Abstract: The invention provides for a method of operating a magnetic resonance imaging system for imaging a subject. The method comprises acquiring (700) tagged magnetic resonance data (642) and a first portion (644) of fingerprinting magnetic resonance data by controlling the magnetic resonance imaging system with tagging pulse sequence commands (100). The tagging pulse sequence commands comprise a tagging inversion pulse portion (102) for spin labeling a tagging location within the subject. The tagging pulse sequence commands comprise a background suppression portion (104). The background suppression portion comprises MRF pulse sequence commands for acquiring fingerprinting magnetic resonance data according to a magnetic resonance fingerprinting protocol. The tagging pulse sequence commands comprise an image acquisition portion (106).

Abstract: Currently most cancers, including breast cancers, are removed without any intraoperative margin control. Post-operative methods inspect 1-2% of the surgical margin and are prone to sampling errors. The present invention relates to an optical imaging system that will enable evaluation of the surgical margin in vivo and in real-time. The invention provides for simultaneous fluorescence and fluorescence polarization imaging. The contrast of the acquired images will be enhanced using fluorescent agents approved for diagnostic use in patients. As the staining pattern of fluorescence images is similar to that of histology, and the values of fluorescence polarization are significantly higher in cancerous as compared to normal cells, the invention provides for further improvements in diagnostic methods. The systems and methods can be applied to the intra-operative delineation of cancerous tissue.

Abstract: Disclosed herein is an ultrasound imaging apparatus capable of setting a region of interest having a shape corresponding to a shape of the cervix canal in an elasticity image of the cervix and displaying the region of interest, and a control method thereof. The ultrasound imaging apparatus includes a display unit configured to display an ultrasound elasticity image and a controller configured to select a point included in a path corresponding to the cervix canal in the elasticity image of the cervix displayed on the display unit, configured to set a region of interest having a shape corresponding to a shape of at least one portion of the cervix canal based on the selected point, and configured to display the region of interest on the display unit.

Abstract: The present invention discloses means and methods for detecting irregularities in the cells throughout a healthy tissue. The method generally relates to cancer detection, diagnosis and treatment, and more specifically pertains to detection, diagnosis and treatment guidance of cancerous or precancerous conditions through the use of thermal imaging technology and analysis.

Abstract: A system includes an assembly, a pinhole array, and a processor. The assembly includes a K by L photodetector array comprising a plurality of photodetectors and configured to detect light that exits a body at a second location after the light enters the body at a first location different than the second location and scatters within the body, and output a plurality of electronic signals representative of the detected light as a function of time. The pinhole array has a K by L array of pinholes configured to be aligned with the photodetectors and is configured to allow a certain amount of light to be incident upon each of the photodetectors. The processor is configured to generate a correlation map that includes a plurality of spatiotemporal correlation measure values corresponding to the light detected by the photodetector array.

Abstract: An ablation system for treating atrial fibrillation in a patient comprises an elongate shaft having proximal and distal ends, a lumen therebetween and a housing adjacent the distal end of the elongate shaft. An energy source is coupled to the housing and is adapted to deliver energy to a target tissue so as to create a zone of ablation in the target tissue that blocks abnormal electrical activity thereby reducing or eliminating the atrial fibrillation in the patient. A sensor is adjacent the energy source and adapted to detect relative position of the energy source to the target tissue or characteristics of the target tissue. The system also has a reflecting element operably coupled with the energy source and adapted to redirect energy emitted from the energy source in a desired direction or pattern.

Abstract: A treatment device includes a unit having an ultrasound imaging element and an ablation electrode, mechanism for receiving signals from the imaging element, the signals representing plural frames of ultrasound data; and mechanism for processing the signals to provide, in use, at least one of ultrasound data and data indicating mechanical strains within tissue being monitored by the sensor element, the strains being generated by movement of the tissue or the body being treated, the movement being generated naturally by the tissue or by the device operator's motion, or both.

Abstract: The present invention is directed towards a system and method for transarterial chemoembolization using differently sized drug-eluting microsphere beads filled with drugs and determining a delivered drug concentration using an imaging system.

Abstract: An apparatus can be provided according to certain exemplary embodiments. For example, the apparatus can include a waveguiding first arrangement providing at least one electromagnetic radiation. A configuration can be provided that receives and splits the at least one electromagnetic radiation into a first radiation and a second radiation. The apparatus can further include a waveguiding second arrangement which has a first waveguide and a second waveguide, whereas the first waveguide receives the first radiation, and the second waveguide receives the second radiation. The first arrangement, the second arrangement and the configuration can be housed in a probe.

Abstract: An interchangeable tip for ultrasound probe housing includes: at least one ultrasound transducer constructed and configured to emit and receive ultrasound signals, at least one electrical contact of tip, each electrical contact of tip being constructed and configured to cooperate with an electrical connector, a tip connector constructed and configured to secure the interchangeable tip with an ultrasound probe housing.

Abstract: Systems, apparatuses, methods, and non-transitory computer-readable media for mapping a section of a vasculature of a subject are described herein, including moving a probe to a first position adjacent the section of the vasculature; transmitting, by the probe, a first ultra-sound beam into a first portion of the section of the vasculature through the body of the subject; receiving first ultra-sound data including at least one imaging parameter; moving the probe to a second position at the body of the subject adjacent the section of the vasculature and different from the first position; transmitting, by the probe, a second ultrasound beam into a second portion of the section of the vasculature through the body of the subject; receiving second ultrasound data including the at least one imaging parameter; and constructing a map of the section of the vasculature based on the first ultrasound data and the second ultrasound data.

Abstract: Provided herein is a method of optically recording neural activity in one or more regions of a target tissue. Also provided is a method of optically modulating the activity of a neural tissue. Further provided is a system that finds use in performing the present methods.

Abstract: A pulse wave measuring apparatus includes a visible light receiver having a first surface and a pulse wave calculator. When a vehicle with the visible light receiver is viewed from a side, the first surface is in a first region between a first optical path of first reflection light and a second optical path of second reflection light, first light comes from an eye of a user on a seat of the vehicle, second light comes from a cheek of the user, an upper end of a rearview mirror of the vehicle reflects the first light to produce the first reflection light and reflects the second light to produce the second reflection light, and the pulse wave calculator calculates a pulse wave of the user on the basis of a waveform of visible light received by the visible light receiver via the first surface and outputs the calculated pulse wave.

Abstract: The systems and methods generally relate to blood speckle imaging. The systems and methods transmit a plurality of transmit (Tx) beams from an ultrasound probe to a region of interest (ROI). The plurality of Tx beams are transmitted successively with respect to each other. At least two of the plurality of Tx beams overlap at a common position. The systems and methods estimate velocity fields from the speckle tracking, and weight the velocity fields based on weighting signals to form weighted velocity fields. The weighting signal being centered at transmit beam axes of the plurality of Tx beams. The systems and methods interpolate the weighted velocity fields that overlap at the common position to adjust a portion of the weighted velocity fields, and generate an image on a display of a combined velocity field by combining the weighted velocity fields.

Abstract: Closed cavity adjustable sensor mount systems include a sealed, closed cavity enclosing a sensor and forming a closed cavity sensor assembly. The closed cavity sensor assembly may be tilted and/or translated relative to a platform in order to adjust the orientation of the sensor to align it with an imaging optical axis. Following alignment, the closed cavity sensor assembly may be permanently or reversibly fixed in place. The closed cavity adjustable sensor mount systems may be part of medical imaging systems such as endoscopic imaging systems and/or open field imaging systems.

Abstract: A fiber optic tracking system includes a light source, a first optical fiber, a second optical fiber, a sensing unit, and a controller operatively coupled to the sensing unit. Each optical fiber includes a plurality of sensing sections and has a fixed sensing point located along its respective length that is fixed relative to tissue. Each optical fiber is configured to receive an optical signal from the light source. The sensing sections are configured to modify the optical signals in response to a deformation of the respective optical fiber. The sensing unit is configured to receive modified optical signals from the first optical fiber and the second optical fiber. The controller is configured to determine locations in a working coordinate system of the fixed sensing points using the modified optical signals and determine a pose of the tissue based on the locations of the fixed sensing points.

Abstract: Devices, systems, and methods are described including an invasive medical device with a magnetic region. The magnetic region can include a discontinuity in the magnetic region providing a diameter transition, a plurality of spaced magnetic regions can be provided or the magnetic regions can be encoded with data. Systems and methods are described that include ways to read the data.

Abstract: Rapid exchange balloon catheter, and applications thereof. The balloon catheter includes a shaft and a guidewire channel. Shaft includes infusion and inflation walls. Infusion wall encloses an infusion lumen and comprises fluid inlet and fluid outlet located distally to fluid inlet. The inflation lumen extending axially therealong opened at a distal end thereof into an inner volume of a dilatation balloon. Guidewire channel is sized to closely fit over a pre-scribed guidewire for allowing unhindered passing therethrough with the guidewire. Guidewire channel includes a channel distal end protruding distally from the balloon with a distal guidewire opening, and a channel proximal end with a proximal guidewire opening at the shaft between fluid inlet and fluid outlet. Applications include methods for angioplasty and revascularization in which a single balloon catheter is used for dilatation and/or occlusion, and for delivering fluid proximally to the balloon.

Abstract: Embodiments of the present invention allow more full characterization of a stenotic lesion by measuring both pressure drop across the stenotic lesion and the size of the vessel lumen adjacent the stenotic lesion, both with sensors delivered intravascularly to the stenotic lesion site. In preferred embodiments, the size (e.g., inner diameter, cross-sectional profile) of the vessel lumen adjacent the stenotic lesion can be measured via one or more intravascular ultrasound transducers. In preferred embodiments, the intravascular ultrasound transducer(s) can be delivered to the site of the stenotic lesion with the same delivery device that carries the pressure transducer(s).

Abstract: A method of performing an ultrasound scan of cellular tissue by placing a flexible membrane overlaid with ultrasonic coupling material as part of a probe enclosure adjacent the cellular tissue, pressurizing the probe enclosure, moving an ultrasound probe within the probe enclosure over the flexible membrane with the head of the ultrasound probe submerged in the ultrasonic coupling material and displaced from the flexible membrane and generating a plurality of cross-sectional images of the cellular tissue as the ultrasound probe moves over the flexible membrane. The ultrasonic probe may be driven by a programmable controller. A flat surface of an axilla pad may be placed adjacent the flexible membrane and an examination wedge may be placed under one lateral side of a patient to raise the one lateral side of the patient above the other lateral side of the patient when the flexible membrane is placed adjacent to the cellular tissue.