Patents Examined by Charles Zoltan Constantine
  • Patent number: 9615903
    Abstract: A device having a catheter and a hub which facilitates the transfer of an embryo containing solution into the uterus of a mammal, for example, a small mammal such as a rat or mouse. The catheter's shape and tip is designed to simplify insertion and minimize injury to the mammal. The hub is designed to further control the insertion of the catheter and to interface with a pipette, for example, that provides the force required for the transfer of an embryo containing solution. As a result, the transfer can occur without requiring surgery.
    Type: Grant
    Filed: May 22, 2009
    Date of Patent: April 11, 2017
    Assignee: ParaTechs Corp.
    Inventors: Michael A. Green, Brett Thomas Spear
  • Patent number: 9615599
    Abstract: Glucosyl stevia compositions are prepared from steviol glycosides of Stevia rebaudiana Bertoni. The glucosylation was performed by cyclodextrin glucanotransferase using the starch as source of glucose residues. The compositions were purified to >95% content of total steviol glycosides. The compositions can be used as sweetness enhancers, flavor enhancers and sweeteners in foods, beverages, cosmetics and pharmaceuticals.
    Type: Grant
    Filed: August 28, 2012
    Date of Patent: April 11, 2017
    Assignee: PureCircle Sdn Bhd
    Inventor: Avetik Markosyan
  • Patent number: 9611495
    Abstract: [Problem] To provide a bacterial cellulose which is highly dispersible in a liquid, shows excellent molding properties and high miscibility with other materials when applied to materials, and, therefore, has a high applicability as a practical material, and a bacterium which produces the bacterial cellulose. [Solution] A bacterial cellulose, water that contains said bacterial cellulose at a final concentration of 0.1±0.006 (w/w) showing a light transmittance at a wavelength of 500 nm of 35% or greater, and a bacterium producing the bacterial cellulose. According to the present invention, the bacterial cellulose that is uniformly dispersible in a liquid such as water can be obtained. The bacterial cellulose shows excellent molding properties and high miscibility with other materials and, therefore, can contribute to the improvement in the qualities of a final product or production efficiency thereof or to the reduction of production cost.
    Type: Grant
    Filed: December 27, 2013
    Date of Patent: April 4, 2017
    Inventors: Kenji Tajima, Ryota Kose
  • Patent number: 9603373
    Abstract: Glucosyl stevia compositions are prepared from steviol glycosides of Stevia rebaudiana Bertoni. The glucosylation was performed by cyclodextrin glucanotransferase using the starch as source of glucose residues. The glucosyl stevia compositions were purified to >95% content of total steviol glycosides. The compositions can be used as sweetness enhancers, flavors, flavor enhancers and sweeteners in foods, beverages, cosmetics and pharmaceuticals.
    Type: Grant
    Filed: February 17, 2015
    Date of Patent: March 28, 2017
    Assignee: PureCircle Sdn Bhd
    Inventor: Avetik Markosyan
  • Patent number: 9593355
    Abstract: The present invention concerns a production of liquefied lignocellulosic substrate by enzymatic reaction. 10% to 40% by weight dry matter of pre-treated lignocellulosic substrate is contacted, with water and enzymes at 0.1 to 60 mg of enzymes per gram of cellulose for a period of 1 to 24 hours. Over time, at least the value of one of the rheological characteristics of the reaction medium is measured. If a reduction of the value is detected over time, the following step a) is carried out: a) the feeding flow rate of pre-treated lignocellulosic substrate is increased, with or without modification of the flow rate of enzymes and/or water; If an increase of the value is detected over time, a step b) is carried out: b) the feeding flow rate of water and/or enzymes is increased, with or without modification of the flow rate of pre-treated lignocellulosic substrate.
    Type: Grant
    Filed: November 29, 2012
    Date of Patent: March 14, 2017
    Assignee: IFP ENERGIES NOUVELLES
    Inventors: Sylvain Louret, Romain Rousset
  • Patent number: 9574217
    Abstract: Immune function of an animal can be modulated by administration of a composition that includes algae meal or beta glucan. The algae meal can be made by growing Euglena using particular methods and conditions, including certain continuous, semi-continuous, fed-batch, and repeat batch methods in sterile fermenters. Euglena provides a form of beta glucan that is different from other organisms, where the beta glucan is predominantly unbranched beta-1,3-glucan. Use of algae meal and beta glucan produced by the disclosed processes can improve the wellbeing of an animal or human, and may augment or even replace the use of antibiotics in certain circumstances.
    Type: Grant
    Filed: May 7, 2013
    Date of Patent: February 21, 2017
    Assignee: Algal Scientific Corporation
    Inventors: Robert Bernard Levine, Jeffrey Richard LeBrun, Geoffrey Paul Horst
  • Patent number: 9565852
    Abstract: A composition and method for generating reagents and the composition of these reagents for the stabilization and preservation of viability of cancer tissue which has been surgically excised and the suspension and/or termination of apoptosis (cell death) by significant modulation of cell metabolism by low molar concentrations of synergistic chemistries and hormonal growth enhancers while maintaining normal gene expression patterns of the surgically excised tissue.
    Type: Grant
    Filed: May 1, 2015
    Date of Patent: February 14, 2017
    Assignee: Truckee Applied Genomics, LLC
    Inventor: Tony K. Baker
  • Patent number: 9523103
    Abstract: A process for converting biomass hydrolysate into biofuel, the process comprising the steps of: obtaining a biomass hydrolysate solution comprising monosaccharides; immobilizing Pachysolen tannophilus; contacting the solution with the immobilized Pachysolen tannophilus; and recovering a fermented biofuel.
    Type: Grant
    Filed: May 20, 2015
    Date of Patent: December 20, 2016
    Assignee: GeoSynFuels, LLC
    Inventors: Lisa Beckler Andersen, John H. Evans, IV, Christine A. Singer
  • Patent number: 9512405
    Abstract: A simple method was developed to extract adipose-derived stromal stem cells (ASCs) without using enzymatic digestion of the collagen in adipose tissue. The resulting ASCs isolated by the simple wash method have lower levels of CD34 expression, a hematopoietic stem cell marker, as compared to ASCs isolated using conventional enzymatic digestion using collagenase. This characteristic is consistent with non-enzymatically treated stem cells obtained from bone marrow aspirates, which are negative for CD34. Additionally, the washed ASCs have higher levels of CD44 expression, a hyaluronate receptor, and lower levels of contaminating hematopoietic cells, as evidenced by low CD45 expression, as compared to enzymatically digested cells. The cells produced by this simple method can be used therapeutically for allogenic or autologous tissue regeneration, and can be administered using any pharmaceutically acceptable carrier.
    Type: Grant
    Filed: December 13, 2012
    Date of Patent: December 6, 2016
    Assignee: Board of Supervisors of Louisiana State University And Agricultural and Mechanical College
    Inventors: Jeffrey M. Gimble, Forum S. Shah, Xiying Wu
  • Patent number: 9474296
    Abstract: Glucosyl stevia compositions are prepared from steviol glycosides of Stevia rebaudiana Bertoni. The glucosylation was performed by cyclodextrin glucanotransferase using the starch as source of glucose residues. The compositions mainly comprise glucosyl derivatives with superior taste characteristics and can be used as sweetness enhancers, flavor enhancers and sweeteners in foods, beverages, cosmetics and pharmaceuticals.
    Type: Grant
    Filed: August 28, 2012
    Date of Patent: October 25, 2016
    Assignee: PureCircle Sdn Bhd
    Inventor: Avetik Markosyan
  • Patent number: 9445586
    Abstract: A composition and method for generating reagents and the composition of these reagents for the stabilization and preservation of viability of cancer tissue which has been surgically excised and the suspension and/or termination of apoptosis (cell death) by significant modulation of cell metabolism by low molar concentrations of synergistic chemistries and hormonal growth enhancers while maintaining normal gene expression patterns of the surgically excised tissue.
    Type: Grant
    Filed: May 14, 2015
    Date of Patent: September 20, 2016
    Assignee: TRUCKEE APPLIED GENOMICS, LLC
    Inventor: Tony K. Baker
  • Patent number: 9422579
    Abstract: Described is a process for the conversion of halophytic plant biomass containing saline organic solids into biogas through anaerobic digestion. Operation of the process with saline (e.g., seawater) as liquid media under the method conditions taught leads to biological conversion of the organic matter into biogas. Additionally described is a method for pretreatment of the biomass under mild physicochemical conditions to increase the bioavailable fraction of the biomass for conversion.
    Type: Grant
    Filed: June 25, 2014
    Date of Patent: August 23, 2016
    Assignee: Masdar Institute of Science and Technology
    Inventors: Jorge Rodriguez, Joao Marcus Uratani
  • Patent number: 9408879
    Abstract: The present invention provides a strain of Bifidobacterium bifidum or mutant or variant thereof showing at least an adhesion of about 10 bacterial cells per mm2 of epithelial cell monolayer or having at least an adhesion index of 1.5 and a strain of Bifidobacterium bifidum or mutant or variant thereof being Bifidobacterium bifidum MIMBb75, deposited under deposit No. DSM 24514, or a mutant or variant thereof for use as probiotic, in foodstuff and/or as a medicament. Further provided is a probiotic for mulation, comprising any of the strains, mutants or variants mentioned above, uses of said probiotic formulation, strains, mutants and variants thereof and a method for producing said probiotic formulation.
    Type: Grant
    Filed: January 27, 2012
    Date of Patent: August 9, 2016
    Assignee: Naturewohl Pharma GmbH
    Inventors: Simone Guglielmetti, Diego Mora
  • Patent number: 9392799
    Abstract: Glucosyl stevia compositions are prepared from steviol glycosides of Stevia rebaudiana Bertoni. The glucosylation was performed by cyclodextrin glucanotransferase using the starch as source of glucose residues. The short-chain glucosyl stevia compositions were purified to >95% content of total steviol glycosides. The compositions can be used as sweetness enhancers, flavor enhancers and sweeteners in foods, beverages, cosmetics and pharmaceuticals.
    Type: Grant
    Filed: April 16, 2014
    Date of Patent: July 19, 2016
    Assignee: PureCircle Sdn Bhd
    Inventor: Avetik Markosyan
  • Patent number: 9394516
    Abstract: An object of the present invention to provide an agent for promoting the self-renewal of the neural stem cells and a method of using the same. ECF-L contained in a culture supernatant of endothelial progenitor cells derived from bone marrow has an effect of promoting the self-renewal of neural stem cells. Accordingly, ECF-L can be used as an ingredient of an agent for promoting the self-renewal of the neural stem cells, a pharmaceutical composition for growing the neural stem cells, and a pharmaceutical composition for treating a disease associated with neural dysfunction.
    Type: Grant
    Filed: April 26, 2011
    Date of Patent: July 19, 2016
    Assignee: Keio University
    Inventors: Jun Namiki, Hideyuki Okano
  • Patent number: 9386797
    Abstract: Glucosyl stevia compositions are prepared from steviol glycosides of Stevia rebaudiana Bertoni. The glucosylation was performed by cyclodextrin glucanotransferase using the starch as source of glucose residues. The short-chain glucosyl stevia compositions were purified to >95% content of total steviol glycosides. The compositions can be used as sweetness enhancers, flavor enhancers and sweeteners in foods, beverages, cosmetics and pharmaceuticals.
    Type: Grant
    Filed: April 16, 2014
    Date of Patent: July 12, 2016
    Assignee: PureCircle Sdn Bhd
    Inventor: Avetik Markosyan
  • Patent number: 9388378
    Abstract: A strain of Candida sake, CAT H430, is provided. The methods of using CAT H430 for producing dicarboxylic acids are also provided.
    Type: Grant
    Filed: March 9, 2012
    Date of Patent: July 12, 2016
    Assignees: CATHAY R&D CENTER CO., LTD., CATHAY INDUSTRIAL BIOTECH LTD.
    Inventors: Charlie Liu, Jinxiu Liao, Jianglin Wang, Haibin Qin, Naiqiang Li
  • Patent number: 9382573
    Abstract: A reagent composition for a biosensor sensor strip is disclosed that provides for rapid rehydration after drying. The composition includes porous particles and is preferably formed as a colloidal suspension. The dried reagent composition including porous particles may provide analytically useful output from the sensor strip in a shorter time period than observed from dried reagent compositions using solid particles. The output signal from the porous particle compositions may be correlated to the analyte concentration of a sample within about two seconds. In this manner, an accurate concentration determination of an analyte concentration in a sample may be obtained in less time than from sensor strips including conventional compositions. The reagent composition including the porous particles also may allow for the redox reaction between the reagents and the analyte to reach a maximum kinetic performance in a shorter time period than observed from conventional sensor strips.
    Type: Grant
    Filed: December 2, 2013
    Date of Patent: July 5, 2016
    Assignee: Ascensia Diabetes Care Holdings AG
    Inventor: Boru Zhu
  • Patent number: 9376705
    Abstract: A method for detecting susceptibility of microorganisms to chemical agents or antibiotics through a combination of exposing the microorganisms to the chemical agents or antibiotics after having exposed the microorganisms to a stress response-inducing stimulus and subsequently analyzing the response of the microorganisms by mass spectrometry.
    Type: Grant
    Filed: June 6, 2013
    Date of Patent: June 28, 2016
    Assignee: Idmic SA
    Inventors: Vadim Govorun, Elena Ilina, Alexei Podoplelov
  • Patent number: 9340802
    Abstract: Processes, as well as associated systems, are disclosed for the biological conversion of CO into desired end products such as ethanol. The use of a plurality of perforated plates, for example in the riser section of a bioreactor, which are positioned substantially horizontally and normal to the upward flow of both a CO-containing substrate and liquid culture medium, can significantly improve CO utilization of the bacteria and consequently the overall process economics. The geometry of apertures in the perforated plates is an important determinant of their performance, with fractal patterns and other multi-edged shapes leading to particularly advantageous results.
    Type: Grant
    Filed: June 19, 2014
    Date of Patent: May 17, 2016
    Assignee: LANZATECH NEW ZEALAND LIMITED
    Inventor: Simon Richard Trevethick