Abstract: A method for monitoring a blood glucose level of a user is provided. The method includes receiving a time-varying electrical signal from an analyte sensor during a temporal phase of a monitoring session. The method includes selecting a calibration model from a plurality of calibration models, wherein the selected calibration model comprises one or more calibration model parameters. The method includes estimating at least one of the one or more calibration model parameters of the selected calibration model based on at least the time-varying electrical signal during the temporal phase of the monitoring session. The method includes estimating the blood glucose level of the user based on the selected calibration model and using the at least one estimated parameter. An apparatus and non-transitory computer readable medium having similar functionality are also provided.

Abstract: A hearing aid includes a plurality of electrode units, where each of the plurality of electrode units includes an electrode configured to provide an electrical stimulation to a user of the hearing aid and/or to measure a bio response signal of the user; a plurality of electrode channel circuits, where each of the plurality of electrode channel circuits includes: an operational amplifier comprising a first input terminal configured to receive the bio response signal and provide an amplified bio response signal, and the operational amplifier includes a first load input; a first DC offset unit configured to reduce the impact of DC offset in the electrode channel circuit of the plurality of electrode channel circuits by receiving a part of the amplified bio response signal and converting it to a feedback current signal which is transmitted to the first load input for providing balanced drain currents in the operational amplifier.

Abstract: The present disclosure relates to a smart contact lens for diabetes diagnosis in which a diabetic diagnosis sensor is composed of platinum-plated electrodes, and a driving system using the same. The smart contact lens of the present disclosure is easy to mass-produce, has good wireless power transfer efficiency due to high electrical conductivity, may perform good communication with an external driving board, and may perform physically and electrochemically stable driving.

Abstract: In some aspects, an apparatus for a biosensor includes a sensor wire and a rigid member. The rigid member may be coupled to the sensor wire and include a contact surface. The contact surface may be sized to enable a suction head of a robotic placement device to create a vacuum seal on the contact surface for lifting the sensor wire and rigid member.

Abstract: Implementations of a wearable physical characteristic monitoring (PCM) device can include a substrate including two or more electrical traces, the two or more electrical traces being formed as laser-induced graphene (LIG) in a starch-based material layer, a sensor that provides a signal responsive to physiological characteristics of a patient wearing the PCM device, a processing system that provides physiological characteristics data based on the signal, and a communications system that enables communication of the physiological characteristics data from the PCM device, wherein the two or more electrical traces connect one or more of the sensor, the processing system, and the communications system.

Abstract: A dialysis catheter with an elongate body has a distal end defining blood removal and return ports communicating with internal blood removal and return lumens extending through the elongate body. A sensing pathway is disposed in or on the elongate body. A vascular dimension sensor is provided to dynamically measure changes in dimension of the SVC or IVC during dialysis. The sensor communicates with a control system and may be controlled or positioned via the communication pathway of the catheter body. Systems disclosed included integrated closed-loop treatment based on monitored vascular dimension input. Methods included patient optimized treatments incorporating treatment modulation based on dynamic vascular dimension monitoring.

Abstract: Intraocular physiological sensor implants include a physiological sensor, and a housing comprising a faceplate. The physiological sensor is integrated with the faceplate. The physiological sensor typically comprises an intraocular pressure sensor, such as a capacitive pressure sensor that may further include a flexible diaphragm electrode spaced apart from a counter electrode. The intraocular pressure sensor detects intraocular pressure, to identify patient conditions such as glaucoma.

Abstract: The invention discloses a compact implantable biosensor assembly and a biological information monitoring device containing the assembly. The lower part of the implanted sensing section and of the needled for implantation are sealed in a closed space formed by the barrier, the lower part of the enclosure and the lower part of the needle aid. The horizontal connection section of the implantable sensing electrode is embedded in the enclosure. The export electrode is used to connect with a transmitter. The implantable biosensor assembly is directly connected with the circuit board of the transmitter through the export electrode, whereby the structure is compact.

Abstract: The present invention relates to apparatus for measuring physiological parameters in a blood vessel. The apparatus comprises at least one acoustic sensor positionable on a part of a subject's body which is configured to receive an acoustic signal from a target blood vessel. The acoustic sensor is attached to the part of the subject's body by an attachment means.

Abstract: Analyte sensors and associated insertion devices are disclosed herein. According to some embodiments, the present technology includes a sensor applicator comprising a housing having an insertion end configured to be positioned at or adjacent a user's skin at an insertion site, a needle carried by the housing and configured for insertion into the user's skin at the insertion site, and a sensor assembly comprising a base and a sensing portion extending from the base. The base is supported by the housing in a first position during insertion of the needle and configured to rotate into a second, laid-flat position on the user's skin after removal of the housing from the insertion site.

Abstract: There is described a pressure guidewire. It comprises a sensor housing and a sensor assembly embedded in the sensor housing and comprising a pressure sensor. There is a band to support the pressure sensor assembly, the band being embedded inside the sensor housing and fixed to the pressure sensor assembly for holding the pressure sensor inside the sensor housing.

Abstract: There is provided a method of diagnosing a medical state associated with a neuro-psychiatric disorder in a subject, comprising: receiving EEG datasets from EEG electrodes monitoring a head of the subject, computing events for the EEG datasets, clustering the events into clusters, computing a p-adic representation of the clusters, extracting a p-adic topology from the p-adic representation of the clusters, computing a personal universal dendrogramic holographic signature (PUDHS) of the p-acid topology relative to a personalized threshold that separates between a relative large distance between events and a relatively small distance between events, the PUDHS denoting number of events below the personalized threshold, and diagnosing the medical state associated with the neuro-psychiatric disorder according to the PUDHS relative to a medical threshold that separates between presence of the medical state and non-presence of the medical state.

Abstract: Microchannels in hydrogels play an essential role in enabling a smart contact lens. A wearable contact lens is disclosed herein that uses microchannels and connected chambers located in poly-2-hydroxyethyl methacrylate (poly(HEMA)) hydrogel that is used in a commercial contact lens with three-dimensional (3D) printed mold. The corresponding capillary flow behaviors in these microchannels were investigated. Different capillary flow regimes were observed in these microchannels, depending on the hydration level of the hydrogel material. In particular, it was found that a peristaltic pressure could reinstate flow in a dehydrated microchannel, indicating the motion of eye-blinking may help tear flow in a microchannel-containing contact lens. Colorimetric pH and electrochemical Na+ sensing capabilities were demonstrated in these microchannels. Micro-engineered contact lenses formed using poly(HEMA) hydrogel can be used for various biomedical applications such as eye-care and wearable biosensing.

Abstract: An on-body insertion system is described. The on-body system includes a sensor in a first position being substantially parallel to an insertion surface. Activation of an actuator transitions the sensor to a second position. Wherein the transition imparts movement to the sensor that is substantially parallel to the insertion surface and the second position results in the sensing area being beneath the insertion surface.

Abstract: An epidural needle with a mechanism to receive real-time feedback on the location of the epidural needle during insertion process of the epidural needle. In particular, the epidural needle includes a spring and a pair of needles coupled to a force-measuring sensor for a continuous measurement of the force at a tip of the epidural needle as the epidural needle is inserted. The spring is enclosed in a spring section between a lug section and a needle section. The lug section comprises the force-measuring sensor and the needle section comprises a needle to be inserted. The lug section, the spring section and the needle section are axially aligned along an epidural needle axis. A force is transmitted from the needle section through the spring of the spring section to the force-measuring sensor of the lug section.

Abstract: A non-invasive analyte sensor includes at least one transmit antenna and at least one receive antenna. A transmit circuit is electrically connectable to the at least one transmit antenna, where the transmit circuit is configured to generate a transmit signal in a radio or microwave frequency range of the electromagnetic spectrum. A receive circuit is electrically connectable to the at least one receive antenna. A trigger mechanism is associated with the non-invasive analyte sensor that triggers an analyte reading by the non-invasive analyte sensor.

Abstract: Described herein are variations of an analyte monitoring system, including an analyte monitoring device. For example, an analyte monitoring device may include an implantable microneedle array for use in measuring one or more analytes (e.g., glucose), such as in a continuous manner. Each microneedle of the microneedle array may include a microneedle body, an electrode material on the microneedle body, a biorecognition layer on the electrode material, a diffusion-limiting layer on the biorecognition layer, an interferent blocking agent, and/or an attachment enhancer between the biorecognition layer and the diffusion-limiting layer, where the interferent blocking agent and the attachment enhancer are configured to improve sensor sensitivity variability.

Abstract: A continuous glucose monitor (CGM) sensor includes a glucose oxidation electrode and a counter electrode, and does not include a glucose-specific enzyme. The glucose oxidation electrode includes a nanoporous layer comprising metal nanoparticles. The CGM sensor generates an electrical signal indicative glucose oxidation in a liquid containing glucose, which has a correlation with an effective surface area of the metal nanoparticles in the nanoporous layer. When the CGM sensor is implanted in a subject's body, an AC voltage is applied between the glucose oxidation electrode and the counter electrode, and impedance is obtained. A glucose level for the subject is determined using the impedance without use of information or data related to glucose sensitivity of a sensor or sensors over use or time.

Abstract: An adapter for a syringe having a barrel, a pair of syringe flanges secured to the barrel, and a plunger with a plunger top, the plunger being slidably disposed within the barrel, the adapter having a barrel guide configured to movably surround the barrel, a plunger lock configured to secure the plunger to the adapter, a support body disposed between and associated with the barrel guide and the plunger lock and a front grip associated with the barrel guide. By compressing the syringe flanges and the front grip toward each other, the barrel may travel forward through the barrel guide, thus drawing fluid into the syringe. The adapter, by allowing a compression force to be used to draw a fluid into the syringe, allows an individual to quickly and easily perform a blood draw or other fluid drawing operation with one hand, removing the need for a second user.

Abstract: A method of measuring skin moisture includes: measuring, in response to a touch on a touch panel, a first capacitance for a touch area in association with driving first and second electrodes of the touch panel in a mutual sensing mode; measuring, in response to the touch, a second capacitance for the touch area in association with driving one electrode of the first and second electrodes in a self-sensing mode; comparing the first capacitance with a first reference capacitance; determining, in response to the first capacitance being greater than the first reference capacitance, a skin moisture level using the first capacitance and the second capacitance; comparing, in response to the first capacitance being less than the first reference capacitance, the second capacitance with a second reference capacitance; and compensating, in response to the second capacitance being greater than the second reference capacitance, the first capacitance using the second capacitance.