Patents Examined by Chris L Chin
  • Multiple analyte immunoassay
    Patent number: 8404493
    Abstract: Methods for measuring the amount of two or more analytes of interest in a fluid sample, and kits useful in the methods, are disclosed. The methods involve determining a ratio of a detected amount of a single analyte of interest, to the sum of a detected amount of each of the analytes of interest plus a detected amount of a control, wherein the amount of each analyte of interest is directly or inversely related to the ratio for each analyte of interest.
    Type: Grant
    Filed: June 4, 2009
    Date of Patent: March 26, 2013
    Assignee: Response Biomedical Corporation
    Inventors: Whalley K. Fong, Paul C. Harris, Brian G. Richards
  • Lateral flow assay system and methods for its use
    Patent number: 8399261
    Abstract: A lateral flow test system together with methods for its use in the detection of one or more analytes, or components, of interest within a sample, such as a biological sample, is provided. The system comprises a liquid formulation of a gold conjugate and a lateral flow assay device that does not include a conjugate pad having conjugate dried thereon.
    Type: Grant
    Filed: June 27, 2008
    Date of Patent: March 19, 2013
    Assignee: Inbios International, Inc.
    Inventors: Mazbahul Kabir, Syamal Raychaudhuri, James William Needham, Stanislaw Morkowski
  • Methods, immunoassays and devices for detection of anti-lipoidal antibodies
    Patent number: 8394600
    Abstract: Compositions, methods and devices for the detection of anti-lipoidal antibodies and the diagnosis of disease, for example, syphilis, are described. In particular, a method for immobilizing a lipoidal antigen, comprising cardiolipin, lecithin, and cholesterol, on a solid support (such as a nitrocellulose membrane) is described. The ability to immobilize a lipoidal antigen on a membrane satisfies a long-felt need for a membrane-based assay for the detection of anti-lipoidal antibodies. Also described are immunoassay devices for concurrently performing treponemal and non-treponemal tests for syphilis.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: March 12, 2013
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention
    Inventor: Arnold R. Castro
  • Specimen collection and assay container
    Patent number: 8394626
    Abstract: The present invention includes but is not limited to a specimen collection device that includes a chamber capable of collecting a specimen, a specimen passage slot, a reservoir, a reservoir seal, and a test device. A sample or specimen added to the chamber flows through the specimen passage slot into the reservoir. Flow into the reservoir may be limited by the reservoir seal. The test device positioned within the reservoir detects the presence or concentration of an analyte within the sample or specimen.
    Type: Grant
    Filed: June 2, 2009
    Date of Patent: March 12, 2013
    Assignee: Alere Switzerland GmbH
    Inventors: James T. Ramsey, Larry Hartselle
  • Methods, immunoassays and devices for detection of anti-lipoidal antibodies
    Patent number: 8389229
    Abstract: Compositions, methods and devices for the detection of anti-lipoidal antibodies and the diagnosis of disease, for example, syphilis, are described. In particular, a method for immobilizing a lipoidal antigen, comprising cardiolipin, lecithin, and cholesterol, on a solid support (such as a nitrocellulose membrane) is described. The ability to immobilize a lipoidal antigen on a membrane satisfies a long-felt need for membrane-based assay for the detection of anti-lipoidal antibodies. Also described are immunoassay devices for concurrently performing treponemal and non-treponemal tests for syphilis.
    Type: Grant
    Filed: March 15, 2012
    Date of Patent: March 5, 2013
    Assignee: The United States of America as Represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention
    Inventors: Arnold R. Castro, Robert W. George
  • Assay devices and methods and components for use therein
    Patent number: 8389296
    Abstract: Dipsticks and other assay devices suitable for the assay of haptens are disclosed. Also disclosed are blocking agents for use in such devices.
    Type: Grant
    Filed: April 22, 2008
    Date of Patent: March 5, 2013
    Assignee: Selective Antibodies Limited
    Inventors: Colin Henry Self, Michael Chard
  • Peptide-coated nanoparticles with graded shell compositions
    Patent number: 8383423
    Abstract: A peptide-coated nanoparticle that includes a nanocrystal surrounded by a graded shell that is composed of at least two different semiconductor molecules. At least one peptide is attached to the surface of the graded shell to render the nanoparticle biocompatible. The nanocrystal core and graded shell are optionally annealed with ultra violet radiation prior to and/or after attachment of the peptide(s).
    Type: Grant
    Filed: March 29, 2011
    Date of Patent: February 26, 2013
    Assignee: The Regents of the University of California
    Inventors: Shimon Weiss, James M. Tsay, Fabien Pinaud, Soren Doose
  • Immunochromatographic device
    Patent number: 8383422
    Abstract: The present invention provides an immunochromatographic device, which contains the following (a) and (b): (a) a first device part holding a first insoluble carrier used for developing a complex formed with an analyte and a labeling substance comprising a metal labeled with a first binding substance that can bind to the analyte and capturing the analyte and the labeling substance at a reaction portion containing a second binding substance that can bind to the analyte, and (b) a second device part holding a second insoluble carrier used for developing a liquid and a third insoluble carrier used for absorbing a liquid, in such a way that the first insoluble carrier does not come into contact with the second insoluble carrier and the third insoluble carrier.
    Type: Grant
    Filed: May 26, 2009
    Date of Patent: February 26, 2013
    Assignee: FUJIFILM Corporation
    Inventors: Junichi Katada, Hideyuki Karaki, Takayoshi Oyamada
  • High resolution label free analysis of cellular properties
    Patent number: 8372592
    Abstract: The invention provides methods of detecting a change in cell growth patterns.
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: February 12, 2013
    Assignee: X-Body, Inc.
    Inventors: Lance G. Laing, Rafael Fernandez, Rick Wagner
  • Method for increasing the dynamic measuring range of test elements based on specific binding reactions
    Patent number: 8354235
    Abstract: The invention concerns a method for increasing the dynamic measuring range of especially immunological test elements in particular immunological chromatography test strips that can be evaluated optically that are based on specific binding reactions. The invention enables the dynamic measuring range of test elements based on specific binding reagents, especially of immunological test elements to be shifted towards higher analyte concentrations without impairing the lower detection limit.
    Type: Grant
    Filed: November 7, 2006
    Date of Patent: January 15, 2013
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Ludger Bodenbach, Juergen Schaeffler, Juergen Spinke
  • Microdevices for chemical sensing and chemical actuation
    Patent number: 8343755
    Abstract: The invention relates to sensors for detecting chemical and biological material and for chemical actuation. In particular, the sensors of the present invention incorporates membranes or beams that are deformable in the presence of chemical adsorption on its surface. The sensor of the present invention contains a polymeric membrane or beam (102) that is clamped at least at two opposing ends (104) and (106).
    Type: Grant
    Filed: August 1, 2006
    Date of Patent: January 1, 2013
    Assignee: University of Virginia Patent Foundation
    Inventors: Matthew R. Begley, James P. Landers, Jerome P. Ferrance, Ling Huang, Michael H. Jones, Marcel Utz, Scott Barker
  • Method and system for the analysis of high density cells samples
    Patent number: 8323882
    Abstract: Methods for forming cell arrays of multiple cell samples arranged substantially in a monolayer on a single substrate particularly suited for diagnostic analysis are disclosed. The cell arrays are formed with a high-speed dispensing apparatus capable of dispensing small volumes in precise, complex patterns. Also disclosed are substrates upon which cell arrays may be formed, and methods for conducting diagnostic analyses on the formed cell arrays.
    Type: Grant
    Filed: July 9, 2010
    Date of Patent: December 4, 2012
    Assignees: Biodot, Inc., Accupath Diagnostic Laboratories, Inc.
    Inventors: Mathew Moore, Miriam Reyes, David Baunoch, Thomas Tisone, Brendan O'Farrell
  • Devices and methods for detecting analytes
    Patent number: 8313955
    Abstract: This invention provides devices and methods for detecting an analyte suspected to be present in a sample. The subject devices and methods are particularly useful for performing immunoassays on a variety of analyte, especially those present in a bodily fluid.
    Type: Grant
    Filed: March 17, 2008
    Date of Patent: November 20, 2012
    Assignee: Alere Switzerland GmbH
    Inventors: Xin Wu, Fuquan Zhao, Yinfei Wu, Fei Gao
  • Methods and devices to enhance sensitivity and evaluate sample adequacy and reagent reactivity in rapid lateral flow immunoassays
    Patent number: 8309366
    Abstract: Methods and devices for rapid lateral flow immunoassays to detect specific antibodies within a liquid sample while also validating the adequacy of the liquid sample for the presence of immunoglobulin and the integrity and immunoreactivity of the test reagents that detect the antibodies of interest, without requiring instrumentation. The methods and devices provide for delivery of a diluted liquid sample to a single location that simultaneously directs the liquid flow along two or more separate flow paths, one that serves as a positive control to confirm that all critical reagents of the test are immunoreactive, and that the sample being tested is adequate, and the other to detect specific antibodies if present.
    Type: Grant
    Filed: December 23, 2011
    Date of Patent: November 13, 2012
    Inventor: Thomas M. Buchanan
  • Detection system and method for high sensitivity fluorescent assays
    Patent number: 8309369
    Abstract: This invention relates to a detection system for measuring a fluorescent signal in a fluorescent assay. The system comprises a probe having a small sensing surface bound with a fluorescent label, and a light source and a detector both mounted at the proximal side of the sensing surface of the substrate. The invention also relates to a method for detecting an analyte in a liquid sample using a probe tip having a small surface area (?5 mm) and a high molecular weight polymer (?1 MD) having multiple binding molecules and multiple fluorescent labels. The binding reaction is accelerated by flowing the reaction solutions laterally and moving the probe tip up and down in the reaction vessels. The invention furthers relates to a fluorescent labeling composition comprising a cross-linked Ficoll molecule having a plurality of binding molecules and a plurality of fluorescent labels.
    Type: Grant
    Filed: September 1, 2011
    Date of Patent: November 13, 2012
    Assignee: Access Medical Systems, Ltd.
    Inventors: Hong Tan, Robert F. Zuk, Yushan Tan, Erhua Cao, Min Xia, Jun Chen
  • Methods of detection of changes in cells
    Patent number: 8298780
    Abstract: Methods are provided to detect changes in cells without the use of detection labels.
    Type: Grant
    Filed: December 15, 2008
    Date of Patent: October 30, 2012
    Assignee: X-Body, Inc.
    Inventors: Rick Wagner, Rafael Fernandez, Brian T. Cunningham, Lance Laing
  • Assay modules having assay reagents and methods of making and using same
    Patent number: 8298834
    Abstract: We describe assay modules (e.g., assay plates, cartridges, multi-well assay plates, reaction vessels, etc.), processes for their preparation, and method of their use for conducting assays. Reagents may be present in free form or supported on solid phases including the surfaces of compartments (e.g., chambers, channels, flow cells, wells, etc.) in the assay modules or the surface of colloids, beads, or other particulate supports. In particular, dry reagents can be incorporated into the compartments of these assay modules and reconstituted prior to their use in accordance with the assay methods. A desiccant material may be used to maintain and stabilize these reagents in a dry state.
    Type: Grant
    Filed: August 31, 2010
    Date of Patent: October 30, 2012
    Assignee: Meso Scale Technologies, L.L.C.
    Inventors: Eli N. Glezer, Bandele Jeffrey-Coker, Jeff D. Debad, Sudeep M. Kumar, George Sigal, Gisbert Spieles, Michael Tsionsky, Michael Warnock
  • Real time binding analysis of antigens on a biosensor surface
    Patent number: 8293542
    Abstract: The invention provides methods for detecting interactions between phage and antigen or antigen and antibody using biosensors.
    Type: Grant
    Filed: March 12, 2009
    Date of Patent: October 23, 2012
    Assignee: X-Body, Inc.
    Inventors: Lara Madison, John Gerstenmaier
  • Waveguide-based optical scanning systems
    Patent number: 8288157
    Abstract: A scanning sensor system, methods of use and kits for detecting a biologically active analyte are provided. The scanning sensor system includes a light source, a detector, a substrate comprising a plurality of waveguides and a plurality of optical sensing sites in optical communication with one or more waveguide of the substrate, and at least one adapter configured to couple with the substrate and provide optical communication between the light source, the waveguides of the substrate, and the detector.
    Type: Grant
    Filed: September 12, 2008
    Date of Patent: October 16, 2012
    Assignee: PLC Diagnostics, Inc.
    Inventor: Reuven Duer
  • Ultrasensitive biochemical sensor
    Patent number: RE43978
    Abstract: An electronic sensor is provided for detecting the presence of one or more analytes of interest in a sample. The sensor preferably comprises a field effect transistor in which conductance is enhanced altered by analyte binding to receptors in the active region. An array of sensors may be formed to analyze a sample for multiple analytes.
    Type: Grant
    Filed: September 23, 2008
    Date of Patent: February 5, 2013
    Assignee: University of Hawaii
    Inventor: James W. Holm-Kennedy