Patents Examined by Chu Chuan (JJ) Liu
  • Patent number: 10265006
    Abstract: The present invention provides an optical sensor unit (10) for measuring gas concentration, comprising: sensor means (12, 13) and first thermal insulation means (14, 16) at least partially surrounding said sensor means (12, 13). The sensor means (12,13) includes at least one sensing layer (12) adapted to be irradiated with a predetermined radiation (100), and at least one gas-permeable layer (13) adjacent to one side of the at least one sensing layer (12) and adapted to pass gas, which concentration is to measured, through the gas-permeable layer (13) towards the at least one sensing layer (12). The optical sensor unit (10) is adapted to measure an optical response of the at least one sensing layer (12), which optical response depends on the gas concentration.
    Type: Grant
    Filed: December 30, 2013
    Date of Patent: April 23, 2019
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Josephus Arnoldus Henricus Maria Kahlman, Hans Willem Van Kesteren, Nicolaas Lambert, Theodorus Petrus Henricus Gerardus Jansen
  • Patent number: 10264977
    Abstract: Disclosed herein is a method for the transcutaneous determination of organ function in a subject. The method includes administering a fluorescent indicator substance to the subject, determining a first and a second concentration-time curve of the fluorescent indicator in a body fluid of the patient and fitting the concentration-time curves to a four compartment kinetic model.
    Type: Grant
    Filed: October 20, 2014
    Date of Patent: April 23, 2019
    Assignee: MediBeacon Inc.
    Inventors: Ralf Heinrich, Johannes Pill, Sabine Neudecker, Daniel Schock-Kusch, Juergen Guenther, Stefan Koenig, Jochen Friedmann
  • Patent number: 10265002
    Abstract: The present invention provides a personal hand-held monitor (PHHM) comprising a signal acquisition device for acquiring signals which can be used to derive a measurement of a parameter related to the health of the user, wherein the signal acquisition device comprises a blood photosensor having one or more photo-emitters for transmitting light to a body part of a user, one or more photo-detectors for detecting light transmitted through or scattered by the body part and two or more optical cells, at least one of which contains an analyte to be detected or which mimics the absorption spectrum of the analyte, through which the light that has been or will be transmitted through or scattered by the body part passes before it reaches the photo-detector(s).
    Type: Grant
    Filed: February 10, 2014
    Date of Patent: April 23, 2019
    Assignee: LEMAN MICRO DEVICES SA
    Inventors: Christopher Elliott, Mark-Eric Jones, Arushi Varshney, Matthieu Ruegg
  • Patent number: 10258292
    Abstract: A method is provided for predicting that a patient will require a blood transfusion during a treatment. The method includes obtaining, on a processor, first data that indicates values for one or more parameters of a characteristic of a continuous photoplethysmographic (PPG) waveform collected during the treatment. The method further includes applying, on the processor, coefficients to the values for the one or more parameters. The method further includes determining, on the processor, second data that indicates a prediction that the patient will require the blood transfusion during the treatment based on applying the coefficients to the values for the one or more parameters. An apparatus is also provided for predicting that the patient will require the blood transfusion during the treatment.
    Type: Grant
    Filed: August 12, 2014
    Date of Patent: April 16, 2019
    Assignee: University of Maryland, Baltimore
    Inventors: Fu-Ming Hu, Colin Mackenzie, Shiming Yang, Hegang Chen
  • Patent number: 10258268
    Abstract: A tissue oximetry system employing diffuse optical spectroscopy includes an optical subsystem and an electronics and processing subsystem, together generating modulated optical signals processing a response optical signal in order to obtain measurements of blood oxygen values for a tissue from per-wavelength absorption values. Signal sources generate RF modulation signals, and ADC circuitry generates streams of digital sample values from analog detection signals.
    Type: Grant
    Filed: April 24, 2018
    Date of Patent: April 16, 2019
    Assignee: Trustees of Boston University
    Inventors: Darren Roblyer, Alyssa Torjesen
  • Patent number: 10251605
    Abstract: A flexible, body-mountable analyte sensing device includes a flexible substrate configured for mounting to skin of a living body. The sensing device additionally includes a sensor probe attached to the flexible substrate and configured to penetrate the skin such that a sensor disposed on the sensor probe can detect an analyte in interstitial fluid. The sensor probe can include an elongate extension of the flexible substrate. The sensor can be, for example, an electrochemical sensor or an optical sensor. The sensing device is configured to wirelessly indicate detected concentrations or other information about the analyte in the interstitial fluid. The flexible substrate of the sensing device is configured to be adhered or otherwise mounted to the skin in a manner that minimally impacts activities of the living body.
    Type: Grant
    Filed: February 16, 2015
    Date of Patent: April 9, 2019
    Assignee: Verily Life Sciences LLC
    Inventors: Zenghe Liu, Brian Otis, Jaclyn Leverett Wasson, William James Biederman
  • Patent number: 10244978
    Abstract: A system device and method are presented for determining if cerebral blood flow autoregulation functionality has been compromised in a patient. The system includes sensors for detecting and measuring at least two physiological parameters such as oxygenation and blood pressure. The system analyzes these measurements and presents them as waveforms. Episodes of interest in each waveform are determined and compared. Any time lag between the occurrence of episodes of interest in each waveform is established and accounted for. Where there is correspondence between episodes of interest in each waveform then impairment of cerebral blood flow autoregulation is likely.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: April 2, 2019
    Assignee: Brain Check Medical, LLC
    Inventors: John A. Borgos, Isabelle Richmond
  • Patent number: 10238290
    Abstract: With a probe 2 in which an end of the organic photoelectric-conversion layer 23 on a projection optical path 10 side is covered by an upper electrode 24 having a light-blocking effect, light passing through the projection optical path 10 from a light source can be prevented from directly entering the organic photoelectric-conversion layer 23.
    Type: Grant
    Filed: March 24, 2015
    Date of Patent: March 26, 2019
    Assignee: HAMAMATSU PHOTONICS K.K.
    Inventors: Takahiko Yamanaka, Shigeo Hara, Toru Hirohata, Takashi Watanabe
  • Patent number: 10231658
    Abstract: Information for assisting a doctor based on the oxygen saturation of an observation target is presented. An endoscope system includes a light source device, an image sensor, an oxygen saturation calculation unit, a distribution pattern generation unit, a disease state score calculation unit, and a monitor. The light source device emits light to irradiate the observation target. The image sensor images the observation target with reflected light of the light, and outputs an image signal. The oxygen saturation calculation unit calculates an oxygen saturation of the observation target based on the image signal. The distribution pattern generation unit generates a distribution pattern showing the distribution of the oxygen saturation. The disease state score calculation unit calculates a disease state score indicating the disease state of the observation target based on the distribution pattern. The monitor displays the disease state score or information based on the disease state score.
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: March 19, 2019
    Assignee: FUJIFILM Corporation
    Inventor: Yasushi Shiraishi
  • Patent number: 10226216
    Abstract: Wearable patches comprising multiple separable adhesive layers. One or more of the layers can comprise electronics, mechanical components, gauze, medicine and/or other types of hardware suitable for the intended use of the patch. In use, a first layer of the patch is adhered to a user. When it is time to change layers, the patch is removed from the user, the first layer is removed from the patch to expose a second adhesive layer, and the second layer is applied to the user. The process may be repeated until the remaining layers of the patch have been used.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: March 12, 2019
    Assignee: Zansors LLC
    Inventors: Ranjit Das, Mark Travaglini
  • Patent number: 10226215
    Abstract: A coupling portion of a wearable medical monitor may include an attachment member configured to reversibly couple the coupling portion to a body portion of the wearable medical monitor. The wearable medical monitor may be coupled to a sensor via a cable. The coupling portion may also include a cable retention feature including a channel configured to receive the cable. The cable retention feature may be configured to apply a retaining force to the cable when the cable is disposed in the channel.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: March 12, 2019
    Assignee: Covidien LP
    Inventors: Kristine M. Cohrs, David P. Besko, Ryan M. Miller, Jenna Dancy, Loren L. Lohrman
  • Patent number: 10219711
    Abstract: Some embodiments relate to a device, method, and/or computer-readable medium storing processor-executable process steps for processing a photoplethysmographic (“PPG”) signal in a monitoring device that monitors a property of blood flow. In some embodiments, the processing includes obtaining a first digital signal representing a detected light signal having a non-pulsatile (e.g., DC) component and a pulsatile component (e.g., AC). An offset control signal is generated from an estimation of the non-pulsatile component and a second digital signal is generated after subtracting the offset control signal from the detected light signal and applying a gain to the subtracted signal. A reconstructed signal is generated that is calculated from the gain and one or more of (i) the first digital signal, and (ii) the second digital signal and the offset control signal.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: March 5, 2019
    Assignee: Fitbit, Inc.
    Inventors: Anjian Wu, Peter W. Richards, Shelten Gee Jao Yuen
  • Patent number: 10209794
    Abstract: The present disclosure provides a device for touch-sensing. The device includes a touch surface configured to receive a touch by an object; a measuring portion configured to measure a blood oxygen level of the object; and a control portion configured to calculate a level of pressing force corresponding to the blood oxygen level.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: February 19, 2019
    Assignee: BOE TECHNOLOGY GROUP CO., LTD.
    Inventors: Xuefei Wang, Xiangxiang Zou, Tieshi Wang, Wanpeng Teng, Yan Wei, Chunfang Zhang
  • Patent number: 10206628
    Abstract: A method for the validation of physiological data, acquired in two or more parts of the human body by sensors connected to a medical device, for the statistical validation of the relationship among the signals retrieved by the medical devices, in order to select information that increases the accuracy of the study being carried out, with a high statistical certainty. The purpose of the actual invention is to make this statistically validated data available for use by protocols or reference values, according to the field of application, which increase accuracy of the studies being carried out.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: February 19, 2019
    Assignee: GENOMI-K. S.A.P.I. DE .C.V.
    Inventors: Francisco Xavier Toussaint Nasta, Hector Cruz Camino, Hector Daniel Guerrero Marquez, Rene Daniel Gomez Gutierrez, Ricardo Mendoza Gonzalez, Roberto Carlos Arriaga Sosa, Roberto Mercado Hernandez
  • Patent number: 10201295
    Abstract: A body-mountable device includes a flexible substrate configured for mounting to a skin surface. The device includes an input component configured to receive inputs from a user, e.g., finger presses, swipes, motions of the sensing platform, or gestures. Received inputs could include calibration data, for example, known values of a sensed property to compare with corresponding values obtained by a sensor of the device. The device can additionally include an output component configured to provide outputs to a user. Outputs could include indications of sensor readings, medical alerts, or operational states of the device. The flexible substrate of the device is configured to be adhered or otherwise mounted to the skin in a manner that minimally impacts activities of the body.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: February 12, 2019
    Assignee: Verily Life Sciences LLC
    Inventors: Jaclyn Leverett Wasson, Zenghe Liu, Brian Otis, William James Biederman
  • Patent number: 10194939
    Abstract: A sensor embedding device according to the present disclosure is a sensor embedding device which embeds a sensor in a subject, the sensor having a sensing region in which to detect a state of the subject, including: a needle to be inserted in the subject, the needle having a hole; a sensor retainer to retain the sensor so that the sensor is ready to be embedded inside the subject in such a manner that the sensing region is oriented in a predetermined direction; and a movable section to move the sensor into the subject with a slide of the sensor retainer inside the hole.
    Type: Grant
    Filed: November 13, 2015
    Date of Patent: February 5, 2019
    Assignee: Panasonic Intellectual Property Management Co., Ltd.
    Inventors: Masaru Minamiguchi, Yasuaki Okumura, Tatsurou Kawamura, Takahiro Aoki, Masahiko Shioi
  • Patent number: 10197498
    Abstract: Disclosed herein sensor matrices comprising nanofibers and one or more sensor components, wherein the one or more sensor components detect an analyte. In addition, methods of making and detecting the sensor matrices are disclosed. For example, a nanofiber with a shell and coaxial core may be made with a sensor in the shell.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: February 5, 2019
    Assignee: Northeastern University
    Inventors: Timothy T. Ruckh, Mary K. Balaconis, Heather A. Clark, Christopher Skipwith
  • Patent number: 10194845
    Abstract: A continuous glucose monitoring system may include a hand-held monitor, a transmitter, an insulin pump, and an orthogonally redundant glucose sensor, which may comprise an optical glucose sensor and a non-optical glucose sensor. The former may be a fiber optical sensor, including a competitive glucose binding affinity assay with a glucose analog and a fluorophore-labeled glucose receptor, which is interrogated by an optical interrogating system, e.g., a stacked planar integrated optical system. The non-optical sensor may be an electrochemical sensor having a plurality of electrodes distributed along the length thereof. Proximal portions of the optical and electrochemical sensors may be housed inside the transmitter and operationally coupled with instrumentation for, e.g., receiving signals from the sensors, converting to respective glucose values, and communicating the glucose values.
    Type: Grant
    Filed: March 30, 2017
    Date of Patent: February 5, 2019
    Assignee: MEDTRONIC MINIMED, INC.
    Inventors: Rajiv Shah, Jesper Svenning Kristensen, Katherine T. Wolfe, Soren Aasmul, Anubhuti Bansal
  • Patent number: 10182749
    Abstract: A health care apparatus and an operating method thereof are provided. The method includes generating a first blood glucose pattern of an examinee that indicates a blood glucose level of the examinee over a first period of time, generating a second blood glucose pattern of the examinee that indicates the blood glucose level of the examinee over a second period of time, generating a third blood glucose pattern of the examinee that indicates the blood glucose level of the examinee over a third period of time, and calculating a glycemic index of the examinee based on the first blood glucose pattern, the second blood glucose pattern, and the third blood glucose pattern.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: January 22, 2019
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Jinyoung Park, Eunsung Park, Seongho Cho
  • Patent number: 10165969
    Abstract: A method that includes receiving first and second detection signals and electrocardiograph signals; wherein the first detection signals result from an illumination, by an oxygen saturation sensor included in a device that may be removably attached to a user, of a sternal angle of a user by infrared pulses; wherein the second detection signals result from an illumination, by the oxygen saturation sensor, of the sternal angle of a user by visible light pulses; wherein the electrocardiograph signals may be detected by an electrocardiography sensor that may be included in the device; generating a first waveform template that may be responsive to the first detection signals; generating a second waveform template that may be responsive to the second detection signals; calculating an indication of the oxygen saturation characteristic of the user in response to the first and second detection signals; detecting cardiac cycle durations that may be based upon the first and second detection signals; detecting electrocard
    Type: Grant
    Filed: April 27, 2015
    Date of Patent: January 1, 2019
    Assignee: BRAEMAR MANUFACTURING, LLC
    Inventors: Anna Levant, Zohar Brachia Halevi, Mordehay Amirim