Patents Examined by Christine T Mui
  • Microfluidic apparatus, method of detecting substance in microfluidic apparatus, and light extraction apparatus
    Patent number: 11491484
    Abstract: A microfluidic apparatus is provided. The microfluidic apparatus includes a base substrate; a microfluidic device on the base substrate and including a plurality of micro fluidic channels; a plurality of light sources of different colors respectively emitting light of different wavelength ranges; a light extraction apparatus for extracting light respectively from the plurality of light sources of different colors and a plurality of photosensors. The light extraction apparatus includes a light guide plate having a plurality of light incident portions for respectively receiving light respectively incident from the plurality of light sources of different colors, the plurality of light incident portions being on a side of the light guide plate away from the microfluidic device; and a plurality of light extractors on the light guide plate.
    Type: Grant
    Filed: June 24, 2019
    Date of Patent: November 8, 2022
    Assignee: Beijing BOE Technology Development Co., Ltd.
    Inventors: Xianqin Meng, Wei Wang, Jifeng Tan, Xiandong Meng, Xiaochuan Chen, Jian Gao, Pengxia Liang, Fangzhou Wang
  • Colorimetric drug test strip using porous support material
    Patent number: 11493451
    Abstract: A test strip includes a substantially transparent substrate and one or more colorimetric test spots on the transparent substrate. Each colorimetric test spot has one or more sensing chemicals chemically attached onto a porous support material. The porous support material has at least one exposed surface configured to absorb a body fluid. The one or more sensing chemicals are configured to change a color in response to a presence of a target drug in the body fluid.
    Type: Grant
    Filed: December 23, 2019
    Date of Patent: November 8, 2022
    Assignee: Palo Alto Research Center Incorporated
    Inventors: Gabriel Iftime, Stephen Matthew Meckler, David Eric Schwartz, Joerg Martini, Jessica Louis Baker Rivest
  • System and method for monitoring a reaction within a receptacle vessel
    Patent number: 11493445
    Abstract: A system for monitoring reactions with a plurality of receptacle vessels that includes: an incubator; a movable receptacle carrier contained within a temperature-controlled chamber of the incubator; one or more fixed fluorometers configured to measure a fluorescent emission and positioned with respect to the receptacle carrier to measure fluorescent emissions from receptacle vessels carried on the receptacle carrier into an operative position with respect to each fluorometer; one or more fluorescent reference standards mounted on the receptacle carrier; and a controller configured to control operation of the receptacle carrier and the one or more fluorometers to determine if a fluorescent emission intensity of one or more of the fluorescent reference standards deviates from an expected fluorescent emission intensity.
    Type: Grant
    Filed: June 24, 2020
    Date of Patent: November 8, 2022
    Assignee: GEN-PROBE INCORPORATED
    Inventors: Haitao Li, David Opalsky, R. Eric Heinz, Norbert D. Hagen
  • Binding domain mapping
    Patent number: 11493518
    Abstract: The present disclosure relates to compositions and methodology for revealing binding sites between proteins, proteins and nucleic acids, or proteins and small molecules. The disclosure provides rapid and direct positive identification and sequencing of the contact region between such molecules, and can be applied to individual interacting pairs, as well as large-scale or global interactions.
    Type: Grant
    Filed: September 25, 2018
    Date of Patent: November 8, 2022
    Assignee: GEORGE MASON RESEARCH FOUNDATION, INC.
    Inventors: Alessandra Luchini Kunkel, Lance Liotta, Virginia Espina
  • Microdevice for detecting aldehydes or ketones
    Patent number: 11484880
    Abstract: A device and system for detecting aldehydes or ketones and, more particularly, a device and system, for detecting aldehydes or ketones, utilized in a rotating platform are provided.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: November 1, 2022
    Inventors: Gyeongjin Lee, Byung Hyun Park, Su Youn Han, Byoung Hyoun Kim
  • Microfluidic chip and microfluidic device
    Patent number: 11478790
    Abstract: A microfluidic chip includes a flow passage plate, a flat plate, and an annular seal. In the flow passage plate, a recess forming a flow passage for liquid and a communication hole communicating with the recess are formed. The flat plate is stacked on or under the flow passage plate to close the recess for defining the flow passage. In the flat plate, a communication through-hole communicating with the recess is formed. The annular seal is located on, or formed on, an outer surface of at least one of the flow passage plate and the flat plate, the annular seal surrounding at least one of the communication hole and the communication through-hole. The annular seal is made of an elastomer.
    Type: Grant
    Filed: September 19, 2018
    Date of Patent: October 25, 2022
    Assignee: NOK CORPORATION
    Inventors: Takayuki Komori, Takahiro Hayashi
  • Reagent mixer and fluid control devices
    Patent number: 11478786
    Abstract: An apparatus for preparing a reagent solution includes an enclosure and a container disposed within the enclosure. The container defines an internal cavity having a compressible volume and defines a passage providing fluidic communication between the internal cavity and the exterior of the container. Optionally, a compressible member is disposed within the internal cavity. A reagent is disposed within the internal cavity.
    Type: Grant
    Filed: August 27, 2020
    Date of Patent: October 25, 2022
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Jonathan Schultz, Todd Roswech
  • Fluidic chip
    Patent number: 11477857
    Abstract: A fluidic chip comprising: a sealing layer having an upper surface and a lower surface; and a formed part comprising a generally planar body having a lower surface sealed with the upper surface of the sealing layer, the generally planar body having a number of through holes and a number of wells in fluid communication with the number of through holes, wherein together with the upper surface of the sealing layer, the number of through holes and the number of wells respectively define a number of fluid inlets and a number of fluid chambers in fluid connection with each other in the fluidic chip.
    Type: Grant
    Filed: June 11, 2020
    Date of Patent: October 18, 2022
    Assignee: CELL ID PTE LTD
    Inventor: Lye Hock Sim
  • Small volume sample collection device and related systems and methods
    Patent number: 11465146
    Abstract: A system, mixing-enhanced microfluidic container, and methods for small volume sample collection and/or analysis is disclosed. Namely, the invention is directed to a small volume sample collection system that includes a mixing-enhanced microfluidic container and a durable reusable actuation chuck. The mixing-enhanced microfluidic container is used to collect small volumes of sample fluid and includes a means for mixing the sample fluid with reagents disposed within the microfluidic container. The mixing means utilize an array of surface-attached structures (e.g., a micropost array). The application of an “actuation force,” such as a magnetic or electric field, actuates the surface-attached structures into movement, wherein the actuation chuck in close proximity to the mixing-enhanced microfluidic container provides the “actuation force.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: October 11, 2022
    Assignees: Redbud Labs, Inc., The University of North Carolina at Chapel Hill
    Inventors: Richard Chasen Spero, Jay Kenneth Fisher, Richard Superfine
  • Rapid test breathalyzer and methods of use thereof
    Patent number: 11460466
    Abstract: Described herein are rapid breath testing devices, systems and methods. The device may include a mouthpiece operable to receive air flow from a breath; and a cassette comprising a biosensor and a cassette conduit, the cassette removably connected to the mouthpiece such that at least a sample of the air flow passes through the cassette conduit and over the biosensor. The biosensor may include a plurality of graphene-based sensors and may be operable to detect at least one volatile organic compound in the air flow sample.
    Type: Grant
    Filed: December 17, 2021
    Date of Patent: October 4, 2022
    Assignee: JLabs, Co.
    Inventors: Jamil Husain, Jeffrey Dawson, David White
  • Systems and methods for analyzing platelet function
    Patent number: 11458470
    Abstract: Provided herein are devices, systems, and methods for analyzing platelet function. In particular, provided herein are simple, portable, accurate and inexpensive small footprint platelet aggregometry devices, systems, and methods.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: October 4, 2022
    Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA
    Inventors: Marvin Slepian, Alberto Redaelli
  • In situ-generated microfluidic assay structures, related kits, and methods of use thereof
    Patent number: 11454629
    Abstract: In situ-generated microfluidic capture structures incorporating a solidified polymer network, methods of preparation and use, compositions and kits therefor are described. Microfluidic capture structures may be advantageously used for assays performed within the microfluidic environment, providing flexibility in assaying micro-objects such as biological cells. Assay reagents and analytes may be incorporated within the microfluidic capture structures.
    Type: Grant
    Filed: June 22, 2020
    Date of Patent: September 27, 2022
    Assignee: Berkeley Lights, Inc.
    Inventors: Kristin G. Beaumont, Peter J. Beemiller, Volker L. S. Kurz, Gregory G. Lavieu, Xiaohua Wang, Aathavan Karunakaran
  • Device for receiving, dispensing, and moving liquids
    Patent number: 11446657
    Abstract: A microfluidic system comprising a chamber closed by movable elements and connected to at least one channel. The system has at least one structured component and at least one component attached to the structured component. The chamber is used such that the movable element can be moved into the chamber as well as out of the chamber by a movement of the movable element. Liquids or gases can be moved via one or more channels connected to the chamber by the movement and dispensed or received out of the structured component via a connection of the channel. A liquid reagent reservoir is connected to the pump chamber via the sample supply channel. Thus, the system can be used to receive, pump, dilute, mix, and dispense liquids or gases.
    Type: Grant
    Filed: November 16, 2017
    Date of Patent: September 20, 2022
    Assignee: MICROFLUIDIC CHIPSHOP GMBH
    Inventors: Christian Moche, Richard Klemm, Claudia Gärtner
  • Rapid fluorescence tagging of glycans and other biomolecules with enhanced MS signals
    Patent number: 11448652
    Abstract: Reagents comprising MS active, fluorescent molecules with an activated functionality for reaction with amines useful in tagging biomolecules such as N-glycans and uses thereof are taught and described. In particular, compounds for use as a reagent for rapid fluorescence tagging of biomolecules and enhanced MS signaling are provided. The compounds may have optical centers and therefore may occur in different enantiomeric and diastereomeric configurations. These MS active, fluorescent compounds may have three functional components: (a) a tertiary amino group or other MS active atom; (b) a highly fluorescent moiety, and (c) a reactive group that rapidly reacts with amines. The reactive group provides rapid tagging of desired bio-molecules. The fluorescent moiety provides the fluorescent signal. The tertiary amino group provides the MS signal.
    Type: Grant
    Filed: September 5, 2019
    Date of Patent: September 20, 2022
    Assignee: WATERS TECHNOLOGIES CORPORATION
    Inventors: Darryl W. Brousmiche, Ying-Qing Yu, Matthew Lauber
  • Microfluidic device
    Patent number: 11446658
    Abstract: A microfluidic device has a cavity in which a functionalized mesh is arranged in a layered configuration to provide a high surface area. The cavity is housed in a body that is easily configured for sample flow to concentrate the analyte, heat release of the analyte from the mesh, and elution of the released analyte. The microfluidic device can be used in a variety of applications by functionalizing the mesh with a suitable affinity media.
    Type: Grant
    Filed: March 12, 2018
    Date of Patent: September 20, 2022
    Assignee: EPIGEM LIMITED
    Inventors: Timothy George Ryan, Philip Summersgill, Simon Allen, Andrew Baker
  • Driving method and driving system for digital microfluidic chip
    Patent number: 11446656
    Abstract: A driving method for a digital microfluidic chip, the digital microfluidic chip including a first electrode and a second electrode that are adjacent, the driving method including: applying a first driving signal to the first electrode and a second driving signal to the second electrode, wherein an applying period of the first driving signal and an applying period of the second driving signal are mutually staggered, and a total time length of the applying period of the first driving signal is less than a total time length of the applying period of the second driving signal.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: September 20, 2022
    Assignees: BEIJING BOE OPTOELECTRONICS TECHNOLOGY CO., LTD., BEIJING BOE TECHNOLOGY DEVELOPMENT CO., LTD.
    Inventor: Feng Long
  • Gel forming composition for radiation dosimetry and radiation dosimeter using gel that is formed from said composition
    Patent number: 11442181
    Abstract: A gel forming composition for radiation dosimetry, and a high sensitivity and high safety radiation dosimeter using a gel formed from the composition. A gel forming composition for radiation dosimetry comprising a gelator and a compound of Formula (1): (wherein R1 is a hydrogen atom, a halogen atom, an optionally substituted C1-12 alkyl group, etc.; and R2 and R3 are each independently a hydrogen atom, an optionally substituted C1-12 alkyl group, an optionally substituted monovalent C6-12 aromatic group, or R2 and R3 form a 4- to 8-membered ring together with a carbon atom to which R2 and R3 are bonded, and the 4-to 8-membered ring may have 0 to 3 nitrogen atoms, oxygen atoms, or sulfur atoms as a ring atom, provided that R2 and R3 are not simultaneously a hydrogen atom).
    Type: Grant
    Filed: June 19, 2017
    Date of Patent: September 13, 2022
    Assignees: RIKEN, NISSAN CHEMICAL CORPORATION
    Inventors: Takuya Maeyama, Kazuaki Fukasaku, Yasuhiro Ishida, Yoshihiro Kudo
  • Microfluidic detection chip for multi-channel rapid detection
    Patent number: 11440006
    Abstract: A microfluidic detection chip for multi-channel rapid detection, including a chip body. A chip sampling port, a plurality of independent detection chambers, and a microfluidic channel are disposed on the chip body, and the chip sampling port is connected to the detection chambers by means of the microfluidic channel. The chip body further includes an electrode. The detection chambers are connected to the electrode. The microfluidic channel includes a main flow channel and a plurality of branching microfluidic channels. A tail end of the main flow channel is divided into the plurality of branching microfluidic channels, and the plurality of branching microfluidic channels are connected to the plurality of independent detection chambers in a one-to-one corresponding manner. And, the other end of the main flow channel is connected to the chip sampling port.
    Type: Grant
    Filed: January 24, 2019
    Date of Patent: September 13, 2022
    Assignee: LANSION BIOTECHNOLOGY CO., LTD
    Inventors: Xingshang Xu, Jeffery Chen
  • Device comprising microbeads capable of adjusting pH of sample
    Patent number: 11440005
    Abstract: The present disclosure relates to a device capable of adjusting the pH of a sample and provides a device comprising microbeads capable of adjusting the pH of a sample to a predetermined value. The device comprises microbeads enabling adjustment to different pH values in each of a plurality of channels, and enables adjustment of the pH of the sample to a plurality of different pH values simultaneously upon injection of the sample.
    Type: Grant
    Filed: August 30, 2019
    Date of Patent: September 13, 2022
    Assignee: LG CHEM, LTD.
    Inventors: Byung Hyun Park, Byoung Hyoun Kim, Su Youn Han
  • Methods for detecting and determining levels of monolignol ester conjugates incorporated into lignin and compounds relating thereto
    Patent number: 11414372
    Abstract: Methods of detecting and, optionally, determining a level of incorporation of monolignol ester conjugates into lignin. The methods include derivatizing lignin to acylate at least a portion of free phenolic and aliphatic hydroxyls and to halogenate at least a portion of benzylic alcohols present in the lignin to yield derivatized lignin, treating the derivatized lignin with a reducing agent to cleave at least a portion of the derivatized lignin to yield lignin cleavage products, acetylating at least a portion of free hydroxyl groups in the lignin cleavage products with a labeled acetylation agent to yield labeled lignin fragments, and detecting the labeled lignin fragments.
    Type: Grant
    Filed: January 21, 2019
    Date of Patent: August 16, 2022
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: John Ralph, Steven D Karlen, Fachuang Lu, Dharshana Padmakshan