Abstract: According to various embodiments of this disclosure, pharmaceutical compositions comprising solubilized estradiol are provided. In various embodiments, such compositions are encapsulated in soft capsules which may be vaginally inserted for the treatment of vulvovaginal atrophy.

Abstract: The present invention relates to a composition, notably cosmetic, nutraceutical, dermatological, pharmaceutical or dietary, including at least one unsaponifiable extract, a drug including one such composition, the use of one such composition, a treatment method consisting in administering one such composition and a method comprising the administration of one such composition.

Abstract: The present invention relates to a pharmaceutical composition comprising an insulin compound in a concentration that is sufficient to maintain a therapeutically effective level of the insulin compound in blood plasma for at least 3 days characterized by having a pharmacokinetic profile in vivo with substantially no burst of the insulin compound. The present invention further relates to the use of an insulin compound for preparing said pharmaceutical composition as well as a kit of parts comprising said pharmaceutical composition.

Abstract: Methods for identifying defects in blood vessels and treating such defects are provided. The methods comprise administering to a patient a composition comprising a labeled delivery ligand capable of preferentially accumulating at or near blood vessels defects. In some embodiments, the delivery ligand may carry one or more active agents to the defect.

Abstract: Provided is a highly palatable and safe glucosyltransferase inhibitor or anti-dental caries agent. A glucosyltransferase inhibitor or anti-dental caries agent having an epigallocatechin gallate polymer or a salt thereof. Particularly, the above agent containing an epigallocatechin gallate polymer, which is a compound in which chroman rings are bonded at position 6 and/or 8 via a methylene group.

Abstract: A transdermal patch for the treatment of Alzheimer's disease includes: a backing, a rivastigmine-containing layer, a pressure-sensitive adhesive layer, and a release liner. In the transdermal patch, the rivastigmine-containing layer contains rivastigmine and an alkyl(meth)acrylate resin, the pressure-sensitive adhesive layer is composed of an acrylic pressure-sensitive adhesive containing a (meth)acrylic acid ester having a hydroxyl group, and neither the rivastigmine-containing layer nor the pressure-sensitive adhesive layer contains an anti-oxidizing agent.

Abstract: The present invention relates to methods for preparing porous natural or synthetic material scaffolds with keratin for improving cell affinity.

Abstract: The present invention relates to a method of the dietary management of depression, which method comprises a step of administering to a subject in need thereof a water containing from 0.0002 to 0.0278 molecular % of isotopologue HOD.

Abstract: A method and compositions for treating a patient that prevent or reduce drug abuse and overdose events.

Abstract: This invention provides compounds, compositions and methods for treating Autism Spectrum Disorders (ASD) using glycyl-2-methylprolyl-glutamic acid (G-2-MePE) and analogs thereof. Autism Spectrum Disorders include Autism, Autistic Disorder, Asperger Syndrome, Childhood Disintegrative Disorder, Pervasive Developmental Disorder—Not Otherwise Specified (PDD-NOS), Fragile X Syndrome, and Rett Syndrome. Compositions containing compounds include water-soluble formulations, water-in-oil micro-emulsions, water-in-oil coarse emulsions, water-in-oil liquid crystals, nanocapsules, tablets, and orally administered gels. The compounds and compositions of this invention can be administered intravenously, intraventricularly, parenterally, or orally, and can be effective in treating neurodegeneration, promoting neurological function, treating seizure activity and other symptoms of ASD, and can prolong life in animals including human beings having Autism Spectrum Disorders.

Abstract: A capsule of compound danshen dripping pills are disclosed. The color of the capsule's shell is orange, yellow, green or blue and all of these colors are in the wavelength range of 446-620 nm.

Abstract: Composite spherical polymer particles contain a nanoparticulate pigment having an average primary particle size of from 0.1 to 0.005 ?m, a high molecular dispersant having adsorptive property to the nanoparticulate pigment, and a (meth)acrylic resin. The nanoparticulate pigment is enclosed in a dispersed state in the high molecular dispersant and (meth)acrylic resin. The content of the nanoparticulate pigment ranges from 5 to 70 wt % based on the composite spherical polymer particles. The composite spherical polymer particles have an average particle size of from 1 to 20 ?m. A production process of the composite spherical polymer particles and cosmetics containing the composite spherical polymer particles are also disclosed.

Abstract: A cosmetic method for releasing an active principle in a controlled fashion to uninjured skin, as a function of the ion content in or on skin, by exchange with the ions, in order to provide at least one cosmetic benefit to the skin, the method includes applying onto skin a composition containing, in a cosmetically acceptable medium, at least one resinate including one organic ion-exchange resin and at least one ionizable cosmetic active principle bonded in noncovalent fashion to the resin.

Abstract: The embodiments and examples provided herein are put forth so as to provide those of ordinary skill in the art with a complete disclosure and description of how to make and use the present invention, and are not intended to limit the present invention relates to compositions and methods of preparing a hydrogel comprising a water soluble cellulose compound, as well as preparing a three-dimensional matrix of micron sized electrospun fibers, wherein the electrospun fibers are formed from a electrospun composite comprising a water soluble cellulose compound. The matrix provides a scaffold supporting and promoting cartilage regeneration and repair.

Abstract: Oral compositions containing a combination of antioxidants consisting of a water soluble vitamin, a water insoluble vitamin, a tea extract and gallic acid are used to maintain a beneficial amount of such antioxidants in a consumers bloodstream for maintenance and protection of healthy skin. The unique combination of ingredients provides a decrease in oxidative stress when exposed to UVB radiation, thereby promoting healthy skin.

Abstract: The present invention relates to a green tea formulation stabilized by natural antioxidants such as OPC together with vitamin C or vitamin C analogs. The invention also relates to the use of a mixture of OPC and ascorbic acid to increase bioavailability of green tea catechins. It also relates to a food, pharmaceutical or cosmetic composition that contains the stabilized green tea formulation.

Abstract: The present invention relates to hydrogel or scaffold compositions and methods of use for cell growth and/or regenerative medicine. The hydrogel comprises a water soluble cellulose compound and, in certain aspects, a fibrous or filamentous matrix. The hydrogels as described provide a support or scaffold that promotes, facilitates, and/or enhances progenitor or stem cell growth and/or differentiation. In addition, the hydrogel is useful for tissue, e.g., cartilage, regeneration and repair.

Abstract: A high efficiency, environmentally friendly bioorganic product for treating agricultural and ornamental plants combining fertilizing, stimulating and protective property is proposed, in the first variant intended for pre-sowing seed treatment (tubers, bulbs); in the second variant for foliar application on cereals, vegetables, ornamental crops and potatoes. Each of the variants of the proposed bioproduct contains microbiologically fermented organic agricultural waste, for example, cow or poultry manure, with microelements including copper, cobalt and zinc and macroelements: nitrogen, phosphorous and potassium in bound form available to plants, wherein the biological and organic constituents are combined. The product contains substances that have fungicidal and bactericidal properties, i.e., sulfur and benzoic acid, and phytohormones: auxins, gibberellics and cytokinines in different combinations for each of the variants of the product.

Abstract: The invention relates to a respiratory preparation providing cough relief in a human comprising: a film forming agent; a thickening agent; and the respiratory preparation provides on demand relief. Additionally, the invention relates to a method of providing cough relief in a human comprising: the steps of administering to a human a respiratory preparation comprising: a film forming agent; a thickening agent; and wherein said respiratory preparation provides on demand cough relief as needed.

Abstract: Compositions are disclosed comprising novel fluorinated cationic alcohols in a cosmetically acceptable vehicle. The fluorinated compounds alter a surface property of the hair to provide hair conditioning, for example. In embodiments, the compounds have improved water solubility and deposition properties.