Patents Examined by Carlos Azpuru
  • Sterile lyophilized drug compositions and methods for treating ocular diseases or conditions
    Patent number: 11564834
    Abstract: The present invention provides a drug composition comprising particles comprising a biodegradable or bioerodable polymer and a drug, a soluble, biodegradable or bioerodible excipient, a bulking agent and a reconstitution aid. The invention also provides a pharmaceutical formulation and a unit dosage form of the pharmaceutical formulation. The invention provides methods of treatment of a disease or condition accordingly. The invention also provides a drug composition for use in a cannulation device.
    Type: Grant
    Filed: September 14, 2018
    Date of Patent: January 31, 2023
    Assignee: Oxular Limited
    Inventors: Robert Steven Bley, Stanley R. Conston, Ronald K. Yamamoto, Tien T. Nguyen, John P. Lunsford, Dillon Daniel Martinez, Loc X. Phan
  • Biodegradable cationic polycarbonates as adjuvants for vaccines
    Patent number: 11559578
    Abstract: A method for formation of a vaccine comprising combining a cationic polymer adjuvant with an antigen to form first immunoparticles through charge interactions and producing a treatment formulation for the vaccine comprising the first immunoparticles.
    Type: Grant
    Filed: June 30, 2020
    Date of Patent: January 24, 2023
    Assignee: International Business Machines Corporation
    Inventors: James L. Hedrick, Yi Yan Yang, Ashlynn Lee, Chuan Yang
  • Assembly comprising a resorbable material having antibacterial activity
    Patent number: 11547775
    Abstract: The invention relates to an arrangement (1) comprising at least one structural element (2) made of an absorbable material with an antibacterial effect with a mount, which possesses an aspect ratio greater than 10 and whereat the material is a rapidly corroding magnesium alloy. The invention further relates to a mount (10) with an arrangement (1) carried by the mount (10) comprising at least one structural element (2) made of an absorbable material with an antibacterial effect.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: January 10, 2023
    Assignee: Meotec GmbH & Co. KG
    Inventors: Alexander Kopp, Francesco D'Elia, Ralf Smeets
  • Graded porous scaffolds as immunomodulatory wound patches
    Patent number: 11547776
    Abstract: The present invention provides porous biomimetic scaffolds and methods for making the same. The scaffolds have graded pore sizes for enhanced cell penetration. The scaffolds are useful for wound regeneration by facilitating cell penetration into the scaffold interior and due to their inherent immunomodulatory effects. The scaffolds have tissue modeling specification by mimicking the inherent stratified structure of certain tissues.
    Type: Grant
    Filed: April 26, 2018
    Date of Patent: January 10, 2023
    Assignee: Temple University-Of The Commonwealth System of Higher Education
    Inventors: Azadeh Timnak, Peter I. Lelkes, Yah-el H. Har-el
  • Methods of attenuating an immune response by inhibition of BFL1
    Patent number: 11541073
    Abstract: The disclosure provides methods of modulating an immune response by inhibiting BFL1, and related methods for treating and preventing diseases and disorders characterized by inflammation, especially neutrophil induced inflammation.
    Type: Grant
    Filed: January 14, 2019
    Date of Patent: January 3, 2023
    Assignee: Children's Hospital Medical Center
    Inventors: David A. Hildeman, Andrew Herr, Suhas G. Kallapur, Jarek Meller, Alexander Thorman
  • Methods of treatment with an ocular implant containing a tyrosine kinase inhibitor
    Patent number: 11534396
    Abstract: This invention relates to methods of treatment with a sustained release biodegradable ocular implant containing a tyrosine inhibitor dispersed in a hydrogel.
    Type: Grant
    Filed: May 13, 2022
    Date of Patent: December 27, 2022
    Assignee: Ocular Therapeutix, Inc.
    Inventors: Charles D. Blizzard, Arthur Driscoll, Rami El-Hayek, Michael Goldstein, Joseph Iacona, Peter Jarrett, Timothy S. Jarrett, Erica Kahn, Zachary Lattrell
  • Composition comprising porous silica particles carrying a cell fate modulating factor
    Patent number: 11530132
    Abstract: A composition includes porous silica particles to carry a cell fate modulating factor therein. A method for modulating cell fate includes treating various cells with the composition. The cell fate modulating factor is delivered to a stable target receptor, toxicity to subject cells for delivery may be reduced, a fate of the subject cells can be controlled through sustained release of at least 99 wt. % of the cell fate modulating factor.
    Type: Grant
    Filed: September 5, 2018
    Date of Patent: December 20, 2022
    Assignee: LEMONEX INC.
    Inventors: Dal-Hee Min, Cheolhee Won, Sejin Park, Seongchan Kim
  • Pharmaceutical formulations and systems for delivery of an androgenic agent and an aromatase inhibitor with sustained multi-phasic release profiles and methods of use
    Patent number: 11524014
    Abstract: The present disclosure is directed formulations, delivery systems and/or methods of use that have a novel a sustained release multi-phasic concentration pattern that may be used, among other things, for reducing mammographic breast density and/or breast stiffness in warm-blooded animals. For example, the formulation may comprise: the administration of an effective amount of androgenic agent and an effective amount of an aromatase inhibitor to a subject that provides a sustained release multi-phasic concentration pattern in the blood of the subject over time as measured by serum concentration for the androgen and plasma concentration for the aromatase inhibitor and improves, among other things, breast tissue stabilization and/or increases of the levels of androgen receptor expression.
    Type: Grant
    Filed: June 3, 2020
    Date of Patent: December 13, 2022
    Assignee: Havah Therapeutics Pty Ltd.
    Inventor: Stephen Nigel Birrell
  • Antibiotic implant coatings and process for manufacturing implant coatings
    Patent number: 11517650
    Abstract: Methods for applying a coating to a surface of a substrate for inhibition and prevention of implant-associated complications (including implant-associated infections), methods for inhibiting and preventing implant-associated complications (including implant-associated infections), implant-associated infection inhibiting coatings, and coated devices are provided. Coating processes include a) providing a saturated or supersaturated solution of an antibiotic in a fast-evaporating or medium-evaporating organic solvent; b) coating the surface of the substrate with at least one application of solution, each application followed directly by a solvent evaporation period.
    Type: Grant
    Filed: October 24, 2018
    Date of Patent: December 6, 2022
    Assignee: University of Cincinnati
    Inventors: Aaron Seitz, Michael Edwards, Erich Gulbins, Ryan Gobble
  • Composition for skin soothing containing liquid-phase plasma
    Patent number: 11510853
    Abstract: The present invention is to provide a composition for skin soothing, which is safe from a risk of side effects, and relates to a composition for skin soothing containing a liquid-phase plasma. The liquid-phase plasma of the present invention is obtained by applying plasma as pure energy to a liquid-phase material, and can be used in the skin sensitive to a chemical material without a risk of side effects. Furthermore, the liquid-phase plasma has remarkable effects on the prevention or treatment of dermatitis or photo-aging due to ultraviolet light, and thus is expected to be greatly used in beauty care and mechanical fields.
    Type: Grant
    Filed: September 17, 2018
    Date of Patent: November 29, 2022
    Assignee: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Chul Ho Kim, Kyoungwon Jung
  • GM3 functionalized nanoparticles
    Patent number: 11504338
    Abstract: Embodiments disclosed herein relates to ganglioside GM3-containing mixed lipids nanoparticles having an overall size between 60-100 nm, the making thereof and the uses. The nanoparticles selectively targeted to CD169+ expressing cells such as dendritic cells and macrophage. The nanoparticles are endocytosed by the CD169+ expressing cells.
    Type: Grant
    Filed: April 9, 2020
    Date of Patent: November 22, 2022
    Assignee: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Bjoern Markus Reinhard, Suryaram Gummuluru
  • Supercritical method of making a biocompatible composite implant
    Patent number: 11497834
    Abstract: Disclosed herein is biocompatible composite material impregnated with antiinfective agents to reduce the rate of infection in patients with medical implants. Also disclosed herein is the utilization of super critical fluid (SCF) methodology to impregnate medical implant materials with antiinfective agents (e.g., antimicrobial, antibiofilm agents, etc.).
    Type: Grant
    Filed: November 2, 2021
    Date of Patent: November 15, 2022
    Assignee: BIO PROTECTANT TECHNOLOGIES, INC.
    Inventors: Joseph Frederick Buell, Pleasant Fite Hooper, Brandon Joseph Iglesias, Chad Joseph Roy
  • Method of making osteoinductive bone implant
    Patent number: 11491260
    Abstract: Disclosed are various bioactive grafts and methods of making the same. In one embodiment, bone material is harvested from a donor. The harvested bone material is exposed to a lysing agent, the lysing agent configured to release growth factors and bioactive materials from cellular material of the harvested bone material. The harvested bone material is then rinsed with a rinsing agent. The pH of the harvested bone material is substantially neutralized.
    Type: Grant
    Filed: July 2, 2019
    Date of Patent: November 8, 2022
    Assignee: BIOVENTUS, LLC
    Inventor: Amit Prakash Govil
  • Sustained-release 9-cis retinoic acid implantable drug delivery pellets for the prevention of postsurgical edema and lymphedema
    Patent number: 11484496
    Abstract: A method of treating post-surgical edema includes a step of administering an effective amount of a pharmaceutical composition to a subject identified a risk of post-surgical edema. The pharmaceutic composition include a retinoic acid component selected from the group consisting of 9-cis retinoic acid, geometric isomers of 9-cis retinoic acid, metabolites of 9-cis retinoic acid, substituted derivatives thereof, and combinations thereof. An implantable pellet including the retinoic acid component is also provided.
    Type: Grant
    Filed: April 24, 2020
    Date of Patent: November 1, 2022
    Assignee: University of Southern California
    Inventors: Alex K. Wong, Young-Kwon Hong
  • Polymer nanodiscs for biotechnology and medical applications
    Patent number: 11471411
    Abstract: The present invention includes compositions, methods, and methods of making and using a nanoscale discoidal membrane comprising: an amphiphilic membrane patch comprising self-assembled molecular amphiphiles capable of supporting one or more membrane proteins in the amphiphilic membrane patch; and one or more amphipathic scaffold macromolecules that encase the nanoscale discoidal membrane.
    Type: Grant
    Filed: September 18, 2018
    Date of Patent: October 18, 2022
    Assignee: Texas Tech University System
    Inventors: Guillermo A. Altenberg, Hongjun Liang
  • Compositions and methods for delivery of nucleic acid-lipid nanoparticle complexes encoding for viral RNA polymerase region and protein antigen
    Patent number: 11458209
    Abstract: The disclosure provides nanoemulsion compositions and methods of making and using thereof to deliver a bioactive agent such as a nucleic acid to a subject. Compositions of the disclosure include nucleic-acid lipid nanoparticle complexes encoding for viral RNA polymerase region and protein antigen. The nanoemulsion compositions of the disclosure comprises a hydrophobic core, optionally including inorganic nanoparticles in a lipid nanoparticle that allows imaging as well as delivering nucleic acids. Methods of using these particles for treatment and vaccination are also provided, including methods for administering to a subject a composition of the disclosure in an amount sufficient to generate an immune response.
    Type: Grant
    Filed: November 10, 2021
    Date of Patent: October 4, 2022
    Assignee: HDT Bio Corp.
    Inventors: Amit Khandhar, Steven Reed, Malcolm Duthie, Jesse Erasmus, Darrick Carter, Bryan J. Berube
  • Method of delivering an anesthetic agent and glucocorticoid micro and nano bioerodible particles
    Patent number: 11452700
    Abstract: The present disclosure provides polymeric particles and scaffolds comprising a matrix and an anesthetic agent. In one embodiment, the matrix comprises a bioerodible polymer. The disclosure further relates to the use of the polymeric particles and scaffolds for sustained local delivery of anesthetic agents, reduction of pain killer addiction and addiction risk. The disclosure also provides methods of fabricating and administering polymeric particles and scaffolds containing an anesthetic agent described herein.
    Type: Grant
    Filed: August 3, 2018
    Date of Patent: September 27, 2022
    Inventor: Eric Haas
  • Preparation of highly stable concentrated dispersions of silver nanoparticles using synergistic dispersing agents
    Patent number: 11453058
    Abstract: Methods for preparing highly stable concentrated dispersions of silver nanoparticles and described herein. Contemplated methods comprise combining a selected polysaccharidic dispersant with a selected non-reacting dispersant to yield concentrated silver dispersions with enhanced stability and lowered undesirable residual organics. Contemplated methods further comprise selecting an appropriate source of silver ions to reduce the ionic strength of the reaction medium and final silver dispersions.
    Type: Grant
    Filed: May 20, 2020
    Date of Patent: September 27, 2022
    Assignee: NOBEL /NOBLE ELEMENTS/ LLC
    Inventor: Dan Goia
  • Device for adsorbing odours
    Patent number: 11439724
    Abstract: The invention relates to a device for adsorbing odours comprising an absorbent layer and an adsorbent layer, said adsorbent layer being provided with a material permeable to volatile organic compounds (VOCs) and an adsorbent particulate filler comprising at least one spice. Such a device is particularly useful for adsorbing and masking body odours.
    Type: Grant
    Filed: June 23, 2020
    Date of Patent: September 13, 2022
    Assignees: Institute Curie, Ecole Superieure De Physique Et De Chimie Industrielle (ESPCI), Ecole Nationale Superieure De Chimie De Paris (ENSCP), Centre National De La Recherche Scientifique, Cemag Care
    Inventors: Aurélie Thuleau, Isabelle Fromantin, Vincent Semetey, José Dugay, Jean-François Le Meur
  • Ocular implant containing a tyrosine kinase inhibitor
    Patent number: 11439592
    Abstract: The invention relates to a sustained release biodegradable ocular implant containing a tyrosine kinase inhibitor dispersed in a hydrogel for the treatment of a retinal disease for an extended period of time.
    Type: Grant
    Filed: March 24, 2021
    Date of Patent: September 13, 2022
    Assignee: Ocular Therapeutix, Inc.
    Inventors: Charles D. Blizzard, Arthur Driscoll, Rami El-Hayek, Michael Goldstein, Joseph Iacona, Peter Jarrett, Timothy S. Jarrett, Erica Kahn, Zachary Lattrell