Patents Examined by Christopher Adam Hixson
  • Patent number: 11782036
    Abstract: Methods and systems for detecting and limiting the water in a photoionization detector are provided. The method may include powering off a lamp configured to ionize particles of air. The method may also include monitoring a signal from the photoionization detector. The signal may be monitored based on a current between a signal electrode and a bias electrode. In an instance the signal is above a signal threshold, the method may also include electrolyzing one or more particles of water present in the photoionization detector by closing a leakage switch in order to allow current to flow through the bias electrode and the signal electrode. In an instance the signal is below the signal threshold, the method may include powering on the lamp to begin photoionization detection. Corresponding systems are also provided.
    Type: Grant
    Filed: June 30, 2020
    Date of Patent: October 10, 2023
    Inventors: Chuang Huang, Tengfei Zhang, Bing Chen, Feng Liang
  • Patent number: 11740245
    Abstract: The present invention proposes a novel method for the detection of circulating histones H3 and H2B in plasma from sepsis or septic shock (SS) patients, based on mass spectrometry-based methods, in particular based on multiple reaction monitoring targeted mass spectrometry (MRM-MS). Such methods allow quantification of histones using an internal standard and show strong specificity and sensitivity values.
    Type: Grant
    Filed: November 6, 2017
    Date of Patent: August 29, 2023
    Assignees: Centro de Investigación Biomédica en Red (CIBER-ISCIII), Fundación INCLIVA, Universitat de Valencia Estudi General
    Inventors: José Luis García Giménez, Carlos Romá Mateo, Federico V. Pallardó Calatayud
  • Patent number: 11726078
    Abstract: A device for rapid detection of a tuberculosis lipoarabinomannan (TB-LAM) is provided. The device includes a pre-concentrator unit for concentrating the TB-LAM comprising: an ion-exchange medium comprising one or more ligands configured to capture the TB-LAM from the source biological sample, wherein the captured-TB-LAM is eluted from the ion-exchange medium as an eluate comprising a concentrated form of TB-LAM; a cassette; a lateral flow assay unit disposed in the cassette; and an integration unit attached to the pre-concentrator unit and the cassette. The integration unit is configured to operatively couple and de-couple the pre-concentrator unit and the cassette. The pre-concentrator unit and the lateral flow assay unit disposed in the cassette are in a fluidic communication in a coupled form. The device for rapid detection of TB-LAM further comprises a dilutor unit.
    Type: Grant
    Filed: November 6, 2020
    Date of Patent: August 15, 2023
    Assignees: General Electric Company, Tokitae LLC
    Inventors: Matthew Jeremiah Misner, Gregory Andrew Grossmann, Cathryn Ellen Olsen, John Richard Nelson, David Roger Moore, Paul Michael Smigelski, Jr., John Thomas Connelly, Benjamin David Grant, Bernhard Hans Weigl
  • Patent number: 11692995
    Abstract: Biomarkers and/or risk assessments identify patients having an increased risk of certain clinical disease states including, for example, CHD, type 2 diabetes, dementia, or all-cause death (ACD) using NMR signal to measure a level of “GlycA” in arbitrary units or in defined units (e.g., ?mol/L) that can be determined using a defined single peak region of proton NMR spectra. The GlycA measurement can be used as an inflammation biomarker for clinical disease states. The NMR signal for GlycA can include a fitting region of signal between about 2.080 ppm and 1.845 ppm of the proton NMR spectra.
    Type: Grant
    Filed: November 13, 2020
    Date of Patent: July 4, 2023
    Inventors: James D. Otvos, Irina Y. Shalaurova, Dennis W. Bennett, Justyna E. Wolak-Dinsmore
  • Patent number: 11692939
    Abstract: This disclosure relates generally to detecting multiple biomarkers on or within a sample, though more specifically, to detecting individual detection moieties within a plurality of detection moieties.
    Type: Grant
    Filed: July 21, 2020
    Date of Patent: July 4, 2023
    Assignee: RareCyte, Inc.
    Inventor: Jeremy Ryan Cooper
  • Patent number: 11680921
    Abstract: A sensor for sensing diols and triols includes (a) a substrate, (b) a conductive coating disposed on the substrate and having affinity for binding with a substance selected from the group consisting of diols, triols, and a combination thereof, and (c) two electrodes in contact with the conductive coating to probe conductivity of the conductive coating so as to detect the substance from a reduction in the conductivity. A method for detecting vaping includes (a) measuring conductivity of a conductive coating having affinity for binding with an airborne substance selected from the group consisting of diols, triols, and a combination thereof, and (b) detecting presence of the airborne substance as a decrease in the conductivity.
    Type: Grant
    Filed: October 17, 2019
    Date of Patent: June 20, 2023
    Assignee: FreshAir Sensor, LLC
    Inventors: Joseph J. BelBruno, Andrei Burnin, Katie Shelton, Matthew Curtin, Jacob Fisher
  • Patent number: 11674939
    Abstract: The present disclosure relates to methods, devices, and systems for measuring nitric oxide released from a material. For example, a method of measuring nitric oxide release from a material can include introducing a continuous flow of a carrier gas into a sample holding chamber via a carrier gas inlet at an effective flow rate, introducing an amount of the nitric oxide releasing material into the sample holding chamber via a separate sample inlet to contact the continuous flow of the carrier gas, directing the carrier gas and released nitric oxide out of the sample holding chamber via a nitric oxide outlet toward a nitric oxide detector, and quantifying an amount of released nitric oxide using the nitric oxide detector.
    Type: Grant
    Filed: August 14, 2019
    Date of Patent: June 13, 2023
    Assignee: SaNOtize Research and Development Corp.
    Inventors: Gilly Regev, Christopher C. Miller
  • Patent number: 11674968
    Abstract: Compositions and methods for identifying free thiols in protein are provided. An exemplary method labeling peptides with a tag to identify free thiols and a tag to identify native disulfide bonds and analyzing the tags using targeted MS2. In one embodiment, the method provides complete coverage of all 32 cysteine residues in an IgG molecule. In other embodiments the method covers the 16 cysteine residues on the heavy and light chains in an IgG molecule. In another embodiment, the method covers the 5 cysteine residues on each light chain of an IgG molecule. In another embodiment, the method covers the 11 cysteine residues on each heavy chain of an IgG molecule.
    Type: Grant
    Filed: January 16, 2020
    Date of Patent: June 13, 2023
    Assignee: Regeneran Pharmaceuticals, Inc.
    Inventors: Sook Yen E, David Bramhall, Haibo Qiu
  • Patent number: 11666900
    Abstract: Disclosed is a liquid discharging nozzle, including a needle stem having a hollow chamber and an outlet end located at one end of the needle stem, an angle between a normal line of an end surface of the outlet end of the liquid discharging nozzle and an extension direction of the needle stem is equal to or smaller than 90°. Further disclosed are a motion controlling mechanism, a microdroplet generating device and method, a liquid driving mechanism and method, a microdroplet generating method, and a surface processing method of a liquid discharging nozzle.
    Type: Grant
    Filed: January 24, 2019
    Date of Patent: June 6, 2023
    Assignee: Sniper (Suzhou) Life Technology Co.
    Inventor: Guang-Ji Sheng
  • Patent number: 11666694
    Abstract: The invention relates to a device for separation of fluidal biological material components, particularly separation of components of the material collected by liposuction for subsequent transfer of the adipose tissue in an injection form. The device comprises a container with an outlet duct arranged in it, the outlet duct having its upper end adapted for collecting the material, and its lower end that is in fluid communication with the inner space of the container at its bottom. Further, the invention relates to a separating float for separation of the fluidal biological material components, the float being intended to be used in the device, wherein the float comprises at least one by-pass opening for passage of the fluidal biological material contained in the container from the area below the separating float into the area above it. The invention also relates to a kit including the device and the float.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: June 6, 2023
    Inventor: Libor Streit
  • Patent number: 11635416
    Abstract: A gas sensing device includes chemo-resistive gas sensors; heating elements for heating each of the gas sensors; an information extraction block for receiving signal samples and for generating representations for the received signal samples; and a decision making block configured for receiving the representations, wherein the decision making block comprises a weighting block and a trained model based algorithm stage, wherein the weighting block receives feature samples of the representations and applies time-variant weighting functions to the feature samples of the respective representation in order to calculate a weighted representation including weighted feature samples.
    Type: Grant
    Filed: April 2, 2020
    Date of Patent: April 25, 2023
    Assignee: Infineon Technologies AG
    Inventors: Cecilia Carbonelli, Alexander Jesipow, Alexandra Marina Roth, Alexander Zoepfl
  • Patent number: 11623218
    Abstract: The object of the present invention is to provide a novel flow analysis method and a novel flow analyzer each of which makes it possible to improve accuracy of an analysis. A flow analysis method in accordance with an embodiment of the present invention attains the above object by including: a sample introducing step of introducing a sample into a tube (100); a reagent adding step of adding a reagent to the sample which is transferred through the tube (100); and an analyzing step of quantitatively or qualitatively analyzing the sample to which the reagent has been added and further including, after the reagent adding step and before the analyzing step, a gas-liquid separating step of sequentially removing gas which is present in the tube (100).
    Type: Grant
    Filed: January 22, 2021
    Date of Patent: April 11, 2023
    Assignee: BL TEC K.K.
    Inventor: Takashi Nishimura
  • Patent number: 11614442
    Abstract: The present invention relates to a method for determining the distinctive nutritional requirements of a patient with specific nutritional needs and providing a composition meeting the distinctive nutritional requirements of said patient.
    Type: Grant
    Filed: August 6, 2020
    Date of Patent: March 28, 2023
    Assignee: Societe des Produits Nestle S.A.
    Inventors: Serge Andre Dominique Rezzi, Stephanie Blum-Sperisen, Magali Faure, Denis Breuille
  • Patent number: 11607681
    Abstract: According to an example aspect of the present invention, there is provided a liquid handling device comprising: means for harvesting energy; energy storage arranged for storing the harvested energy in the liquid handling device; and an electronic component connected to the energy storage and configured to use the energy storage as a power source.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: March 21, 2023
    Assignee: Sartorius Biohit Liquid Handling Oy
    Inventors: Sami Alt, Janne Leinonen
  • Patent number: 11609225
    Abstract: Electrochemical sensors commonly used in breath alcohol testing devices detect a concentration of alcohol in a sample of fluid. The sample of fluid is introduced into the electrochemical sensor and a current is generated by the oxidation of the alcohol within the fluid. The electrical output from the electrochemical sensor, plotted over time, forms an output curve, which may be used to estimate the concentration of alcohol in the fluid sample. The technology disclosed herein includes various methods for determining the quantity of an electrochemically convertible substance in a fluid sample using a breath alcohol content device, including detecting water saturation level of the fluid sample. The disclosed technology involves measuring electrochemical sensor outputs to quantify alcohol content of the fluid sample.
    Type: Grant
    Filed: January 9, 2020
    Date of Patent: March 21, 2023
    Inventors: Wayne Robert Willkomm, Mark Anthony Lary
  • Patent number: 11590490
    Abstract: Disclosed here are pipette tips useful for acquiring or dispelling liquids, and include one or more design that may increase fluid delivery precision and/or accuracy, and may reduce certain repetitive motions.
    Type: Grant
    Filed: September 17, 2020
    Date of Patent: February 28, 2023
    Assignee: BIOTIX, INC.
    Inventors: Arta Motadel, Peter Paul Blaszcak, Phillip Chad Hairfield, Sean Michael Callahan
  • Patent number: 11592361
    Abstract: A system for generating data relating to a tissue core comprises a core needle biopsy module configured to obtain a tissue core from a locus within the body, and a tissue disintegration module operably connected to the core needle biopsy module and configured to receive a tissue core from the core needle biopsy module and convert at least a portion of the tissue core into gaseous tissue molecules. The system also comprises first vacuum pump means configured to convey a tissue core from the needle biopsy module to the tissue disintegration module, and second vacuum pump means configured to convey gaseous tissue molecules from the tissue disintegration module to an analyser module.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: February 28, 2023
    Assignee: Diopsy Limited
    Inventors: Maximillian Frederick Ryan, Len McCarthy
  • Patent number: 11592373
    Abstract: The disclosure relates to a method for pretreating a sample for metals determination.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: February 28, 2023
    Inventors: Thomas Schuelke, Cory A. Rusinek, Michael Becker, Mary Ensch
  • Patent number: 11577239
    Abstract: In one configuration, a handheld compound tester to process and detect presence of a compound in a tablet is disclosed. The handheld compound tester may include a sampling chamber configured to receive a tablet and a lid couplable with the sampling chamber. The coupling of the lid with the sampling chamber may cause cutting of the tablet. A liquid may be added inside the sampling chamber to create a mixture with segments of the tablet. The mixture may be then received by a housing adjoining the sampling chamber. A test strip disposed within the housing, upon contacting the mixture, may be configured to indicate a presence of the compound in the mixture.
    Type: Grant
    Filed: July 11, 2022
    Date of Patent: February 14, 2023
    Assignee: JACKLE LLC
    Inventors: Jeanie C. Leddon, Richard L. Leddon, Jeffrey A Hartman
  • Patent number: 11579103
    Abstract: Embodiments described herein provide for the flameless premixed combustion of the pyrolysis gases of a milligram-sized sample of solid material in a microscale fire calorimeter (MFC) at high temperatures of combustion and under precisely controlled fuel-to-oxygen ratios. The microscale fire calorimeter (MFC) device and techniques set out herein provide for the generation of fuel gases from solids and the mixing of those fuel gases with oxygen under controlled conditions to obtain precise fuel/oxygen ratios during combustion. Combustion is conducted under flameless, premixed conditions in a rapid test that can generate soot and other products of incomplete combustion, which may then be analyzed to determine their type and nature. This allows for microscale, accurate, and convenient techniques for the generation and determination of the type and nature of combustion species produced over the full range of fire stages from early stage (over-ventilated) fires to late-stage (under-ventilated/high-toxicity) fires.
    Type: Grant
    Filed: April 6, 2020
    Date of Patent: February 14, 2023
    Assignee: The United States of America, as represented by the Administrator of the Federal Aviation Administration
    Inventors: Richard E. Lyon, Louise Speitel, Richard N. Walters