Abstract: The present invention provides methods of treating LAL deficiency comprising administering to a mammal a therapeutically effective amount of lysosomal acid lipase with an effective dosage frequency. Methods of improving growth and river function, increasing LAL tissue concentration, and increasing LAL activity in a human patient suffering from LAL deficiency are also provided.
Abstract: High levels of polyhydroxyalkanoates (PHA) can be produced from wastewater comprising Readily Biodegradable COD (RBCOD) using activated sludge comprising microorganisms capable of accumulating PHA by contacting the wastewater with the activated sludge in the presence of dissolved oxygen during a first period of time, to obtain PHA-loaded activated sludge, and then supplying elements essential for growth such as nitrogen and phosphorus and allowing up-take of these elements and limited growth during a second period of time, the supplied amount of at least of one of said essential elements compared to the amount of RBCOD supplied in step a) limiting the growth to an extent that not all PHA is used for growth, to obtain grown activated sludge; and removing or harvesting part of the PHA-loaded activated sludge and/or part of the grown activated sludge, so that the total average retention time of the sludge is less than 72 h.
Abstract: The present invention relates to a composition for preserving cells and a method for preserving cells and, more specifically, to: a composition for preserving cells, containing, as active ingredients, plant-derived recombinant human serum albumin and plant peptides, wherein the composition maintains a high cellular survival rate while maintaining animal-free and xeno-free properties and is stable without changes in cellular morphology or surface expression factors in the short-term preservation of cells such as stem cells or primary cultured cells; and a method for preserving cells by using the same.
Type:
Grant
Filed:
August 6, 2015
Date of Patent:
May 31, 2022
Assignee:
CEFO CO., LTD
Inventors:
Hyun Sook Park, Sun Ray Lee, Jin Yup Lee, Hyun Jung Mo
Abstract: The invention relates to a method for controlling an enzymatic pre-treatment process, e.g. a mashing process. The method allows for accurate determination of specific sugar molecules as well as the average length of the sugar chains in real-time during e.g. a mashing process. Further information on e.g. the concentration of dissolved protein and free amino acids can also be obtained simultaneously. The method comprises the use of an infrared (IR) spectometer for continuously measuring attenuated total reflectance (ATR) IR spectra of samples obtained during pre-treatment of biomass.
Type:
Grant
Filed:
April 10, 2015
Date of Patent:
May 10, 2022
Assignee:
SPECSHELL, ApS
Inventors:
Erik Hoffmann-Petersen, Andreas Jonas Kunov-Kruse
Abstract: The present invention provides a method for preparation of an enzyme-modified stevia sugar. The method includes the steps of adding a ?-fructosidase to a solution in which a stevia sugar raw material and sucrose are dissolved to obtain a reaction solution, adjusting the pH of the reaction solution to be 5.0-8.0, maintaining a reaction temperature at 20-45° C., and after a reaction with stirring, collecting the enzyme-modified stevia sugar. The stevia sugar raw material includes one or more of stevioside and rebaudioside A, and the ?-fructosidase is derived from Microbacterium saccharophilum or Aspergillus japonicus. The preparation method takes a short time, is efficient and convenient to operate, low in cost, high in conversion rate, green and environmentally friendly, and can be widely applied to industrial scale production. The present invention further provides an enzyme for preparation of the enzyme-modified stevia sugar and application thereof.
Abstract: This document provides dietary supplements. For example, composition having a combination of ingredients useful in reducing cholesterol and improving overall cardiovascular health as well as methods for reducing cholesterol and improving overall cardiovascular health are provided.
Abstract: The present invention pertains to a cell culture medium comprising copper as a media supplement, which was shown to control recombinant protein glycosylation and methods of using thereof. The present invention further pertains to a method of controlling or manipulating glycosylation of a recombinant protein of interest in a large scale cell culture.
Type:
Grant
Filed:
October 16, 2015
Date of Patent:
March 8, 2022
Assignee:
Biogen MA Inc.
Inventors:
Fernie Mitchelson, Erik Heller Hughes, Jessica Mondia, Robin Parish Hyde-Deruyscher
Abstract: Provided is a microorganism of the genus Epidermidibacterium belonging to the family Sporichthyaceae, or a culture thereof, or a composition for preventing, improving, or treating skin conditions or inflammatory diseases including the same.
Type:
Grant
Filed:
June 27, 2017
Date of Patent:
March 1, 2022
Assignee:
COSMAX CO., LTD.
Inventors:
Dong Geol Lee, Jin Ju Nam, Min Ji Kim, Seung Hyun Kang, Youn Joon Kim
Abstract: A method for ex vivo treating blood or plasma is provided. The method includes (a) ex vivo contacting a blood or plasma with an enzyme composition to react the enzyme composition with the blood or plasma, wherein the enzyme composition is capable of eliminating electronegative low-density lipoprotein from the blood or plasma by the activity of the enzyme composition, and the enzyme composition is selected from a group consisting of: a first enzyme for eliminating a glycan residue of an electronegative low-density lipoprotein (LDL); a second enzyme for eliminating ceramide carried by a electronegative low-density lipoprotein (LDL); and a combination thereof; and (b) terminating contact between the blood or plasma and the enzyme composition to terminate the reaction of the enzyme composition with the blood or plasma.
Type:
Grant
Filed:
September 21, 2018
Date of Patent:
February 8, 2022
Assignee:
INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Abstract: Glucosyl stevia compositions are prepared from steviol glycosides of Stevia rebaudiana Bertoni. The glucosylation was performed by cyclodextrin glucanotransferase using the starch as source of glucose residues. The short-chain glucosyl stevia compositions were purified to >95% content of total steviol glycosides. The compositions can be used as sweetness enhancers, flavor enhancers and sweeteners in foods, beverages, cosmetics and pharmaceuticals.
Abstract: This invention relates to a process for producing lipids and amino acids from a gaseous substrate comprising methane and oxygen. The process uses a culture of a methanotrophic microorganism in a liquid nutrient medium. The methanotrophic microorganism can be a Methylomicrobium bacterium and more specifically Methylomicrobium buryatense 5GB1. The lipid products can be in the cellular membrane of the methanotroph and can be extracted in a separate extraction zone.
Type:
Grant
Filed:
October 20, 2014
Date of Patent:
January 11, 2022
Assignees:
LanzaTech New Zealand Limited, UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION, ALLIANCE FOR SUSTAINABLE ENERGY, LLC
Inventors:
Mary Elizabeth Lidstrom, Marina Georgievna Kalyuzhnaya, Derek Wayne Griffin, Nicholas Bourdakos, Philip Thomas Pienkos, Lieve Maria Louisa Laurens
Abstract: Disclosed is a method for producing 2?-fucosyllactose from a recombinant Corynebacterium sp. introduced with fucosyltransferase derived from Pseudopedobacter saltans. The recombinant Corynebacterium sp. microorganism introduced with fucosyltransferase derived from Pseudopedobacter saltans is capable of producing 2?-fucosyllactose at a high concentration, high yield and high productivity.
Type:
Grant
Filed:
February 14, 2019
Date of Patent:
January 4, 2022
Assignee:
ADVANCED PROTEIN TECHNOLOGIES CORP.
Inventors:
Chul Soo Shin, Jong Won Yoon, Young Ha Song, Young Sun You, Bo Mee Kim, Jin Kyung Kim, Ga Eun Lee
Abstract: Methods of inhibiting or reducing tumor metabolism and growth are disclosed. A composition containing oxygen scavenging membrane fragments is administered within a tumor to create a hypoxic environment. This interferes with tumor growth and metabolism, and can lead to tumor death.
Abstract: The disclosure discloses a method for producing long-chain glycosylated genistein and belongs to the technical fields of enzyme engineering and fermentation engineering. The disclosure provides a method for producing long-chain glycosylated genistein. By using this method to produce long-chain glycosylated genistein, the content of long-chain glycosylated genistein in a reaction solution and the ratio of the content of long-chain glycosylated genistein in the reaction solution to the content of total glycosylated genistein in the reaction solution can be increased. The content of long-chain glycosylated genistein in the reaction solution can be increased to 10.3 g/L, and the ratio of the content of long-chain glycosylated genistein in the reaction solution to the content of total glycosylated genistein in the reaction solution can be increased to 70%.
Abstract: The present invention provides a process for producing biogas and/or methane from solid spent cereal products derived from, for example, the mashing process of malt whisk(e)y and/or beer production. There is also provided a system for producing biogas and/or methane from solid spent cereal products derived from, for example, the mashing process of malt whisk(e)y and/or beer production.
Type:
Grant
Filed:
June 29, 2018
Date of Patent:
December 7, 2021
Assignee:
Blaygow Limited
Inventors:
John Morris Ross, Cornelius Martin Lynch
Abstract: A method for producing a food or a precursor of the same, including the steps: (a) providing a mash or a wort or last runnings as a first nutrient medium; and (b) treatment of the first nutrient medium with lactic acid bacteria of the species Lactobacillus rossiae (DSM 15814T) or with lactic acid bacteria of at least two kinds of species including Lactobacillus rossiae (DSM 15814T). Furthermore, a corresponding food and corresponding uses are claimed.
Type:
Grant
Filed:
August 31, 2018
Date of Patent:
November 2, 2021
Inventors:
Malaika Fischer, Peter Liebert, Stefan Kreisz
Abstract: Provided herein are methods and compositions for use in the treatment of depression, anxiety or a depressive or anxiety-related disorder. Embodiments describe the administration of orotic acid or a salt thereof, or the administration of one or more probiotic microorganisms, or administration of a combination of orotic acid or a salt thereof and one or more probiotic microorganisms.
Type:
Grant
Filed:
October 28, 2015
Date of Patent:
October 5, 2021
Assignee:
Medlab IP Pty Ltd
Inventors:
Luis Vitetta, Samantha Maree Coulson, Sean Hall
Abstract: Disclosed herein are processes for obtaining a microbial oil comprising one or more polyunsaturated fatty acids (PUFAs) from one or more microbial cells by lysing the cells to form a lysed cell composition and then recovering the oil from the lysed cell composition. Further disclosed herein is microbial oil comprising one or more PUFAs that is recovered from microbial cells by at least one process described herein.
Type:
Grant
Filed:
December 19, 2014
Date of Patent:
September 21, 2021
Assignee:
DSM IP Assets B.V.
Inventors:
Brock Triplett, Micah Needham, Nasrin Tabayehnejad, Ginger Shank, Kirt Lyvell Matthews, John Hogan, Mark Barker, Neil Leininger
Abstract: Provided are a variant of 5?-inosinic acid dehydrogenase, a microorganism including the same, and a method of preparing 5?-inosinic acid using the same.
Type:
Grant
Filed:
August 16, 2018
Date of Patent:
July 20, 2021
Assignee:
CJ CHEILJEDANG CORPORATION
Inventors:
Ji Hye Lee, So-jung Park, Min Ji Baek, Jin Sook Chang, Byoung Hoon Yoon