Patents Examined by Christopher R. Tate
  • Process for the extraction, purification and enzymatic modification of soy 7S globulin alpha' subunit for use as hypocholesterolemizing agent
    Patent number: 8257758
    Abstract: A purified amino-terminal polypeptide fragment of the soy ?-conglycinin ?? subunit is prepared by selective extraction of defatted soy with an aqueous solution of sodium bisulfite, precipitation with ethanol, and Metal Affinity Chromatography (MAC) under denaturing conditions to obtain the ?? subunit. The ?? subunit is then enzymatically treated with chymotrypsin and subjected to further MAC to recover the amino-terminal fragment of the polypeptide (MW 28,000 Da).
    Type: Grant
    Filed: January 26, 2011
    Date of Patent: September 4, 2012
    Assignee: Indena S.p.A.
    Inventors: Marcello Duranti, Paolo Morazzoni
  • Antitussive composition and method for making the same
    Patent number: 8257759
    Abstract: An antitussive composition is provided. A pharmaceutical composition for relieving, preventing and/or treating a cough includes a sufficient amount of the Morus australis Poir extract as an active component. The effective Morus australis Poir extract is prepared by extracting the root-bark of the Morus australis Poir with water, ethanol, acetone, ethyl acetate, or a combination thereof. The crude extract can be further fractioned by ultrafiltration or reverse phase column.
    Type: Grant
    Filed: December 25, 2008
    Date of Patent: September 4, 2012
    Assignee: Medical and Pharmaceutical Industry Technology and Development Center
    Inventors: Yuan-Ling Ku, Chien-Jen Shih, Hsiao-Chu Huang, Chun-Hung Kuo, Yi-Chen Lin, Yueh-Chu Chen, Feng-Nien Ko
  • Tumor-associated peptides binding promiscuously to human leukocyte antigen (HLA) class II molecules
    Patent number: 8258260
    Abstract: The present invention relates to immunotherapeutic methods, and molecules and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-helper cell peptide epitopes, alone or in combination with other tumor-associated peptides, that serve as active pharmaceutical ingredients of vaccine compositions which stimulate anti-tumor immune responses. In particular, the present invention relates to 49 novel peptide sequences derived from HLA class II molecules of human tumor cell lines which can be used in vaccine compositions for eliciting anti-tumor immune responses.
    Type: Grant
    Filed: November 19, 2007
    Date of Patent: September 4, 2012
    Assignee: Immatics Biotechnologies GmbH
    Inventor: Jörn Dengjel
  • Stabilizing and antioxidant composition containing saw palmetto berry component and method of use
    Patent number: 8252347
    Abstract: A stabilizing and antioxidant composition is prepared from the residue obtained from the saw palmetto berry. The residue from the saw palmetto berry exhibits antioxidant properties that can be used to stabilize various compositions such as food or edible compositions and cosmetics. The saw palmetto residue is also delivered topically or orally to a patient to administer an effective amount of an antioxidant to a patient.
    Type: Grant
    Filed: November 30, 2006
    Date of Patent: August 28, 2012
    Assignee: Bio-Botanica, Inc.
    Inventor: Frank S. D'Amelio, Sr.
  • Methods for modulating eicosanoid metabolism
    Patent number: 8252345
    Abstract: The inventive subject matter relates to methods for modulating an eicosanoid metabolic process in cells of an animal in need thereof, which comprises administering to the animal an amount of the inventive compositions effective for regulating the activity of an eicosanoid oxygenase. In particular, the inventive subject matter relates to methods for modulating arachidonic acid metabolism by administering an amount of the inventive compositions effective for regulating the activity of lipoxygenases and cyclooxygenases.
    Type: Grant
    Filed: December 29, 2008
    Date of Patent: August 28, 2012
    Assignee: New Chapter Inc.
    Inventors: Thomas Newmark, Paul Schulick, Robert Newman, Bharat Aggarwal
  • Isolation of growth and differentiating factors from colostrum
    Patent number: 8252341
    Abstract: The present invention concerns a novel process for isolating growth and differentiating factors present in colostrum, all in a natural way. This process is characterized by maturation steps (controlled mild acid hydrolysis) and physical steps (molecular filtration) which optimize recovery of measured growth factors and their ability to entice a response on human cells. Advantageously, this process allows the derivation and isolation of growth and differentiating factors with highly disparate sizes (or molecule weights) in pools. These pools can be used in select and varied ways, including cosmetic, cosmeceutical, nutraceutical, dermatological, pharmaceutical, medical and veterinary applications. It can also be used as a replacement to fetal calf serum to promote cell proliferation, and above all, cell differentiation.
    Type: Grant
    Filed: September 14, 2005
    Date of Patent: August 28, 2012
    Inventor: Paul Brazeau
  • Composition for treating atopic dermatitis comprising extracts of bamboo and
    Patent number: 8247007
    Abstract: The present invention relates to a composition comprising of plant extract as an active component, specifically, Bamboo extract and Scutellaria extract, for the treatment and prevention of atopic dermatitis. The present invention is a natural ingredient obtained from a plant. The present invention can control immune responses by inhibiting the release of histamine and leukotrien, and thus, has effect in the treatment or prevention of allergic diseases, inflammatory diseases and skin diseases, specifically atopic dermatitis. The present invention has been proven safe and beneficial effecting the treatment of atopic dermatitis through clinical trials, and thus, can be used for the treatment and prevention of atopic dermatitis.
    Type: Grant
    Filed: October 12, 2007
    Date of Patent: August 21, 2012
    Assignee: Unigen, Inc.
    Inventors: Sung Sick Woo, Dong Seon Kim, Young Chul Lee, Eun Jung Son
  • Controlled release composition and method of producing the same
    Patent number: 8246987
    Abstract: A controlled release composition containing a physiologically active substance in high content, suppressing the initial excess release, and achieving a stable release speed over a long period of time is provided. A controlled release composition comprising (1) a physiologically active substance or salt thereof in an amount of about 14% (w/w) to about 24% (w/w) based on the total composition weight, (2) hydroxynaphthoic acid selected from the group consisting of 3-hydroxy-2-naphthoic acid and 1-hydroxy-2-naphthoic acid or salt thereof, and (3) a lactic acid polymer or salt thereof having a weight-average molecular weight of 15000 to 50000 in which the content of polymers having molecular weights of 5000 or less is about 5% by weight or less, wherein the molar ratio of said hydroxynaphthoic acid or salt thereof to said physiologically active substance or salt thereof is from 3:4 to 4:3.
    Type: Grant
    Filed: March 16, 2011
    Date of Patent: August 21, 2012
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Kazumichi Yamamoto, Akiko Yamada, Yoshio Hata
  • Composition comprising the extract of crude drug complex having neuroprotective activity for preventing and treating stroke and neurodegenerative diseases
    Patent number: 8241679
    Abstract: The present invention relates to a composition comprising an extract of crude drug complex comprising Panax ginseng C. A. Meyer, Acanthopanax senticosus HARMS, Angelica sinensis DIELS, Scutellaria baicalensis GEORGI, prevention and treatment of stroke and neurodegenerative diseases such apoplexy, Alzheimer's disease (AD), Parkinson's disease (PD), Pick's disease, Creutzfeldt-Jakob disease and senile dementia.
    Type: Grant
    Filed: November 4, 2009
    Date of Patent: August 14, 2012
    Assignee: Neumed Inc.
    Inventors: Hocheol Kim, Young Min Boo
  • Use of a extract as a cosmetic agent, and cosmetic composition containing same
    Patent number: 8241676
    Abstract: The invention relates to the use of a plant extract of a plant of the Limnophila genus, in particular an extract of the plant species Limnophila conferta, as a cosmetic agent or as an active agent in cosmetic compositions.
    Type: Grant
    Filed: June 3, 2009
    Date of Patent: August 14, 2012
    Assignee: LVMH Recherche
    Inventors: Virginie Leplanquais, Virginie Pecher, Marc C M Dumas, Krystell Lazou
  • Decolonizing agent for helicobacter pylori
    Patent number: 8241683
    Abstract: The invention provides a decolonizing agent that can effectively decolonize Helicobacter pylori. The decolonizing agent for Helicobacter pylori contains Elsholtzia rugulosa hemsl honey as an active ingredient.
    Type: Grant
    Filed: April 15, 2008
    Date of Patent: August 14, 2012
    Assignee: Kikuji Yamaguchi
    Inventors: Kikuji Yamaguchi, Toru Kono
  • Rapid glycopeptide optimization via neoglycosylation
    Patent number: 8236926
    Abstract: The present invention generally relates to methods and compositions for generating vancomycin analogs. Specifically the invention relates to generating a vancomycin library through chemoselective ligation of a sugar moiety with a vancomycin aglycon. In particular, the present invention provides a library of vancomycin analogs, where the member of the library comprises at least one vancomycin analog selected from 2?-N-acyldecanoyl-glucosyl vancomycin neoglycoside, 3?-N-acyldecanoyl-glucosyl vancomycin neoglycoside, 4?-N-acyldecanoyl-glucosyl vancomycin neoglycoside, 6?-N-acyldecanoyl-glucosyl vancomycin neoglycoside, 2?-N-acylbiphenyl-glucosyl vancomycin neoglycoside, 3?-N-acylbiphenoyl-glucosyl vancomycin neoglycoside, 4?-N-acylbiphenoyl-glucosyl vancomycin neoglycoside and 6?-N-acylbiphenoyl-glucosyl vancomycin neoglycoside.
    Type: Grant
    Filed: September 6, 2007
    Date of Patent: August 7, 2012
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Jon S. Thorson, Byron R. Griffith
  • Supercritical COliquorice extract and products made there from
    Patent number: 8236360
    Abstract: The present invention provides, in one aspect, to products made from a novel and non-obvious supercritical CO2 extract of the roots of Glycyrrhiza sp., effective as an anti-inflammatory, anti-bacterial, anti-fungal and anti-adherent agent, including, but not limited to, products for oral care and body care.
    Type: Grant
    Filed: May 2, 2007
    Date of Patent: August 7, 2012
    Assignee: Tom's of Maine, Inc.
    Inventors: Chantal Bergeron, Stefan Gafner
  • Stabilizer molecule-depleted albumin solution
    Patent number: 8236927
    Abstract: The invention concerns a method for producing an aqueous albumin solution from a starting albumin solution which contains stabilizer molecules which are capable of occupying binding sites of the albumin, wherein in a method for increasing the albumin binding capacity (ABiC) for other molecules, at least a portion of the stabilizer molecules is removed from the albumin of the starting albumin solution and separated from the starting albumin solution.
    Type: Grant
    Filed: May 11, 2006
    Date of Patent: August 7, 2012
    Assignee: Albutec GmbH
    Inventor: Katrin Stange
  • Tyrosine- and tryptophan-containing peptides as antioxidants
    Patent number: 8232243
    Abstract: The invention relates to the use of tryptophan-containing, in particular tryptophan- and tyrosine-containing, peptides as antioxidants. The compounds can be used for the therapy or prophylaxis of syndromes and disorders associated with unwanted oxidative processes in the extracellular space.
    Type: Grant
    Filed: December 4, 2000
    Date of Patent: July 31, 2012
    Assignee: Max-Planck-Gesellschaft zur Forderung der Wissenschaften E.V.
    Inventors: Bernd Moosmann, Christian Behl
  • Angina pectoris and ischemic heart disease and synergistic phytoceutical composition for same
    Patent number: 8231913
    Abstract: Phytoceutical compositions for the prevention and treatment of circulatory disorders, such as Angina Pectoris and Ischemic Heart Disease are taught. A specific combination of extracts of plants is taught, as well as principles for varying the formulations based on categorizing plants into one of three groups, Energy, Bio-Intelligence, and Organization and selecting several plants from each group. Such combinations have synergistic effects as demonstrated by gene expression levels, yet exhibits minimal side effects.
    Type: Grant
    Filed: November 9, 2009
    Date of Patent: July 31, 2012
    Inventor: Jose Angel Olalde Rangel
  • Highly potent full and partial agonists and antagonists of the nociceptin/orphanin FQ receptor
    Patent number: 8227414
    Abstract: Peptide analogs of nociceptin/orphanin FQ, compositions thereof, and their use in treatment of disorders and dysfunctions related to activation or blocking of NOP receptors are described.
    Type: Grant
    Filed: February 15, 2006
    Date of Patent: July 24, 2012
    Assignee: UFPEPTIDES S.R.L.
    Inventors: Remo Guerrini, Severo Salvadori, Girolamo Calo', Domenico Regoli
  • Methods of using pomegranate extracts for causing regression in lesions due to arteriosclerosis in humans
    Patent number: 8221806
    Abstract: Methods of using pomegranate extracts of the present invention for treating patients with atherosclerosis, or increased intima-media thickness of an artery, are provided. The methods comprise the step of administering to the patient a composition comprising a therapeutically effective amount of an extract from pomegranate. The methods of the present invention may also be used to decrease the incidence of stroke or heart attack in a patient.
    Type: Grant
    Filed: November 30, 2009
    Date of Patent: July 17, 2012
    Assignee: Stewart and Lynda Resnick Revocable Trust
    Inventors: Michael Aviram, Leslie Dornfeld
  • Compositions and methods for enhancing cognitive function
    Patent number: 8221804
    Abstract: The invention encompasses novel compositions containing a methylation modifying compound isolated from botanical raw materials, including a fruit of the genus Coffea, and microbial raw materials, methods of making such compositions, and methods of treating or preventing human disease using such compositions. The methylation modifying compound in botanical extracts of the present invention can dramatically increase the level of methylation of PP2A, thus increasing cognitive function, particularly in persons suffering from or prone to developing Alzheimer's disease.
    Type: Grant
    Filed: February 3, 2006
    Date of Patent: July 17, 2012
    Assignees: Signum Biosciences, Inc., Trustees of Princeton University
    Inventors: Jeffry B. Stock, Maxwell Stock, Haoming Gu, Gregory B Stock, Zhu Li, Peter Michael Wolanin
  • Inhibiting GS-FDH to modulate no bioactivity
    Patent number: 8217006
    Abstract: Patients needing NO donor therapy or inhibition of pathologically proliferating cells or increased NO bioactivity are treated with a therapeutically effective amount of an inhibitor of glutathione-dependent formaldehyde dehydrogenase.
    Type: Grant
    Filed: September 24, 2009
    Date of Patent: July 10, 2012
    Assignee: Duke University
    Inventors: Jonathan S. Stamler, Limin Liu, Alfred Hausladen, Raphael Nudelman