Patents Examined by Deborah K. Ware
  • Patent number: 10844417
    Abstract: Disclosed are methods of diagnosing constipation and constipation-predominant irritable bowel syndrome by screening for the presence of abnormally high levels of methane and/or methanogenic organisms in a subject.
    Type: Grant
    Filed: August 2, 2018
    Date of Patent: November 24, 2020
    Assignee: Cedars-Sinai Medical Center
    Inventors: Mark Pimentel, Henry C. Lin
  • Patent number: 10829734
    Abstract: Provided is a preparation method for olfactory ensheathing cells. The method comprises the steps of formulation of a cell medium, collection and pretreatment of tissues, enzymatic digestion, cell culture, cryopreservation, and differentiation culture. The prepared olfactory ensheathing cells can maintain the proliferative capacity for a long time, and still possess the activity of olfactory ensheathing cells after 11th passage.
    Type: Grant
    Filed: August 11, 2016
    Date of Patent: November 10, 2020
    Assignee: BEIJING HONGTIANJI NEUROSCIENCE ACADEMY
    Inventors: Hongyun Huang, Wenyong Gao, Juan Xiao
  • Patent number: 10821139
    Abstract: Compositions and methods use Bifidobacterium longum NCC3001 (ATCC BAA-999) to treat or prevent a depressive symptom. Prolonged anti-depressive effects can continue after administration of the compositions is ended. Non-limiting examples of a depressive symptom which can be treated or prevented include depressed mood; sadness; anxiety; “empty” feelings; loss of interest or pleasure; irritability; restlessness; changes in appetite or weight; sleep disturbances; lack of or decreased energy; feelings of worthlessness; guilt; helplessness; anger and hostility; difficulty in thinking, concentrating, or making decisions; hopelessness; tiredness; fatigue; memory difficulties; tearfulness; brooding; phobias; excessive worry over physical health; sexual dysfunction; persistent physical symptoms that do not respond to treatment; and combinations thereof.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: November 3, 2020
    Assignee: Societe des Produits Nestle S.A.
    Inventors: Gabriela Bergonzelli Degonda, Tiago Alves Nunes, Valerie Marquardt, Jeroen Antonius Johannes Schmitt
  • Patent number: 10826118
    Abstract: The invention relates to a process for preparing unipolar cation-conducting ionomers from fluoro ionic monomers, to said unipolar cation-conducting ionomers, to the uses thereof, to an electrolytic composition comprising at least one of said unipolar cation-conducting ionomers and to an electrochemical device comprising at least one of said unipolar cation-conducting ionomers, especially as electrolyte.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: November 3, 2020
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT POLYTECHNIQUE DE GRENOBLE
    Inventors: Cristina Iojoiu, Amadou Thiam, Olesia Danyliv, Régis Mercier, Jean-Yves Sanchez
  • Patent number: 10821075
    Abstract: Drug-delivery systems are described which can serve as platforms for topical delivery of a variety of active pharmaceutical ingredients (API) to the surface of a mammalian body. Methods for the preparation and use of the compositions are also described. In some embodiments, the disclosed topical formulations include an API, a penetration enhancer/cosolvent, a gelling agent, and a neutralizing agent (to adjust pH). As compared to prior compositions, the disclosed topical formulations use a relatively small number of safe components and are easy to prepare with a high yield of finished product.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: November 3, 2020
    Inventor: James Blanchard
  • Patent number: 10822636
    Abstract: The invention relates to the field of blood clotting diagnosis and relates to a kinetic method for determining the fibrinogen concentration in a human plasma sample according to the Clauss method.
    Type: Grant
    Filed: March 28, 2017
    Date of Patent: November 3, 2020
    Assignee: Siemens Healthcare Diagnostics Products GmbH
    Inventors: Dirk Greis, Norbert Zander
  • Patent number: 10813983
    Abstract: The present invention provides compositions and methods for prevention, amelioration and treatment of gram positive bacteria, particularly Staphylococcal bacteria, with combinations of lysin, particularly Streptococcal lysin, particularly the lysin PlySs2, and one or more antibiotic, including daptomycin, vancomycin, oxacillin, linezolid, or related antibiotic(s).
    Type: Grant
    Filed: May 9, 2013
    Date of Patent: October 27, 2020
    Assignee: CONTRAFECT CORPORATION
    Inventors: Raymond Schuch, Robert C. Nowinski, Michael Wittekind, Han Lee, Brent Schneider
  • Patent number: 10815456
    Abstract: The present disclosure provides for a cryopreservation composition comprising a permeating cryoprotectant, a saccharide and a macromolecule. The cryopreservation composition has a low toxicity to cells and tissues, and promotes survival and retention of viability of the biological material during cryopreservation.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: October 27, 2020
    Assignee: TRANSWELL BIOTECH CO., LTD.
    Inventors: Bin-Ru She, Kun-Chi Chiang, Cheng-Yi Lin, Ting-Yu Huang
  • Patent number: 10806758
    Abstract: A method for culturing and preserving the probiotic gut microorganism Eubacterium hallii is disclosed. The method provides an E. hallii preparation that is suitable for administration or ingestion to humans and that provides high E. hallii biomass yields. Preferably, the medium used for culturing E. hallii to high biomass yields comprises food grade components only, is free of any animal sources, and/or is kosher. Further, including a method of treating disease using the E. hallii preparation.
    Type: Grant
    Filed: January 2, 2017
    Date of Patent: October 20, 2020
    Assignee: Caelus Pharmaceuticals B.V.
    Inventors: Willem Meindert De Vos, Jozef Franciscus Maria Louis Seegers
  • Patent number: 10808218
    Abstract: A fluid pumping and bioreactor system including at least two cassettes, at least one storage reservoir, at least one bioreactor, at least one manifold including valve modules, and tubing to connect the cassettes to the storage reservoir and the bioreactor. The cassettes can include pumps, valves, and fluid conduits and can be communicatively connected to the at least one manifold. The bioreactor can include an adapter and fluid conduits extending through the adapter from the exterior of the bioreactor to the interior of the bioreactor. System and method for generating a tissue for transplant by decellularizing and recellularizing a supplied tissue.
    Type: Grant
    Filed: March 21, 2019
    Date of Patent: October 20, 2020
    Assignee: DEKA Products Limited Partnership
    Inventors: Dean Kamen, Jason A. Demers, Frederick Morgan, Timothy D. Moreau, Brian D. Tracey, Matthew Ware, Dirk A. van der Merwe, Richard J. Lanigan, Michael A. Baker, David Blumberg, Jr.
  • Patent number: 10808263
    Abstract: The invention is directed to a process for producing one or more fermentation product in a multi-stage process including an inoculation reactor and at least one bioreactor. The inoculation reactor is fed a C1-containing gaseous substrate containing a reduced amount of hydrogen. The hydrogen is reduced to increase the proportion of CO in the C1-containing gaseous substrate being provided to the inoculation reactor. The inoculation reactor ferments the CO-rich C1-containing gaseous substrate and produces an inoculum, which is fed to at least one bioreactor. The bioreactor receives the C1-containing gaseous substrate, which may or may not contain reduced amounts of hydrogen, to produce one or more fermentation product. By providing a CO-rich C1-containing gaseous substrate to the inoculation reactor, both the inoculation reactor and the subsequent bioreactor(s), are able to have increased stability and product selectivity.
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: October 20, 2020
    Assignee: LANZATECH, INC.
    Inventors: Robert John Conrado, Guy William Waters, Matthew Puglisi, Joshua Jeremy Conolly
  • Patent number: 10801949
    Abstract: To perform more accurate analysis of a composition of a substance given at a sampling time, provided is an optical analysis apparatus, including: a flow passage, which is connected to a vessel, and is configured to allow a first substance to flow therethrough; an introduction unit, which is provided to the flow passage, and is configured to introduce at least two second substances to the flow passage, to thereby divide the first substance flowing through the flow passage; and a measurement unit, which is provided to the flow passage, and is configured to perform measurement by irradiating the first substance and the second substance flowing through the flow passage with light.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: October 13, 2020
    Assignee: Hitachi, Ltd.
    Inventors: Toshimitsu Noguchi, Takuya Kambayashi, Shinichi Taniguchi
  • Patent number: 10793481
    Abstract: Methods of treating a plant exposed to a phytotoxicant are provided. Embodiments of the subject methods include identifying a plant exposed to a phytotoxicant and applying an assimilable carbon-skeleton energy component-comprising composition to the identified plant. Embodiments of the subject compositions may include one or more of a macronutrient component, micronutrient component, vitamin/cofactor component, complexing agent and microbe. Kits for use in practicing the subject invention are also provided. The subject methods find use in a variety of different applications in which a plant is phytotoxic or at least in danger of becoming phytotoxic due to exposure or potential exposure to a phytotoxicant.
    Type: Grant
    Filed: May 1, 2018
    Date of Patent: October 6, 2020
    Inventor: Thomas T. Yamashita
  • Patent number: 10793824
    Abstract: Growth medium are disclosed for use in fermenting a marine microorganism. The medium comprise Potassium, Calcium, Strontium, Borate and Fluoride at specific concentrations. Alternatively, the growth medium comprises cobalt at specified concentrations or comprises vitamin B12 at specified concentrations. Methods of producing certain desired compound by fermentation of a marine microorganism are also disclosed.
    Type: Grant
    Filed: June 5, 2018
    Date of Patent: October 6, 2020
    Assignee: Celgene International II Sárl
    Inventors: Kin Sing Lam, Ginger Tsueng
  • Patent number: 10794803
    Abstract: A formal-in-free fixative composition, suitable for the fixation of cells in particular in liquid samples, the use of said fixative for the treatment of biological samples, a method for the treatment of cell-comprising liquid samples, a kit comprising said fixative and a method for diagnosis of cell-comprising biological material samples.
    Type: Grant
    Filed: May 27, 2015
    Date of Patent: October 6, 2020
    Assignee: QIAGEN GMBH
    Inventor: Daniel Grölz
  • Patent number: 10772912
    Abstract: Provided herein are pharmaceutical compositions comprising tumoricidal and/or antimicrobial components isolated from the supernatant of NK-92 cell medium and methods of using the compositions for killing cancer cells.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: September 15, 2020
    Assignee: NantKwest, Inc.
    Inventors: Hans G. Klingemann, Barry J. Simon
  • Patent number: 10767148
    Abstract: Organic matter digesting apparatus and methods are provided that can include a digestion tank operatively coupled to a vertically aligned gas collection tower and methods that can include providing a biodigesting apparatus; inputting organic matter into the biodigesting apparatus; initiating the biodigesting apparatus; and outputting water, methane gas, and solid carbon-based material.
    Type: Grant
    Filed: May 17, 2019
    Date of Patent: September 8, 2020
    Inventors: Daniel Bruce, Margaret Ruhl
  • Patent number: 10758509
    Abstract: Processes for producing a nutritional supplement that contains sulforaphane, and supplements formed thereby. Such a process includes combining a cruciferous vegetable, for example, broccoli sprouts, with strains of Bifidobacterium, Lactobacillus, and Streptococcus to form a mixture, causing the mixture to undergo lactic acid fermentation, transform a glucosinolate within the cruciferous vegetable to sulforaphane, and yield a fermented mixture that contains sulforaphane, and then producing from the fermented mixture a supplement that can be ingested by an individual.
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: September 1, 2020
    Inventor: Anne-Marie Kosi-Kupe
  • Patent number: 10753899
    Abstract: A whole blood measurement method associated to hematocrit (HCT) and a whole blood measurement circuit thereof is applied in the detection of HCT of a whole blood sample to be tested. Herein, a time to digital converting circuit (TDC) is used for counting charging time or discharging time of a fixed capacitor and a to-be-tested sample, and a capacitance difference that is related to HCT is generated according to the charging time or the discharging time, so as to provide a reference for a whole blood feature test.
    Type: Grant
    Filed: November 1, 2018
    Date of Patent: August 25, 2020
    Assignee: HOLTEK SEMICONDUCTOR INC.
    Inventors: Kuo-Hsiang Chen, Kuo-Yang Li, Hung-Yu Liu
  • Patent number: 10753837
    Abstract: In one aspect, devices for collecting and enriching microbes are described herein. In some embodiments, such a device comprises a shape memory gel and a plurality of nanoantennas dispersed in the gel. The nanoantennas can be non-uniformly dispersed in the gel. Additionally, the nanoantennas are operable to receive an external signal and thereby induce a local change in state of the gel, such as a local change in thermodynamic state of the gel.
    Type: Grant
    Filed: May 24, 2018
    Date of Patent: August 25, 2020
    Assignee: The Board of Trustees of the University of Arkansas
    Inventor: Donald Keith Roper