Patents Examined by Danielle B Henkel
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Patent number: 11781100Abstract: Methods and apparatus of bioreactors for therapeutic cells manufacturing are provided herein. In some embodiments, a bioreactor includes: an upper bioreactor reservoir configured to perform multiple cell therapy manufacturing process steps including genetic modification and expansion to a plurality of cells disposed therein, wherein the upper bioreactor reservoir includes a plurality of ports for delivering fluids into and out of the upper bioreactor reservoir; a lower bioreactor compartment configured to hold a suspension comprising a molecular species; and a membrane disposed between the lower bioreactor compartment and the upper bioreactor reservoir, wherein the membrane includes a plurality of micro-straws extending through the membrane and into the upper bioreactor reservoir to transfect the plurality of cells with the molecular species.Type: GrantFiled: December 3, 2020Date of Patent: October 10, 2023Assignee: APPLIED MATERIALS, INC.Inventors: Samer Banna, Mukhles Sowwan, Gary E. Dickerson
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Patent number: 11781105Abstract: A system for quickly determining antibiotic sensitivity of a microorganism comprising a triangular-shaped plate and cover for culturing, recovering, and re-suspending recovered microbial colonies and a second triangular-shaped plate comprising a non-liquid medium cut with concentric trenches over which the re-suspended microbial colonies are distributed by centrifugation and contacted with antimicrobial strips or disks.Type: GrantFiled: June 5, 2020Date of Patent: October 10, 2023Assignees: National Guard Health Affairs, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research CenterInventor: Ahmad Mohammed Shikan Aljefri
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Patent number: 11773361Abstract: Miniature stirred tank bioreactor and system; the bioreactor configured for single use culturing providing unobstructed culturing volume with sensors, probes and ports using minimally invasive placement in-wall or across the wall methods; the bioreactor further capable of containing scaffolds and features for culturing cells and tissue, including structures providing surfaces for cell growth, and screens for retaining microparticles during media exchange.Type: GrantFiled: May 10, 2018Date of Patent: October 3, 2023Inventor: Jerry Shevitz
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Patent number: 11773365Abstract: The present disclosure provides cassettes for use in automated cell engineering systems that include cell concentration filters for reducing fluid volume of a cell sample during or following automated processing. The disclosure also provides methods of concentrating a cell population, as well as automated cell engineering systems that can utilize the cassettes and carry out the methods.Type: GrantFiled: February 5, 2020Date of Patent: October 3, 2023Assignee: LONZA WALKERSVILLE, INC.Inventors: Joseph O'Connor, Erika McAfee, Samatha Bandapalle, Yaling Shi, Eytan Abraham
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Patent number: 11732242Abstract: The invention provides an automated system for producing induced pluripotent stem cells (iPSCs) from adult somatic cells. Further, the system is used for producing differentiated adult cells from stem cells.Type: GrantFiled: March 5, 2021Date of Patent: August 22, 2023Assignee: New York Stem Cell Foundation, Inc.Inventors: Scott Noggle, Kevin C. Eggan, Stephen Chang, Susan L. Solomon
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Patent number: 11718818Abstract: A system includes a photobioreactor that provides a channel configured to contain an algae slurry, a duct positioned adjacent the channel and configured to convey a gas, and a barrier separating the duct from the channel and providing one or more apertures to allow a portion of the gas to be injected into the algae slurry from the duct.Type: GrantFiled: June 3, 2020Date of Patent: August 8, 2023Assignee: EXXONMOBIL TECHNOLOGY AND ENGINEERING COMPANYInventors: Everett J. O'Neal, Patrick L. Hanks, Kevin B. Daly
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Patent number: 11713440Abstract: According to one embodiment of the present disclosure, a cell culture system includes: a cell culture container; a liquid storage part configured to store a liquid including a culture medium or a reagent to be supplied to the cell culture container; and a cell collection part configured to collect cells cultured in the cell culture container, wherein the cell culture container, the liquid storage part, and the cell collection part are connected by spatially closed-system lines at least during a period from feeding of the liquid to the cell culture container to removal of the cultured cells, and wherein the cell culture container is arranged in an incubator in a form of a multistage shelf including a liquid supply/discharge port.Type: GrantFiled: December 20, 2019Date of Patent: August 1, 2023Assignee: Sinfonia Technology Co., Ltd.Inventors: Daichi Horii, Kazuhiro Tsuji, Yoshihiko Nishikawa, Haruki Takeuchi
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Patent number: 11708555Abstract: An apparatus for draining a bioreactor vessel includes a tubular body portion having an interior passageway, and at least one aperture in the tubular body portion providing for fluid communication with the interior passageway, the tubular body portion being configured for positioning at a bottom of a vessel, and a suction tube having a first end configured for fluid coupling with the tubular body portion, and a second end configured for fluid coupling with a port in a sidewall of the vessel.Type: GrantFiled: May 30, 2019Date of Patent: July 25, 2023Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Richard Damren, Colin Tuohey, Ralph Stankowski
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Patent number: 11667589Abstract: The disclosure relates to a composting device including a housing defining an interior, and having a top wall defining an access opening providing access to the interior, a door moveable relative to the access opening between open/closed positions to selectively open/close the access opening, a trim bezel with a trim bezel opening, and a bin located within the interior and having a fill opening in communication with the trim bezel opening.Type: GrantFiled: October 15, 2020Date of Patent: June 6, 2023Assignee: Whirlpool CorporationInventors: Abhishek P. Buzruk, Christopher C. Wilcox, Michael S. Seeley
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Patent number: 11661575Abstract: Provided is a cell culture device that has a simple structure and ensures sufficient nutrient supply to cells and oxygenation of the cells to thereby enable mass cell culture. The cell culture device comprises: a cell culture container which is an approximately cylindrical body provided with a flat bottom part at the lower end; a dish-shaped body having an approximately disc shape which is provided with a plurality of magnetic attraction members, said magnetic attraction members being positioned in the circumferential part at equal intervals, and horizontally disposed in a non-contact state within a hollow space inside the cell culture container; and a cyclic body which is provided with a plurality of magnetic attraction members and positioned outside the cell culture container so that the cell culture container is located within the cycle thereof. The cyclic body and the dish-shaped body move vertically in magnetic conjunction to thereby agitate a medium and supply nutrients to cells.Type: GrantFiled: February 14, 2019Date of Patent: May 30, 2023Assignee: FULLSTEM CO., LTD.Inventors: Shunmei Chiba, Young-Jin Lee, Takaki Ushifusa
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Patent number: 11655442Abstract: A system for incubating one or more cells and/or organotypic cultures for biological investigation, in particular for toxicology assessment, comprising a bio-incubator and a pressure system fluidly connected with the bio-incubator. The pressure system is a cyclic gas pressure system configured for cyclically varying the gas pressure in the bio-incubator between a negative pressure and a positive pressure compared to the atmospheric pressure, so as to reproduce the pressure conditions in lungs of a living mammal. The system is remarkable in that the cyclic gas pressure system comprises a feedthrough with a pipe configured to deviate the air influx from the one or more cells and/or organotypic cultures.Type: GrantFiled: December 31, 2018Date of Patent: May 23, 2023Assignee: LUXEMBOURG INSTITUTE OF SCIENCE AND TECHNOLOGY (LIST)Inventors: Arno Gutleb, Tommaso Serchi, Mathieu Gerard
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Patent number: 11643677Abstract: The invention features devices and kits for capturing and culturing microorganisms (e.g., bacteria, fungi, or protists) and methods of using the devices and kits to detect microorganisms in environmental and other samples. The device includes a nutrient media having a flat growth area on which microorganisms can grow. Samples are collected by contacting the device with any environmental sample, e.g., rolling device on a work surface or exposing device to air, or by filtering a sample through a membrane. Microorganisms deposited on the membrane derive nutrients from the underlying media and grow into colonies that can then be detected using methods known in the art. The detected colonies can be imaged digitally or with film.Type: GrantFiled: September 9, 2019Date of Patent: May 9, 2023Assignee: RAPID MICRO BIOSYSTEMS, INC.Inventors: Douglas J. Browne, Sarkis Karakozian, Xiaowei Chen
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Patent number: 11623216Abstract: A sample testing apparatus for characterizing at least one target molecule in a testing sample includes a substrate and at least one detection device over the substrate. Each detection device includes a plurality of electrodes, a plurality of data lines, and a probe. Each electrode is configured, upon reaction of the probe with one of the at least one target molecule, to sense an electrical signal, and then to transmit the electrical signal via the one data line. Each data line includes a first film layer and at least one other film layer disposed over the first film layer. The first film layer can be at a substantially same layer, and have a first composition substantially same, as the electrodes. One or more of the at least one other film layer can have a composition having a relatively lower electric resistance than the first composition.Type: GrantFiled: May 17, 2018Date of Patent: April 11, 2023Assignees: Beijing Boe Optoelectronics Technology Co., Ltd., BOE TECHNOLOGY GROUP CO., LTD.Inventors: Tiansheng Li, Zhenyu Xie, Lijun Mao
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Patent number: 11618872Abstract: An anaerobic digestion device based on self-sustained air flotation includes an anaerobic digestion tank unit, a self-sustained air flotation screening unit and a biogas measurement and collection unit. The self-sustained air flotation screening unit includes an air flotation screening part, a material sedimentation part, a reflux part and a three-phase separation part connected sequentially from bottom to top. A digested material in the anaerobic digestion tank unit is pumped into the air flotation screening part, overflows into the material sedimentation part, and then is raised to the reflux part. Gas passing through the three-phase separation part and gas produced in the anaerobic digestion tank unit enter the biogas measurement and collection unit to be measured and collected.Type: GrantFiled: December 31, 2021Date of Patent: April 4, 2023Assignee: TONGJI UNIVERSITYInventors: Xiaohu Dai, Yue Zhang, Yu Hua, Chen Cai
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Patent number: 11608484Abstract: The invention relates to a single-use connection device for insertion into a connection opening of a bioreactor, in particular in a connection opening of a top plate of a dimensionally-stable bioreactor or in a connection opening of a connection element of a pouch bioreactor. The single-use connection device is inserted in a connection opening of a top plate of a bioreactor and/or in a connection opening of a pouch reactor and is provided with multiple passages and an attachment section, wherein the single-use connection device is formed as a single piece and is made of plastic. The attachment section, on an outer peripheral surface, has an attachment structure for attaching the single-use connection device in the connection opening.Type: GrantFiled: January 27, 2017Date of Patent: March 21, 2023Assignee: EPPENDORF AGInventors: Matthias Arnold, Sebastian Selzer, Sven Eikelmann, Jochen Beese
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Patent number: 11608482Abstract: The invention discloses a device for producing biogas with high methane content by utilizing livestock and poultry feces, wherein the interior of a tank body of a biogas fermentation tank is divided by a baffle, so as to form a main reaction chamber and an auxiliary reaction chamber which are communicated in upper portions, so that a reactant flows into the auxiliary reaction chamber only after entering the main reaction chamber via a relatively low feeding hole and then reaching a high position of a liquid level, and extension of fermentation time is realized, meanwhile, scales formed at the top of fermentation broth flow into the auxiliary reaction chamber along with liquid, so that the interior of the main reaction chamber keeps a liquid state all the time, and sealing and reduction of quantity of anaerobic bacteria are avoided.Type: GrantFiled: January 17, 2020Date of Patent: March 21, 2023Assignees: South China University of Technology, Guangdong University of Petrochemical Technology, Guangzhou Institute of Energy Conversion, Chinese Academy of SciencesInventors: XiaoJun Niu, MengYu Lv, Xia Li, Li Zhang, NingYu Tu, XingYao Ye, DongQing Zhang, LiHua Cheng, HuaFang Guo
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Patent number: 11597905Abstract: An automated cell culture and tissue engineering system comprising defined and separate environmental zones provide for increased control and maintenance of the internal environment of the system such that the temperature, air flow and gases surrounding the bioreactor module form one zone that is maintained separately to a second zone formed surrounding the reagent fluid reservoir. The system further comprises means for elimination and/or management of condensation within the second zone of the system.Type: GrantFiled: December 26, 2019Date of Patent: March 7, 2023Assignee: OCTANE BIOTECH INC.Inventors: Guy Oram, Taylor Plant, Ian Grant, Timothy Smith
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Patent number: 11591559Abstract: The disclosure relates to bioreactors, for example for biological treatment and, more specifically to bioreactor insert apparatus including biofilms and related methods. The bioreactor insert apparatus provides a means for circulation of reaction medium within the bioreactor, a biofilm support, and biological treatment of an inlet feed to the reactor/insert apparatus. The bioreactor insert apparatus has a high relative surface area for biofilm attachment and is capable of generating complex flow patterns and increasing treatment efficiency/biological conversion activity in a biologically-active reactor. The high surface area structure incorporates multiple biofilm support structures such as meshes at inlet and outlet portions of the structure. The biofilm support structures and biofilms thereon can increase overall reaction rate of the bioreactor and/or perform some solid/liquid separation in the treatment of the wastewater or other influent.Type: GrantFiled: September 30, 2019Date of Patent: February 28, 2023Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Steven Skerlos, Lutgarde Raskin, Timothy Fairley, Nishant Jalgaonkar
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Patent number: 11572536Abstract: Disclosed is a well insert for cell culture, including: a membrane support having an upper end and a lower end, the upper end being adapted to engage a well of a microplate so as to suspend the well insert therein; and a permeable membrane for supporting a tissue culture, the permeable membrane being attached at the lower end of the membrane support and sealed thereto, the permeable membrane being of brittle material. The membrane support is overmolded or fastened on to the permeable membrane so as be sealed thereto.Type: GrantFiled: May 10, 2016Date of Patent: February 7, 2023Assignee: SIMPLINEXT SAInventors: Silvia Angeloni Suter, Kaspar Suter, Eric Marguet, Sylvain Bergerat, Charlotte Voutat
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Patent number: 11570985Abstract: The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.Type: GrantFiled: June 30, 2020Date of Patent: February 7, 2023Assignee: TRANSMEDICS, INC.Inventors: Waleed H. Hassanein, Tamer I. Khayal, Ahmed Elbetanony, Paul Lezberg, Giovanni Cecere, Dennis Sousa, Elizabeth Hansen Bulger