Patents Examined by Christopher Adam Hixson
  • Patent number: 10676719
    Abstract: Devices for non-invasive, label-free separation of particles in liquid, including circulating tumors cells in blood, are provided. Embodiments of the disclosure provide for devices employing magnetic fluids and magnets for separation of circulating tumor cells from blood. Methods for separation of particles including circulating tumor cells are also provided.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: June 9, 2020
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Leidong Mao, Carsten Schroeder, Wujun Zhao
  • Patent number: 10670573
    Abstract: An embodiment provides a method for measuring ions in a solution, including: preparing a measurement device comprising an active indicator, wherein the active indicator comprises a silver complex; introducing the measurement device to a solution, wherein the silver complex reacts with the solution and generates a precipitation comprising one of the elements selected from the group consisting of: silver chloride, silver sulfide, and mixtures thereof; and measuring an amount of one of the elements selected from the group consisting of: chloride and sulfide, in the solution, wherein the measuring comprises identifying a peak of the precipitation on a portion of the measurement device and comparing the peak to a measurement chart.
    Type: Grant
    Filed: September 25, 2017
    Date of Patent: June 2, 2020
    Assignee: HACH COMPANY
    Inventor: Arnold Bertron Kidd, IV
  • Patent number: 10663449
    Abstract: Elevated temperature liquid testing apparatus and methodology in which a thin film of test liquid and a reactant/control gas are provided about the top of a depositor member that is surrounded by a special mantle, for example, a substantially cylindrically walled glass mantle. As an oxidative engine oil test, it may mimic turbocharger conditions of a modern internal combustion engine. For example, employing moist air, the apparatus can test a thin film of engine oil for oxidation deposits at a predetermined temperature, say, 285° C., 290° C., or cycled between 285° C. or 290° C. and 320° C. or 330° C.
    Type: Grant
    Filed: November 1, 2018
    Date of Patent: May 26, 2020
    Assignee: TANNAS COMPANY
    Inventors: Jonathan C. Evans, Theodore W. Selby, Marta Manning, Gregory C. Miiller, William John VanBergen
  • Patent number: 10663458
    Abstract: The present invention relates to a new method for the determination of free copper in serum. In particular to a method with a high degree of sensitivity and accuracy for the determination of free copper in serum samples of patients with Alzheimer's disease and Wilson's disease and other forms of free copper dyshomeostasis. The invention also relates to kits for the determination of free copper in serum comprising filter devices and coumarin fluorescent probe.
    Type: Grant
    Filed: November 7, 2012
    Date of Patent: May 26, 2020
    Assignee: IGEA RESEARCH CORPORATION
    Inventors: Nicola Antonio Colabufo, Rosanna Squitti
  • Patent number: 10640513
    Abstract: The present invention relates to a compound for detecting phosgene and DCP (diethyl chlorophosphate) and a composition for detecting phosgene and DCP (diethyl chlorophosphate) comprising the said compound. More precisely, the compound for detecting phosgene and DCP of the present invention can selectively detect phosgene and DCP either in the liquid phase of gas phase by detecting the changes of fluorescence and color development very quickly within a few seconds with nM sensitivity. Therefore, the compound can also be effectively used as an ingredient for the composition and kit for the detection of one or more materials selected from the group consisting of phosgene and DCP.
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: May 5, 2020
    Assignee: EWHA UNIVERSITY - INDUSTRY COLLABORATION FOUNDATION
    Inventors: Juyoung Yoon, Xin Zhou, Ying Hu, Liyan Chen
  • Patent number: 10641752
    Abstract: A compact explosive detecting system collects explosive residues in the form of vapor powder. The residues are accumulated on a desorber which is subjected to pyrolysis to release a gaseous sample. The sample is pumped to a detecting system through a metering valve. A luminol cell reacts with the gaseous sample to create chemiluminescence, the light output of which is measured by a photo multiplier tube. The light intensity is indicative of the amount of explosive present. Based on the amount of explosive present, a metering valve is adjusted to pass the gaseous sample into a highly sensitive metal oxide sensor array to detect NO2 from nitrogen containing explosive and CO/CO2 from non nitrogen containing explosive. The metal oxide sensor array reliably selects explosives from those compounds indicating chemiluminescence.
    Type: Grant
    Filed: May 30, 2017
    Date of Patent: May 5, 2020
    Assignee: SCINTREX TRACE CORPORATION
    Inventor: Dao Hinh Nguyen
  • Patent number: 10632465
    Abstract: The present invention relates to a contact-less priming system for loading a solution in a microfluidic device comprising: at least one microfluidic device, a pressure chamber configured to enclose said at least one microfluidic device, a pressurization unit fluidly connected to the pressure chamber and at least one closing member. The present invention also relates to a contact-less priming method for loading a solution in a microfluidic device.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: April 28, 2020
    Assignee: Stilla Technologies
    Inventors: Rémi Dangla, Étienne Fradet
  • Patent number: 10626141
    Abstract: The present invention provides a method for specifically cleaving a C?-C bond of a peptide backbone and/or a side chain of a protein and a peptide, and a method for determining amino acid sequences of protein and peptide. A method for specifically cleaving a C?-C bond of a peptide backbone and/or a side chain bond of a protein or a peptide, comprising irradiating a protein or a peptide with laser light in the presence of at least one hydroxynitrobenzoic acid selected from the group consisting of 3-hydroxy-2-nitrobenzoic acid, 4-hydroxy-3-nitrobenzoic acid, 5-hydroxy-2-nitrobenzoic acid, 3-hydroxy-5-nitrobenzoic acid, and 4-hydroxy-2-nitrobenzoic acid. A method for determining an amino acid sequence of a protein or a peptide, comprising irradiating a protein or a peptide with laser light in the presence of the above specific hydroxynitrobenzoic acid to specifically cleave a C?-C bond of a peptide backbone and/or a side chain bond, and analyzing generated fragment ions by mass spectrometry.
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: April 21, 2020
    Assignees: SHIMADZU CORPORATION, NATIONAL UNIVERSITY OF CORPORATION HIROSHIMA UNIVERSITY
    Inventors: Shunsuke Izumi, Koichi Tanaka, Yuko Fukuyama
  • Patent number: 10618050
    Abstract: A microfluidic device includes a flow path through which a reaction solution flows, and an introducing portion for introducing the reaction solution into the flow path, wherein the flow path passes alternately and repeatedly several times through a first temperature region and a second temperature region having different predetermined temperatures, and the flow path includes the repeating unit portions passing through the first temperature region and the second temperature region, the repeating unit portions having decreasing lengths as the repeating unit portions are located farther away from the introducing portion.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: April 14, 2020
    Assignee: Panasonic Intellectual Property Management Co., Ltd.
    Inventors: Narimasa Iwamoto, Takao Miyai, Nobuyuki Miyagawa, Tsutomu Ichihara, Masashi Ishimaru, Toshihiko Sato, Hiroaki Tachibana
  • Patent number: 10620171
    Abstract: The present disclosure generally relates to improved methods for separating and analyzing compounds by liquid chromatography, particularly when coupled with mass spectrometry. The methods include the addition of an additive to a mobile phase carrying a sample. The mobile phase additive may be effective for improving peak shapes of targeted analytes in acquired data, and/or eliminating or at least reducing ion suppression. The methods are particularly suited for anionic compounds such as phosphorylated compounds.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: April 14, 2020
    Assignee: AGILENT TECHNOLOGIES, INC.
    Inventors: Jordy J. Hsiao, Hongfeng Yin, Oscar G. Potter
  • Patent number: 10610125
    Abstract: Methods of treating and evaluating subjects having neoactive mutants are described herein.
    Type: Grant
    Filed: May 8, 2017
    Date of Patent: April 7, 2020
    Assignee: Agios Pharmaceuticals, Inc.
    Inventors: Lenny Dang, Valeria Fantin, Stefan Gross, Hyun Gyung Jang, Shengfang Jin, Francesco G. Salituro, Jeffrey O. Saunders, Shin-San Michael Su, Katharine Yen
  • Patent number: 10605799
    Abstract: A method of selective detection of a concentration of a metal ion species in a subject is provided in which a biofluid sample is obtained from the subject. The biofluid sample is exposed to a functionalized porous aromatic polymer. The polymer selectively captures and concentrates the metal ion species from the biofluid. Subsequently, the biofluid is washed from the polymer. The polymer is then exposed to a solution comprising a colorimetric indicator that extracts the metal ion species from the washed polymer thereby changing a color of the solution as a function of an amount of the metal ion species in the polymer. The concentration of the metal ion species in the subject is then spectroscopically determined from the color of the solution.
    Type: Grant
    Filed: May 11, 2017
    Date of Patent: March 31, 2020
    Assignee: The Regents of The University of California
    Inventors: Christopher J. Chang, Jeffrey R. Long, Sumin Lee, Gokhan Barin
  • Patent number: 10605802
    Abstract: A saturation indication system includes a sorbent body with a film backing being irreversibly bonded to the sorbent body. A universal indicating ink formulation is at least partially coated onto the film backing such that the ink formulation is disposed between the film backing and the sorbent body. The universal indicating ink formulation includes a resin and a dye dispersed in the resin. The dye is configured to indicate a state of saturation of the sorbent body, with the resin and the dye being soluble in a plurality of categories of sorbates consisting of hydrophobic sorbates, hydrophilic sorbates, neutral sorbates, and amphiphilic sorbates.
    Type: Grant
    Filed: May 8, 2017
    Date of Patent: March 31, 2020
    Assignee: Brady Worldwide, Inc.
    Inventors: Matthew Kasper, Michael Labelle, Nicholas Krogman, Bethany Grillo
  • Patent number: 10598652
    Abstract: Disclosed herein are methods of using serum nitric oxide levels to diagnose subjects as having or likely to develop a post-operative complication.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: March 24, 2020
    Assignee: The Regents of the University of California
    Inventors: Hua Cai, Kimberly Howard-Quijano, Aman Mahajan, Ji Youn Youn
  • Patent number: 10591483
    Abstract: [Problem] To provide a method for acquisition of data able to serve as an index for determining the likelihood that an ovarian endometriosis cyst is cancerous. Solution This data acquisition method for determining the likelihood that an ovarian endometriosis cyst is cancerous includes an iron concentration measurement step for measuring the iron concentration in the cystic fluid of the ovarian endometriosis cyst. This diagnostic device for diagnosing the likelihood that an ovarian endometriosis cyst is cancerous is provided, at a minimum, with an iron concentration measurement unit for measuring the iron concentration in the cystic fluid of the ovarian endometriosis cyst.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: March 17, 2020
    Assignee: CELLSPECT CO., LTD.
    Inventors: Hiroshi Kobayashi, Chiharu Yoshimoto, Junko Takahama, Takuya Iwabuchi
  • Patent number: 10590389
    Abstract: The present invention provides an endodermal cell production method that can induce differentiation of pluripotent cells into endodermal cells even when the pluripotent cells are dispersed and can achieve improved endodermal cell production efficiency. The endodermal cell production method according to the present invention is a method for producing endodermal cells by inducing differentiation of pluripotent cells into the endodermal cells, including the step of: inducing differentiation of the pluripotent cells into the endodermal cells in the presence of an endodermal cell inducing factor. In the induction step, the cell density of the pluripotent cells at the start of the induction preferably is from 0.5×104 to 2×104 cells/cm2.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: March 17, 2020
    Assignee: Kyoto University
    Inventors: Kenichiro Kamei, Momoko Honda
  • Patent number: 10578525
    Abstract: A method for detection and identification of a chemical using a preconcentrator to collect a sample of the chemical, process said sample of the chemical, and introduce said processed chemical into a chemical analysis instrument for the detection of and identification of the chemical. A system for detecting and identifying a chemical comprising a preconcentrator having at least dual concentrating elements.
    Type: Grant
    Filed: August 3, 2017
    Date of Patent: March 3, 2020
    Assignee: BAE Systems Information and Electronic Systems Integration Inc.
    Inventors: Michael J. Bowers, II, John E. King, Tadd C. Kippeny
  • Patent number: 10578577
    Abstract: Embodiments of the invention are directed to a solid-state zinc sensor. A non-limiting example of the sensor includes a semiconductor substrate. The sensor can also include an assembly surface on the semiconductor substrate. The sensor can also include a zinc detection monolayer chemically bound to the assembly surface. The sensor can also include a power supply electrically connected to the semiconductor substrate.
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: March 3, 2020
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Ali Afzali-Ardakani, Abram L. Falk, Bharat Kumar
  • Patent number: 10564147
    Abstract: Novel systems and methods are provided that rapidly separate particles from a liquid. In an embodiment, a small volume of liquid (such as a blood sample, or any other solution with a concentration of particles) is input into a flow device implemented as a unilateral channel. When activated by an acoustic energy source (such as an ultrasound pulse), gas-liquid interfaces naturally occurring between the liquid in the flow device and a plurality of gas-filled cavities that line the channel will oscillate and create stable cavitation streaming within a localized region of the surrounding liquid. These oscillations create micro-vortices that gently remove and trap particles and debris from the liquid and adjacent surfaces. Fluid and particle manipulation can thus be accomplished on a passive, disposable chip that is placed on top of an external acoustic transducer with a coupling medium.
    Type: Grant
    Filed: May 24, 2013
    Date of Patent: February 18, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Arlene Doria, Maulik Patel, Nicholas E Martin, Yuka Okabe, Abraham Lee
  • Patent number: 10557862
    Abstract: The present invention relates to systems and methods of determining quality compliance for a set of biological sample testing devices used with one or more test instruments at the point-of-care in a hospital or other location that delivers medical care. In particular, the systems and methods ensure that only biological sample testing devices that pass a quality assurance protocol are used for point-of-care testing.
    Type: Grant
    Filed: May 4, 2016
    Date of Patent: February 11, 2020
    Assignee: Abbott Point of Care Inc.
    Inventors: Paul Glavina, Jody Ann Tirinato