Patents Examined by Deborah K. Ware
  • Patent number: 10202328
    Abstract: A process for extraction of ferulic acid present in an aqueous phase, obtained by treatment of at least one plant material, and also containing polysaccharides, is described, said process comprising at least the following steps: 1) the treatment of said plant material followed by a solid/liquid separation to recover a solid phase and an aqueous liquid phase comprising the ferulic acid and said polysaccharides, 2) the treatment of said liquid phase to selectively separate, on the one hand, the polysaccharides and, on the other hand, the ferulic acid present in an aqueous fraction, 3) the concentration of said aqueous fraction containing the ferulic acid so as to recover a ferulic acid-concentrated stream, 4) the recovery of the ferulic acid in solid form.
    Type: Grant
    Filed: May 19, 2014
    Date of Patent: February 12, 2019
    Assignee: Rhodia Operations
    Inventors: Denis Revelant, Stephanie Foucher, Dominique Horbez, Philippe Marion
  • Patent number: 10195171
    Abstract: Processes for producing a nutritional supplement that contains sulforaphane, and supplements formed thereby. Such a process includes combining a cruciferous vegetable, for example, broccoli sprouts, with strains of Lactobacillus, Streptococcus and Bifidobacterium to form a mixture, causing the mixture to undergo lactic acid fermentation, transform a glucosinolate within the cruciferous vegetable to sulforaphane, and yield a fermented mixture that contains sulforaphane, and then producing from the fermented mixture a supplement that can be ingested by an individual.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: February 5, 2019
    Assignee: CLOJJIC LLC
    Inventor: Anne-Marie Kosi-Kupe
  • Patent number: 10190142
    Abstract: Provided is a method of preparing a high-purity galactooligosaccharide composition by fermentation of a low-purity galactooligosaccharide mixture with a yeast strain, Kluyveromyces lactis ATCC 8585. The high-purity galactooligosaccharide composition includes at least 99% of galactooligosaccharides selected from the group consisting of galactotriose, galactotetrose, galactooligosaccharides with five or more sugar units, and combinations thereof and lower than 1% of monosaccharides and disaccharides. Also provided is a high-purity galactooligosaccharide composition and applications thereof in regulating blood glucose level and improving gut microbiota. For example, the high-purity galactooligosaccharide composition may be used to manufacture food products, beverages, health food products, nutritional supplements, and pharmaceutical compositions for patients or pets afflicted with diabetes mellitus or lactose intolerance.
    Type: Grant
    Filed: January 5, 2017
    Date of Patent: January 29, 2019
    Inventors: Chang-Lung Tsai, Ping-Ju Tsai
  • Patent number: 10179355
    Abstract: A method for treating contaminated water or other contaminated media has been developed. Bioremediation enhancing agents (BEAs) such as yeast metabolites (YM) and other yeast derived products are used to facilitate microbial treatment of the contaminated material. Polysaccharides are also an effective BEA when used alone or in combination with the yeast derived products. The BEAs may work with microbes and electron donors to improve the rate of contaminant degradation and to increase the efficiency of electron donor utilization. A number of novel electron donors are also disclosed.
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: January 15, 2019
    Inventors: Donovan N. Smith, Michael R. Sieczkowski, Wayne H. Wilke
  • Patent number: 10179926
    Abstract: Devices, methods, and kits for easy, accurate, and fast estimation of soil microbial load are provided. The devices include membranes that are rapidly wettable with aqueous fluids and retain soil microorganisms of up to 200 micrometers in size, without retaining soil pigments. The method requires reconstituting a soil sample in an extraction fluid so that the microorganisms in the soil sample are released from particles of the soil sample and into the extraction fluid. The method does not require a filtration step. The extraction fluid containing the microorganisms suspended therein is then pipetted onto the membrane device, or the membrane is dipped into the extraction fluid. The color appearing on the membrane is then compared to color intensity gray scale strips to determine the soil microbial load.
    Type: Grant
    Filed: August 2, 2016
    Date of Patent: January 15, 2019
    Assignee: Prolific Earth Sciences Corporation
    Inventor: Judith Fitzpatrick
  • Patent number: 10175255
    Abstract: An assay that informs precision-based intrapleural fibrinolytic therapy (IPFT) is disclosed. Provided is a simple assay based on measurement of the Fibrinolytic Potential (FP)—total fibrinolytic activity in pleural fluid when plasminogen activator inhibitors (PAIs) are neutralized and endogenous plasminogen (PLG) is activated. The assay is used to determine FP in baseline pleural fluids of patients undergoing IPFT with agents such as tPA or scuPA to determine the dose and dose intervals for the particular patient. Pleural fluids are also collected after IPFT to confirm that intrapleural fibrinolysis is inhibited and endogenous PLG accumulates in the pleural fluid. Inhibition of intrapleural fibrinolysis in combination with its increase after supplementation of pleural fluid with a plasminogen activator indicates whether or not the subject should be treated with more or higher doses of an IPFT drug.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: January 8, 2019
    Assignee: Board of Regents, The University of Texas System
    Inventors: Andrey A. Komissarov, Galina Florova, Steven Idell
  • Patent number: 10175231
    Abstract: A chromogenic absorbent material for an animal litter includes an oxidizing agent responsive to peroxidatic/pseudoperoxidatic activity in an animal excretion or a first catalytic compound generating the oxidizing agent in situ. The material also includes a chromogenic indicator being chromogenically responsive to the oxidizing activity of the oxidizing agent, and an absorptive material which is porous, for absorbing the animal excretion. The absorptive material includes a water-absorbing polysaccharide providing absorptive properties to the chromogenic absorbent material; and may also include a second polysaccharide and a superabsorbent polymer. The material may be obtained in the form of particles having a low density and a high porosity, and is usable in conjunction with an animal litter for detecting various diseases in animals.
    Type: Grant
    Filed: February 27, 2014
    Date of Patent: January 8, 2019
    Assignee: 7905122 Canada Inc.
    Inventor: Paul Jollez
  • Patent number: 10174357
    Abstract: A method for quantifying cardiolipin in a sample, comprises the steps of: (1) treating the sample with phospholipase D, glycerol kinase, glycerol-3-phosphate oxidase, and peroxidase and (2) measuring the fluorescence intensity, absorbance, or luminescence intensity of a compound generated in step (1) to quantify cardiolipin using a calibration curve obtained beforehand; and a kit for quantifying cardiolipin comprises phospholipase D, glycerol kinase, glycerol-3-phosphate oxidase, and peroxidase.
    Type: Grant
    Filed: March 17, 2015
    Date of Patent: January 8, 2019
    Inventor: Shin-ya Morita
  • Patent number: 10167465
    Abstract: The present invention provides methods of differentiating mesenchymal stem cells or adult stem cells into nerve cells by treating the mesenchymal stem cells or the adult stem cells with an electromagnetic field having a high intensity of 100 to 1,500 mT and a low frequency of 0.01 to 100 Hz. These methods also provide injecting the mesenchymal stem cells or adult stem cells into a subject prior to treating the mesenchymal stem cells or adult stem cells with an electromagnetic field having a high intensity of 100 to 1,500 mT and a low frequency of 0.01 to 100 Hz.
    Type: Grant
    Filed: April 2, 2015
    Date of Patent: January 1, 2019
    Inventors: Young Kwon Seo, Jung Keug Park, Hee Hun Yoon, Hyun Jin Cho, Hee Jung Park, Yu Mi Kim, Bo-Young Yoo, Sang Eun Cho, Sang Heon Kim
  • Patent number: 10166314
    Abstract: The present disclosure relates to a corneal implant comprising a matrix material and a core part wherein the core part is arranged essentially in the middle of the matrix material. The core part is anti fouling in order to stop cell proliferation across said part. The present disclosure further relates to a method of preparing the said product and the use of the same.
    Type: Grant
    Filed: October 14, 2014
    Date of Patent: January 1, 2019
    Assignee: UAB Ferentis
    Inventors: Jaywant Phopase, May Griffith, Mohammad Mirazul Islam, Ramunas Valiokas, Ranjithkumar Ravichandran, Vytautas Cepla, Zivile Ruzele, Tomas Rakickas
  • Patent number: 10167446
    Abstract: A method for cultivating antrodia cinnamomea includes transplanting bacterial strains of antrodia cinnamomea into a petri dish receiving culture ingredients. The bacterial strains of antrodia cinnamomea are transferred into a culture container after mycelia of the bacterial strains of antrodia cinnamomea have grown to a predetermined area. The culture container receives a culture fluid. A formula composition of a culture medium for cultivating antrodia cinnamomea is added into the culture container after the mycelia of the bacterial strains of antrodia cinnamomea have grown in the culture container. The formula composition of the culture medium for cultivating antrodia cinnamomea includes growth basal ingredients and cultivating basal ingredients. The growth basal ingredients includes hydroxyhopanone.
    Type: Grant
    Filed: June 1, 2015
    Date of Patent: January 1, 2019
    Inventor: Min-Shih Chen
  • Patent number: 10154679
    Abstract: Disclosed are processes for contacting a protein containing material with one or more wet-mill streams. The protein content of the protein containing material is increased.
    Type: Grant
    Filed: January 9, 2015
    Date of Patent: December 18, 2018
    Inventors: Johannis Cornelis Slabbekoorn, Johan Willy Gabriel De Meester, Jacobus Stephanus Vercouteren, Cornelis Johannes Maria Schot, Annemiek F. S. Van Cauteren, Rita Delrue, Eugene J. Fox, Donald Lee Shandera, Jr., Charles P. Anderson, Eric Bell
  • Patent number: 10151721
    Abstract: A whole blood measurement method associated to hematocrit (HCT) and a whole blood measurement circuit thereof is applied in the detection of HCT of a whole blood sample to be tested. Herein, a time to digital converting circuit (TDC) is used for counting charging time or discharging time of a fixed capacitor and a to-be-tested sample, and a capacitance difference that is related to HCT is generated according to the charging time or the discharging time, so as to provide a reference for a whole blood feature test.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: December 11, 2018
    Inventors: Kuo-Hsiang Chen, Kuo-Yang Li, Hung-Yu Liu
  • Patent number: 10113213
    Abstract: The present disclosure describes a process for using saline water, and saline reject water produced in water purification, to use for gold mining production, and growing and harvesting algae. The disclosure also describes a method for growing and harvesting algae utilizing saline water as growth medium for recycling waste water to extract the remaining metals out of waste water. The harvested algae may be used in various applications including but not limited to water purification for gold mining production and to extract metals out of remaining waste water.
    Type: Grant
    Filed: September 13, 2016
    Date of Patent: October 30, 2018
    Assignees: University of Bisha, Prince Sattam Bin Abdulaziz University
    Inventors: Khaled A. Abuhasel, Saleh Ali Alkahtani
  • Patent number: 10100276
    Abstract: The invention relates to a method for cell defrosting, comprising a step of defrosting a cell suspension consisting of a freezing medium and of cells, followed by a step of removing said freezing medium by filtration, said step of removing the freezing medium being carried out without the previous or simultaneous supply of medium. In particular, the filter is hydrophobic or, before addition of the cell suspension to be frozen, has been covered with a hydrophobic liquid forming a temporary barrier between the filter and the cell suspension. During defrosting, said hydrophobic liquid is removed by the application of a driving force which makes the liquid pass through the filter.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: October 16, 2018
    Assignee: GENBIOTECH
    Inventors: Dominique Vacher, Jean-Noël Gouze, Yannis Guillemin
  • Patent number: 10087475
    Abstract: The disclosure relates to a process for the preparation of a sugar product from lignocellulosic material, comprising the following steps: a) optionally, pretreatment of the lignocellulosic material; b) optionally, washing of the optionally pretreated lignocellulosic material; c) enzymatic hydrolysis of the optionally washed and/or optionally pretreated lignocellulosic material in a hydrolysis reactor using an enzyme composition comprising at least two cellulase; and d) optionally, recovery of a sugar product; wherein during the enzymatic hydrolysis oxygen-containing gas is added to the lignocellulosic material in the hydrolysis reactor and wherein part of the oxygen-containing gas, added to the lignocellulosic material, is gas originating from the headspace of the reactor, preferably during part of the time of the enzymatic hydrolysis less oxygen is added to the lignocellulosic material compared to the other part of the time of the enzymatic hydrolysis, or preferably during part of the time of the enzymatic
    Type: Grant
    Filed: January 29, 2015
    Date of Patent: October 2, 2018
    Assignee: DSM IP ASSETS B.V.
    Inventors: Bertus Noordam, Michael Petrus Jozef Berkhout, Joseph Johannes Maria Hofmeester
  • Patent number: 10087476
    Abstract: A process for hydrolyzing a pretreated lignocellulosic feedstock is disclosed herein. The process comprises hydrolyzing the pretreated lignocellulosic feedstock with an enzyme mixture comprising at least cellulase enzymes to produce a hydrolyzed slurry comprising glucose and lignin solids. The hydrolyzing is conducted in the presence of a polymer, such as an aliphatic polyether. A solids-liquid separation is conducted to recover lignin solids from a process stream comprising the lignin solids and the polymer. A process stream is then obtained comprising recovered lignin solids resulting from the solids-liquid separation. Also provided are processes for recovering the polymer from the lignin solids and/or from solution.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: October 2, 2018
    Inventors: Brian E. Foody, Kristin Martens, Patrick J. Foody, Jeffrey S. Tolan
  • Patent number: 10066254
    Abstract: Disclosed are methods of diagnosing constipation and constipation-predominant irritable bowel syndrome by screening for the presence of abnormally high levels of methane and/or methanogenic organisms in a subject.
    Type: Grant
    Filed: March 18, 2008
    Date of Patent: September 4, 2018
    Assignee: Cedars-Sinai Medical Center
    Inventors: Mark Pimentel, Henry C. Lin
  • Patent number: 10066200
    Abstract: Compositions and methods are described for preparing media, feeds, and supplements. Such methods and medias may display increased stability of labile components and may use, for example, microsuspension and/or encapsulation technologies, chelation, and optionally, coating and/or mixing the labile compounds with anti-oxidants. The compositions may withstand thermal and/or irradiation treatment and have reduced virus number. These techniques may result in product with extended shelf-life, extended release of their internal components into culture, or in product that can be added aseptically into a bioreactor using minimal volumes. The compositions and methods may optimize the bioproduction workflow and increase efficiency.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: September 4, 2018
    Assignee: Life Technologies Corporation
    Inventors: Richard Fike, Shawn Barrett, Zhou Jiang, David Judd
  • Patent number: 10066247
    Abstract: The invention relates to a process for producing a fuel, in particular a liquid fuel, or another organic product, from a carbon-based matter feedstock, comprising the following steps: a/ gasification of the carbon-based matter feedstock in a first reactor, termed gasifier (1), b/ downstream of the gasification, fermentation of the synthesis gas produced according to step a/, by means of microorganisms, water and nutrients in a second reactor, termed fermenter (2), c/ recovery, downstream of the fermenter, of the microorganisms and of the water, d/ injection of at least a part of the recovered microorganisms and, where appropriate, of at least a part of the recovered water at the inlet (10) of the gasifier.
    Type: Grant
    Filed: October 22, 2014
    Date of Patent: September 4, 2018
    Assignee: Commissariat A L'Energie Atomique Et Aux Energies Alternatives
    Inventors: Pierre-Alexandre Setier, Florian Delrue