Patent number: 8097590
Abstract: The invention relates to a dipeptide conjugate having general formula I, AA2-AA1-NH2, wherein A represent the radical corresponding to a monocarboxylic acid with general formula II, HOOC—R, in which: R represents a linear or branched aliphatic radical at C1-C24, which is optionally substituted by a hydroxyl group and which can comprise one or more unsaturations, preferably between 1 and 6 unsaturations, and/or which can comprise a phenyl group or lipoic acid or the reduced form thereof, dihydrolipoic acid or N-lipoyllysine; and AA1 and AA2 represent identical or different amino acids which are selected from the group containing Ala, Asn, Cys, Gln, Gly, Ile, Leu, Met, Phe, Pro, Ser, Thr, Trp, Tyr, Val, Asp, Glu, Arg, His, Lys, Orn, Dap, Dab, the corresponding homo-amino acids and the corresponding beta-amino acids in the form of enantiomers or diastereoisomers and mixtures thereof, including racemic mixtures.
Type:
Grant
Filed:
May 10, 2005
Date of Patent:
January 17, 2012
Assignees:
Centre National de la Recherche Scientifique (CNRS), Institut Europeen de Biologie Cellulaire, Universite de Montpellier I, Universite de Montpellier II
Inventors:
Anne-Marie Pinel, Pascal Verdie, Pascaline Dubs, Jean Martinez, Gilles Subra