Patents Examined by Ernst V. Arnold
  • Abuse resistant forms of extended release hydrocodone, method of use and method of making
    Patent number: 11278500
    Abstract: An abuse resistant oral pharmaceutical composition, comprising: a barrier layer, comprising a first polymer; a diffusion layer, comprising a second polymer, substantially covering the barrier layer, wherein the diffusion layer is bonded to the barrier layer and comprises a drug that is substantially homogeneously distributed within the second polymer and diffuses from the diffusion layer within the gastrointestinal (GI) tract; and optionally an expansion layer comprising an expandable polymer, wherein the expansion layer is substantially covered by the barrier layer. Methods of making the same and methods of using the same are also provided.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: March 22, 2022
    Assignee: OHEMO LIFE SCIENCES, INC.
    Inventors: Manish S. Shah, Ray J. DiFalco
  • Method and system for forming a dosage form within a packaging
    Patent number: 11278501
    Abstract: A method and system of forming a pharmaceutical dosage form within a portion of a blister packaging. The method includes the steps of providing a blister packaging for the dosage form with depressions. A predetermined amount of a drug-containing powder material comprising drug-containing particles is deposited into a substantially uniform powder layer within the depressions. A binding liquid is then deposited in a pattern on the powder layer within the depressions, to bind the particles of the powder layer and form an incremental wetted layer. Excess solvent in the binding material can be removed to form an incremental bound layer. These steps are repeated in sequence at least one or more times to form the pharmaceutical dosage form within the blister packaging.
    Type: Grant
    Filed: October 15, 2019
    Date of Patent: March 22, 2022
    Assignee: APRECIA PHARMACEUTICALS LLC
    Inventors: Lauren E. Beach-Herrera, Matthew F. Boldt, Thomas J. Bradbury, Henry Cabral, Kelly E. Caputo, William R. Gross, Munhee Lee, Mahendra R. Patel, Aleece M. Phillips, Timothy S. Tracy, Thomas G. West, Jaedeok Yoo
  • Methocarbamol composition and related methods
    Patent number: 11266621
    Abstract: Stable methocarbamol ready to use compositions for parenteral administration including parenteral infusion are provided. In certain embodiments, the compositions are sterile, isotonic, and particulate-matter-free. Further, the compositions reduce or avoid allergic reactions to latex, reduce or avoid extravasation, and permit administration of methocarbamol to subjects having renal pathology. Methods of manufacture and methods of administration are also provided.
    Type: Grant
    Filed: November 19, 2020
    Date of Patent: March 8, 2022
    Assignee: Exela Sterile Medicines LLC
    Inventors: Phanesh B. Koneru, John Maloney
  • Approaches for improving skin hydration and moisturization
    Patent number: 11260018
    Abstract: The present disclosure generally relates to approaches for improving water absorption and retention by the skin's surface. In particular, the disclosure provides compositions and methods for preparing mixtures comprised of ethoxylated oils and water or mixtures comprised of micro or nano emulsions and water, which provide enhanced skin hydration or moisturization to a subject.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: March 1, 2022
    Assignee: JRX BIOTECHNOLOGY, INC.
    Inventors: Frederick L. Jordan, Chris Jordan
  • Pharmaceutical compositions and dosage forms
    Patent number: 11253515
    Abstract: Disclosed herein are pharmaceutical compositions and dosage forms including N-[5-(3,5-difluorobenzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-2H-pyran-4-ylamino) benzamide that are useful in the treatment of subjects having cancer. The present disclosure also provides methods for preparing these pharmaceutical compositions and dosage forms, and methods of treating subjects having cancer utilizing the pharmaceutical compositions and dosage forms provided herein.
    Type: Grant
    Filed: January 17, 2020
    Date of Patent: February 22, 2022
    Assignee: Ignyta, Inc.
    Inventors: Daniel Codallos, Jr., Robert Orr, Ching-Yuan Li, Valerie Denise Start
  • Rectal mucosal administration preparation of saponin B4 and preparation method therefor
    Patent number: 11253471
    Abstract: A rectal mucosal administration preparation of Pulsatilla chinensis (Bge.) Regel saponin B4 contains Pulsatilla chinensis (Bge.) Regel saponin B4 and a pharmaceutically acceptable substrate. The drug preparation is a rectal gel or a rectal suppository. Compared with oral administration, the rectal mucosal administration preparation of Pulsatilla chinensis (Bge.) Regel saponin B4 has a lower effective dose, and has a better medicinal effect at the same dose.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: February 22, 2022
    Inventor: Qi Liu
  • Polymer nanofiber scaffolds and uses thereof
    Patent number: 11246956
    Abstract: A polymer nanofiber scaffold includes a plurality of melt extruded nanofibers that are chemically modified to append surface functionality to the nanofibers.
    Type: Grant
    Filed: March 16, 2020
    Date of Patent: February 15, 2022
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventor: Jonathan Pokorski
  • Pharmaceutical composition to treat health conditions associated with elevated glucose levels
    Patent number: 11246855
    Abstract: A threefold decrease in ?-amylase inhibition, increase in insulin secretion and glucose uptake increase by the pharmaceutical composition of several naturally occurring substances and vitamins were observed when compared to the control cells, and a c.a. 1-1.5 fold decrease when compared to the positive control. More specifically Mix A and Mix B applied together with VitaminD+K2 shows significant effect on increased insulin secretion and glucose uptake by cells.
    Type: Grant
    Filed: July 16, 2021
    Date of Patent: February 15, 2022
    Inventor: Matthias W Rath
  • Solid solution compositions and use in severe pain
    Patent number: 11224659
    Abstract: The present specification discloses solid solution pharmaceutical compositions comprising therapeutic compound comprising a phytocannabinoid, an endocannabinoid, a synthetic cannabinoid, or a combination thereof, one or more pharmaceutically-acceptable hard fats in an amount of at least 30% by weight of the pharmaceutical composition, and one or more pharmaceutically-acceptable liquid lipids in an amount of less than 45% by weight of the pharmaceutical composition, methods of preparing such pharmaceutical compositions, and methods and uses of treating a chronic inflammation and/or an inflammatory disease in an individual using such pharmaceutical compositions.
    Type: Grant
    Filed: May 25, 2020
    Date of Patent: January 18, 2022
    Assignee: Infirst Healthcare Limited
    Inventors: Robin M. Bannister, John Brew, Richard R. Reiley, III, Wilson Caparros Wanderley
  • Ophthalmic drug sustained release device
    Patent number: 11219598
    Abstract: An object of the present invention is to provide a sustained drug release system useful for treating eye diseases. There is provided a device for sustained release of an ophthalmic drug, comprising a drug enclosing part and an intraocular retention gas enclosing part adjacent to the drug enclosing part, the enclosing parts being provided in a hollow container having at least one opening part, wherein the drug enclosing part is isolated from the opening part by the intervention of the intraocular retention gas enclosing part.
    Type: Grant
    Filed: April 19, 2017
    Date of Patent: January 11, 2022
    Assignee: PUBLIC UNIVERSITY CORPORATION NAGOYA CITY UNIVERSITY
    Inventor: Tsutomu Yasukawa
  • Solid solution compositions and use in cardiovascular disease
    Patent number: 11202831
    Abstract: The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a chronic inflammation and/or an inflammatory disease in an individual using such pharmaceutical compositions.
    Type: Grant
    Filed: May 25, 2020
    Date of Patent: December 21, 2021
    Assignee: Infirst Healthcare Limited
    Inventors: Robin M. Bannister, John Brew, Richard R. Reiley, III, Wilson Caparros Wanderley
  • Patch
    Patent number: 11202764
    Abstract: A patch comprises a backing layer and an adhesive layer, wherein the adhesive layer contains at least one selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof, and contains a rubber-based adhesive base and a silicone-based adhesive base, and a mass ratio of the rubber-based adhesive base to the silicone-based adhesive base (the mass of the rubber-based adhesive base:the mass of silicone-based adhesive base) in the adhesive layer is 9.5:0.5 to 1.9:8.1.
    Type: Grant
    Filed: April 19, 2018
    Date of Patent: December 21, 2021
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Kazuya Kominami, Takito Shima, Naoyuki Uchida, Naoko Fujita, Shigeo Suzuki, Terumitsu Kaiho
  • Self-restorable core-shell capsule
    Patent number: 11202741
    Abstract: The present invention relates to a core-shell capsule comprising: a core comprising an oil, a solvent satisfying relational expression 1 below, and a water-insoluble polymer compound dissolved in the solvent; and a water-insoluble polymer shell enclosing the core. 0.01?CA/CB?100??[Relational expression 1] (in relational expression 1, CA/CB is the distribution coefficient of solvent, and when the solvent is dissolved in oil and water to reach equilibrium, CA is the concentration of the solvent dissolved in the oil and CB is the concentration of the solvent dissolved in water).
    Type: Grant
    Filed: September 26, 2016
    Date of Patent: December 21, 2021
    Assignee: AMOREPACIFIC CORPORATION
    Inventors: Ji Sik Shin, Young Suk Cho, Seung Han Park, Byung Geun Chae
  • Teeth whitening methods, visually perceptible signals and compositions therefor
    Patent number: 11197811
    Abstract: Described herein are methods of cleaning a tooth comprising administering a composition comprising a zinc amino acid halide complex to the oral cavity; and retaining the composition in the oral cavity for a time sufficient to form a precipitate.
    Type: Grant
    Filed: February 24, 2020
    Date of Patent: December 14, 2021
    Assignee: Colgate-Palmolive Company
    Inventors: Zhiqiang Liu, Long Pan, Shaotang Yuan, Jairajh Mattai, James Masters
  • Abuse resistant forms of immediate release hydromorphone, method of use and method of making
    Patent number: 11191730
    Abstract: An abuse resistant oral pharmaceutical composition, comprising: a barrier layer, comprising a first polymer; a diffusion layer, comprising a second polymer, substantially covering the barrier layer, wherein the diffusion layer is bonded to the barrier layer and comprises a drug that is substantially homogeneously distributed within the second polymer and diffuses from the diffusion layer within the gastrointestinal (GI) tract; and optionally an expansion layer comprising an expandable polymer, wherein the expansion layer is substantially covered by the barrier layer. Methods of making the same and methods of using the same are also provided.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: December 7, 2021
    Assignee: OHEMO LIFE SCIENCES INC.
    Inventors: Manish S. Shah, Ray J. DiFalco
  • Excipient free N-Acetyl glucosamine tablets and method of making
    Patent number: 11191701
    Abstract: The present invention is a method of making excipient free N-Acetylglucosamine tablets and also the excipient free N-Acetylglucosamine tablets in a variety of sizes, in particular 10 gram tablets. These excipient free tablets are palatable and suitable for consumption by horses, smaller animals and humans. In the method of making these tablets, of N-Acetylglucosamine powder is mixed with a specific amount of water, to bring about a moldable mass which is formed into suitably sized tablets through compression in a tablet mold. The solvent water is then allowed to evaporate leaving behind an excipient free N-Acetylglucosamine tablet.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: December 7, 2021
    Assignee: PurePharm, Inc.
    Inventors: Willem Wassenaar, Brandon Wren
  • Preserving functionally-coated API particles produced by solventless mixing processes in aqueous suspension
    Patent number: 11185508
    Abstract: Provided are pharmaceutical compositions and methods for preparing pharmaceutical compositions that preserve the coating of coated API particles in a pharmaceutical suspension. Pharmaceutical compositions include coated active pharmaceutical ingredient (API) particles comprising: an API particle; a first coating comprising one or more deformed components coating the API particle; a second coating comprising silica surrounding and/or partially or fully embedded into the first coating, a matrix former, and a structure former.
    Type: Grant
    Filed: February 21, 2020
    Date of Patent: November 30, 2021
    Assignee: Catalent U.K. Swindon Zydis Limited
    Inventors: Rosaleen McLaughlin, Adam Parker, Jonathon Whitehouse
  • Preparation method of calcium peroxide-mediated in situ crosslinkable hydrogel as a sustained oxygen-generating matrix, and biomedical use thereof
    Patent number: 11185607
    Abstract: A preparation method of calcium peroxide-mediated in situ crosslinkable hydrogel as a sustained oxygen-generating matrix, includes: a) reacting a natural or a synthetic polymer with Traut's reagent (TR) in a solvent, and synthesizing a polymer derivative having thiol group in backbone of the polymer derivative; and b) mixing and reacting a solution of the polymer derivative having thiol group with calcium peroxide (CaO2), and thereby forming a hydrogel, wherein in the step b), disulfide bonds (—S—S) are induced between backbones of the polymer derivative having thiol group attached by decomposition of calcium peroxide (CaO2), and thereby in situ crosslinking is formed.
    Type: Grant
    Filed: August 3, 2017
    Date of Patent: November 30, 2021
    Assignees: INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION, AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Kyung Min Park, Ki Dong Park, Su Jin Park
  • Composition and method for treating osteoarthritis with manganese dioxide nanoparticles
    Patent number: 11179416
    Abstract: The present disclosure relates to manganese dioxide nanoparticles and their use in treatment of oxidative stress and conditions related to or characterized by oxidative stress, including osteoarthritis.
    Type: Grant
    Filed: February 20, 2019
    Date of Patent: November 23, 2021
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
    Inventors: Blanka Sharma, Isaac Adjei, Shreedevi Kumar
  • Nanocrystalline calcium hydroxyapatites, method for its manufacture and use thereof in regenerative medicine and theranostic
    Patent number: 11180370
    Abstract: A method of manufacturing the calcium nanohydroxyapatite Ca10(PO4)6(OH)2 structurally modified with Li+ ions (nHAP:Li+) Li0.1Ca9.9(PO4)6(OH)2 optionally doped with 1-2% mol of Eu3+ cations in the form of nanocrystalline powder and use of Li0.1Ca9.9(PO4)6(OH)2 in regenerative medicine as an agent improving of proliferative activity of progenitor cells and demonstrating an anti-apoptotic effect on progenitor cells and in addition use of Li0.1Ca9.9(PO4)6(OH)2 doped with 1-2% mol Eu3+ cations as an agent improving of proliferative activity of progenitor cells and demonstrating the luminescence signal used in diagnostic application.
    Type: Grant
    Filed: January 25, 2017
    Date of Patent: November 23, 2021
    Assignee: INSTYTUT NISKICH TEMPERATUR I BADAN STRUKTURALNYCH PAN IM.W.TRZRBIATOWSKIEGO
    Inventors: Rafal Wiglusz, Krzysztof Marycz