Patents Examined by Carlos Azpuru
  • Formulations for treating a fibrotic disease
    Patent number: 11439685
    Abstract: The present invention provides formulations for the treatment of fibrotic diseases and disorders. In some embodiments, the formulation comprises a microparticle that includes an antifibrotic.
    Type: Grant
    Filed: May 21, 2021
    Date of Patent: September 13, 2022
    Assignees: TRUSTEES OF BOSTON UNIVERSITY, BETH ISRAEL DEACONESS MEDICAL CENTER
    Inventors: Mark W. Grinstaff, William Blessing, Amanda Williamson, Jack Kirsch, Katherine Cook, Ara Nazarian, Edward K. Rodriguez
  • Lipid-polymer based complexation and delivery of nucleic acids
    Patent number: 11434317
    Abstract: The invention provides novel polymers, crosslinked polymer-nucleic acid complexes, lipid-polymer-nucleic acid-based complexation and nanoassemblies, and nanoassembly-based intracellular delivery of nucleic acids and controlled release thereof upon degradation of the nanoassemblies in response to specific microenvironment in the cell, and compositions and methods of preparation and use thereof.
    Type: Grant
    Filed: April 15, 2020
    Date of Patent: September 6, 2022
    Assignee: University of Massachusetts
    Inventors: Sankaran Thayumanavan, Kingshuk Dutta
  • Compositions and methods for delivery of RNA-lipid nanoparticle complexes encoding for viral RNA polymerase region and protein antigen
    Patent number: 11433142
    Abstract: The disclosure provides nanoemulsion compositions and methods of making and using thereof to deliver a bioactive agent such as a nucleic acid to a subject. Compositions of the disclosure include RNA-lipid nanoparticle complexes encoding for viral RNA polymerase region and protein antigen. Compositions are further described where the lipid nanoparticles are characterized as having a z-average diameter particle size measurement of 20 nm to 80 nm when measured using dynamic light scattering. The nanoemulsion compositions of the disclosure comprises a hydrophobic core, optionally including inorganic nanoparticles, in a lipid nanoparticle that allows imaging as well as delivering nucleic acids. Methods of using these particles for treatment and vaccination are also provided.
    Type: Grant
    Filed: March 23, 2022
    Date of Patent: September 6, 2022
    Assignee: HDT Bio Corp.
    Inventors: Amit Khandhar, Steven Reed, Malcolm Duthie, Jesse Erasmus, Darrick Carter, Bryan J. Berube
  • Surface-modified mesoporous silica nanoparticle for blood-brain barrier penetration,tumor targeting and cancer metastasis treatment, methods of production and uses thereof
    Patent number: 11419826
    Abstract: The present disclosure relates to mesoporous silica nanoparticles (MSNs) with specific modifications as drug delivery systems containing both tumor targeting and blood-brain barrier (BBB) penetration properties suitable for cancer treatment and/or CNS disease treatment. The present disclosure also relates to method of preparing MSNs and the MSNs prepared by the method as described herein.
    Type: Grant
    Filed: April 30, 2020
    Date of Patent: August 23, 2022
    Assignee: NANO TARGETING & THERAPY BIOPHARMA INC.
    Inventors: Cheng-Hsun Wu, Yi-Ping Chen, Si-Han Wu, Chung-Yuan Mou
  • Oral preparation of obeticholic acid
    Patent number: 11413295
    Abstract: The present invention pertains to an oral preparation having exceptional elutability, the oral preparation containing obeticholic acid or a pharmacologically acceptable salt thereof, a water-soluble excipient, a disintegrating agent, and a water-soluble polymer binder, wherein the oral preparation is a quick-release tablet.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: August 16, 2022
    Assignee: INTERCEPT PHARMACEUTICALS, INC.
    Inventors: Mitsuhiro Matono, Tetsuya Hayama
  • Green methodology to create polymeric nanocarriers containing hydrophilic low molecular-weight drugs and providing a very high drug loading and a very high prolonged release
    Patent number: 11413349
    Abstract: In one aspect, provided herein is a nanocarrier composition for formulating a hydrophilic and aromatic low molecular-weight drug (HALMD), the composition comprising: an aromatic polymer; and a hydrophilic and aromatic low molecular-weight drug (HALMD); wherein the aromatic polymer has a positive or negative charge or is a zwitterion, and the hydrophilic and aromatic low molecular-weight drug (HALMD) has an opposing positive or negative charge or is a zwitterion; and wherein the composition has a size of between 50-400 nm and optionally, a zeta potential of from +100 to ?100 mV. A method for preparing the nanocarrier composition, as well as pharmaceutical compositions and therapeutic uses thereof, are also disclosed.
    Type: Grant
    Filed: May 29, 2020
    Date of Patent: August 16, 2022
    Assignees: UNIVERSIDAD DE CHILE, UNIVERSIDAD AUSTRAL DE CHILE
    Inventors: Felipe Andrés Oyarzún Ampuero, Ignacio Moreno Villoslada, Maria Gabriela Villamizar Sarmiento, Elton Fabian Molina Soto
  • Batch-wise melt extrusion process and device for preparing a solid dispersion
    Patent number: 11413247
    Abstract: The present invention relates to a melt extrusion process for preparing a solid dispersion comprising a pharmaceutically active ingredient, a polymeric binder, and, optionally, one or more auxiliary agents, comprising a) in a batch-wise operation, placing a pre-determined amount of the polymeric binder, a pre-determined amount of the active ingredient, and, optionally, a pre-determined amount of the auxiliary agent(s) in a melting vessel; melting the polymeric binder with agitation to disperse the active ingredient in the polymeric binder to obtain a molten pre-dispersion; b) feeding the pre-dispersion into an extruder to homogenize the pre-dispersion and release a melt through a die; and c) allowing the melt to solidify.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: August 16, 2022
    Inventor: Tiziana Adage
  • Oleogel compositions for retinal drug delivery
    Patent number: 11406594
    Abstract: In one aspect, the disclosure relates to compositions for the extended release of drugs in the retina. In a further aspect, the present disclosure provides methods of preparing extended release compositions comprising a therapeutic agent for use in retinal drug delivery. In various other aspects, the present disclosure provides methods for delivery of the disclosed compositions comprising a therapeutic agent to the retina via intravitreal injection. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: August 9, 2022
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Anuj Chauhan, Russell Macoon
  • Lyophilized compositions of phenobarbital sodium salt
    Patent number: 11406598
    Abstract: A composition of, method for producing, and use of an amorphous lyophilized Phenobarbital Sodium having high purity are presented. The amorphous lyophilized Phenobarbital Sodium is storage-stable being essentially void of impurities (e.g., phenylethylacetylurea (PEAU), 2-ethyl-2-phenylmalonamide (2EPMM), and/or alpha-phenylbutyrylguanidine (PBG)) upon reconstitution in water.
    Type: Grant
    Filed: September 18, 2020
    Date of Patent: August 9, 2022
    Assignee: NIVAGEN PHARMACEUTICALS, INC.
    Inventors: Bala Tripura Sundari Chodavarapu, Thirupathi Mangali, Jay Shukla, Anand Shukla, Dasaradhi Lakkaraju
  • Gastroretentive treatment of nocturnal symptoms and morning akinesia in subjects with parkinson's disease
    Patent number: 11389398
    Abstract: Provided are methods and compositions for treating nocturnal symptoms of Parkinson's disease, morning akinesia, or associated symptoms thereof in a human subject in need thereof, wherein circulating plasma levels of levodopa are provided for an extended period of time following a period of delay after administration.
    Type: Grant
    Filed: May 14, 2020
    Date of Patent: July 19, 2022
    Assignee: Clexio Biosciences Ltd.
    Inventor: Richard Fisher
  • Gel for treating periocular and/or orbital pathologies and conditions
    Patent number: 11382862
    Abstract: A method comprising treating a periocular wound in a subject, comprising topically administering to the periocular wound a composition comprising at least one thermoresponsive gel.
    Type: Grant
    Filed: November 15, 2018
    Date of Patent: July 12, 2022
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Morgan V. Fedorchak, Jenny Yu, Michael A. Washington
  • RNA-lipid nanoparticle complexes of viral RNA polymerase region and SARS-CoV-2 spike protein region
    Patent number: 11376335
    Abstract: The disclosure provides nanoemulsion compositions and methods of making and using thereof to deliver a bioactive agent such as a nucleic acid to a subject. The nanoemulsion composition comprises a hydrophobic core based on inorganic nanoparticles in a lipid nanoparticle that allows imaging as well as delivering nucleic acids. Methods of using these particles for treatment and vaccination are also provided.
    Type: Grant
    Filed: November 10, 2021
    Date of Patent: July 5, 2022
    Assignee: HDT BIO CORP.
    Inventors: Amit Khandhar, Steven Reed, Malcolm Duthie, Jesse Erasmus, Darrick Carter, Bryan J. Berube
  • Xylan-based dual network nanocomposite hydrogel, preparation method thereof and use therefor
    Patent number: 11365293
    Abstract: This invention belongs to the technical field of composite materials, and discloses a xylan-based dual network nanocomposite hydrogel, preparation method thereof and use therefor. The method comprises (1) adding graphite oxide powder into deionized water, ultrasonically dispersing to obtain a GO aqueous dispersion; (2) adding xylan into deionized water, heating and stirring to obtain a xylan solution; (3) adding a water-soluble calcium salt, a reaction monomer and the xylan solution into the GO aqueous dispersion, and stirring and dispersing uniformly under an ice-bath condition, then adding an initiator, a crosslinking agent and an accelerator, stirring and mixing uniformly to obtain a mixed solution; and 4) drying and reacting the mixed solution (in the step (3) to obtain a xylan-based dual network nanocomposite hydrogel.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: June 21, 2022
    Assignee: SOUTH CHINA UNIVERSITY OF TECHNOLOGY
    Inventors: Junli Ren, Weiqing Kong, Runcang Sun, Danyang Huang, Guibin Xu
  • Cariprazine release formulations
    Patent number: 11344503
    Abstract: The patent discloses long-term injectable formulations and delivery systems of cariprazine and related salts and derivatives in the prevention and treatment of various psychotic diseases, such as schizophrenia, mania, and bipolar disorder. The dosage forms are either microsphere, microparticle, nanoparticle drug delivery systems in a pharmaceutically acceptable carrier, or devices that contain long-term injectable formulation of such cariprazine and related salts and derivatives.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: May 31, 2022
    Assignee: HALO SCIENCE LLC
    Inventors: Yu Hui, Kevin Yuan, Tian Zhang
  • Powder solid dispersions comprising quercetin, process for their preparation and formulations thereof
    Patent number: 11331298
    Abstract: Disclosed are powder solid dispersions including quercetin, phospholipids and a very to freely water soluble carrier. Also disclosed are a process for the preparation of the powder solid dispersions and pharmaceutical, nutraceutical and cosmetic compositions including the solid dispersions.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: May 17, 2022
    Assignee: INDENA S.P.A.
    Inventors: Massimo Ronchi, Elisabetta Frattini, Antonella Riva
  • Conditioning irradiated tissue for increasing vascularity
    Patent number: 11331288
    Abstract: Methods of increasing perfusion and vascularity in irradiated tissue and of increasing retention of fat cells in a fat graft in irradiated tissue by applying an effective amount of DFO to the irradiated tissue at a treatment site. The DFO may be administered transdermally by applying a transdermal delivery device to a tissue surface at the treatment site in multiple discrete doses. The transdermal delivery system comprises DFO encapsulated in reverse micelles.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: May 17, 2022
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Derrick C. Wan, Geoffrey C. Gurtner, Michael T. Longaker
  • Transmucosal delivery of tocotrienol
    Patent number: 11331302
    Abstract: The present invention relates to pharmaceutical compositions formulated for transmucosal delivery, and in particular sublingual delivery, comprising at least one tocotrienol or derivative thereof together with one or more pharmaceutically acceptable excipients. The present further relates to the use of said compositions for treating or preventing post exercise muscle soreness, delayed onset muscle soreness, cardiac fibrosis, hypertension, inflammation, stroke, cancer, elevated cholesterol and/or triglycerides, baldness, hypertrophy, conditions resulting from radiation exposure, stabilizing and/or controlling blood glucose levels, and improving exercise endurance and capacity.
    Type: Grant
    Filed: April 23, 2020
    Date of Patent: May 17, 2022
    Assignee: INVICTUS BIOTECHNOLOGY PTY LTD.
    Inventor: Glenn Tong
  • Methods and kits for providing support to pelvic tissue
    Patent number: 11324863
    Abstract: In some aspects, the present invention provides surgical procedures that comprise applying compositions into and/or onto pelvic tissue to provide support to the pelvic tissue. The injectable hydrogel composition comprises a polysaccharide. In embodiments, the polysaccharide comprises one or more of a glycosaminoglycan, chitosan, hyaluronic acid, dextran, alginic acid and hydroxyethyl starch. In other aspects, the present disclosure pertains to kits that are useful for performing such procedures.
    Type: Grant
    Filed: February 5, 2021
    Date of Patent: May 10, 2022
    Assignee: BOSTON SCIENTIFIC SCIMED, INC.
    Inventors: Sandra Nagale, Mark W. Boden, Andrew Dolan
  • Solid dispersion of dutasteride, method for preparing the solid dispersion, and pharmaceutical composition including the solid dispersion
    Patent number: 11324760
    Abstract: A solid dispersion of dutasteride for improving the solubility or dissolution rate of poorly soluble dutasteride, a method for preparing the solid dispersion, and a pharmaceutical composition including the solid dispersion are provided. The solid dispersion includes: a coprecipitate including dutasteride and a water-soluble polymeric carrier; and an adsorbent. The dutasteride and the water-soluble polymeric carrier are present in a weight ratio of 1:10-100 in the coprecipitate.
    Type: Grant
    Filed: November 12, 2018
    Date of Patent: May 10, 2022
    Assignee: KOREA PRIME PHARM CO., LTD.
    Inventors: Dae Ik Kim, Woo Cheoul Shin
  • Bismuth-thiol compositions and methods for treating wounds
    Patent number: 11324715
    Abstract: The invention relates to bismuth-thiol compounds and pharmaceutical preparations thereof. The invention further relates to methods for treating a topical wound, comprising administering to a subject in need thereof a therapeutically effective amount of a composition comprising a bismuth-thiol compound, wherein the composition is applied to the infection. Methods for treating microbial infections such as diabetic foot infections are also provided.
    Type: Grant
    Filed: November 15, 2021
    Date of Patent: May 10, 2022
    Assignee: MICROBION CORPORATION
    Inventor: Brett Hugh James Baker