobutene-2.Type: GrantFiled: August 15, 1975Date of Patent: January 25, 1977Assignee: E. I. Du Pont de Nemours and CompanyInventor: Carl George Krespan
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Patent number: 4003904Abstract: The present invention encompasses a compound of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein Y is alkylene having 1-4 carbon atoms; R.sub.1 and R.sub. 2 together with N is a heterocyclic ring system consisting of an azamonocyclic ring of the formula ##STR2## wherein Z is oxygen, methylene, phenylhydroxymethylene, phenylcarboxymethylene or, phenylloweralkoxymethylene, or an azabicycloalkane structure having 6-9 carbon atoms and having at least 5 atoms in each ring of the azabicycloalkane structure; X is hydrogen, halogen, loweralkyl having 1-7 carbon atoms, or loweralkoxy having 1-7 carbon atoms; and Ar is phenyl, pyridyl, or monosubstituted phenyl wherein the substituent is halogen, loweralkyl having 1-7 carbon atoms, or loweralkoxy having 1-7 carbon atoms when R.sub.3 is hydrogen or Ar is 3 or 4 pyridyl when R.sub.3 is lower alkyl having 1-7 carbon atoms.Type: GrantFiled: April 16, 1975Date of Patent: January 18, 1977Assignee: G. D. Searle & Co.Inventor: Gilbert W. Adelstein
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Patent number: 4004022Abstract: A compound of the formula ##STR1## wherein R.sub.1 is lower alkyl;R.sub.2 and R.sub.3 are methyl, and R.sub.2 forms cyclo-alkylene of 5 to 6 carbon atoms by combining with R.sub.3 ;M is a substituent selected from the group consisting of --CH.sub.2 X and --CHX.sub.2 in which X is halogen;Is useful as fungicide.Type: GrantFiled: July 28, 1975Date of Patent: January 18, 1977Assignee: Nippon Soda Company LimitedInventors: Izumi Kumita, Akiyoshi Ueda, Kazuhiko Ohkuma, Sho Hashimoto, Akira Nakada, Masami Mizuno
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Patent number: 4004019Abstract: The invention is novel hydrocarbon ethers of aminophenol derivatives, and their use in preventing the proliferation of insects by interfering with their normal development and growth pattern.Type: GrantFiled: September 12, 1975Date of Patent: January 18, 1977Assignee: American Cyanamid CompanyInventors: William Wayne Brand, James Byron Lovell
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Patent number: 4003915Abstract: Tricyclic imines of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, X, m and n are as hereinafter described, prepared from the corresponding ketones of the formula ##STR2## wherein R.sup.1, X and m are as hereinafter described, are disclosed. The compounds of formula I are useful as antidepressants, as well as anticonvulsants and agents for the treatment of Parkinsonism.Type: GrantFiled: June 19, 1975Date of Patent: January 18, 1977Assignee: Hoffmann-La Roche Inc.Inventors: Philippe Dostert, Emilio Kyburz
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Patent number: 4002644Abstract: 2,3-Thioepoxytetralin, poly(2,3-thioepoxytetralin) and bis-(1,4-dihydronaphtho)[2,3-c; 2,3-f]1,2,5-trithiepane.Type: GrantFiled: May 19, 1975Date of Patent: January 11, 1977Assignee: Standard Oil Company (Indiana)Inventor: David J. Fenoglio