Abstract: A method of controlling a gas delivery apparatus including an apparatus controllable variable using an iterative algorithm to deliver a test gas (TG) for non-invasively determining a subject's pulmonary blood flow comprising iteratively generating and evaluating test values of a iterated variable based on an iterative algorithm in order output a test value of the iterated variable that meets a test criterion wherein iterative algorithm is characterized in that it defines a test mathematical relationship between the at least one apparatus controllable variable, the iterated variable and an end tidal concentration of test gas attained by setting the apparatus controllable variable, such that the iterative algorithm is determinative of whether iteration on the test value satisfies a test criterion or iteratively generates a progressively refined test value.

Abstract: Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have a sensing surface that includes two or more sensing elements disposed laterally to each other, where the sensing surface is on a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.

Abstract: The present invention relates to a system and method for assessing and training the quality of attentional awareness and control of an individual. The individual's attention is monitored using a neurophysiological system such as EEG while using a computer system and display that provides signals that allow the correlation of behavioral measures of attention with neurophysiological measures. The combination of those signals is a novel, accurate and reliable system for assessing any individual's true attention capabilities.

Abstract: A system for obtaining and outputting real time blood glucose values or one or more indicators related thereto is described. The system comprises a sensor for obtaining blood glucose data from an individual in real time. The system includes an analyzer for comparing in a first comparison some or all of the blood glucose data obtained in real time and for generating an indicator in real time when the analyzer in comparing some or all of the blood glucose data identifies blood glucose data as unacceptable, the indicator provided as output on the user interface in real time.

Abstract: The present invention provides a biofluid sensing device capable of concentrating a biofluid sample with respect to a target analyte, so that the analyte can be accurately detected or measured by EAB sensors. Methods for using such a device provide qualitative information about the presence of the analyte, and/or quantitative information about relative concentrations of the analyte in the biofluid. The disclosed device includes a concentration channel for concentrating the biofluid sample, as well as a selectively permeable membrane, one or more EAB sensors, and one or more secondary sensors carried on a water-impermeable substrate. A method for using the disclosed device to collect a biofluid sample, concentrate the sample relative to a target analyte, and measure the target analyte is also disclosed.

Abstract: A device for generating alerts for Hypo and Hyperglycemia Prevention from Continuous Glucose Monitoring (CGM) determines a dynamic risk based on both information of glucose level and a trend obtainable from a CGM signals. The device includes a display whose color depends on the DR (for example, red for high DR, green for low risk). When DR exceeds a certain threshold, alerts are generated to suggest the patient to pay attention to the current glucose reading and to its trend, both of which are shown on the display in numbers and symbols (e.g. an arrow with different slope or color).

Abstract: A system is provided for advanced health monitoring and diagnosis based on wearable nano-biosensing networks. Nanophotonic and wireless communication technologies are synergistically leveraged to bridge the gap between nano-biosensing technologies and commercial wearable devices. Embodiments of the presently-disclosed system may include: (1) a nanoplasmonic biochip, implanted subcutaneously and built on a flexible substrate; (2) a nanophotonic smart band or wearable device that is able to collect in-vivo signals on-demand and relay them wirelessly to the user's smartphone by means of a secure data transfer; and (3) advanced signal processing techniques implemented on a remote processor to extract relevant data from the received signals and provide a diagnosis in real-time.

Abstract: A system for use in monitoring one or more parameters of a subject's body is described. The system comprising: an illumination unit configured for providing pulsed coherent illumination and directing said illumination onto an inspected region on said subject's body; a collection unit configured for collecting light returning from said inspection region and generate a plurality of data pieces associated with secondary speckle patterns in said light; an external field stimulation unit configured for selectively generating external field stimulation onto the subject's body; and a control unit. The control unit is configured and operable for operating said illumination unit said collection unit and said external field stimulation unit and for receiving said plurality of data pieces from said collection unit to thereby determine said one or more conditions of the subject's body.

Abstract: A method and apparatus for monitoring a cardiovascular pressure signal in a medical device that includes determining whether the sensed pressure signal is greater than a first pressure threshold, determining a first metric of the pressure signal in response to the sensed pressure signal being greater than the first pressure threshold, determining whether the sensed pressure signal is greater than a second pressure threshold not equal to the first pressure threshold, determining a second metric of the pressure signal in response to the sensed pressure signal being greater than the first pressure threshold, and determining at least one of a systolic pressure or a diastolic pressure, wherein the at least one of a systolic pressure or a diastolic pressure is determined based on the first metric in response to the pressure signal not being greater than the second threshold, and based on the second metric in response to the pressure signal being greater than the second threshold.

Abstract: The systems and methods described herein provide a wearable sweat sensing device. The device includes a sweat patch component including a sweat biochemical sensor patch having a substrate defining a hole, at least one biochemical sensor, and a capture wick including a tip that extends through the hole, the capture wick configured to channel sweat across the at least one biochemical sensor. The sweat patch component further includes a wick downstream from the capture wick and separated from the capture wick by a gap, and electronic circuitry disposed against at least one face of the wick, wherein an electronic response of the electronic circuitry changes as sweat flows through the wick. The wearable sweat sensing device further includes an electronics module component configured to facilitate assessing hydration of a wearer based on signals from the at least one biochemical sensor and the electronic circuitry.

Abstract: A method for estimating blood pressure of a care recipient includes establishing a pre-maneuver reference value of blood pressure and a companion nonreference value of blood pressure, subjecting the care recipient to a maneuver, establishing a post-maneuver reference value of blood pressure and a companion post-manuever nonreference value of blood pressure, establishing an operational post-maneuver nonreference value of blood pressure, and adjusting the operational value as a function of the pre-maneuver and post-maneuver values. An associated apparatus includes a sensor, a processor and a memory which contains instructions.

Abstract: A flexible, multi-layered device for automatically sensing sweat biomarkers, storing and transmitting sensed data via wireless network to a computing device having software applications operable thereon for receiving and analyzing the sensed data. The device is functional in extreme conditions, including extremely hot temperatures, extremely cold temperatures, high salinity, high altitude, extreme pHs, and/or extreme pressures.

Abstract: Analyte sensing and response methods include using a non-invasive analyte sensor to detect at least one analyte in a medium. The sensor uses decoupled transmit and receive elements or antennas to transmit a signal, and to receive a response to the signal transmitted into the medium. An action is determined based on the detection of the analyte, which can affect a property of the analyte or the medium, and the action is automatically carried out. The action can be increasing or decreasing flow from a source of the analyte, increasing or decreasing flow of a chemical compound interacting with the analyte, or modifying a temperature of the medium. An example of the action is controlling an insulin pump, where the analyte is glucose.

Abstract: A blood pressure measuring apparatus according to an aspect of the present invention includes: a touch sensor; a pulse wave measurer configured to measure pulse waves from a user; a contact force measurer including at least three force sensors and configured to measure a contact force between the touch sensor and the user by using the at least three force sensors; a contact area measurer configured to measure a contact area between the user and the touch sensor; and a processor configured to determine a vertical direction error, which indicates a degree of deviation of a direction of force, applied by the user to press the touch sensor, from a vertical direction to a surface of the touch sensor based on sensor values sensed by the at least three force sensors, and estimate blood pressure according to a determination result of the vertical direction error based on the pulse waves, the contact force, and the contact area.

Abstract: The invention relates to a method for the controlled delivery of a drug as a function of bioavailable drug concentration, a sensor device for detecting bioavailable drug concentration, and a delivery device that controls delivery of the drug based on the real-time detection of bioavailable drug concentration.

Abstract: A medical device includes an antenna external to a case, package, or encapsulant for the electronic systems of the medical device. In one embodiment, a diabetes infusion pump is enclosed within a metal case, the pump including a processor and a communication module for wireless communications. An antenna is disposed in the delivery tubing of the pump outside the case with an antenna feed interconnecting the external antenna with the internal communication module. In another aspect, a thin film antenna is formed on the outer surf ace of the case in which a physiological parameter sensor, such as a glucose sensor, is enclosed. Multiple antennas may be used for communications on different frequencies.

Abstract: Systems and methods are disclosed for monitoring a user by calibrating one or more noninvasive sensors to track a user glucose level at one or more user physical activity conditions; generating a calibration based on the one or more user conditions; and in real time detecting a current user condition and applying the calibration to accurately estimate the user glucose or insulin level.

Abstract: Aspects of the of the disclosure relate to a non-contact physiological motion sensor and a monitor device that can incorporate use of the Doppler effect. A continuous wave of electromagnetic radiation can be transmitted toward one or more subjects and the Doppler-shifted received signals can be digitized and/or processed subsequently to extract information related to the cardiopulmonary motion in the one or more subjects. The extracted information can be used, for example, to determine apneic events and/or snoring events and/or to provide apnea or snoring therapy to subjects when used in conjunction with an apnea or snoring therapy device. In addition, methods of use are disclosed for sway cancellation, realization of cessation of breath, integration with multi-parameter patient monitoring systems, providing positive providing patient identification, or any combination thereof.

Abstract: The present invention belongs to the technical field of material fabrication, and particularly relates to an ultra-sensitive glucose sensor based on a graphene and carbon fiber substrate and a fabrication method thereof. The method includes fabricating a carbon fiber cloth with vertical graphene growth on a surface thereof, performing pretreatment to make the carbon fiber cloth hydrophilic, directly soaking the carbon fiber cloth in a PBS solution of glucose oxidase with the pH of 7.4, and then taking out and drying the carbon fiber cloth at room temperature to obtain a glucose sensor. According to the present invention, the lower limit of glucose detection reaches about 0.1 mM, and the glucose sensor also has multistage corresponding characteristics, so that different detection coefficients and capabilities can be achieved in different glucose concentration ranges. The application range and precision of the glucose sensor are greatly improved.

Abstract: Systems, devices, and methods for determining a user's lung capacity may employ a sound-producing breathing device and a recording device such as a microphone included in a user electronic device (e.g., smart phone or tablet computer). A user may inhale or exhale through the sound-producing breathing device, thereby producing a sound that is received by the microphone and communicated to a processor. The processor may analyze the received sound recording to determine one or more sound intensity values over, for example, the duration of the received sound and/or points in time within the sound recording. The sound intensity values may then be used to determine the user's lung capacity.