Patents Examined by Deborah K. Ware
  • Patent number: 10449229
    Abstract: Provided are methods and compositions for cartilage repair. The method involves performing a surgical procedure at the site of a cartilage defect and administering a composition comprising a receptor for hyaluronan mediated motility (RHAMM)-mimetic peptide, and a high molecular weight hyaluronan.
    Type: Grant
    Filed: August 19, 2015
    Date of Patent: October 22, 2019
    Assignees: New York University, London Health Sciences Centre Research Inc.
    Inventors: Mary K. Cowman, Thorsten Kirsch, Eric J. Strauss, Eva Ann Turley, Cornelia Toelg, Leonard G. Luyt
  • Patent number: 10442939
    Abstract: In the field of consumable materials for automatic analytical instruments, a method for producing transparent plastic cuvettes with increased scratch resistance includes contacting exclusively an outer surface of the transparent plastic cuvette with a liquid comprising at least one surfactant or with a triglyceride and subsequently drying the outer surface such that scattered-light optical properties of the transparent plastic are not adversely affected.
    Type: Grant
    Filed: October 24, 2016
    Date of Patent: October 15, 2019
    Assignee: Siemens Healthcare Diagnostics Products GmbH
    Inventors: Josef Meindl, Oksana Pryshchepna
  • Patent number: 10435722
    Abstract: The invention relates to a method for producing products by microbial fermentation. The method comprises first converting a feed stream containing methane to a gaseous substrate comprising CO, of the invention include converting CO H2, and CO2 using a steam reforming zone and a water gas shift zone. The gaseous substrate is then converted to products such as alcohols and/or acids by to one or more products including alcohols and/or acids by fermentation using a carboxydotrophic microorganism.
    Type: Grant
    Filed: July 26, 2017
    Date of Patent: October 8, 2019
    Inventors: Sean Dennis Simpson, Christophe Collet, Michael Cockrem, Simon David Oakley, Michael Koepke
  • Patent number: 10428395
    Abstract: The aim of the present invention is a method for the preparation of anallergic probiotic bacterial cultures.
    Type: Grant
    Filed: July 26, 2006
    Date of Patent: October 1, 2019
    Assignee: PROBIOTICAL S.P.A.
    Inventors: Giovanni Mogna, Gian Paolo Strozzi
  • Patent number: 10428324
    Abstract: An acoustic resonator device includes a fluid chamber with a carrier surface and a reflector surface. The fluid chamber is filled with a volume of a fluid that includes a phase-separate material such as algae. The carrier surface is coupled to a transducer, which may be a lead zirconate titanate (PZT) transducer. The transducer, when supplied with electricity, emits an acoustic wave-based output of an output frequency (e.g., ultrasound). A sensor may be used to track one or more eigenfrequencies of the volume of fluid, the acoustic resonator device, or some combination thereof. A controller may receive tracking data from the sensor and control the voltage source, the transducer, or some combination thereof to ensure that the output frequency matches one of the tracked eigenfrequencies, thereby maximizing excitation of the fluid to improve efficiency of mixing, stimulation, and separation of materials from fluid (e.g., for algal biocrude production).
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: October 1, 2019
    Inventors: James E. Coons, James A. Ten Cate, Eric Y. Raby, Daniel M. Kalb
  • Patent number: 10407700
    Abstract: A surfactant-improved simultaneous saccharification and co-fermentation method for lignocelluloses in which a pretreated lignocellulose substrate is directly subjected to surfactant-improved simultaneous saccharification and co-fermentation without any detoxification by adding a surfactant, and the surfactant may be selectively added before or after pre-enzymatic hydrolysis, having economic, effective and feasible application prospects in reducing the loss of glucose, simplifying the production process, reducing equipment investment, reducing water consumption, improving ethanol production and reducing the total cost of the ethanol production process.
    Type: Grant
    Filed: December 29, 2014
    Date of Patent: September 10, 2019
    Inventors: Zongchao Zhang, Xiumei Liu, Liaoyuan Mao
  • Patent number: 10407708
    Abstract: Method for determining microorganism growth in a biological sample likely to contain microorganisms, said biological sample being contained in an analysis container, said analysis container being subjected to an incubation of a determined duration, said method comprising: acquiring a first plurality of initial images of the analysis container at a first acquisition time T1, before or during the incubation; acquiring a second plurality of final images of the analysis container at a second acquisition time T2, during or after the incubation; realigning each initial image of the first plurality of initial images acquired, with each corresponding final image of the second plurality of final images acquired; locating at least one potential microorganism growth zone in at least one image of the second plurality of images acquired; evaluating the content of the potential microorganism growth zone identified in order to determine the presence of microorganisms.
    Type: Grant
    Filed: November 26, 2015
    Date of Patent: September 10, 2019
    Assignees: Commissariat a L'Energie Atomique et aux Energies Alternatives, Biomerieux
    Inventors: Marthe Lagarrigue-Charbonnier, Lorène Allano, Marine Depecker
  • Patent number: 10391491
    Abstract: Methods and systems for isolating platelet-associated nucleated target cells, e.g., such as circulating epithelial cells, circulating tumor cells (CTCs), circulating endothelial cells (CECs), circulating stem cells (CSCs), neutrophils, and macrophages, from sample fluids, e.g., biological fluids, such as blood, bone marrow, plural effusions, and ascites fluid, are described. The methods include obtaining a cell capture chamber including a plurality of binding moieties bound to one or more walls of the chamber, wherein the binding moieties specifically bind to platelets; flowing the sample fluid through the cell capture chamber under conditions that allow the binding moieties to bind to any platelet-associated nucleated target cells in the sample to form complexes; and separating and collecting platelet-associated nucleated target cells from the complexes.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: August 27, 2019
    Assignee: The General Hospital Corporation
    Inventors: Mehmet Toner, Shannon Stott, Eduardo Reategui, Xiaocheng Jiang
  • Patent number: 10385373
    Abstract: Provided is a method of preparing a high-purity galactooligosaccharide composition by fermentation of a low-purity galactooligosaccharide mixture with a yeast strain, Kluyveromyces lactis ATCC 8585. The high-purity galactooligosaccharide composition includes at least 99% of galactooligosaccharides selected from the group consisting of galactotriose, galactotetrose, galactooligosaccharides with five or more sugar units, and combinations thereof and lower than 1% of monosaccharides and disaccharides. Also provided is a high-purity galactooligosaccharide composition and applications thereof in regulating blood glucose level and improving gut microbiota. For example, the high-purity galactooligosaccharide composition may be used to manufacture food products, beverages, health food products, nutritional supplements, and pharmaceutical compositions for patients or pets afflicted with diabetes mellitus or lactose intolerance.
    Type: Grant
    Filed: February 22, 2018
    Date of Patent: August 20, 2019
    Inventors: Chang-Lung Tsai, Ping-Ju Tsai
  • Patent number: 10385310
    Abstract: The invention provides methods and compositions for increasing photosynthetic efficiency and biomass production in cyanobacterial cultures by minimizing the phycobilisome light-harvesting antenna size through disruption of the phycocyanin-encoding CPC-operon.
    Type: Grant
    Filed: May 21, 2015
    Date of Patent: August 20, 2019
    Assignee: The Regents of the University of California
    Inventors: Anastasios Melis, Henning Kirst
  • Patent number: 10368559
    Abstract: The present invention relates to Streptococcus thermophilus strains, usable as starter cultures, able to provide both satisfactory rheological and organoleptic properties, and satisfactory shelf life to the media into which they are incorporated. In particular, these strains are also bacteriophage-resistant, thereby minimizing bacteriophage infection. The invention also provides a composition comprising one of these Streptococcus thermophilus strains, and feed or food products obtained with these strains.
    Type: Grant
    Filed: July 16, 2014
    Date of Patent: August 6, 2019
    Assignee: DuPont Nutrition Biosciences ApS
    Inventors: Philippe Horvath, Christophe Fremaux, Pascal Fourcassie
  • Patent number: 10364426
    Abstract: A process for reducing cell death in eukaryotic and prokaryotic organisms includes the steps of mixing the organisms with water in a first reactor, strobing light onto the mixture of organisms and water for a period of time, passing the strobed mixture into another reactor, and discharging the mixture from the another reactor. The step of strobing light includes strobing light to the mixture of organisms and water at a frequency of between 10 Hz and 40 Hz. The strobing of the light is between twenty flashes per second and eighty flashes per second. The first reactor is a continuously stirred reactor. The another reactor is a plug flow reactor. The organisms are in an algal culture.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: July 30, 2019
    Inventor: Samuel L. Shepherd
  • Patent number: 10364207
    Abstract: Disclosed herein are processes for obtaining a microbial oil comprising one or more polyunsaturated fatty acids (PU-FAs) from one or more microbial cells by lysing the cells to form a lysed cell composition and then recovering the oil from the lysed cell composition. Further disclosed herein is microbial oil comprising one or more PUFAs that is recovered from microbial cells by at least one process described herein.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: July 30, 2019
    Assignee: DSM IP Assets B.V.
    Inventors: Mark Barker, Nasrin Tabayehnejad, Ginger Shank, Neil Francis Leininger, Kirt Lyvell Matthews, Sr.
  • Patent number: 10358662
    Abstract: The invention provides schemes for the integration of a fermentation process, with an electrolysis process, and a C1-generating industrial process. In particular, the invention provides process for utilizing electrolysis products, for example H2 and/or O2, to improve the process efficiency of at least one of the fermentation process or the C1-generating industrial process. More particularly, the invention provides a process whereby, H2 generated by electrolysis is used to improve the substrate efficiency for a fermentation process, and the O2 generated by the electrolysis process is used to improve the composition of the C1-containing tail gas generated by the C1-generating industrial process.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: July 23, 2019
    Inventors: Sean Dennis Simpson, Robert John Conrado, Christophe Daniel Mihalcea, Michael Emerson Martin
  • Patent number: 10342772
    Abstract: Processes are disclosed for obtaining a lipid from a cell by lysing the cell to form a lysed cell composition, adding an acid to lower the pH of the lysed cell composition, and demulsify the lysed cell composition, and obtaining the lipid from the demulsified lysed cell composition. Also disclosed are lipids prepared by the processes of the present invention wherein the lipids have a particular anisidine value, peroxide value, and/or phosphorus content.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: July 9, 2019
    Assignee: DSM IP Assets B.V.
    Inventors: Mark Barker, Nasrin Tabayehnejad, Ginger Shank, Neil Leininger, Kirt Lyvell Matthews, Sr.
  • Patent number: 10336633
    Abstract: Processes and systems for maintaining a live culture of activated sludge in the activated sludge unit of a petroleum refinery during an extended refinery shut-down. In the absence of a source of refinery wastewater, a living culture of activated sludge comprising aerobic prokaryotes and/or eukaryotes that nitrify ammonia is maintained by redirecting at least a portion of clarified wastewater leaving the clarifier portion of an activated sludge unit. The redirected clarified wastewater is mixed with an organic food source that may be ammonia and/or ethyl acetate, a source of phosphate ion, and the pH is adjusted to produce a growth media that is returned to the aeration chamber of the activated sludge unit. After a time exceeding one week, the input of refinery wastewater to the aeration chamber is resumed while discontinuing the redirecting of the clarified wastewater.
    Type: Grant
    Filed: February 22, 2017
    Date of Patent: July 2, 2019
    Assignee: Phillips 66 Company
    Inventors: Gennaro Dicataldo, Joshua D. Crow, Shana L. Bender
  • Patent number: 10323228
    Abstract: Disclosed are methods of differentiating stem cells in order to obtain hepatocyte-like cells, the method comprising the steps of a) subjecting definitive endoderm to at least one epigenetic modulator to obtain hepatoblasts and b) subjecting the hepatoblasts to at least one stem cell differentiation pathway inhibitor to obtain hepatocyte-like cells; wherein steps a) and b) do not comprise the use of a growth factor. In one preferred embodiment, the epigenetic modulator may be sodium butyrate and/or DMSO and the stem cell differentiation pathway inhibitor may be SB431542 and/or DMSO. Also disclosed are hepatocyte-like cells obtained from the method and uses of these cells such as drug screening.
    Type: Grant
    Filed: September 17, 2015
    Date of Patent: June 18, 2019
    Assignee: Agency for Science, Technology and Research
    Inventors: Hanry Yu, Derek Phan, Yi-chin Toh, Farah Tasnim
  • Patent number: 10323266
    Abstract: Provided is a antimicrobial susceptibility testing device, including: an ATP examination culture plate that includes a reaction vessel, a reagent holding parts for holding reagents to be supplied to the reaction vessel, and a culture solution holding part for holding a culture solution to be supplied to the reaction vessel, and has plural layers that can be joined and separated; a gas feeding path for feeding a gas into the ATP examination culture plate; a heater; an optical detection unit; and a determination unit for determining sensitivity of a bacterial strain contained in the culture solution to a drug based on a detection result of the optical detection unit, wherein when the plural layers of the ATP examination culture plate are joined, at least the culture solution holding part and the reaction vessel are in a sealed state while communicating with each other.
    Type: Grant
    Filed: March 17, 2015
    Date of Patent: June 18, 2019
    Assignee: HITACHI, LTD.
    Inventors: Hideyuki Noda, Hiroko Tada, Chihiro Uematsu, Masahiro Okanojo
  • Patent number: 10300090
    Abstract: The present disclosure provides distinct therapeutic populations of cells that form a pharmaceutical composition useful in hematopoietic stem/progenitor cell transplant. For example, the present disclosure provides a therapeutic population of cells, comprising an enriched population of hematopoietic stem/progenitor cells, memory T cells, regulatory T cells, and wherein the population of cells is depleted of naïve conventional ??-T cells. The present disclosure further provides methods of treatment using the therapeutic population of cells. In other embodiments, the present disclosure provides methods of producing a therapeutic population of cells.
    Type: Grant
    Filed: March 15, 2018
    Date of Patent: May 28, 2019
    Assignee: Orca Biosystems, Inc.
    Inventors: Ivan K. Dimov, Nathaniel Fernhoff, Kevin Sheehan
  • Patent number: 10300043
    Abstract: This document provides materials and methods related to bacterial compositions containing at least one bacterial organism having tryptophan decarboxylase activity. For example, bacterial compositions containing at least one bacterial organism having tryptophan decarboxylase activity and methods for using such bacterial compositions to improve gastrointestinal epithelial function and/or to treat gastrointestinal disorders are provided.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: May 28, 2019
    Assignees: Mayo Foundation for Medical Education and Research, The Regents of the University of California
    Inventors: Purna C. Kashyap, Michael Fischbach