Patents Examined by Ernst V. Arnold
  • Method of treating diseases
    Patent number: 11338011
    Abstract: Methods of treating acromegaly in a subject are described herein. Exemplary methods include orally administering to the subject at least once daily at least one dosage form comprising octreotide, wherein the octreotide in each dosage form is 20 mg, and wherein the administering occurs at least 1 hour before a meal or at least 2 hours after a meal.
    Type: Grant
    Filed: November 10, 2020
    Date of Patent: May 24, 2022
    Assignee: Amryt Endo, Inc.
    Inventors: Roni Mamluk, Sam L. Teichman
  • Mixture of stabilized biologically available curcumin for orodispersible formulations, formulations of biologically available curcumin, and an orodispersible tablet with biologically available curcumin, and its application
    Patent number: 11331281
    Abstract: Mixture of stabilised biologically available curcumin for orodispersible formulations, formulations of biologically available curcumin and orodispersible tablet with biologically available curcumin and its application. An orodispersible tablet with biologically available curcumin contains particles of extract of rhizome of plant Curcuma longa, which contains, at least, 95% by weight of curcumin, grounded to size 100 to 250 nm in mixture with mannitol in weight ratio 1 to 3:1 (mannitol:curcumin). Orodispersible tablet also contains an orodispersible carrier, and curcumin 100% biologically available through oral mucosa.
    Type: Grant
    Filed: May 7, 2018
    Date of Patent: May 17, 2022
    Inventors: Jan Stonis, Ivan Mikes, Andrea Dolezalova, Jarmila Kralova, Milan Jakubek, Pavel Martasek, Vladimir Kral
  • Pharmaceutical active-containing film delivery device for oral transmucosal administration
    Patent number: 11318107
    Abstract: A transmucosal delivery device comprises a polymer film comprising a polymer matrix, and a pharmaceutical composition disposed on a surface of the polymer film, the composition comprising at least one pharmaceutical active, a binding polymer, a surfactant, a solubilizing solvent, and an anti-crystallization agent, wherein a dry concentration of the pharmaceutical active is greater than 10 wt % and the composition has a pH in a range of about 4 to about 8. The delivery device exhibits a residence time in the mouth of a subject ranging from about 5 minutes to about 15 minutes and is substantially mucoadhesive to a mucosal surface when placed sublingually under the tongue or placed buccally at the inner lining of the cheek of the subject.
    Type: Grant
    Filed: August 21, 2020
    Date of Patent: May 3, 2022
    Assignee: Avior, Inc.
    Inventors: Niraj Vasisht, Karl D. Kelly
  • Abuse resistant forms of extended release oxymorphone, method of use and method of making
    Patent number: 11291634
    Abstract: An abuse resistant oral pharmaceutical composition, comprising: a barrier layer, comprising a first polymer; a diffusion layer, comprising a second polymer, substantially covering the barrier layer, wherein the diffusion layer is bonded to the barrier layer and comprises a drug that is substantially homogeneously distributed within the second polymer and diffuses from the diffusion layer within the gastrointestinal (GI) tract; and optionally an expansion layer comprising an expandable polymer, wherein the expansion layer is substantially covered by the barrier layer. Methods of making the same and methods of using the same are also provided.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: April 5, 2022
    Assignee: Ohemo Life Sciences, Inc.
    Inventors: Manish S. Shah, Ray J. DiFalco
  • Abuse resistant forms of immediate release oxymorphone, method of use and method of making
    Patent number: 11285112
    Abstract: An abuse resistant oral pharmaceutical composition, comprising: a barrier layer, comprising a first polymer; a diffusion layer, comprising a second polymer, substantially covering the barrier layer, wherein the diffusion layer is bonded to the barrier layer and comprises a drug that is substantially homogeneously distributed within the second polymer and diffuses from the diffusion layer within the gastrointestinal (GI) tract; and optionally an expansion layer comprising an expandable polymer, wherein the expansion layer is substantially covered by the barrier layer. Methods of making the same and methods of using the same are also provided.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: March 29, 2022
    Assignee: Oheno Life Sciences, Inc
    Inventors: Manish S. Shah, Ray J. DiFalco
  • Nitric oxide releasing suppositories and methods of use thereof
    Patent number: 11285171
    Abstract: The present invention relates generally to suppositories that release nitric oxide, and methods of using the same. According to some embodiments of the present invention provided herein is a nitric oxide (NO) releasing suppository (e.g., vaginal suppositories) are described herein. Some embodiments are directed to compositions, kits, and/or methods for treating and/or preventing an infection (e.g., a viral infection). In some embodiments, a method of treating and/or preventing a viral infection in a subject in need thereof is provided.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: March 29, 2022
    Assignee: Novan, Inc.
    Inventor: Hussaini Syed Sha Qhattal
  • Allografts containing viable cells and methods thereof
    Patent number: 11285177
    Abstract: Allograft biomaterials, implants made therefrom, methods of making the biomaterial and implants, methods of promoting cartilage, tissue, bone or wound healing in a mammal by administering the biomaterial or implant to the mammal, and kits that include such biomaterials, implants, or components thereof. For example, the allograft may include viable cells, for example, which were native to intervertebral discs and/or umbilical cords that the allograft was derived from.
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: March 29, 2022
    Assignee: Globus Medical, Inc.
    Inventors: David C. Paul, Archana Bhat, Breanna Seiber
  • Abuse resistant forms of extended release hydrocodone, method of use and method of making
    Patent number: 11278500
    Abstract: An abuse resistant oral pharmaceutical composition, comprising: a barrier layer, comprising a first polymer; a diffusion layer, comprising a second polymer, substantially covering the barrier layer, wherein the diffusion layer is bonded to the barrier layer and comprises a drug that is substantially homogeneously distributed within the second polymer and diffuses from the diffusion layer within the gastrointestinal (GI) tract; and optionally an expansion layer comprising an expandable polymer, wherein the expansion layer is substantially covered by the barrier layer. Methods of making the same and methods of using the same are also provided.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: March 22, 2022
    Assignee: OHEMO LIFE SCIENCES, INC.
    Inventors: Manish S. Shah, Ray J. DiFalco
  • Method and system for forming a dosage form within a packaging
    Patent number: 11278501
    Abstract: A method and system of forming a pharmaceutical dosage form within a portion of a blister packaging. The method includes the steps of providing a blister packaging for the dosage form with depressions. A predetermined amount of a drug-containing powder material comprising drug-containing particles is deposited into a substantially uniform powder layer within the depressions. A binding liquid is then deposited in a pattern on the powder layer within the depressions, to bind the particles of the powder layer and form an incremental wetted layer. Excess solvent in the binding material can be removed to form an incremental bound layer. These steps are repeated in sequence at least one or more times to form the pharmaceutical dosage form within the blister packaging.
    Type: Grant
    Filed: October 15, 2019
    Date of Patent: March 22, 2022
    Assignee: APRECIA PHARMACEUTICALS LLC
    Inventors: Lauren E. Beach-Herrera, Matthew F. Boldt, Thomas J. Bradbury, Henry Cabral, Kelly E. Caputo, William R. Gross, Munhee Lee, Mahendra R. Patel, Aleece M. Phillips, Timothy S. Tracy, Thomas G. West, Jaedeok Yoo
  • Methocarbamol composition and related methods
    Patent number: 11266621
    Abstract: Stable methocarbamol ready to use compositions for parenteral administration including parenteral infusion are provided. In certain embodiments, the compositions are sterile, isotonic, and particulate-matter-free. Further, the compositions reduce or avoid allergic reactions to latex, reduce or avoid extravasation, and permit administration of methocarbamol to subjects having renal pathology. Methods of manufacture and methods of administration are also provided.
    Type: Grant
    Filed: November 19, 2020
    Date of Patent: March 8, 2022
    Assignee: Exela Sterile Medicines LLC
    Inventors: Phanesh B. Koneru, John Maloney
  • Approaches for improving skin hydration and moisturization
    Patent number: 11260018
    Abstract: The present disclosure generally relates to approaches for improving water absorption and retention by the skin's surface. In particular, the disclosure provides compositions and methods for preparing mixtures comprised of ethoxylated oils and water or mixtures comprised of micro or nano emulsions and water, which provide enhanced skin hydration or moisturization to a subject.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: March 1, 2022
    Assignee: JRX BIOTECHNOLOGY, INC.
    Inventors: Frederick L. Jordan, Chris Jordan
  • Pharmaceutical compositions and dosage forms
    Patent number: 11253515
    Abstract: Disclosed herein are pharmaceutical compositions and dosage forms including N-[5-(3,5-difluorobenzyl)-1H-indazol-3-yl]-4-(4-methyl-piperazin-1-yl)-2-(tetrahydro-2H-pyran-4-ylamino) benzamide that are useful in the treatment of subjects having cancer. The present disclosure also provides methods for preparing these pharmaceutical compositions and dosage forms, and methods of treating subjects having cancer utilizing the pharmaceutical compositions and dosage forms provided herein.
    Type: Grant
    Filed: January 17, 2020
    Date of Patent: February 22, 2022
    Assignee: Ignyta, Inc.
    Inventors: Daniel Codallos, Jr., Robert Orr, Ching-Yuan Li, Valerie Denise Start
  • Rectal mucosal administration preparation of saponin B4 and preparation method therefor
    Patent number: 11253471
    Abstract: A rectal mucosal administration preparation of Pulsatilla chinensis (Bge.) Regel saponin B4 contains Pulsatilla chinensis (Bge.) Regel saponin B4 and a pharmaceutically acceptable substrate. The drug preparation is a rectal gel or a rectal suppository. Compared with oral administration, the rectal mucosal administration preparation of Pulsatilla chinensis (Bge.) Regel saponin B4 has a lower effective dose, and has a better medicinal effect at the same dose.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: February 22, 2022
    Inventor: Qi Liu
  • Pharmaceutical composition to treat health conditions associated with elevated glucose levels
    Patent number: 11246855
    Abstract: A threefold decrease in ?-amylase inhibition, increase in insulin secretion and glucose uptake increase by the pharmaceutical composition of several naturally occurring substances and vitamins were observed when compared to the control cells, and a c.a. 1-1.5 fold decrease when compared to the positive control. More specifically Mix A and Mix B applied together with VitaminD+K2 shows significant effect on increased insulin secretion and glucose uptake by cells.
    Type: Grant
    Filed: July 16, 2021
    Date of Patent: February 15, 2022
    Inventor: Matthias W Rath
  • Polymer nanofiber scaffolds and uses thereof
    Patent number: 11246956
    Abstract: A polymer nanofiber scaffold includes a plurality of melt extruded nanofibers that are chemically modified to append surface functionality to the nanofibers.
    Type: Grant
    Filed: March 16, 2020
    Date of Patent: February 15, 2022
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventor: Jonathan Pokorski
  • Solid solution compositions and use in severe pain
    Patent number: 11224659
    Abstract: The present specification discloses solid solution pharmaceutical compositions comprising therapeutic compound comprising a phytocannabinoid, an endocannabinoid, a synthetic cannabinoid, or a combination thereof, one or more pharmaceutically-acceptable hard fats in an amount of at least 30% by weight of the pharmaceutical composition, and one or more pharmaceutically-acceptable liquid lipids in an amount of less than 45% by weight of the pharmaceutical composition, methods of preparing such pharmaceutical compositions, and methods and uses of treating a chronic inflammation and/or an inflammatory disease in an individual using such pharmaceutical compositions.
    Type: Grant
    Filed: May 25, 2020
    Date of Patent: January 18, 2022
    Assignee: Infirst Healthcare Limited
    Inventors: Robin M. Bannister, John Brew, Richard R. Reiley, III, Wilson Caparros Wanderley
  • Ophthalmic drug sustained release device
    Patent number: 11219598
    Abstract: An object of the present invention is to provide a sustained drug release system useful for treating eye diseases. There is provided a device for sustained release of an ophthalmic drug, comprising a drug enclosing part and an intraocular retention gas enclosing part adjacent to the drug enclosing part, the enclosing parts being provided in a hollow container having at least one opening part, wherein the drug enclosing part is isolated from the opening part by the intervention of the intraocular retention gas enclosing part.
    Type: Grant
    Filed: April 19, 2017
    Date of Patent: January 11, 2022
    Assignee: PUBLIC UNIVERSITY CORPORATION NAGOYA CITY UNIVERSITY
    Inventor: Tsutomu Yasukawa
  • Self-restorable core-shell capsule
    Patent number: 11202741
    Abstract: The present invention relates to a core-shell capsule comprising: a core comprising an oil, a solvent satisfying relational expression 1 below, and a water-insoluble polymer compound dissolved in the solvent; and a water-insoluble polymer shell enclosing the core. 0.01?CA/CB?100??[Relational expression 1] (in relational expression 1, CA/CB is the distribution coefficient of solvent, and when the solvent is dissolved in oil and water to reach equilibrium, CA is the concentration of the solvent dissolved in the oil and CB is the concentration of the solvent dissolved in water).
    Type: Grant
    Filed: September 26, 2016
    Date of Patent: December 21, 2021
    Assignee: AMOREPACIFIC CORPORATION
    Inventors: Ji Sik Shin, Young Suk Cho, Seung Han Park, Byung Geun Chae
  • Patch
    Patent number: 11202764
    Abstract: A patch comprises a backing layer and an adhesive layer, wherein the adhesive layer contains at least one selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof, and contains a rubber-based adhesive base and a silicone-based adhesive base, and a mass ratio of the rubber-based adhesive base to the silicone-based adhesive base (the mass of the rubber-based adhesive base:the mass of silicone-based adhesive base) in the adhesive layer is 9.5:0.5 to 1.9:8.1.
    Type: Grant
    Filed: April 19, 2018
    Date of Patent: December 21, 2021
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Kazuya Kominami, Takito Shima, Naoyuki Uchida, Naoko Fujita, Shigeo Suzuki, Terumitsu Kaiho
  • Solid solution compositions and use in cardiovascular disease
    Patent number: 11202831
    Abstract: The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a chronic inflammation and/or an inflammatory disease in an individual using such pharmaceutical compositions.
    Type: Grant
    Filed: May 25, 2020
    Date of Patent: December 21, 2021
    Assignee: Infirst Healthcare Limited
    Inventors: Robin M. Bannister, John Brew, Richard R. Reiley, III, Wilson Caparros Wanderley