Abstract: In order for it to be possible for the user of a manual metering apparatus (1) to be provided with different options for adjusting a manual metering apparatus (1), in particular a pipette, the manual metering apparatus (1) according to the invention is proposed, in the case of which the operating element (5) for operating the volume adjusting mechanism (3) of the manual metering apparatus (1) is constructed in two pieces and comprises a display adjusting element (7) which is connected to the volume display (4) of the manual metering apparatus (1), and the volume adjusting element (8) which is connected to the volume adjusting mechanism (3) of the manual metering apparatus (1). The display adjusting element (7) and the volume adjusting element (8) are connected to one another via the releasable coupling (9), with the result that a volume adjustment leads to a corresponding adjustment of the volume display and vice versa, as long as the coupling (9) is closed.

Abstract: The glucose testing device with test strip dispenser is a blood glucose testing device. The blood glucose testing device tests for the concentration of the sugar known as glucose in the blood of a patient. The blood sample tested by the blood glucose testing device is presented to the blood glucose testing device on a sheeting known as a glucose test strip. The glucose testing device with test strip dispenser comprises a strip dispenser and the blood glucose testing device. The strip dispenser attaches to the blood glucose testing device. The strip dispenser is a refillable storage device that stores a plurality of glucose test strips.

Abstract: A portable chemical contaminant detection system and related method is provided. The detection system includes a detector having one or more probes and associated detector circuitry that is in communication with a mobile device. The system is in communication with a remotely located server, where the detection system transmits contaminant detection signals while measuring a fluid from a product or a container of a chemical used on the product. The contaminant detection signals are transmitted in real-time and the detection system receives contaminant level information determined by the server. The server may process data from multiple probes to track multiple contaminants or a single contaminant based on the multiple different probe data from a single detector. The system displays real-time decontamination feedback and displays process completion notification or automatically implements decontamination shut-off.

Abstract: A method for measuring TOC in test water is disclosed. Test water is injected into a combustion tube, which is controlled to be heated in a state of flowing carrier air generated by discharging stored water filled in a combustion gas or carrier air storage tank. After the drying process, temperature in the combustion tube is increased, and the dried organic carbon is burned. Combustion gas is guided to the combustion gas storage tank. An inside of the combustion tube is purified due to high pressure steam generated by injecting pure water and organic carbon removed in the purification process is burned and oxidized. The generated combustion gas is guided to the combustion gas storage tank and is pushed into an infrared meter to measure a carbon dioxide gas concentration. Otherwise, the generated combustion gas is guided to the infrared meter to measure the carbon dioxide gas concentration.

Abstract: Provided are methods for determining the amount of estrone in a sample using mass spectrometry. The methods generally involve ionizing estrone in a sample and detecting and quantifying the amount of the ion to determine the amount of estrone in the sample.

Abstract: Systems and methods are provided for processing a biological sample. In one embodiment, the method comprises receiving a sample vessel containing the sample; retrieving information from an information storage unit associated with the sample; using said information for selecting at least one cartridge front at least two or more different cartridges, each configured for use with a sample processing device; loading at least one or more reagents onto the cartridge, wherein the one or more reagents to be added are selected based at least in part on the information or instructions derived from the information; and placing the sample vessel in the cartridge.

Abstract: An in vitro method for diagnosing a urological cancer comprising the comparison of a secretome of isolated cells from a urine sample from a patient to be diagnosed with respect: either to a reference secretome obtained from secretions of healthy isolated cells from a urine sample from a healthy person, or to a reference secretome obtained from secretions of healthy cells which are derivatives of standard cell line cultures, characteristic of a determined urological organ, the secretome and the reference secretome being constituted of all the components forming the respective secretions thereof.

Abstract: Methods of increasing the capture efficiency of a microfluidic device for a target reagent, without additional complications to the design of existing microfluidic devices, and more particularly methods of increasing the capture efficiency of a microfluidic device for magnetic microbeads within a microfluidic channel using sequentially switched electroosmotic flows.

Abstract: A blood coagulation analyzer and analyzing method perform following: (a) preparing a measurement specimen by dispensing a blood specimen and a reagent into a reaction container; (b) emitting light of a plurality of wavelengths to the measurement specimen in the reaction container, the wavelengths comprising a first wavelength for use in a measurement by a blood coagulation time method, and at least one of a second wavelength for use in a measurement by a synthetic substrate method and a third wavelength for use in a measurement by an immunoturbidimetric method; (c) detecting light of a plurality of wavelengths corresponding to the light emitted in (b), from the measurement specimen, by a light receiving element, and acquiring data corresponding to each wavelength; and (d) conducting an analysis based on the data corresponding to one of the wavelengths among the acquired data, and acquiring a result of the analysis.

Abstract: Provided herein are reagents, methods and biochemical markers for identifying individuals with glucoregulatory dysfunction and providing therapeutic intervention for individuals identified as at risk for glucoregulatory dysfunction. Specifically provided herein are methods for identifying a subject with glucoregulatory dysfunction based on changes in fasting blood lipid concentrations including, inter alia, diacylglycerols.

Abstract: A method is provided for detecting a polypeptide of interest in a plant without the use of a reference standard. The method comprises the steps of obtaining a plant expressing the polypeptide of interest and a negative control plant that does not express the polypeptide of interest, and analyzing a sample from each in an information-dependent acquisition (IDA) method. A method is also provided for determining the relative expression level of a polypeptide of interest in a plurality of plants without the use of a reference standard. This method comprises the steps of obtaining a plurality of plants expressing the polypeptide of interest and a negative control plant that does not express the polypeptide of interest, analyzing samples from each in an IDA method, and determining the relative expression level of the polypeptide in each of the plurality of plants.

Abstract: The present invention relates to systems and methods of determining quality compliance for a set of biological sample testing devices used with one or more test instruments at the point-of-care in a hospital or other location that delivers medical care. In particular, the systems and methods ensure that only biological sample testing devices that pass a quality assurance protocol are used for point-of-care testing.

Abstract: This invention relates to the detection and quantification of D-dimer levels in a sample derived from a patient having or suspected of having periprosthetic joint infection (PJI) and subsequent diagnosis of PJI.

Abstract: Systems and methods for concentrating an analyte preparatory to analysis thereof include processing the effluent of an analyte concentrator to produce an eluent for eluting an analyte retained in the same or separate concentrator, and systems implementing the same. The analyte concentrator system connects the effluent outlet of an analyte concentrator column to an eluent generation module such that the substantially analyte-free effluent discharged from the analyte concentrator column passes fluidly into the eluent generation module. Eluent generated from the substantially analyte-free effluent in the eluent generation module is likewise substantially free of the analyte. The systems and methods can minimize and/or (substantially) eliminate background signal during analysis of the concentrated analyte.

Abstract: Provided is a system for detection and discrimination of gases, such as volatile organic compounds (VOCs), in a sample comprising two chambers, a first chamber equipped with a crystalline microporous material (CMM) and a second chamber equipped with a gas detector. A gas sample is introduced first into the second chamber for detection by the gas detector and is then re-routed to the first chamber for adsorption/desorption on the CMM. The gas detector in the second chamber produces electronic signals that correspond to the adsorption/desorption profile for the gas, which allows for discrimination of the gas in the sample from other possible gas samples.

Abstract: A housing for a simulation chamber having a chamber body, a door arranged on the chamber body, and a controller housing, wherein the controller housing is arranged on the chamber body and comprises an outer surface, an inner surface, and at least one side surface, in that the door comprises an outer surface, an inner surface, and at least five side surfaces, wherein the controller housing is arranged on the chamber body in such a manner that, when the door is closed, at least one of the side surfaces of the door is arranged facing at least one of the side surfaces of the controller housing.

Abstract: Methods and systems for separating, detecting, and/or quantifying sample enantiomers using differential mobility spectrometry (DMS) are provided herein. In accordance with various aspects of the applicant's teachings, the methods and systems can provide for the separation of racemic or non-racemic mixtures of sample enantiomers that may be difficult to separate with conventional techniques, such as mass spectrometry (MS), by reacting the sample enantiomers with an enantiomerically-pure compound to form diastereomers separable by DMS.

Abstract: Disclosed herein are cellular cassettes for the storage, collection, and analysis of biological samples. The cellular cassette can enable easy sample collection and sealing of microwell arrays with semi-permeable membrane for stable storage and future processing of single cells. Also disclosed herein are systems and kits comprising one or more described cassettes. The described cassettes, systems, and kits can be used to create barcoded, single-cell sequencing libraries. Further described herein are methods of using the cassettes, systems, and kits.

Abstract: A test system for analyzing a sample of a bodily fluid is provided and comprises: at least one test strip comprising at least one capillary channel comprising an inlet opening configured to receive the sample; a vent opening configured to provide an air vent to the capillary channel; and at least one zone consisting of a detection zone and a reagent zone; at least one measuring device configured for interacting with the test strip, the measuring device comprising at least one sealing element for hermetically sealing the vent opening from an ambient atmosphere; and at least one suction device adapted to provide an underpressure to the vent opening; wherein the measuring device further comprises at least one valve or is connectable to the valve, wherein the valve is configured to vent the vent opening of the test strip when the measuring device interacts with the test strip.

Abstract: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect Chitinase-3-like protein 1 as diagnostic and prognostic biomarker assays in renal injuries.