Abstract: Pyrrolo[3,4-c]pyrroles of formula ##STR1## wherein D and E are each independently of the other a group of formula ##STR2## The symbols Q, R.sub.8, R.sub.9, R.sub.10, R.sub.11, X, Y, Z, m and n are as defined in claim 1.These pyrrolo[3,4-c]pyrroles are distinguished by outstanding solid state fluorescence in the UV range as well as by the ease with which they can be converted to pyrrolopyrrole pigments even in the substrate in which they are incorporated.

Abstract: Disclosed are low solids, high density fluids useful as drilling, workover, and completion fluids and the like in oil and gas well operations. The fluids comprise one or more brines having a density greater than about 1500 kg/m.sup.3, a viscosifier which is a high surface area silica, a fluid loss control additive which is preferably a starch derivative, one or more water soluble or acid soluble bridging agents, and, optionally, an alkaline buffer and a polar additive.Also disclosed is an additive for the preparation of low solids, high density fluids which comprises a fumed silica and a bridging agent in a weight ratio of bridging agent to fumed silica from about 2 to about 20, and optionally, an alkaline buffer in a weight ratio of alkaline buffer to fumed silica from about 0.03 to about 2.5.

Abstract: Disclosed herein are compounds of formula 1 ##STR1## wherein X is a terminal group, for example, an aryloxycarbonyl, an alkanoyl or an optionally mono- or disubstituted carbamoyl; B is absent or an amino acid residue, for example, Val or Ash; R.sup.1 is hydrogen or a ring substituent, for example, fluoro or methyl; R.sup.2 is alkyl; and Y is a ring substituent, for example, phenoxy, 2-pyridinylmethoxy, phenylthio or 2-pyridinylthio. The compounds inhibit the activity of human immunodeficiency virus (HIV) protease and interfere with HIV induced cytopathogenic effects in human cells. These properties render the compounds useful for combating HIV infections.

Abstract: A novel fracturing fluid composition comprising:(1) a carboxyalkyl derivatized polygalactomannan having a degree of substitution of between about 0.01 and about 3.0;(2) a zirconium salt crosslinking agent;(3) one or more thermal stabilizing agents;(4) one or more pH buffers; and(5) water;wherein said fluid is capable of maintaining at least 10 percent of its original cross-linked viscosity after three hours at a temperature greater to or equal to 250.degree. F. is provided.

Abstract: This invention provides novel heterocyclic derivatives, their pharmaceutical formulations, and their use for antagonizing angiotensin II receptors in mammals.

Abstract: There is provided a method of drilling an oil or gas well, comprising drilling a wellbore into an underground formation in which a drill bit at the lower end of a drill pipe is placed at the bottom of the wellbore; pumping a first drilling fluid into the wellbore; determining the producing zone of the underground formation; and introducing a second drilling fluid into the wellbore through the drill pipe when the borehole is within the producing zone of the underground formation, wherein the second drilling fluid is a high density drill-in fluid, having a composition different from that of the first drilling fluid and including a brine system with at least one dissolved monovalent salt and at least one dissolved divalent salt together with a suspension polymer, said drilling fluid having a density of at least about 1.50 g/cm.sup.3 and a plastic viscosity of less than about 50 lbs/100 ft.sup.2.

Abstract: Novel acylated amino acids which are antagonists of endothelin are described. Methods for their preparation and pharmaceutical compositions containing them are also included. The compounds are expected to be useful in treating elevated levels of endothelin, acute and chronic renal failure, hypertension, myocardial infarction, myocardial ischemia, cerebral vasospasm, cirrhosis, septic shock, congestive heart failure, endotoxic shock, subarachnoid hemorrhage, arrhythmias, asthma, preeclampsia, atherosclerotic disorders including Raynaud's disease and restenosis, angina, cancer, pulmonary hypertension, ischemic disease, gastric mucosal damage, hemorrhagic shock, ischemic bowel disease, diabetes, head injury, and stroke.

Abstract: The invention herein is directed to a process for producing a lactam of the formula ##STR1## from a methionine analog of the formula ##STR2## by treating the methionine analog with trimethylsulfonium halide or trimethylsulfoxonium halide in the presence of a base in a suitable aprotic solvent.The invention herein is further directed to the preparation of amidinophenyl pyrrolidinyl .beta.-alanine urea analogs using such methionine and lactam compounds as intermediates, which .beta.-alanine urea analogs are useful as antithrombotics.

Abstract: The invention concerns tachykinin antagonists. The compounds are alcohols, amines and prodrugs of nonpeptides which have utility in treating disorders mediated by tachykinins. Such disorders are respiratory, inflammatory, gastrointestinal, ophthalmic, allergies, pain, vascular, diseases of the central nervous system, and migraine. Methods of preparing compounds and novel intermediates are also included.The compounds are expected to be especially useful in asthma, multiple sclerosis, rheumatoid arthritis, the management of pain, migraine, and antiemetic agents.

Abstract: Maleimide pesticides having enhanced efficacy represented by the formula (I), ##STR1## wherein X represents a halogen atom or a hydrogen atom, and R represents an alkyl group a cycloalkyl or haloalkyl group, a pesticidal composition containing the same as an active ingredient, and a process for producing the same.

Abstract: The present invention provides nonionic alkanolamides which may be added to drilling fluids in order to minimize hydration and prevent erosion loss of water-sensitive shale substrates. Preferred alkanolamides are acetamide mono- and diethanolamines.

Abstract: 2--R.sub.2 --R.sub.4 -substituted-3--R.sub.3 --CO--1--[(C-attached-N-heteryl)-(Alk).sub.n ]--1H-indoles useful as analgesic, anti-rheumatic, anti-inflammatory or anti-glaucoma agents.

Abstract: The present invention encompasses structures of the formula I: ##STR1## and the pharmaceutically acceptable non-toxic salts thereof wherein: ##STR2## wherein: W represents substituted or unsubstituted aryl groups;X is hydrogen, hydroxy or lower alkyl;T is hydrogen, halogen, hydroxyl, amino or alkyl;R.sub.3 is hydrogen or an organic group;R.sub.4 is hydrogen or substituted or unsubstituted organic substituent;R.sub.5 and R.sub.6 represent organic, and inorganic substituents; andn is 1, 2, 3, or 4.These compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain recpetors. These compounds are useful in the diagnosis and treatment of anxiety, sleep and seizure disorders, overdose with benzodiazepine drugs and for enhancement of memory.

Abstract: Polymorphic forms of Losartan (Formula I) ##STR1## and a process for the preparation of Form II of Losartan. Losartan is known to be useful in the treatment of hypertension.

Abstract: A class of substituted imidazole, triazole and tetrazole derivatives are selective agonists of 5-HT.sub.1 -like receptors and are therefore useful in the treatment of clinical conditions, in particular migraine and associated disorders, for which a selective agonist of these receptors is indicated.

Abstract: An environmentally acceptable, thermally insulating annular fluid comprised of a liquid which is non-aqueous, non-corrosive, and thermally insulating, a clay gellant, and a clay dispersant. A preferred packer fluid includes an ester originated from a vegetable or animal oil as at least a major portion of the liquid phase.

Abstract: An improved process for the preparation of 3-chlorobenzo[b]thiophene-2-carbonyl chlorides is described where a cinnamic acid is converted in the presence of thionyl chloride and a 4-N,N'-disubstituted aminopyridine in one step to the desired product.

Abstract: The present invention provides non-toxic, biodegradable olefin isomers which may be used as lubricants, rate of penetration enhancers, and/or spotting fluids for water-based drilling muds. When used as a spotting fluid additive, the olefin isomers preferably are supplemented with functional additives, namely emulsifiers, viscosifiers, surfactants, and/or brine. When used as lubricants and/or rate of penetration enhancers, the olefin isomers preferably are used alone or in combination with surfactants.

Abstract: The invention provides heterobifunctional cross-linking reagents and methods of using the cross-linking reagents. The cross-linking reagents of the invention combine a nucleophilic hydrazide residue with an electrophilic maleimide residue, allowing coupling of aldehydes to free thiols. In the methods of the invention, human immunodeficiency virus (HIV) infected cells can be detected using conjugates that include CD4 molecules conjugated to detectable markers via the disclosed cross-linking reagents.

Abstract: Disclosed is an improvement in a method for propping a fracture adjacent a wellbore formed by injecting in said fracture a carrier fluid containing proppant coated with a curable resin which improvement comprises:a) using proppant coated with a resin fluid containing a polymerizable oligomer of furfuryl alcohol resin, a catalyst comprising an oil soluble, slightly water soluble organic acid and an ester of a weak organic acid to consume water produced by the polymerization of resin;b) using as a carrier an aqueous saline fluid comprising water which is 70% to 100% saturated with sodium chloride,c) suspending said resin-coated proppant in the carrier fluid, forming a fluid mixture of resin-coated proppant and carrier fluid; and injecting said mixture into said fracture, wherein the timing of the addition of the catalyst can be varied.