Patents Examined by C. M. S. Jaisle
  • Patent number: 4026905
    Abstract: Compounds having a cation which is tetrathiafulvalene of 2,5-cyclohexadiene-1,4-diylidene-bis-1,3-dithiole or both, and an anion which is 7,7,8,8-tetracyano-p-quinodimethane or 11,11,12,12-tetracyano-2,6-naphthaquinonedimethane or both, are described. The above compounds are characterized by anions and cations which are both odd-electron species.
    Type: Grant
    Filed: December 26, 1972
    Date of Patent: May 31, 1977
    Assignee: Monsanto Company
    Inventors: Morrel H. Cohen, Malcolm G. Miles, James D. Wilson
  • Patent number: 4020168
    Abstract: Substituted 2,3-dihydro-1,4-oxathiins of the formula ##STR1## display useful plant growth regulant effects including herbicidal effects. Examples are 2,3-dihydro-5,6-diphenyl-1,4-oxathiin, and 2,3-dihydro-5-(4-methylphenyl)-6-phenyl-1,4-oxathiin 4-oxide. The compounds are useful for the selective control of grasses and as dwarfing agents, as well as for inhibition of vegetative and reproductive axillary growth, and for increasing the sugar content of sugar producing species. A number of these are new compounds.
    Type: Grant
    Filed: November 6, 1975
    Date of Patent: April 26, 1977
    Assignees: Uniroyal Inc., Uniroyal, Ltd.
    Inventors: Bruce A. Graham, Michael A. Puttock, Ethel E. Felauer, Robert W. Neidermyer
  • Patent number: 4012514
    Abstract: Novel olefinic aryl ketone compounds of the formula: ##STR1## wherein R.sup.1 is hydrogen, halogen, C.sub.1-4 alkyl, or C.sub.1-4 alkoxy, R.sup.2 is hydrogen or halogen, and X is a group of the formula: ##STR2## and their non-toxic salts, which possess various useful pharmacological activities and can be produced by reaction of an acetylenic alcohol of the formula: ##STR3## wherein R.sup.1 and R.sup.2 are each as defined above with formaldehyde and an piperidine compound of the formula: , or its non-toxic salt; reduction of the resultant acetylenic aryl alcohol; and oxidation of the resultant olefinic aryl alcohol.
    Type: Grant
    Filed: July 29, 1975
    Date of Patent: March 15, 1977
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Junki Katsube, Masaru Nakao, Kikuo Sasajima, Isamu Maruyama, Masaharu Takayama, Keiichi Ono, Shigenari Katayama, Yoshihiro Tanaka, Shigeho Inaba, Hisao Yamamoto
  • Patent number: 4012515
    Abstract: Novel olefinic aryl ketone compounds of the formula: ##STR1## wherein R.sup.1 is hydrogen, halogen, C.sub.1.sub.-4 alkyl, or C.sub.1.sub.-4 alkoxy, R.sup.2 is hydrogen or halogen, and R.sup.3 and R.sup.4 are each hydrogen, halogen, C.sub.1.sub.-4 alkyl or trifluoromethyl, and their non-toxic salts, which possess various useful pharmacological activities and can be produced by reaction of an acetylenic alcohol of the formula: ##STR2## wherein R.sup.1 and R.sup.2 are each as defined above, with formaldehyde and an amine of the formula: ##STR3## wherein R.sup.3 and R.sup.4 are each as defined above; reduction of the resultant acetylenic aryl alcohol; and oxidation of the resultant olefinic aryl alcohol.
    Type: Grant
    Filed: July 29, 1975
    Date of Patent: March 15, 1977
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Junki Katsube, Masaru Nakao, Kikuo Sasajima, Isamu Maruyama, Masaharu Takayama, Keiichi Ono, Shigenari Katayama, Yoshihiro Tanaka, Shigeho Inaba, Hisao Yamamoto
  • Patent number: 4011235
    Abstract: The polyglycidyl compounds according to the invention can be manufactured by reacting epihalogenohydrin with compounds of the formula IV ##STR1## or the formula V ##STR2## in which 1. N DENOTES 2, 3 OR 4,2. A represents a 2-valent, 3-valent or 4-valent organic radical which either contains a N-heterocyclic or cycloaliphatic ring or 2 N-heterocyclic rings or 2-phenylene rings,3. either B denotes the --CH.sub.2.O.CO-- radical and m denotes the number 1, or B denotes the radical ##STR3## and m denotes O, and 4. R.sup.1 represents a divalent radical, which contains at least one hydrantoin ring or uracil ring.During the reaction hydrogen halide splits off. From curable mixtures containing polyglycidyl compounds according to the invention and a curing agent such as hexahydrophthalic anhydride or phthalic anhydride are obtained products with good mechanical and electrical properties.
    Type: Grant
    Filed: July 7, 1975
    Date of Patent: March 8, 1977
    Assignee: Ciba-Geigy Corporation
    Inventors: Jurgen Habermeier, Hans Batzer, Daniel Porret
  • Patent number: 4011240
    Abstract: This invention relates to a new group of substituted cysteines having the general formula: ##STR1## in which: Ar is an aromatic or heteromonocyclic group, such as 2-thienyl or phenyl, which may be substituted by a halogen atom or by a lower alkyl or alkoxy group, and R is a hydrogen atom or a lower alkyl group.These compounds are of use in human therapeutics as liquifiers for bronchal secretions in complaints of the respiratory passage and, in particular, in chronic bronchitis.The invention also relates to a method of preparing these compounds and to the application of these compounds, particularly in human therapeutics.
    Type: Grant
    Filed: October 12, 1972
    Date of Patent: March 8, 1977
    Assignee: Centre Europeen de Recherches Mauvernay (CERM)
    Inventors: Roland-Yves Mauvernay, Andre Monteil, Jacques Simond, Jacques Moleyre, Norbert Busch
  • Patent number: 4011326
    Abstract: Oxazolo[4,5-b]pyridine substituted in the 2-position with a polyhydrobicycloaryl group are topical anti-inflammatory agents. They are prepared by condensing a 2-amino-3-hydroxypyridine with the appropriate carboxylic compound.
    Type: Grant
    Filed: July 29, 1975
    Date of Patent: March 8, 1977
    Assignee: Merck & Co., Inc.
    Inventor: Norman P. Jensen
  • Patent number: 4010170
    Abstract: Compounds containing the butenolide ring have a wide variety of chemical uses. The invention is a method of synthesizing .beta.-halobutenolides which are valuable intermediates in preparing a variety of butenolide ring containing compounds. The method comprises reacting an acetylenic alcohol with a mercuric halide to provide a vinylmercuric halide and carbonylating the vinylmercuric halide to provide a .beta.-halobutenolide.
    Type: Grant
    Filed: September 24, 1975
    Date of Patent: March 1, 1977
    Assignee: Iowa State University Research Foundation, Inc.
    Inventor: Richard Craig Larock
  • Patent number: 4010169
    Abstract: Preparation and the antilipogenic utility of (E)-4-hydroxy-11,15-dioxoprosta-8(12),13-dien-1-oic acid .gamma.-lactones are disclosed.
    Type: Grant
    Filed: March 10, 1976
    Date of Patent: March 1, 1977
    Assignee: G. D. Searle & Co.
    Inventors: Leland J. Chinn, Karlene W. Salamon
  • Patent number: 4009275
    Abstract: Phenoxypropylamine derivatives of the formula: ##STR1## (in which R.sub.2 is a halogen atom or a trifluoromethyl group) and R.sub.1 is a halogen atom or a C.sub.1 -C.sub.4 alkyl or C.sub.2 -C.sub.4 alkenyl group, and their pharmaceutically acceptable salts, which are useful as neuroleptic agents and can be prepared by reacting a compound of the formula: ##STR2## wherein X is a halogen atom and R.sub.1 is as defined above with a compound of the formula:H-Ywherein Y is as defined above.
    Type: Grant
    Filed: February 28, 1975
    Date of Patent: February 22, 1977
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Isamu Maruyama, Masaru Nakao, Kikuo Sasajima, Shigeho Inaba, Hisao Yamamoto
  • Patent number: 4007279
    Abstract: A fungicidal compound having a general structure corresponding to a member selected from the group of 2,3-dicyano-5,6-dihydro-p-dithiin and its 5-alkyl derivatives, as expressed by the following general formula: ##STR1## wherein R stands for H or an alkyl radical of C.sub.1 - C.sub.6.
    Type: Grant
    Filed: January 28, 1975
    Date of Patent: February 8, 1977
    Assignee: Kureha Kagaku Kogyo Kabushiki Kaisha
    Inventors: Takaaki Ohtsuka, Keigo Satake, Shiro Yamazaki, Takeo Watanabe
  • Patent number: 4007199
    Abstract: The polyglycidyl compounds according to the invention can be manufactured by reacting epihalogenohydrin with compounds of the formula IV ##STR1## or the formula V ##STR2## in which 1.) n denotes 2, 3 or 4, 2.) A represents a 2-valent, 3-valent or 4-valent organic radical which either contains a N-heterocyclic or cycloaliphatic ring or 2 N-heterocyclic rings or 2 phenylene rings, 3.) either B denotes the --CH.sub.2.O.CO-- radical and m denotes the number 1, or B denotes the radical ##STR3## and m denotes 0, and 4.) R.sup.1 represents a divalent radical, which contains at least one hydrantoin ring or uracil ring. During the reaction hydrogen halide splits off. From curable mixtures containing polyglycidyl compounds according to the invention and a curing agent such as hexahydrophthalic anhydride or phthalic anhydride are obtained products with good mechanical and electrical properties.
    Type: Grant
    Filed: July 7, 1975
    Date of Patent: February 8, 1977
    Assignee: Ciba-Geigy Corporation
    Inventors: Jurgen Habermeier, Hans Batzer, Daniel Porret
  • Patent number: 4006165
    Abstract: A process for converting maleic anhydride to .gamma.-butyrolactone by treating the anhydride with hydrogen in the presence of co-catalysts comprising palladium and nickel-copper chromite at elevated pressures and temperatures.
    Type: Grant
    Filed: August 4, 1975
    Date of Patent: February 1, 1977
    Assignee: Deutsche Texaco Aktiengesellschaft
    Inventors: Georg Michalczyk, Karl-Heinz Gluzek
  • Patent number: 4005108
    Abstract: There are provided novel diterpenoid triepoxides, derived from Tripterygium wilfordii Hook F. which possess high and surprising antileukemic activity at dosage levels of micrograms/kilogram body weight.
    Type: Grant
    Filed: April 3, 1973
    Date of Patent: January 25, 1977
    Assignee: Research Corporation
    Inventors: S. Morris Kupchan, William A. Court
  • Patent number: 4005104
    Abstract: Selected novel vic-dialkoxyperfluoroalkyl-vic-diol cyclic sulfates, e.g., 2,3-dimethoxyhexafluorobutane-2,3-diol cyclic sulfate, useful for preparing the corresponding perfluoro-.alpha.-diketones, e.g., hexafluorobiacetyl (known), are synthesized by reacting SO.sub.3 with a vic-dialkoxypolyfluoroalkene, e.g., 2,3-dimethoxyhexafluorobutene-2.
    Type: Grant
    Filed: August 15, 1975
    Date of Patent: January 25, 1977
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: Carl George Krespan
  • Patent number: 4003904
    Abstract: The present invention encompasses a compound of the formula ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein Y is alkylene having 1-4 carbon atoms; R.sub.1 and R.sub. 2 together with N is a heterocyclic ring system consisting of an azamonocyclic ring of the formula ##STR2## wherein Z is oxygen, methylene, phenylhydroxymethylene, phenylcarboxymethylene or, phenylloweralkoxymethylene, or an azabicycloalkane structure having 6-9 carbon atoms and having at least 5 atoms in each ring of the azabicycloalkane structure; X is hydrogen, halogen, loweralkyl having 1-7 carbon atoms, or loweralkoxy having 1-7 carbon atoms; and Ar is phenyl, pyridyl, or monosubstituted phenyl wherein the substituent is halogen, loweralkyl having 1-7 carbon atoms, or loweralkoxy having 1-7 carbon atoms when R.sub.3 is hydrogen or Ar is 3 or 4 pyridyl when R.sub.3 is lower alkyl having 1-7 carbon atoms.
    Type: Grant
    Filed: April 16, 1975
    Date of Patent: January 18, 1977
    Assignee: G. D. Searle & Co.
    Inventor: Gilbert W. Adelstein
  • Patent number: 4004022
    Abstract: A compound of the formula ##STR1## wherein R.sub.1 is lower alkyl;R.sub.2 and R.sub.3 are methyl, and R.sub.2 forms cyclo-alkylene of 5 to 6 carbon atoms by combining with R.sub.3 ;M is a substituent selected from the group consisting of --CH.sub.2 X and --CHX.sub.2 in which X is halogen;Is useful as fungicide.
    Type: Grant
    Filed: July 28, 1975
    Date of Patent: January 18, 1977
    Assignee: Nippon Soda Company Limited
    Inventors: Izumi Kumita, Akiyoshi Ueda, Kazuhiko Ohkuma, Sho Hashimoto, Akira Nakada, Masami Mizuno
  • Patent number: 4004019
    Abstract: The invention is novel hydrocarbon ethers of aminophenol derivatives, and their use in preventing the proliferation of insects by interfering with their normal development and growth pattern.
    Type: Grant
    Filed: September 12, 1975
    Date of Patent: January 18, 1977
    Assignee: American Cyanamid Company
    Inventors: William Wayne Brand, James Byron Lovell
  • Patent number: 4003915
    Abstract: Tricyclic imines of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, X, m and n are as hereinafter described, prepared from the corresponding ketones of the formula ##STR2## wherein R.sup.1, X and m are as hereinafter described, are disclosed. The compounds of formula I are useful as antidepressants, as well as anticonvulsants and agents for the treatment of Parkinsonism.
    Type: Grant
    Filed: June 19, 1975
    Date of Patent: January 18, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Philippe Dostert, Emilio Kyburz
  • Patent number: 4002644
    Abstract: 2,3-Thioepoxytetralin, poly(2,3-thioepoxytetralin) and bis-(1,4-dihydronaphtho)[2,3-c; 2,3-f]1,2,5-trithiepane.
    Type: Grant
    Filed: May 19, 1975
    Date of Patent: January 11, 1977
    Assignee: Standard Oil Company (Indiana)
    Inventor: David J. Fenoglio