Abstract: The invention relates to adhesive articles containing at least one colorant and/or at least one active agent as well as to methods of using such articles on mucosis or keratin materials to achieve a desired result or benefit and to methods of making such adhesive articles.
Abstract: The present invention relates to a macroporous, resorbable and injectable apatitic calcium-phosphate cement with a high compressive strength useful as bone cement and releasing a bone resorption inhibitor, preparation method and uses thereof.
Type:
Grant
Filed:
November 14, 2014
Date of Patent:
March 13, 2018
Assignees:
GRAFTYS, UNIVERSITE DE NANTES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)
Inventors:
Jean-Michel Bouler, Bruno Bujoli, Pascal Janvier, Ibrahim Khairoun, Jean-Noël Argenson
Abstract: Provided is a cosmetic preparation superior in stability and feel. The cosmetic preparation contains an (a) organopolysiloxane emulsion in an amount of not smaller than 0.1% by mass. This organopolysiloxane emulsion is obtained through emulsion polymerization and contains octamethylcyclotetrasiloxane in an amount of not larger than 1,000 ppm by mass.
Abstract: A tissue adhesive including cyanoacrylate and polyethylene glycol (PEG), wherein the PEG remains a polyether and wherein the tissue adhesive is bioabsorbable. A tissue adhesive including cyanoacrylate bulk monomer and cyanoacrylate nanoparticles containing a therapeutic therein. A kit for applying tissue adhesive, including the tissue adhesive described above and an applicator. Methods of accelerating degradation of a cyanoacrylate tissue adhesive applying a tissue adhesive, closing an internal wound, administering a therapeutic to tissue, treating cancer, and preventing infection in a wound. Methods of method of making a bioabsorbable tissue adhesive and making a therapeutic tissue adhesive.
Type:
Grant
Filed:
November 8, 2013
Date of Patent:
January 30, 2018
Assignee:
Adhezion Biomedical, LLC
Inventors:
Jeoung Soo Lee, Charles Kenneth Webb, Robert Zimmerman, Rafael Ruiz, Sr., Sheng Zhang
Abstract: The present disclosure relates to a hydrogel composition and methods of using the same. The hydrogel composition may include precursors that react with each other upon contact as well as precursors that react upon contact with an initiator. In embodiments, the resulting hydrogels may have varying levels of crosslinking with both denser and less dense regions.
Type:
Grant
Filed:
December 7, 2015
Date of Patent:
January 23, 2018
Assignee:
Covidien LP
Inventors:
Steven Bennett, Nathaniel Mast, Kevin Lavigne, Walter Skalla
Abstract: Implants for tissue repair/regeneration include a porous layer combined with dry materials that are activated to form a hydrogel upon contact with aqueous physiological fluids.
Abstract: An antibacterial composition comprising thymol and totarol. This combination provides synergistic effect against gram negative and gram positive bacteria.
Type:
Grant
Filed:
December 15, 2011
Date of Patent:
December 5, 2017
Assignee:
COLGATE-PALMOLIVE COMPANY
Inventors:
Regina Hourigan, Rehana Gafur, Jairajh Mattai, James Masters, Laurence Du-Thumm, Shira Pilch
Abstract: Disclosed herein are polar lipid mixtures, comprising glycerophospholipids such as phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS) and phosphatidyl-inositol (PI), and sphingolipids such as sphyngomyelin (SM). Most importantly, the ratio of phospholipids in said mixture is comparable to that of HMF, and is represented by SM>PC>PE>PS>PI or SM=PC>PE>PS>PI. Processes for the preparation of said mixtures and uses thereof are also described herein.
Type:
Grant
Filed:
August 8, 2011
Date of Patent:
November 14, 2017
Assignee:
ENZYMOTEC LTD.
Inventors:
Avidor Shulman, Rassan Zuabi, Gai Ben Dror, Yoni Twito, Dori Pelled, Yael Herzog
Abstract: A combination of N-acetyl-L-cysteine, selenium in the form of selenomethionine and melatonin, and a medical product or pharmaceutical composition comprising such combination, useful for the treatment of a variety of diseases and conditions is described. The combination of N-acetyl-L-cysteine, selenium in the form of selenomethionine and melatonin is also useful for cosmetic treatment of skin and as an antibacterial agent.
Abstract: Methods for efficient preparation of drug-polymer (or oligomer) conjugates useful in the preparation of particles, including microparticles and nanoparticles, for delivery of the drug in vivo for therapeutic applications are provided. The invention also provides nanoparticles prepared by nanoprecipitation using drug-polymer/oligomer conjugates of the invention. The drug conjugates are formed during polymerization of the polymer or oligomer in which the drug is employed as an initiator of the polymerization of the monomers which form the polymer and/or oligomer. More specifically, the drug conjugates are formed by ring-opening polymerization of cyclic monomers in the presence of an appropriate ring-opening polymerization catalyst and the initiator (the drug). The method is particularly useful for formation of polymer/oligomer conjugates with drugs and other chemical species containing one or more hydroxyl groups or thiol groups.
Type:
Grant
Filed:
October 31, 2014
Date of Patent:
October 17, 2017
Assignee:
The Board of Trustees of the University of Illinois
Abstract: The present disclosure relates to a carrier for oromucosal, especially sublingual administration of physiologically active substances, especially of medicinal drugs, which consists of at least one elastic layer (1) of polymer nanofibers workable according to the shape of the selected wall of mouth cavity to which it should be applied and in this elastic layer (1) of polymer nanofibers a drug and/or other physiologically active substance are deposited in a releasable manner.
Type:
Grant
Filed:
December 12, 2011
Date of Patent:
October 17, 2017
Assignee:
INSTAR TECHNOLOGIES A.S.
Inventors:
Denisa Stranska, Adela Klabanova, Pavel Dolezal, Petr Vrbata, Pavel Berka, Marie Musilova
Abstract: The invention relates to a wound dressing which is particularly suitable for therapeutically dressing wounds. Said wound dressing consists of a multi-layered structure comprising at least one layer containing at least one hydrocolloid, preferably collagen, (“hydrocolloid layer” or “collagen layer”) and at least one layer containing an activated carbon (“activated carbon layer”).
Type:
Grant
Filed:
August 31, 2012
Date of Patent:
October 10, 2017
Assignee:
Blücher GmbH
Inventors:
Hasso von Blücher, Raik Schönfeld, Frank Pallaske
Abstract: Medical devices and methods including polymers having biologically active agents therein are disclosed. The medical devices can be useful as implantable devices such as orthopedic implants.
Type:
Grant
Filed:
September 19, 2008
Date of Patent:
October 3, 2017
Assignee:
Medtronic, Inc.
Inventors:
Phillip Edward McDonald, Christopher M. Hobot
Abstract: A diagnostic formulation is provided comprising a tropane having a radioactive concentration of at least 1.6 mCi/mL at least about 51 hours post creation. The diagnostic formulation optionally comprises a radiolabeled dopamine transporter (DAT) ligand useful in the diagnosis of Parkinson's disease (PS). One example of a radiolabeled dopamine transporter (DAT) ligand example is [123I]-2?-carbomethoxy-3?-(4-flurophenyl)-N-(3-iodo-E-allyl) nortropane.
Type:
Grant
Filed:
October 17, 2014
Date of Patent:
September 12, 2017
Assignee:
Alseres Pharmaceuticals, Inc.
Inventors:
Chris Sterzinger, Cara Ferreira, David Leyh, Richard Thorn
Abstract: The present invention relates to a haemostatic material comprising a carrier layer and a material for wound contact comprising at least one haemostat in particulate, granular, powder, flake or short fibrous form. Such a haemostatic material is useful, for example, in reducing or stopping bleeding of a physiological target site in a person or animal, and can also be used to stem bleeding during medical procedures.
Abstract: The present invention provides methods for treating inflammation or a wound in a subject in need of such wound treatment or inflammation treatment by delivering a volatile anesthetic to the wound or the inflammation site.
Type:
Grant
Filed:
May 5, 2010
Date of Patent:
August 29, 2017
Assignee:
Board of Regents, The University of Texas Systems
Abstract: The present invention is directed to a dual phase mouth wash composition comprising a hydrophilic phase, a hydrophobic phase, and a hydrotrope, and methods of use thereof. The hydrophilic and hydrophobic phases remain separated and form a temporary emulsion when mixed. The emulsion spontaneously reverts back to the two original phases after rest, without the formation of a emulsion.
Abstract: This invention provides compounds, compositions and methods for treating Autism Spectrum Disorders (ASD) using glycyl-2-methylprolyl-glutamic acid (G-2-MePE) and analogs thereof. Autism Spectrum Disorders include Autism, Autistic Disorder Asperger Syndrome, Childhood Disintegrative Disorder, Pervasive Developmental Disorder—Not Otherwise Specified (PDD-NOS), Fragile X Syndrome, and Rett Syndrome. Compositions containing compounds include water-soluble formulations, water-in-oil micro-emulsions, water-in-oil coarse emulsions, water-in-oil liquid crystals, nanocapsules, tablets, and orally administered gels. The compounds and compositions of this invention can be administered intravenously, intraventricularly, parenterally, or orally, and can be effective in treating neurodegeneration, promoting neurological function, treating seizure activity and other symptoms of ASD, and can prolong life in animals including human beings having Autism Spectrum Disorders.
Type:
Grant
Filed:
January 27, 2012
Date of Patent:
July 18, 2017
Assignee:
NEUREN PHARMACEUTICALS LTD.
Inventors:
Larry Glass, Michael John Bickerdike, Michael Frederick Snape
Abstract: Biocompatible adhesive materials, such as for use with biological tissues and/or medical implants, are provided, as well as methods and kits for making and using the biocompatible adhesive materials. The biocompatible adhesive materials include a dendrimer component and a polymer component, and may be tailored for specific tissue types and conditions.
Type:
Grant
Filed:
July 30, 2014
Date of Patent:
July 18, 2017
Assignee:
Massachusetts Institute of Technology
Inventors:
Natalie Artzi, Elazer R. Edelman, Nuria Oliva Jorge, Maria Carcole Solanes