Patents Examined by Carlos Azpuru
  • Hydrogel composition for mucosal lifting procedures within lumenal anatomical structures
    Patent number: 11701449
    Abstract: An injectable medical composition includes an acrylate and a solvent. The composition has a first viscosity at temperatures below body temperature and a second viscosity at body temperature. The first viscosity is lower than the second viscosity.
    Type: Grant
    Filed: November 16, 2022
    Date of Patent: July 18, 2023
    Assignee: QMARK MEDICAL INC.
    Inventors: Patrick H. Ruane, Sameer Sharma
  • Fine particle coating (drug-containing hollow particle and method for manufacturing same)
    Patent number: 11696895
    Abstract: Provided is a manufacturing method of particles coated with coatable microparticles. The method is a manufacturing method of particles coated with coatable microparticles, comprising the step of adding the coatable microparticles to an inner core comprising a component of interest and a macromolecule, and, while rolling the mixture, coating the mixture while spraying a solvent that can dissolve the macromolecule, wherein the particles coated with the coatable microparticles are coated, component of interest-containing hollow particles.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: July 11, 2023
    Assignee: Sumitomo Pharma Co., Ltd.
    Inventors: Takumi Asada, Mitsuaki Kobiki
  • Method for preparing phospholipid micelles
    Patent number: 11697101
    Abstract: Disclosed is a controllable method for preparing phospholipid micelles, including: S1, preparing small phospholipid vesicles; S2, preparing a graphene thin-layer electrode substrate, S3, incubating, and S4, electroforming phospholipid micelles. According to the present application, lamellar graphene is used as the electrode substrate according to the present application, where a phospholipid bilayer film is firstly spread on the surface of the substrate, and phospholipid micelles are controlled in terms of formation as well as formation state by a certain alternating current electric field on the surface of graphene; the developed method of the present application is unique in design, simple in operation, and has the advantages of fast formation, short preparation cycle and good controllability.
    Type: Grant
    Filed: November 2, 2022
    Date of Patent: July 11, 2023
    Assignee: GUANGDONG UNIVERSITY OF PETROCHEMICAL TECHNOLOGY
    Inventors: Hongmei Bi, Guobin Shi, Liuchun Guo, Yingmei Zhang
  • Thermosensitive peptide hydrogel
    Patent number: 11690935
    Abstract: The invention provides a thermosensitive peptide hydrogel, which comprises water, a polyether/polyol polymer and a peptide molecule. The peptide molecule has a structure represented by the following chemical formula (1).
    Type: Grant
    Filed: November 19, 2020
    Date of Patent: July 4, 2023
    Assignee: NATIONAL CHIAO TUNG UNIVERSITY
    Inventors: Hsin-Chieh Lin, Imam Sahroni
  • Cell or tissue embedding device
    Patent number: 11684693
    Abstract: A cell or tissue embedding device having an aqueous gel serving as an immunoisolation layer, the aqueous gel containing, as components thereof, a denatured polyvinyl alcohol resin having an activated carbonyl group and a crosslinking agent is highly capable of supplying a physiologically active substance.
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: June 27, 2023
    Assignees: Japan Vam & Poval Co., Ltd., National University Corporation Tohoku University
    Inventors: Akinobu Oharuda, Yoshihiro Kimura, Masafumi Goto
  • Formulations of hydroxypyridonate actinide/lanthanide decorporation agents
    Patent number: 11684614
    Abstract: Provided herein are pharmaceutical formularions comprising a 1,2-HOPO chelating agent and/or 3,2-HOPO chelating agent.
    Type: Grant
    Filed: September 5, 2017
    Date of Patent: June 27, 2023
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Rebecca J. Abergel, Taylor A. Choi, Kenneth N. Raymond, David K. Shuh
  • Thermosensitive chitosan hydrogel composition and bioink composition comprising the same
    Patent number: 11684694
    Abstract: Provided is a chitosan hydrogel composition including chitosan, glycerol, and a phosphate group, wherein the chitosan is crosslinked via the glycerol, the phosphate group, or a combination thereof. The temperature at which the chitosan hydrogel composition may be induced from a liquid state into a gel state may be controlled according to the content ratio of the phosphate group and the glycerol, and since printing properties and strength are affected by the gelatin concentration, the composition may be used as an ink for 3D printing.
    Type: Grant
    Filed: April 24, 2020
    Date of Patent: June 27, 2023
    Assignee: MEDIFAB CO., LTD.
    Inventors: Mi Sun Cha, Jung Ju Kim
  • Compositions and methods for delivery of RNA
    Patent number: 11679163
    Abstract: The disclosure provides nanoemulsion compositions and methods of making and using thereof to deliver a bioactive agent such as a nucleic acid to a subject. The nanoemulsion composition comprises a hydrophobic core based on inorganic nanoparticles in a lipid nanoparticle that allows imaging as well as delivering nucleic acids. Methods of using these particles for treatment and vaccination are also provided.
    Type: Grant
    Filed: November 22, 2022
    Date of Patent: June 20, 2023
    Assignee: HDT BIO CORP.
    Inventors: Amit Khandhar, Steven Reed, Malcolm Duthie, Jesse Erasmus, Darrick Carter, Bryan J. Berube
  • Ganaxolone for use in treatment of status epilepticus
    Patent number: 11679117
    Abstract: This invention relates to methods for treating status epilepticus by administering to the subject in need thereof an intravenous bolus of ganaxolone and a continuous intravenous infusion of a neurosteroid. The method provides SE suppression and continued suppression of SE.
    Type: Grant
    Filed: April 26, 2022
    Date of Patent: June 20, 2023
    Assignee: Marinus Pharmaceuticals, Inc.
    Inventors: David Czekai, Maciej Gasior, Lorianne Masuoka, Julia Tsai, Joseph Hulihan, Alex Aimetti
  • Bioactive components conjugated to substrates of microneedle arrays
    Patent number: 11672964
    Abstract: Microneedle arrays and methods of forming the same can include one or more bioactive components bonded to a biocompatible material such that the one or more bioactive components are cleavable in vivo to release the bioactive component from the biocompatible material.
    Type: Grant
    Filed: July 29, 2020
    Date of Patent: June 13, 2023
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Louis D. Falo, Jr., Geza Erdos
  • Drug implants containing enzalutamide and methods of use thereof
    Patent number: 11666528
    Abstract: Provided herein are drug implants comprising enzalutamide for the treatment of disease in a subject. In some cases, the drug implant may comprise a polymer matrix and enzalutamide disposed therein. Additionally provided are methods for manufacturing the drug implants and methods of treating diseases with the implants. In some cases, the drug implant may be used for the treatment of a proliferative disease of the prostate.
    Type: Grant
    Filed: April 25, 2022
    Date of Patent: June 6, 2023
    Assignees: The Regents of the University of California, Alessa Therapeutics, Inc.
    Inventors: Maithili Rairkar, Pujan Desai, Carlos Schuler, Keith Hall, Pamela Munster, John Maroney, Scott Thomas
  • Biomaterial comprising poly(itaconate-co-citrate-co-octanediol)
    Patent number: 11666598
    Abstract: A method of treating infection and/or inflammation in a subject includes steps of providing a polyester biomaterial comprising diol monomers and at least first carboxylate monomers, wherein the first carboxylate monomers are itaconate; and administering the polyester biomaterial to the subject. The polyester biomaterial can be in the form of a biomimetic, and characterized by hydrolytic degradability. The polyester biomaterial may further include second carboxylate monomers. The biomaterial can be poly(itaconate-co-citrate-co-octanediol).
    Type: Grant
    Filed: July 13, 2020
    Date of Patent: June 6, 2023
    Inventors: Locke Davenport Huyer, Miles Montgomery, Milica Radisic
  • Compositions and methods for treating keratinous substrates
    Patent number: 11660260
    Abstract: Disclosed are conditioning systems comprising (a) at least one anionic surfactant chosen from isethionate surfactants; (b) coco-caprylate/caprate; and (c) at least one cationic compound, and rinse-off compositions comprising (a) an anionic surfactant system comprising i) a first anionic surfactant chosen from isethionate surfactants, and ii) optionally, a second anionic surfactant; (b) coco-caprylate/caprate; and (c) at least one cationic compound. Also disclosed are methods of treating and/or caring for the skin, hair, and/or scalp with the conditioning systems and/or rinse-off compositions containing the conditioning systems.
    Type: Grant
    Filed: February 29, 2020
    Date of Patent: May 30, 2023
    Assignee: L'OREAL
    Inventors: Liliana Xavier, Anna Botto
  • Anticoagulant compounds and methods and devices for their use
    Patent number: 11654036
    Abstract: Devices, systems, and methods are provided including a structure having one or more surfaces configured for internal use within a patient's body and one or more therapeutic compositions comprising one or more active substances including a direct factor Xa inhibitor, and a direct factor IIa inhibitor disposed in or on the structure. The structure is configured to be positioned adjacent an injury site in the patient's body. The one or more active substances optionally include an anti-proliferative agent. The therapeutic composition is formulated to release the one or more active substances to the injury site to provide one or more of inhibit clot formation, promote clot dissolution, inhibit or dissolute inflammation, inhibit vessel injury, increase time before clotting, and/or inhibit cell proliferation.
    Type: Grant
    Filed: August 13, 2021
    Date of Patent: May 23, 2023
    Assignee: Elixir Medical Corporation
    Inventors: Motasim Sirhan, Xiaoxia Zheng, Vinayak D. Bhat, John Yan
  • Compositions and methods for delivery of RNA
    Patent number: 11654200
    Abstract: The disclosure provides nanoemulsion compositions and methods of making and using thereof to deliver a bioactive agent such as a nucleic acid to a subject. The nanoemulsion composition comprises a hydrophobic core based on inorganic nanoparticles in a lipid nanoparticle that allows imaging as well as delivering nucleic acids. Methods of using these particles for treatment and vaccination are also provided.
    Type: Grant
    Filed: December 5, 2022
    Date of Patent: May 23, 2023
    Assignee: HDT Bio Corp.
    Inventors: Amit Khandhar, Steven Reed, Malcolm Duthie, Jesse Erasmus, Darrick Carter, Bryan J. Berube
  • Compositions and methods for delivery of RNA
    Patent number: 11648321
    Abstract: The disclosure provides nanoemulsion compositions and methods of making and using thereof to deliver a bioactive agent such as a nucleic acid to a subject. The nanoemulsion composition comprises a hydrophobic core based on inorganic nanoparticles in a lipid nanoparticle that allows imaging as well as delivering nucleic acids. Methods of using these particles for treatment and vaccination are also provided.
    Type: Grant
    Filed: August 22, 2022
    Date of Patent: May 16, 2023
    Assignee: HDT BIO CORP.
    Inventors: Amit Khandhar, Steven Reed, Malcolm Duthie, Jesse Erasmus, Darrick Carter, Bryan J. Berube
  • Formulations of hydroxypyridonate actinide/lanthanide decorporation agents
    Patent number: 11648241
    Abstract: Provided herein are pharmaceutical formularions comprising a 1,2-HOPO chelating agent and/or 3,2-HOPO chelating agent.
    Type: Grant
    Filed: September 5, 2017
    Date of Patent: May 16, 2023
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Rebecca J. Abergel, Taylor A. Choi, Kenneth N. Raymond, David K. Shuh
  • Compositions and methods for delivery of RNA
    Patent number: 11648322
    Abstract: The disclosure provides nanoemulsion compositions and methods of making and using thereof to deliver a bioactive agent such as a nucleic acid to a subject. The nanoemulsion composition comprises a hydrophobic core based on inorganic nanoparticles in a lipid nanoparticle that allows imaging as well as delivering nucleic acids. Methods of using these particles for treatment and vaccination are also provided.
    Type: Grant
    Filed: November 22, 2022
    Date of Patent: May 16, 2023
    Assignee: HDT BIO CORP.
    Inventors: Amit Khandhar, Steven Reed, Malcolm Duthie, Jesse Erasmus, Darrick Carter, Bryan J. Berube
  • Method of selecting skin treatment regimens, ingredients and compositions
    Patent number: 11642300
    Abstract: A method of selecting skin treatment regimens, ingredients and compositions that includes measuring the levels of particular small molecule metabolites on skin both before and after product application and testing for a change in small molecule metabolite levels is disclosed.
    Type: Grant
    Filed: May 11, 2020
    Date of Patent: May 9, 2023
    Assignee: Johnson & Johnson Consumer Inc.
    Inventors: Kimberly Capone, Janeta Nikolovski, Lorena Telofski, Georgios Stamatas
  • Biodegradable bone glue
    Patent number: 11642436
    Abstract: The present invention is directed to bioresorbable polymers to be used as bone and tissue adhesives. The present invention is also directed to the synthesis of bioresorbable polymeric molecules bearing adhesive moieties and the use of such compounds in methods to glue and stabilize fractured bones and damaged tissues. The present invention is also directed to the use of such compounds as adhesive sealants for applications in wound care. The present invention is also directed to the use of such compounds as biodegradable ink for applications in tissue engineering and 3D printing. The present invention also relates to the use of such compounds as drug delivery platforms.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: May 9, 2023
    Assignee: Evonik Operations GmbH
    Inventors: Teng Xue, Gianluigi Luppi, Natalia Ruggeri Savietto, Howard K. Bowman, III, Paul Joseph Spencer, Andreas Karau, Jian-Feng Zhang, Rosario Lizio, Marshall Scott Jones