Abstract: Physiologically active substances ML-236 of the formula ##SPC1##Wherein R is hydrogen atom, hydroxy group or 2-methylbutyryloxy group having cholesterol- and lipid-lowering effects in blood and liver and thus utility as hypocholesteremic and hypolipemic medicaments. They are obtained by cultivation of an ML-236-producing microorganism belonging to the genus Penicillium in a culture medium and subsequent recovery thereof from a cultured broth.

Abstract: Chain extended polyurethanes are prepared, using certain 3-(hydroxyhydrocarbylsecondaryamino)thiophene 1,1-dioxides, some of which are new chemicals. E.g., 3-(2-hydroxypropylamino)tetrahydrothiophene 1,1-dioxide is especially useful as a chain extender for high resiliency, flexible polyurethane foams.

Abstract: Sulfoxides and sulfones of the formula ##SPC1##Wherein R.sub.1 is COOH, COOR.sub.4, CH.sub.2 OH, or CH.sub.2 OR.sub.5 ; R.sub.2 is CH.sub.3 or C.sub.2 H.sub.5 ; R.sub.3 is H, F, Cl, or Br; R.sub.4 is alkyl of 1-8 carbon atoms; R.sub.5 is alkanoyl of 2-4 carbon atoms; one of the Y groups is SO or SO.sub.2 and the other Y group is CH.sub.2, O, S, SO, or SO.sub.2 ; and the physiologically acceptable salts thereof, which compounds possess anti-inflammatory activity, can be produced by converting in a compound of the formula ##SPC2##Wherein X is a group convertible into the group --CHR.sub.1 R.sub.2 wherein R.sub.1, R.sub.2, R.sub.3, and Y have the values given above, the group X into the group --CHR.sub.1 R.sub.3.

Abstract: A continuous process for manufacturing gamma sultones, which are detergent intermediates used to produce superior detergent compounds is disclosed. Olefins are treated with at least an equimolar amount of gaseous SO.sub.3 and the resulting "acid mix" of unsaturated sulfonic acids, gamma sultones, and delta sultones is dissolved in a low boiling organic solvent. The resulting solution is cooled and the gamma sultones are precipitated as fine crystals. The gamma sultone crystals are collected, the solvent is evaporated and recovered, and the remaining "acid mix" residue (unsaturated sulfonic acids and delta sultones) is neutralized and hydrolyzed to produce olefin sulfonates.

Abstract: Adducts of polyglycidyl compounds and cyclic ureides containing dialkoxyphosphonomethyl groups, such as 3-dialkoxyphosphonomethylhydantoins or 3-dialkoxyphosphonomethyldihydrouracils, and the use of the adducts for the manufacture of flameproof epoxide resins.

Abstract: Vinylacetic acid and optionally .gamma.-butyrolactone are prepared by reacting an allyl compound substituted by oxygen functions with carbon monoxide in the presence of a heavy metal catalyst. When the reaction is carried out with an allyl ether or a carboxylic acid allyl ester water is added. Vinylacetic acid is obtained in a very good yield in simple and economic manner.

Abstract: Methacrylic acid and butyrolactone are manufactured by hydroformylation of allyl esters of lower carboxylic acids in the presence of rhodium catalysts and inert organic solvents, followed by oxidation of the resulting formyl compounds with molecular oxygen (e.g. with air) in the presence of lower fatty acids, without prior removal of the rhodium catalysts, and elimination of the carboxylic acid from the acyloxybutyric acids formed, at from 150.degree. to 500.degree.C, using catalysts such as aluminum oxide, silicates or active charcoal.

Abstract: 2-Trifluoromethylimino-benzo-heterocyclic compounds of the general formula ##SPC1##In whichX is oxygen or sulfur,Y is oxygen, sulfur or the radical ##EQU1## R is lower alkyl, cycloalkyl, aryl, aryl substituted by at least one of halogen, nitro, methyl and methoxy, alkylcarbalkoxy with up to 6 carbon atoms, alkylsulfonyl, arylsulfonyl, dialkylamidosulfonyl, or --CO--R',R' is alkyl or alkoxy with up to 12 carbon atoms, aryl, amino, lower alkylamino, di-lower alkylamino, or arylamino, each Z independently is halogen, trifluoromethyl, nitro, lower alkyl, lower alkoxy, di-lower alkylamino, acyl with up to 6 carbon atoms, a sulfonic acid group, a sulfonic acid amide group, or a sulfonic acid amide group substituted by alkyl with up to 6 carbon atoms, andm is an integer from 0 to 4,Which possess fungicidal, insecticidal and acaricidal properties, and a process for their preparation wherein a compound of the general formula ##SPC2##Is reacted with perfluoroazapropene of the formulaF.sub.2 C=N-CF.sub.

Abstract: Benzopyrano-benzopyranes and the sulfur analogs thereof, benzothiopyranobenzothiopyranes, useful as medicinal agents. Compositions of matter including 11H,12H-[1]benzopyrano[2,3-b][1]benzopyran-11,12-dione or 11H,12H-[1]benzothiopyrano[2,3-b][1]benzothiopyran-11,12-dione, and derivatives thereof including acid addition salts.

Abstract: Intermediates useful for preparing prostaglandin-type compounds with an alkoxy group replacing the hydroxyl at the C-15 position are disclosed. These products are useful for the same pharmacological properties as the unsubstituted prostaglandins.

Abstract: Adducts of cyclic urea derivatives and dialkyl phosphites, containing glycidyl groups, for example adducts of a diglycidyl compound of hydantoins, substituted in the 5-position by alkyl groups or an alkylene group, and of diethyl phosphite or dimethyl phosphite. These adducts are used for the manufacture of flame-retarding plastics.

Abstract: This invention relates to a class of 1-tertiary-alkyl-3-(substituted furyl)ureas that exhibit antihypertensive activity in warm-blooded animals. A representative compound is 1-tert-butyl-3-(2,5-dihydro-5-oxo-3-furyl)urea. This compound additionally possesses herbicidal activity.

Abstract: The invention relates to bases of the formula ##SPC1##And their acid addition salts with pharmaceutically acceptable acids. In the formula R.sup.1 represents phenyl or phenyl substituted by one or more hydroxyl, lower alkyl lower alkoxy, trifluoromethyl or halogen groups. The compounds have hypoglycemic activity.

Abstract: Novel monocyclic macrocyclic compounds having nitrogen bridgehead atoms and having in the hydrocarbon bridging chains at least two additional hetero atoms selected from the group consisting of sulfur, oxygen, and nitrogen, when admixed with a compatible cation-donor compound form stable cation-containing macrocyclic complexes which, in turn, can be conveniently dissociated by addition of acid or a quaternizing agent. The novel macrocyclics are valuable for use in the same way and for the same purposes as chelating agents.

Abstract: Disclosed is a novel stereospecific synthesis of Prostaglandin E.sub.1.

Abstract: Process for preparing lactones of the formula ##SPC1##Wherein G is R.sub.9, 1-hydroxyhexyl, or 1-hydroxy-cis-3-hexenyl, wherein R.sub.9 is hydrogen, alkyl of one to 12 carbon atoms, inclusive, cycloalkyl of 3 to 10 carbon atoms, inclusive, aralkyl of 7 to 12 carbon atoms, inclusive, phenyl, or phenyl substituted with one, 2, or 3 alkyl of one to 4 carbon atoms, inclusive; wherein M is hydrogen or a blocking group; wherein R.sub.1 is hydrogen, alkyl of one to 12 carbon atoms, inclusive, cycloalkyl of 3 to 10 carbon atoms, inclusive, aralkyl of 7 to 12 carbon atoms, inclusive, phenyl, or phenyl substituted with one, 2, or 3 chloro or alkyl of one to 4 carbon atoms, inclusive, or ethyl substituted in the .beta.-position with 3 chloro, 2 or 3 bromo, or 1, 2, or 3 iodo; and wherein .about. indicates attachment in alpha or beta configuration. The lactones are useful intermediates in preparing prostaglandins having pharmacological utility.

Abstract: Racemic organic carboxylic acids are efficiently resolved into their enantiomers with antipodes of .alpha.-methyl-p-nitrobenzylamine.

Abstract: 1,4-DITHIENE SULFONIUM SALTS OF THE FORMULA ##SPC1##In whichR is alkyl, substituted alkyl, alkenyl, alkynyl of up to 8 carbon atoms; cycloalkyl, aralkyl; or aralkyl substituted in the aryl moiety;Z is hydrogen or alkyl, andA.sup.- is one equivalent of an anionAre outstandingly effective as plant growth regulants, e.g., as plant growth inhibitors.

Abstract: The method comprises administering to an animal a novel pharmaceutical composition containing a substituted-1-oxo-1H-2-benzothiopyran-3-carboxylic acid to inhibit antigen-antibody reaction in said animal. Representative of the compounds that can be used in the method are:1-Oxo-1H-2-benzothiopyran-3-carboxylic acid, andSodium 6-methoxy-1-oxo-1H-2-benzothiopyran-3-carboxylate.

Abstract: Phenyl-thienyl-alkanoic acid derivatives and phenyl-furyl-alkanoic acid derivatives, processes for their preparation, and pharmaceutical compositions comprising them. Compounds have anti-inflammatory, hypocholesterolaemic, analgesic and antipyretic activity. A representative compound is .alpha.-(4-bromo-5-p-chlorophenyl-thien-2-yl)acetic acid.