Patents Examined by Christine T Mui
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Patent number: 11406929Abstract: To provide a new compound with pores finely tunable in size so as to take up a specific element and release the specific element taken up in the pores as necessary, a synthesis method of the new compound, and a separation and recovery agent. The new compound represented by the following molecular formula: (NH4)[Ln(C2O4)2(H2O)] wherein Ln represents a lanthanide selected from Sm, Eu, Tb, Dy, Ho, Er, Tm, Yb, and Lu.Type: GrantFiled: August 18, 2017Date of Patent: August 9, 2022Assignee: Japan Atomic Energy AgencyInventors: Takuya Nankawa, Matthew Rosseinsky, David Stewart, Alexandros Katsoulidis
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Patent number: 11400451Abstract: A microfluidic circuit includes a detection capacitor, having a first terminal and a second terminal that are spaced apart from one another to thereby form a space therebetween. The circuit is configured to detect a droplet present in the space by detecting a change of a capacitance value of the detection capacitor caused by a change of a dielectric constant between the first terminal and the second terminal, and to drive a formation of an electrical field formed using at least one of the first terminal and the second terminal of the detection capacitor to thereby drive the droplet to move in the electrical field.Type: GrantFiled: December 26, 2018Date of Patent: August 2, 2022Assignee: BOE TECHNOLOGY GROUP CO., LTD.Inventors: Pengpeng Wang, Haisheng Wang, Xiaoliang Ding, Yanling Han, Ping Zhang, Xueyou Cao, Chihjen Cheng, Jiabin Wang, Yangbing Li
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Patent number: 11402328Abstract: The present invention relates to a method for detecting an amyloid ? oligomer which includes a test sample and thioflavin T are brought into contact with each other, fluorescence of the thioflavin T is measured to obtain time-resolved fluorescence spectra, the time-resolved fluorescence spectrum of time period t1 to t2 and the time-resolved fluorescence spectrum of time period t3 to t4 are respectively normalized to obtain normalized spectra (t1<t2?t3<t4), and determination is made to confirm the presence or absence of an amyloid ? oligomer in the test sample on the basis of the two normalized spectra, and shifting of the normalized spectrum of time period t3 to t4 towards the low wavelength side in comparison to the normalized spectrum of time period t1 to t2 indicates the presence of an amyloid ? oligomer in the test sample.Type: GrantFiled: September 8, 2016Date of Patent: August 2, 2022Assignee: HAMAMATSU PHOTONICS K.K.Inventors: Akinori Oda, Hiroshi Satozono, Tomomi Shinke, Yohei Takata
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Patent number: 11400453Abstract: The present disclosure relates to new types of fluid packaging devices and methods of making and using such fluid packaging devices. In various embodiments, the present disclosure provides devices, systems, and methods for packaging fluids. In various embodiments, the present disclosure provides a device including a storage compartment; a fluid stored in the storage compartment; a first aperture on the storage compartment; and a second aperture on the storage compartment. The first aperture is initially sealed or closed before the use of the device and configured to be opened to receive a pneumatic pressure. The second aperture is initially sealed or closed before the use of the device and configured to be opened to allow the fluid to exit or enter the storage compartment via the opened second aperture.Type: GrantFiled: May 9, 2018Date of Patent: August 2, 2022Assignee: CytoChip Inc.Inventors: Wendian Shi, Yuzhe Ding
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Patent number: 11400447Abstract: Computerized devices provide microscopy and electrochemistry tests, performed in dual channels. The devices can be brought to the field, for on-site testing with instant results. The dual channels include an imaging (optical or microscopic) channel and a signal channel. Microfluidic chips are disclosed for use with the microscopy channel optics.Type: GrantFiled: August 6, 2019Date of Patent: August 2, 2022Assignee: EFA—ENGINEERING FOR ALL LTD.Inventors: Yoel Ezra, Natalya Mizrahi
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Patent number: 11389796Abstract: Disclosed herein are embodiments of fluidic devices that can be used to detect the presence (or absence) of analytes in samples by providing separate and distinct chromatographic signals for particular analytes. The fluidic devices described herein are highly sensitive and user-friendly. Methods of making and using the disclosed fluidic devices also are disclosed herein.Type: GrantFiled: November 27, 2018Date of Patent: July 19, 2022Assignee: Oregon State UniversityInventors: Gayan C. Bandara, Christopher A. Heist, Vincent T. Remcho
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Patent number: 11389802Abstract: A pierceable cap 11 may be used for containing sample specimens. The pierceable cap 11 may prevent escape of sample specimens before transfer with a transfer device 43. The pierceable cap 11 may fit over a vessel 21. An access port in the shell of the pierceable cap 11 may allow passage of a transfer device 43 through the pierceable cap 11. At least one frangible layer 215, 216 may be configured with cross slits 506 in a particular cross slit geometry. The cross slits 506 may contain an openable portion 644 or be covered by a thin membrane 645. The shell 610 and frangible layer(s) 215, 216 may be integrated into a one piece cap 601, or be separate components 634. The membrane on which the cross slits 506 are placed can be flat or contoured to guide the transfer device 43 to the cross slits 506.Type: GrantFiled: December 7, 2016Date of Patent: July 19, 2022Assignee: BECTON, DICKINSON AND COMPANYInventors: Ammon David Lentz, Kevin Bailey, Dustin Diemert, Joel Daniel Krayer, Laurence Michael Vaughan
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Patent number: 11391652Abstract: A system for preparing a calibrated volume of blood plasma that includes a plurality of parts: a device for preparing the calibrated volume of blood plasma, which is in the form of a single card; a pneumatic-type actuating system SP; a treatment and command unit UC configured such as to execute a command sequence of different pneumatic command points of the pneumatic actuation system with a view to obtaining, from a taken blood sample, the calibrated volume of blood plasma. The device includes three distinct modules: a fluidic connection module M1 onto which a blood sampling device may be connected; a module M2 for separation of the blood plasma contained in the blood sample; a module M3 for obtaining at least one calibrated volume of blood plasma, after separation.Type: GrantFiled: November 14, 2019Date of Patent: July 19, 2022Assignee: Commissariat A L'Energie Atomique et aux Energies AlternativesInventors: Myriam-Laure Cubizolles, Manuel Alessio, Remco Den Dulk, Frederic Revol-Cavalier
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Patent number: 11385247Abstract: Disclosed herein is a system for depositing solid waste into a waste bin in an automated analyzer having a transport mechanism for transporting solid waste to a waste bin. The system includes a transport mechanism including a sliding mechanism, a parking position, and an opening that is proximal to the waste bin. The sliding mechanism includes a slider and an extendable ramp and the slider pushes the solid waste along the ramp into the waste bin. The transport mechanism is configured to place the solid waste into the parking position, contact the solid waste with the slider, and push said solid waste towards the waste bin along the ramp until the solid waste moves along the extendable ramp into the waste bin.Type: GrantFiled: July 19, 2019Date of Patent: July 12, 2022Assignee: Roche Molecular Systems, Inc.Inventors: Andre Peter, Markus Troxler
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Patent number: 11383237Abstract: The present disclosure discloses a microfluidic device, a driving method and a microfluidic detection system. The microfluidic device includes: a substrate; two first optical waveguides disposed opposite each other on the substrate with an accommodating chamber defined between the two first optical waveguides; and a plurality of optical detection structures in the accommodating chamber. The first optical waveguide has a refractive index greater than a refractive index of a medium surrounding the first optical waveguide, thereby enabling light rays incident into an end of the first optical waveguide to propagate towards another end of the first optical waveguide in a total reflection mode.Type: GrantFiled: March 27, 2019Date of Patent: July 12, 2022Assignee: BOE TECHNOLOGY GROUP CO., LTD.Inventors: Wei Wang, Xianqin Meng, Xiandong Meng, Jifeng Tan, Pengxia Liang, Jian Gao, Fangzhou Wang, Xiaochuan Chen
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Patent number: 11369958Abstract: Described herein are various embodiments directed to rotor devices, systems, and kits. Embodiments of rotors disclosed herein may be used to characterize one or more analytes of a fluid. An apparatus may include a first layer being substantially transparent. A second layer may be coupled to the first layer to collectively define a set of wells. The second layer may define a channel, and the second layer may be substantially absorbent to infrared radiation. A third layer may be coupled to the second layer. The third layer may define an opening configured to receive a fluid. The third layer may be substantially transparent. The channel may establish a fluid communication path between the opening and the set of wells.Type: GrantFiled: August 22, 2019Date of Patent: June 28, 2022Assignee: Zoetis Services LLCInventors: Robert Justice Shartle, Gregory Trigub
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Patent number: 11371919Abstract: The present invention relates to the preparation of liquid mixtures, and more particularly to the preparation of a liquid mixture, such as a buffer, wherein the conductivity of the liquid mixture is measured and the pH indirectly determined if the buffer concentration is known. Another object of the present invention is to provide a method of preparing a liquid mixture with a predetermined pH value by using conductivity as feedback control parameter.Type: GrantFiled: February 28, 2020Date of Patent: June 28, 2022Assignee: CYTIVA SWEDEN ABInventors: Enrique Napoleon Carredano, Elenor Strandberg
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Patent number: 11370922Abstract: Compounds useful as fluorescent or colored dyes are disclosed. The compounds have the following structure (I), including stereoisomers, salts and tautomers thereof, wherein R1, R2, R3, L1, L2, L3, L4, L5, M, m and n are as defined herein. Methods associated with preparation and use of such compounds are also provided.Type: GrantFiled: May 10, 2017Date of Patent: June 28, 2022Assignee: Sony CorporationInventors: Tracy Matray, Sharat Singh, Michael VanBrunt
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Patent number: 11369967Abstract: A cartridge comprises a housing; a sample mixing compartment disposed within the housing, the sample mixing compartment comprising: an activation pouch, and a sample collection region; and a gas transporter tube having a first end and a second end, the tube being disposed within the housing adjacent to the sample mixing compartment, wherein the sample mixing compartment is partially defined by a moveable door of the housing, the moveable door providing access to the sample mixing compartment when the door is in an open position and preventing access to the sample mixing compartment when the door is in a closed position; and wherein the door is configured to release contents of the activation pouch upon movement from the open position to the closed position.Type: GrantFiled: April 22, 2020Date of Patent: June 28, 2022Assignee: Board of Regents, The University of Texas SystemInventors: Purnendu Dasgupta, Aditya Das
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Patent number: 11372016Abstract: An apparatus includes a fluidic circuit, a bypass fluidic circuit, a first set of fluid wells, a second set of fluid wells, a first valve, and a second valve. The first valve operatively associated with the first set of fluid wells such that the first selectively fluidly connects any one of the first set of fluid wells to a first valve outlet. The second valve operatively associated with the fluidic circuit, the bypass fluidic circuit, the first valve outlet, and the second set of fluid wells such that the second valve selectively fluidly connects any one of the second set of fluid wells and the first valve outlet to the fluidic circuit or the first valve outlet to the bypass fluidic circuit.Type: GrantFiled: September 26, 2019Date of Patent: June 28, 2022Assignee: ILLUMINA, INC.Inventors: Wesley A. Cox-Muranami, James Osmus, Paul Crivelli, Bradley Kent Drews
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Patent number: 11366132Abstract: Since a detergent is a consumption article, it is desirable that a use amount of the detergent be as small as possible in a limit that the washing effect is not substantially reduced. Provided is an automatic analyzer which includes a syringe pump which is connected to a probe and performs the body aspiration and discharge, a feed pump which feeds washing water for washing the inside of the probe to the probe via the syringe pump and a controller which controls the dispensing mechanism and the syringe pump, in which the controller, in a case of washing the probe by sucking a detergent in the probe a plurality of times, controls the syringe pump so as to discharge the detergent after sucking the detergent and to suck the next detergent without feeding the washing water to the probe by the feed pump.Type: GrantFiled: October 5, 2018Date of Patent: June 21, 2022Assignee: HITACHI HIGH-TECH CORPORATIONInventors: Takamichi Mori, Akihiro Nojima, Isao Yamazaki
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Patent number: 11364496Abstract: An apparatus includes a polymer base layer having a surface. A die has a surface that is substantially coplanar with the surface of the polymer base layer. The die includes a fluidic actuator to control fluid flow across the surface of the die. A fluidic channel is coupled to the polymer base layer to provide a fluidic interconnect between the die and a fluidic input/output port.Type: GrantFiled: April 21, 2017Date of Patent: June 21, 2022Assignee: Hewlett-Packard Development Company, L.P.Inventors: Chien-Hua Chen, Michael W. Cumbie, Viktor Shkolnikov
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Patent number: 11366065Abstract: Disclosed are a point-of-care system and method, the system including: an aptamer-based diagnostic reagent; a diagnostic instrument for detecting a Raman signal through a Raman analysis technique; and a diagnostic kit to be operated on the basis of a lateral flow method, wherein blood and the diagnostic reagent are reacted so as to detect a Raman signal when the placement of the diagnostic kit is detected, thereby allowing the type of acute febrile illness to be identified.Type: GrantFiled: February 1, 2018Date of Patent: June 21, 2022Inventors: Doo Ryeon Chung, Min Hee Kang, Nam Yong Lee, Min Young Lee, Kyu Sung Lee, Jae Bum Choo, Sang Yeop Lee, Joon Ki Hwang
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Patent number: 11364493Abstract: A microfluidic apparatus may include, in an example, a substrate, at least one silicon die embedded into the substrate, and a planarization layer layered over, at least, a portion of the substrate that interfaces with the silicon die to prevent a fluid from contacting an edge of the silicon die.Type: GrantFiled: October 12, 2017Date of Patent: June 21, 2022Assignee: Hewlett-Packard Development Company, L.P.Inventors: Michael W. Cumbie, Chien-Hua Chen
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Patent number: 11364497Abstract: A microfluidic system includes, in an example, a substrate and at least two microfluidic devices embedded into the substrate, at least one of the microfluidic devices being different from a remaining number of microfluidic devices. A microfluidic apparatus includes at least two microfluidic devices embedded into a substrate, at least a first microfluidic device of the microfluidic devices being heterogenous to at least a second microfluidic device of the microfluidic devices and a microfluidic channel to fluidically couple the microfluidic devices to each other.Type: GrantFiled: October 12, 2017Date of Patent: June 21, 2022Assignee: Hewlett-Packard Development Company, L.P.Inventors: Chien-Hua Chen, Michael W. Cumbie
