Abstract: Pharmaceutical compositions useful for effecting diuresis and saluresis and for treating hypertension in humans and animals are produced by combining a pyrazol-5-one of the formula: ##STR1## or a pharmaceutically acceptable nontoxic salt thereof wherein R is hydrogen, lower alkyl or amino;X is methylene, ethylene, methylene wherein 1 hydrogen atom is substituted by lower alkyl, or ethylene wherein 1 hydrogen atom is substituted by lower alkyl or 1 hydrogen atom on each of the two carbon atoms is substituted by lower alkyl;Y is a direct bond, oxygen or sulphur, provided that when X is methylene wherein 1 hydrogen atom is substituted by alkyl of 1 to 4 carbon atoms, Y is a direct bond;Z is aryl of 6 to 10 carbon atoms unsubstituted or substituted by:(a) 1 or 2 of the same or different substituents selected from the group consisting of halogen, trifluoromethyl, alkyl of 1 to 4 carbon atoms, alkenyl of 2 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, and alkenoxy of 2 to 4 carbon atoms;(b) lower alkylamino, di
Type:
Grant
Filed:
December 12, 1979
Date of Patent:
September 8, 1981
Assignee:
Bayer Aktiengesellschaft
Inventors:
Eike Moller, Karl Meng, Egbert Wehinger, Harald Horstmann
Abstract: An attractant has been found for the male sunflower moth Homoeosoma electellum (Hulst.). Z-9,E-12-tetradecadien-1-ol has been found effective, optionally in the presence of Z-9-tetradecen-1-ol.
Type:
Grant
Filed:
March 28, 1980
Date of Patent:
August 18, 1981
Assignee:
Canadian Patents & Development Ltd.
Inventors:
Edward W. Underhill, Warren F. Steck, Melvin D. Chisholm, Alfred P. Arthur