Patents Examined by Dolph H. Torrence
  • Patent number: 4716237
    Abstract: 3-oxonitriles are produced by reaction of carboxylic acid esters with carboxylic acid nitriles in the presence of 70 to 80% suspension of sodium hydride in white oil. The oxonitrile are intermediate products for the production of 3-oxocarboxylic acid amides or esters and pesticides.
    Type: Grant
    Filed: March 15, 1983
    Date of Patent: December 29, 1987
    Assignee: Degussa Aktiengesellschaft
    Inventors: Karlheinz Drauz, Axel Kleemann, Elisabeth Wolf-Heuss
  • Patent number: 4711905
    Abstract: A 2,4-dihalogenobenzoyl-(thio)urea of the formula ##STR1## in which X represents sulphur or oxygen,X.sup.1 and X.sup.2 are identical or different and represent fluorine, chlorine, bromine or iodine,R.sup.1 represents hydrogen, halogen or optionally substituted radicals from the series comprising alkyl, alkoxy and alkylthio,R.sup.2 represents hydrogen, halogen, cyano, nitro, or optionally substituted radicals from the series comprising alkyl, alkylthio, alkylsulphonyl, alkoxy, aryloxy, alkylcarbonyl, alkoxycarbonyl, alkoxycarbonylalkyl and alkoxycarbonylalkylthio, orR.sup.1 and R.sup.2 together represent an optionally substituted alkylenedioxy radical or --CF.sub.2 --O--CF.sub.2 --O--,R.sup.3 represents hydrogen, halogen or an optionally substituted alkyl, alkoxy or aryloxy radical, andR.sup.4 represents hydrogen, halogen, or optionally substituted radicals from the series comprising alkyl, alkylthio and alkoxy, with the exception of those cases in which X represents oxygen, X.sup.1 andX.sup.
    Type: Grant
    Filed: June 19, 1985
    Date of Patent: December 8, 1987
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wilhelm Sirrenberg, Erich Klauke, Ingeborg Hammann, Wilhelm Stendel
  • Patent number: 4710514
    Abstract: A compound of the formula: ##STR1## useful as a fungicidal agent against phytopathogenic fungi, particularly their strains resistant to benzimidazole, thiophanate and/or dicarboximide fungicides.
    Type: Grant
    Filed: April 26, 1983
    Date of Patent: December 1, 1987
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Junya Takahashi, Toshiro Kato, Katsuzo Kamoshita
  • Patent number: 4699993
    Abstract: Novel compounds having greatest interest as biologically-active materials for the treatment of diabetic complications in mammals, or intermediates for such materials, are perfluoroalkyl compounds corresponding to the formula: ##STR1## wherein R and R' are independently selected from chloro, fluoro, nitro, hydroxy, and alkyl and alkoxy substituents containing 1-6 carbons; Q is --CN, --COOL, --COX, or --CTN(R")CH.sub.2 COOL; L is hydrogen, alkali metal, or saturated hydrocarbyl; X is halo; T is oxygen or sulfur; R" is an alkyl group containing 1-6 carbons; m is 0 or 1; and n is an integer of at least one.
    Type: Grant
    Filed: December 12, 1985
    Date of Patent: October 13, 1987
    Assignee: Ethyl Corporation
    Inventor: Vernon O. Brandt
  • Patent number: 4699992
    Abstract: Novel 3-amino-2-benzoyl-acrylic acid derivatives of the formula ##STR1## in which R.sup.1 represents the nitrile group, an ester group --COOR.sup.4 or carboxamide group ##STR2## R.sup.4 denoting C.sub.1 -C.sub.6 -alkyl, and R.sup.5 and R.sup.6 representing hydrogen or C.sub.1 -C.sub.3 -alkyl or phenyl,R.sup.2 and R.sup.3, which can be identical or different, represent a C.sub.1 -C.sub.6 -alkyl radical and, furthermore, can form, together with the nitrogen atom to which they are bonded, a 5- or 6-membered heterocyclic ring which can additionally contain as ring member the atoms or groups --O--, --S--, --SO-- or --SO.sub.2 --,X represents halogen,X.sup.1 denotes hydrogen, methyl, nitro or halogen,X.sup.2 denotes halogen or methyl, andX.sup.3 denotes hydrogen or halogen,are prepared by reacting ##STR3## The products can be converted into known antibacterials.
    Type: Grant
    Filed: September 12, 1985
    Date of Patent: October 13, 1987
    Assignee: Bayer Aktiengesellschaft
    Inventor: Klaus Grohe
  • Patent number: 4698094
    Abstract: Phenylacetic esters, thioesters and amides of the formula ##STR1## wherein R is as defined in the disclosure, process for preparation thereof, herbicidal composition and method for destruction of undesirable weeds. The herbicides comprising the above compounds are capable of selectively controlling undesirable weeds among desirable crop plants.
    Type: Grant
    Filed: April 22, 1985
    Date of Patent: October 6, 1987
    Assignee: Asahi Kasei Kogyo Kabushiki Kaisha
    Inventors: Yoshiharu Hayashi, Hiroyuki Kouji
  • Patent number: 4697035
    Abstract: A simplified process for the preparation of basically substituted phenylacetonitriles, in particular of verapamil, is described. This process is carried out with fewer stages and higher yields than the known processes according to the state of the art.
    Type: Grant
    Filed: June 3, 1985
    Date of Patent: September 29, 1987
    Assignee: Ludwig Heumann & Co., GmbH
    Inventors: Lothar Kisielowski, Ingomar Grafe, Walter Liebenow, Kurt H. Ahrens
  • Patent number: 4692463
    Abstract: The present invention describes the finding of potent antiinflammatory properties in 2,3-didemethylcolchicine and its analogs.
    Type: Grant
    Filed: November 29, 1985
    Date of Patent: September 8, 1987
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventor: Arnold Brossi
  • Patent number: 4690917
    Abstract: Compounds of the formula: ##STR1## wherein R.sub.1, R.sub.3 and R.sub.4 each independently represents a hydrogen atom or a protecting group;R.sub.2 represents a halogen atom or a group of formula --NR.sub.a R.sub.b (where R.sub.a and R.sub.b, which may be the same or different, each represents a hydrogen atom or an alkyl group; or R.sub.a and R.sub.b may be linked to form, together with the nitrogen atom to which they are attached, a heterocyclic ring which optionally contains a further heteroatom);and their physiological equivalents as well as salts thereof with acids, exhibit antiviral activity against RNA viruses such as Influenza and/or are intermeidates for the preparation of antivirally active compounds.
    Type: Grant
    Filed: November 22, 1985
    Date of Patent: September 1, 1987
    Assignee: Glaxo Group Limited
    Inventors: David J. Knight, David I. C. Scopes, Richard Storer, Stuart Holman
  • Patent number: 4690946
    Abstract: Use of an N-phenylcarbamate of the formula: ##STR1## as a fungicidal agent against phytopathogenic fungi, particularly strains which are resistant to benzimidazole thiophanate fungicides and/or cyclic imide fungicides.
    Type: Grant
    Filed: October 14, 1983
    Date of Patent: September 1, 1987
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Junya Takahashi, Toshiro Kato, Katsuzo Kamoshita
  • Patent number: 4689432
    Abstract: The present invention discloses a group of calcium chelating compounds which have a descreased affinity for calcium following illumination. These new compounds contain a photolabile nitrobenzyl derivative coupled to a tetracarboxylate Ca.sup.2+ chelating parent compound having the octacoordinate chelating groups characteristic of EGTA or BAPTA. In a first form, the new compounds are comprised of a BAPTA-like chelator coupled to a single 2-nitrobenzyl derivative, which in turn is a photochemical precursor of a 2-nitrosobenzophenone. In a second form, the new compounds are comprised of a BAPTA-like chelator coupled to two 2-nitrobenzyl derivatives, themselves photochemical prcursors of the related 2-nitrosobenzophenones.The present invention also discloses a novel method for preparing 1-hydroxy- or 1-alkoxy-1-(2-nitroaryl)-1-aryl methanes. Methanes of this type are critical to the preparation of, or actually constitute, the photolabile Ca.sup.2+ chelating compounds disclosed and claimed herein.
    Type: Grant
    Filed: September 7, 1984
    Date of Patent: August 25, 1987
    Assignee: The Regents of the University of California
    Inventors: Roger Y. Tsien, Grzegorz Grynkiewicz, Akwasi Minta
  • Patent number: 4684744
    Abstract: Stilbene derivatives of the formula ##STR1## wherein X is chlorine or bromine, R.sub.1 is hydrogen, carboxyl, cyano, C.sub.1 -C.sub.6 -alkyl or a non-chromophorically esterified carboxyl group, and R.sub.2 and R.sub.3 independently of one another are each hydrogen, unsubstituted or non-chromophorically substituted C.sub.1 -C.sub.6 -alkyl or C.sub.3 -C.sub.4 -alkenyl, or a non-chromophoric substituent of the 2nd order.They are valuable intermediates for producing optical brighteners of the 4,4'-disubstituted stilbene series.
    Type: Grant
    Filed: March 21, 1985
    Date of Patent: August 4, 1987
    Assignee: Ciga-Geiby Corporation
    Inventors: Klaus Artz, Hans R. Meyer, Dieter Reinehr, Kurt Weber
  • Patent number: 4681970
    Abstract: The invention relates to compounds of the formula: ##STR1## which are useful cardiovascular agents.
    Type: Grant
    Filed: March 21, 1986
    Date of Patent: July 21, 1987
    Assignee: G. D. Searle & Co.
    Inventor: Chi-Dean Liang
  • Patent number: 4681621
    Abstract: Compounds of the formula ##STR1## wherein R is halogen, preferably chlorine or bromine; C.sub.1 -C.sub.4 alkoxy, preferably methoxy; nitro; cyano; --S(O).sub.n R' wherein n is the integer 0, 1 or 2, preferably 2 and R' is C.sub.1 -C.sub.4 alkyl, preferably methyl; or R is C.sub.1 -C.sub.4 alkyl or methyl and most preferably R is chlorine, bromine, methoxy, nitro, methyl or CF.sub.3 ; R.sup.1 is hydrogen or C.sub.1 -C.sub.4 alkyl; R.sup.2 is hydrogen, C.sub.1 -C.sub.4 alkyl or ##STR2## wherein R.sup.a is C.sub.1 -C.sub.4 alkyl; R.sup.1 and R.sup.2 together are alkylene having 3 to 6 carbon atoms; R.sup.3 is hydrogen or C.sub.1 -C.sub.4 alkyl; R.sup.4 is hydrogen or C.sub.1 -C.sub.4 alkyl; and R.sup.5 and R.sup.6 independently are (1) hydrogen; (2) halogen; (3) C.sub.1 -C.sub.4 alkyl; (4) C.sub.1 -C.sub.4 alkoxy; (5) OCF.sub.3 ; (6) cyano; (7) nitro; (8) C.sub.1 -C.sub.4 haloalkyl; (9) R.sup.b SO.sub.n -- wherein n is the integer 0, 1, or 2; and R.sup.b is (a) C.sub.1 -C.sub.4 alkyl; (b) C.sub.1 -C.sub.
    Type: Grant
    Filed: December 3, 1985
    Date of Patent: July 21, 1987
    Assignee: Stauffer Chemical Company
    Inventors: David L. Lee, William J. Michaely
  • Patent number: 4681969
    Abstract: A process is described by which the pair of isomers represented by (R)-.alpha.-cyano-4-fluoro-3-phenoxybenzyl (1R,cis)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylate and its enantiomer is converted by base catalyzed epimerization in solution into the insecticidally more useful isomer pair represented by (S)-.alpha.-cyano-4-fluoro-3-phenoxybenzyl (1R,cis)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylate and its enantiomer, which may then be caused to crystallize out from the solution.
    Type: Grant
    Filed: August 26, 1985
    Date of Patent: July 21, 1987
    Assignee: Imperial Chemical Industries PLC
    Inventors: John Williams, Michael J. Robson
  • Patent number: 4681951
    Abstract: There are disclosed bicyclo[3.3.0]octene derivatives having the following formula: ##STR1## wherein R.sup.1 is a straight, branched or cyclic alkyl group or alkenyl group each having 5 to 10 carbon atoms; andR.sup.2 and R.sup.3 are each separately a hydrogen atom or a protective group of a hydroxy group,and process for producing the same. These compounds and the process for producing them are available for producing a 9(0)-methano-.DELTA.6(9.alpha.)-PGI.sub.1.
    Type: Grant
    Filed: August 17, 1984
    Date of Patent: July 21, 1987
    Assignee: Sagami Chemical Research Center
    Inventors: Masakatsu Shibasaki, Toshiaki Mase, Mikiko Sodeoka, Yuji Ogawa
  • Patent number: 4681955
    Abstract: New compounds of the formula ##STR1## a process for their preparation and their use as intermediates for insecticides.
    Type: Grant
    Filed: August 6, 1985
    Date of Patent: July 21, 1987
    Assignee: Bayer Aktiengesellschaft
    Inventor: Albrecht Marhold
  • Patent number: 4676924
    Abstract: New compounds of the general formula: ##STR1## wherein the symbols X stand for carbon atom bonded with two hydrogen atoms /--CH.sub.2 -- group/ and the symbols Z stand for oxygen atom or the symbols X stand for oxygen atom and the symbols Z stand for carbon atom bonded with two hydrogen atoms /--CH.sub.2 -- group/, m is an integer of 1 to 2, R represents an alkyl /H.sub.2n+1 C.sub.n / or an 4-alkylphenyl /H.sub.2n+1 C.sub.n --C.sub.6 H.sub.4 / or an alkylbiphenyl /H.sub.2n+1 C.sub.n --C.sub.6 H.sub.4 --C.sub.6 H.sub.4 / or an alkylcyclohexylphenyl group /H.sub.2n+1 C.sub.n --C.sub.6 H.sub.10 --C.sub.6 H.sub.4 /, the term alkyl group signifies an alkyl chain containing 1 to 15 carbon atoms or it also signifies a branched-chain alkyl group C.sub.2 H.sub.5 --CH/CH.sub.3 /--/CH.sub.2 /.sub.k where k in an integer of 1 to 3, have utility as liquid crystals. A process for manufacture of compounds of the general formula I.
    Type: Grant
    Filed: June 28, 1985
    Date of Patent: June 30, 1987
    Assignee: Wojskowa Akademia Techniczna
    Inventors: Roman Dabrowski, Jerzy Dziaduszek, Jaroslaw Szulc, Zygfryd Witkiewicz, Zofia Stolarz, Krystyna Kenig, Gabriela Adamska
  • Patent number: 4677198
    Abstract: Process for the preparation of oligosaccharides-containing products from biomass involving the use of hydrochloric acid for partly hydrolyzing biomass to easily fermentable oligosaccharides-containing products and easy recovery of the hydrochloric acid and the oligosaccharides containing products. The oligosaccharides-containing products themselves and use of the latter for the preparation of useful products like ethanol and penicillin by fermentation.
    Type: Grant
    Filed: November 15, 1984
    Date of Patent: June 30, 1987
    Assignee: Gist-Brocades N.V.
    Inventors: Paul E. Linnett, Johan P. M. Sanders
  • Patent number: 4675437
    Abstract: Cycloaliphatic triisocyanates or isomer mixtures of such triisocyanates corresponding to the formula ##STR1## in which R represents hydrogen or a C.sub.1 -C.sub.4 alkyl group are produced by phosgenating the corresponding cycloaliphatic triamines or isomer mixtures of such triamines or a salt thereof.These triisocyanates are useful in the production of polyisocyanate addition products, particularly polyurethane coatings and lacquers.
    Type: Grant
    Filed: April 29, 1985
    Date of Patent: June 23, 1987
    Assignee: Bayer Aktiengesellschaft
    Inventors: Hartmut Knofel, Stefan Penninger, Michael Brockelt, Gunter Hammen, Herbert Stutz