Patents Examined by Ernst V. Arnold
  • Asenapine-containing patch
    Patent number: 10806705
    Abstract: The present invention provides a patch comprising a backing and an adhesive layer laminated on one side of the backing, wherein the adhesive layer comprises asenapine or a pharmaceutically acceptable salt thereof, an adhesive base and a low molecular weight amine.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: October 20, 2020
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Takashi Yasukochi, Atsushi Sonobe, Satoshi Amano
  • Reducing post-operative adhesion formation with intraperitoneal glutamine
    Patent number: 10799622
    Abstract: The present disclosure relates to a method of treating or reducing adhesions in the peritoneum of a patient in need thereof. The method includes performing adhesiolysis on one or more adhesions involving the patient's peritoneum and/or one or more tissues or organs in the patient's peritoneal cavity; and administering to the peritoneum or the peritoneal cavity of the patient an effective amount of a composition comprising at least one glutamine source. The glutamine source is selected from one or more of L-glutamine, physiologically acceptable salts of L-glutamine, and dipeptides comprising L-glutamine.
    Type: Grant
    Filed: November 5, 2018
    Date of Patent: October 13, 2020
    Assignee: Ade Therapeutics, Inc.
    Inventor: Adebola O. E. Obayan
  • Formulation for the controlled release of one or several substances in the digestive tract of a mammal
    Patent number: 10799460
    Abstract: The present invention relates to a formulation for the controlled release of active ingredients after the passage of the ileo-cecal-valve, comprising one or more active ingredients or one or more active ingredient containing cores (W), enveloped by one or more envelopments (C), which are dissoluble or permeable above an individual defined pH value and are dissoluble or permeable below another individual defined pH value, again enveloped by an envelopment (E), which is dissoluble or permeable above still another individual defined pH value.
    Type: Grant
    Filed: September 7, 2012
    Date of Patent: October 13, 2020
    Inventor: Roland Saur-Brosch
  • Razor cartridge with lubricating strip
    Patent number: 10786916
    Abstract: The disclosure deals with a lubricative skin engaging member with progressive release of lubricating polymer from a water-insoluble matrix containing thermoplastic elastomer compound and maleic anhydride copolymer and lubricating polymer in concentration less than 30%. The disclosure lies in the use of the maleic anhydride in grafted form on polyethylene and the incorporation of water-soluble lubricating polymer in concentration less than 30% in the thermoplastic elastomer compound, leading to a lubricative mixture, and to a skin engaging member, with increased homogeneity and water absorption ability that assist in the lubricating polymer release in a progressive and controllable manner.
    Type: Grant
    Filed: March 8, 2019
    Date of Patent: September 29, 2020
    Assignee: BIC VIOLEX S.A.
    Inventors: Amalia Skarmoutsou, Nikolaos Chatzigrigoriou
  • PH dependent carriers for targeted release of pharmaceuticals along the gastrointestinal tract, compositions therefrom, and making and using same
    Patent number: 10786444
    Abstract: Novel drug carriers capable of targeted and/or pH dependent release of biologically active agents into selected pH environments including the gastrointestinal (GI), ophthalmic, urinary, or reproductive tracts. Unexpectedly, carriers including free fatty acids (FFA) are able to deliver biologically active agents to various pH environments. Such targeted delivery is tailorable and useful for active agents that are: (a) injurious to the upper GI tract (esophagus, stomach, and duodenum), (b) acid labile, (c) impermeable/insoluble compounds in GI fluids, (d) susceptible to first pass metabolism, and/or (e) cause stomach irritation, upset, or dyspepsia.
    Type: Grant
    Filed: March 27, 2020
    Date of Patent: September 29, 2020
    Assignee: PLx Opco Inc.
    Inventors: Upendra Marathi, Susann Childress, Shaun Gammill, Robert W. Strozier
  • Shape changing drug delivery devices and methods
    Patent number: 10786462
    Abstract: Drug delivery using bio-affecting drugs, particularly with shape changing drug delivery devices. Embodiments are included for depots for delivery of a therapeutic agent that change from an elongated state ex vivo to a coil in vivo where the agent is released.
    Type: Grant
    Filed: August 6, 2019
    Date of Patent: September 29, 2020
    Assignee: Incept, LLC
    Inventors: Peter Jarrett, Michael J. McGrath, Timothy S. Jarrett, Rami El-Hayek, Andrew C. Vanslette, Courtney A. Rosales, Charles D. Blizzard, Amarpreet S. Sawhney
  • Methods of producing an osteoinductive calcium phosphate material for bone grafting
    Patent number: 10786597
    Abstract: The present invention relates to methods for producing biphasic calcium phosphate materials using chemical processing methods including exposure to peroxides. The resulting materials exhibit an osteoinductive needle-like surface morphology and are useful as artificial bone grafts.
    Type: Grant
    Filed: March 24, 2020
    Date of Patent: September 29, 2020
    Assignee: SECADA MEDICAL LLC
    Inventors: Sahil Jalota, Russell Cook
  • Sugar-depleted fruit or vegetable juice and juice-retaining fruit or vegetable derived matter, methods of producing the same and the use thereof to maintain health and to treat and prevent medical ailments
    Patent number: 10786452
    Abstract: Described herein is a sugar-depleted fruit or vegetable juice product, wherein said juice product is a fruit or vegetable juice or juice-retaining fruit or vegetable derived matter, wherein said juice product contains at least about 5 g/l gluconic acid and said juice product contains any two or three, of (i) at least about 0.5 g/l Ca2+, (ii) at least about 1 g/l K+, and (iii) at least about 0.1 g/l Mg2+. Also provided are methods of producing the same and the use thereof to assist in maintaining the health and well-being of a subject and in the treatment and prevention of medical ailments, specifically those associated with the over-consumption of glucose and/or sucrose or inappropriate metabolism of glucose, e.g. metabolic syndrome, diabetes mellitus type II, obesity, dyslipidemia, insulin resistance, hypertension and liver steatosis.
    Type: Grant
    Filed: September 18, 2019
    Date of Patent: September 29, 2020
    Assignee: NOFIMA AS
    Inventors: Jurgen Schrezenmeir, Svein Halvor Knutsen, Simon Ballance
  • Dexmedetomidine transdermal delivery devices and methods for using the same
    Patent number: 10772871
    Abstract: Aspects of the invention include transdermal delivery devices for delivering dexmedetomine to a subject, where the transdermal delivery devices include a single layer matrix dexmedetomine composition. Transdermal delivery devices according to certain embodiments include dexmedetomidine and a pressure sensitive adhesive provided as a single layer formulation. Also provide are methods of using the subject transdermal delivery devices to deliver dexmedetomidine to a subject, as well as kits containing the transdermal delivery devices.
    Type: Grant
    Filed: October 3, 2014
    Date of Patent: September 15, 2020
    Assignee: Teikoku Pharma USA, Inc.
    Inventors: Adchara Pongpeerapat, Amit Jain, Bret Berner, Jianye Wen, Jutaro Shudo
  • Methods for the treatment of peri-implantitis
    Patent number: 10758639
    Abstract: The present invention relates to pharmaceutical compositions and methods for the treatment of peri-implant diseases, in particular peri-implant disease characterized by the destruction of the crest of the alveolar bone supporting the implant. Specifically, the method comprising the step of applying to a peri-implant bone displaying crestal resorption a 5 pharmaceutical composition comprising biocompatible bone augmentation material coated with a matrix composition which provides local controlled and prolonged release of at least one pharmaceutically active agent at the bone loss site.
    Type: Grant
    Filed: September 27, 2015
    Date of Patent: September 1, 2020
    Assignee: Polypid Ltd.
    Inventor: Noam Emanuel
  • Amphiphilic entity nanoparticles
    Patent number: 10758485
    Abstract: The present invention provides nanoparticle compositions comprising AE nanoparticles. The present invention provides AE nanoparticles comprising one or more amphiphilic entities and pharmaceutical compositions comprising AE nanoparticles. The present invention provides methods of manufacturing AE nanoparticles. The present invention provides methods of delivering a biologically active agent to a subject by administering AE nanoparticles containing a biologically active agent to a subject.
    Type: Grant
    Filed: April 9, 2019
    Date of Patent: September 1, 2020
    Assignee: Anterios, Inc.
    Inventor: Timothy Kotyla
  • Hydrophilic polyurethane nanofiber and method for manufacturing same
    Patent number: 10751222
    Abstract: The present disclosure is to provide a method for producing polyurethane (PU) nanofibers with significantly improved hydrophilicity by producing water-soluble polymer/PU blend nanofiber by coaxial-electrospinning water-soluble polymer and hydrophobic PU, and, subsequently, dissolving and removing the water-soluble polymer from the blend nanofiber in water.
    Type: Grant
    Filed: March 28, 2017
    Date of Patent: August 25, 2020
    Assignee: Kyungpook National University Industry-Academic Cooperation Foundation
    Inventors: Jin Hyun Choi, Woo Jin Kim
  • Tamper resistant pharmaceutical formulations
    Patent number: 10751287
    Abstract: Disclosed in certain embodiments is a solid oral dosage form comprising a plurality of particles, each particle comprising (i) a core comprising an active agent susceptible to abuse and an internal adhesion promoter, wherein the cores are (i) dispersed in a matrix comprising a controlled release material or (ii) coated with a controlled release material. The dosage form can also include an alcohol resistant material.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: August 25, 2020
    Assignee: Purdue Pharma L.P.
    Inventors: Rama Abu Shmeis, Sheetal Muley, Zhixin Zong
  • Pharmaceutical composition for nasal delivery
    Patent number: 10729687
    Abstract: According to the invention, there is provided a solid pharmaceutical composition formulation for nasal delivery of an opioid antagonist, comprising a pharmacologically-effective amount of an opioid antagonist and a pharmaceutically-acceptable carrier. The compositions are preferably in the form of a powder produced by spray-drying, which are subsequently loaded into single use nasal applicators. Preferred pharmaceutically-acceptable carriers in this regard include disaccharides (e.g. lactose or trehalose) and dextrins (e.g. cyclodextrins or maltodextrins), preferably spray-dried together in combination. Compositions may further comprise an alkyl saccharide, preferably a sucrose ester, such as sucrose monolaurate. The compositions and applicators may be employed in the treatment of opioid overdose in subjects.
    Type: Grant
    Filed: May 18, 2020
    Date of Patent: August 4, 2020
    Assignee: OREXO AB
    Inventors: Jonas Sävmarker, Robert Rönn, Andreas Fischer
  • Fexofenadine microcapsules and compositions containing them
    Patent number: 10729682
    Abstract: The present invention provides a pharmaceutical composition comprising taste-masked immediate release microcapsules which comprise fexofenadine and a water-insoluble polymer coating. These microcapsules and the pharmaceutical compositions comprising them have suitable drug content and desirable pharmaceutical properties, including a quick dissolution rate of fexofenadine combined with a taste masking effect.
    Type: Grant
    Filed: November 9, 2018
    Date of Patent: August 4, 2020
    Assignee: Adare Pharmaceuticals S.R.L.
    Inventors: Luigi Mapelli, Flavio Fabiani, Luigi Boltri, Paolo Gatti, Mauro Serratoni, Roberto Cassanmagnago
  • Dose-dumping resistant controlled release dosage form
    Patent number: 10695336
    Abstract: The present invention provides a simple and improved dosage form that provides a controlled release of methylphenidate contained in the core thereof. The invention also provides methods of administering the dosage form and of treating conditions that are therapeutically responsive to methylphenidate. The dosage form exhibits improved resistance to alcohol-related dose dumping.
    Type: Grant
    Filed: February 6, 2019
    Date of Patent: June 30, 2020
    Assignee: OSMOTICA KERESKEDELMI ES SZOLGALTATO KFT
    Inventors: Hernan D. Benedetti, Cristian R. Franco, Guido S. Bigatti, Joaquina Faour, Ana C. Pastini
  • Solid solution compositions and use in severe pain
    Patent number: 10695432
    Abstract: The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a severe pain in an individual using such pharmaceutical compositions.
    Type: Grant
    Filed: January 14, 2014
    Date of Patent: June 30, 2020
    Assignee: Infirst Healthcare Limited
    Inventors: Robin M. Bannister, John Brew, Richard R. Reiley, III, Wilson Caparros Wanderley
  • Disulfiram formulation
    Patent number: 10695299
    Abstract: Polymeric nanoparticles comprising disulfiram or derivatives thereof, and their use in the treatment of cancer.
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: June 30, 2020
    Inventors: Weiguang Wang, Zhipeng Wang, Xiu-Wu Bian
  • Solid solution compositions and use in cardiovascular disease
    Patent number: 10695431
    Abstract: The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a chronic inflammation and/or an inflammatory disease in an individual using such pharmaceutical compositions.
    Type: Grant
    Filed: January 14, 2014
    Date of Patent: June 30, 2020
    Assignee: Infirst Healthcare Limited
    Inventors: Robin M. Bannister, John Brew, Richard R. Reiley, III, Wilson Caparros Wanderley
  • Formulation preparation to treat mature skin for restoring moisture and retarding aging process
    Patent number: 10688029
    Abstract: Compositions, kits and methods are provided for restoring moisture and retarding the aging process in mature skin. In general, ions, combined amino acids, fatty acids and polyols are included in a physiologically acceptable medium. The compositions, kits and methods can be used as cosmetics, cosmeceuticals or pharmaceuticals for improving mature skin condition, and preventing or treating the aging process and/or lack of moisture.
    Type: Grant
    Filed: July 11, 2018
    Date of Patent: June 23, 2020
    Assignee: DERMSOLACE BIOTECHNOLOGY LLC
    Inventors: Wen Ching Chen, Shu Chen Wang, Bryant Chen, Hanafi Tanojo