Patents Examined by Ethel G. Love
  • Patent number: 4673563
    Abstract: A method of diagnosing and treating arrhythmias caused by re-entry in the A-V node by administering to a human or animal an effective amount of adenosine that restores normal sinus rhythm.
    Type: Grant
    Filed: April 8, 1985
    Date of Patent: June 16, 1987
    Assignee: The University of Virginia Alumni Patents Foundation
    Inventors: Robert M. Berne, Luiz Belardinelli, Rafael Rubio
  • Patent number: 4673670
    Abstract: N.sup.6 -Acenaphthyl adenosines and analogs thereof and pharmaceutically acceptable acid addition salts having highly desirable blood pressure lowering properties, processes for their manufacture and pharmaceutical compositions and methods for using said compounds and compositions are described.
    Type: Grant
    Filed: April 30, 1986
    Date of Patent: June 16, 1987
    Assignee: Warner-Lambert Company
    Inventors: Harriet W. Hamilton, William C. Patt, Bharat K. Trivedi
  • Patent number: 4654073
    Abstract: Cyclohexane-1,3-dione derivatives of the formula ##STR1## where A is tetrahydropyran-4-yl, 3-methyltetrahydropyran-4-yl, 1,4-dioxanyl, 5,5-dimethyl-1,3-dioxan-2-yl, 2,5-dimethyl-1,4-dioxan-3-yl, 2,6-dimethyl-1,4-dioxan-3-yl, 2-methyl-1,3-dithiolan-2-yl, 2,6-dimethyltetrahydrothiopyran-3-yl, 2-methyl-1,3-dithian-2-yl or unsubstituted or substituted 1,3-dioxepan-5-yl, R.sup.1 is hydrogen or methoxycarbonyl, R.sup.2 is alkyl and R.sup.3 is alkyl, alkenyl, haloalkenyl or propargyl, are used for controlling undesirable plant growth of grass species, especially in broadleaved crops and monocotyledon crops which do not belong to the grass family.
    Type: Grant
    Filed: October 31, 1984
    Date of Patent: March 31, 1987
    Assignee: Basf Aktiengesellschaft
    Inventors: Dieter Jahn, Rainer Becker, Michael Keil, Winfried Richarz, Hardo Siegel, Wolfgang Spiegler, Bruno Wuerzer
  • Patent number: 4648895
    Abstract: The invention relates to oxime ethers of the formula I ##STR1## wherein n is 1 or 2, each of R.sub.1 and R.sub.2 is hydrogen or C.sub.1 -C.sub.4 alkyl each of R.sub.3 and R.sub.4 is hydrogen, halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 haloalkylthio, C.sub.1 -C.sub.4 alkylsulfinyl, C.sub.1 -C.sub.4 alkylsulfonyl, C.sub.1 -C.sub.4 haloalkylsulfinyl, C.sub.1 -C.sub.4 haloalkylsulfonyl or nitro; each of R.sub.5 and R.sub.6 independently of the other is hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, phenyl or phenyl which is substituted by halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 haloalkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulfinyl, C.sub.1 -C.sub.4 alkylsulfonyl, carboxyl, carbamoyl, C.sub. 1 -C.sub.4 alkylcarbamoyl, nitro or cyano, or R.sub.5 and R.sub.
    Type: Grant
    Filed: February 8, 1985
    Date of Patent: March 10, 1987
    Assignee: Ciba-Geigy Corporation
    Inventors: Henry Martin, Urs Fricker
  • Patent number: 4644071
    Abstract: This invention relates to substituted aralkoxy and aryloxyalkoxy kojic acid derivatives, which are useful as leukotriene D.sub.4 (LTD.sub.4) inhibitors and therefore useful in the treatment of allergies, inflammatory conditions, and coronary vasoconstriction.
    Type: Grant
    Filed: July 11, 1984
    Date of Patent: February 17, 1987
    Assignee: G. D. Searle & Co.
    Inventors: Miyano Masateru, Robert L. Shone
  • Patent number: 4639437
    Abstract: The present invention relates to a device or kit and a method for the inhalation administration of gangliosides and inner ester ganglioside derivatives useful for the treatment of various nervous disorders, such as those resulting from accidents or diseases which have damaged the nervous tissue.
    Type: Grant
    Filed: April 12, 1984
    Date of Patent: January 27, 1987
    Assignee: Fidia, S.p.A.
    Inventors: Francesco della Valle, Aurelio Romeo
  • Patent number: 4638094
    Abstract: A phenylacetone or its derivative having the general formula (I): ##STR1## wherein X, Y, and Z are independently a hydrogen atom, a hydroxyl group, a halogen atom, a nitro group, an amino group, a lower alkyl group having 1 to 6 carbon atoms, a lower alkoxy group having 1 to 6 carbon atoms, or a benzyloxy group and any two substituents of X, Y, and Z may form, together with the benzene ring, a heterocycling ring having 5 to 7 members including 1 or 2 oxygen atoms is produced at a high yield and a high selectivity by reacting a 3-phenylpropylene or its derivative having the general formula (II): ##STR2## wherein X, Y, and Z are as defined above, with an alkyl nitrite having the general formula (III):RONO (III)wherein R is an aliphatic, aromatic, or alicyclic saturated or unsaturated hydrocarbon group in the presence of (a) water, (b) an alcohol, (c) a palladium catalyst, and (d) an optional amine or copper compound, or by reacting the above-mentioned 3-phenylpropylene or its derivative with the above-mentioned
    Type: Grant
    Filed: July 29, 1983
    Date of Patent: January 20, 1987
    Assignee: Ube Industries, Ltd.
    Inventors: Mamoru Nakai, Takuji Enomiya
  • Patent number: 4636493
    Abstract: Benzothien-3-yl adenosine; benzothien-3-yl adenosine, S-oxide; and benzothien-3-yl adenosine, S,S-dioxide compounds or pharmaceutically acceptable acid addition salts having highly desirable central nervous system and antihypertensive properties, processes for their manufacture and pharmaceutical compositions and methods for using said compounds and compositions are described.
    Type: Grant
    Filed: April 18, 1986
    Date of Patent: January 13, 1987
    Assignee: Warner-Lambert Company
    Inventor: William Patt
  • Patent number: 4636569
    Abstract: Compounds with a flavanone skeleton having the formula I ##STR1## in which R.sub.1 and R.sub.2, which may be the same or different, represent hydrogen, hydroxyl, methoxyl, thiomethyl, amino or substituted amino, are endowed with expectorant, mucolytic, mucopoietic, choleretic and hypolipaemia-producing activity.
    Type: Grant
    Filed: March 6, 1984
    Date of Patent: January 13, 1987
    Assignee: Inverni Della Beffa S.p.A.
    Inventors: Ezio Bombardelli, Bruno Gabetta, Maria J. Magistretti
  • Patent number: 4631292
    Abstract: A series of new 1,3-dioxane derivatives are disclosed. These compounds have an outstanding anti-peptic ulcerative activity and are useful as novel anti-peptic ulcer agents. Such compounds are synthesized by reacting a 1,3-butanediol derivative with suitable ketone.
    Type: Grant
    Filed: July 31, 1984
    Date of Patent: December 23, 1986
    Assignee: Kotobuki Seiyaku Co., Ltd.
    Inventors: Tsuyoshi Tomiyama, Akira Tomiyama
  • Patent number: 4628108
    Abstract: It has been surprisingly discovered in accordance with the present invention that when 1,3-dioxolane is reacted with formaldehyde in the presence of an organic peroxide and an ionizable, at least sparingly soluble metal salt, the reaction preferentially involves an addition of the formaldehyde to the 2-methylene group of the 1,3-dioxolane with only minor reaction with the 4-methylene and 5-methylene groups of the 1,3-dioxolane whereby the reaction product that is formed contains significant quantities of 2-hydroxyalkyl-1,3-dioxolanes. 2-Hydroxyalkyl-1,3-dioxolanes are hydrolyzed with comparative ease to ethylene glycol and the corresponding glycol aldehyde (CHO--CH.sub.2 --OH). The glycol aldehyde in turn can be catalytically hydrogenated to form additional quantities of ethylene glycol.
    Type: Grant
    Filed: December 19, 1984
    Date of Patent: December 9, 1986
    Assignee: Texaco Inc.
    Inventors: John R. Sanderson, Ernest L. Yeakey
  • Patent number: 4626526
    Abstract: (S)-N.sup.6 -2-Hydroxypropyladenosines and pharmaceutically acceptable acid addition salts having highly desirable antihypertensive properties, processes for their manufacture and pharmaceutical compositions and methods for using said compounds and compositions are described.
    Type: Grant
    Filed: October 26, 1984
    Date of Patent: December 2, 1986
    Assignee: Warner-Lambert Company
    Inventor: James A. Bristol
  • Patent number: 4625020
    Abstract: Process for producing 1-halo-2-deoxy-2-fluoroarabinofuranoside derivatives bearing protective ester groups from 1,3,5-tri-O-acylribofuranose; the 1-halo compounds are intermediates in the synthesis of therapeutically active nucleosidic compounds.
    Type: Grant
    Filed: November 18, 1983
    Date of Patent: November 25, 1986
    Assignee: Bristol-Myers Company
    Inventors: Steven P. Brundidge, Henry G. Howell, Chester Sapino, Jr., Chon-Hong Tann
  • Patent number: 4623723
    Abstract: Crude nucleic acid solutions can be selectively separated using a membrane separating process, it being possible for the high molecular weight DNA to be isolated from the retentate and the low molecular weight RNA to be isolated from the permeate. Ultrafiltration on hollow fiber membranes is preferred.
    Type: Grant
    Filed: March 9, 1984
    Date of Patent: November 18, 1986
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Reinhold Keller, Merten Schlingmann
  • Patent number: 4623641
    Abstract: A new method is disclosed for the treatment and prevention of gastrointestinal ulcers or erosions which comprises the administration of a pharmaceutically effective amount of a PGI.sub.2 methyl ester-beta cyclodextrin complex to a patient in need of said treatment wherein the amount of the PGI.sub.2 methyl ester constitutes 1 to 15% by weight of the complex.
    Type: Grant
    Filed: September 9, 1985
    Date of Patent: November 18, 1986
    Assignee: Chinoin Gyogyszer es Vegyeszeti Termekek Gyara R.T.
    Inventors: Jozsef Szejtli, Magdolna Szejtli nee Rengei, Gyorgy Cseh, Istvan Stadler
  • Patent number: 4622392
    Abstract: This invention relates to cytotoxic compounds. More particularly, this invention relates to conjugates of antitumor agents, and thiophospholipids exhibiting enhanced antitumor activity to methods for producing such compounds and to pharmaceutical compositions containing cytotoxically effective amounts of such compounds as a primary effective ingredient.
    Type: Grant
    Filed: June 21, 1984
    Date of Patent: November 11, 1986
    Assignee: Health Research Inc. (Roswell Park Division)
    Inventors: Chung I. Hong, Charles R. West
  • Patent number: 4619943
    Abstract: Novel phenylpropanoid neolignans isolated from Saururus cernuus L and synthetic or semi-synthetic analogs thereof having neuroleptic, insecticidal, or nematicidal activity are disclosed.
    Type: Grant
    Filed: September 10, 1984
    Date of Patent: October 28, 1986
    Inventor: Koppaka V. Rao
  • Patent number: 4620014
    Abstract: Novel 2-furylbutyrolactones are directly formed by reaction of 2,5-dialkoxy-2,5-dihydrofurans and 2,3-dihydroxybutenolides in aqueous media and recovering crystalline product from an anhydrous medium. These novel compounds and compositions containing same may be used for lymophocyte stimulation.
    Type: Grant
    Filed: September 29, 1983
    Date of Patent: October 28, 1986
    Assignee: National Foundation for Cancer Research
    Inventors: Albert Szent-Gyorgyi, Gabor B. Fodor
  • Patent number: 4620018
    Abstract: Compounds of the formula ##STR1## and a process for their preparation by reacting the corresponding dioxo compound with at least 2 moles of phosphorus pentachloride.
    Type: Grant
    Filed: June 26, 1985
    Date of Patent: October 28, 1986
    Assignee: Bayer Aktiengesellschaft
    Inventors: Albrecht Marhold, Erich Klauke
  • Patent number: 4616003
    Abstract: N.sup.6 -Dihydroxypropyladenosines and pharmaceutically acceptable acid addition salts having highly desirable central nervous system properties, processes for their manufacture and pharmaceutical compositions and methods for using said compounds and compositions are described.
    Type: Grant
    Filed: September 5, 1985
    Date of Patent: October 7, 1986
    Assignee: Warner-Lambert Company
    Inventors: Harriet W. Hamilton, William C. Patt