Patents Examined by Ethel G. Love
  • Patent number: 4577012
    Abstract: The industrially favored separation of nucleotides and nucleosides from a solution containing both of them can be conducted by contacting said solution, after adjusted to a pH of not higher than 7, with activated carbon to adsorb the nucleosides and nucleotides and then eluting the nucleotides with an aqueous solution of an alkali metal hydroxide.
    Type: Grant
    Filed: December 2, 1983
    Date of Patent: March 18, 1986
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Masaaki Tsurushima, Gozi Kokubu, Koji Moriya
  • Patent number: 4576960
    Abstract: This invention relates to 6,11-dihydro-11-oxo-dibenz[b, e]oxepin derivatives of the formula ##STR1## where Y is hydrogen, alkyl, alkoxy, halogen and trifluoromethyl, n is 0, 1, 2 or 3; R.sub.9 is hydrogen and alkyl; R is ##STR2## where Hal is a halogen; ##STR3## where R.sub.10 is hydrogen, alkyl and benzyl of the formula ##STR4## where Z is hydrogen, alkyl, alkoxy, halogen, trifluoromethyl, nitro, and amino; where n is 0, 1, 2 or 3; p is 1 or 2; q is 0, 1 or 2; R.sub.1 to R.sub.7 are the same or different and are hydrogen and alkyl; and R.sub.8 is hydrogen, alkyl and phenyl; and R.sub.9 is hydrogen and alkyl, and where appropriate pharmaceutically acceptable acid or base addition salts thereof.
    Type: Grant
    Filed: April 4, 1983
    Date of Patent: March 18, 1986
    Assignee: Hoechst Roussel Pharmaceuticals Incorporated
    Inventors: Lawrence L. Martin, Linda L. Setescak
  • Patent number: 4575558
    Abstract: Described is a process for preparing 2,2'-disubstituted-1,3-dioxolane-4-methanol compounds having the formula ##STR1## wherein R.sub.1 and R.sub.2 are each independently hydrogen, alkyl, cycloalkyl or R.sub.1 and R.sub.2 together with the carbon atom form a 3 to 6 member cycloalkyl group, or aryl, the process comprising: reacting D- or L-serine with a nitrosating agent in an aqueous solution in the presence of formic acid, acetic acid, or propanoic acid to prepare 2,3-dihydroxypropanoic acid (D- or L-glyceric acid), the aqueous solution comprising from about 0.1 to 0.5 liter of water per mole of the serine starting material; reacting the glyceric acid so formed with 2,2-dimethoxypropane in the presence of a loweralkyl alcohol to prepare the D- or L-glyceric acid alkyl ester which is reacted with a selected aldehyde or ketone or the acetal or ketal derivative to prepare the corresponding 1,3-dioxolane derivative.
    Type: Grant
    Filed: February 15, 1984
    Date of Patent: March 11, 1986
    Assignee: American Hospital Supply Corporation
    Inventors: Khuong H. X. Mai, Ghanshyam Patil
  • Patent number: 4574158
    Abstract: Trioxane and other acetals are purified by contact with an alkali metal hydroxide and phase transfer catalyst followed by isolation in a purified form. This reaction provides acetals sufficiently pure for polymerization to high molecular weight.
    Type: Grant
    Filed: November 1, 1982
    Date of Patent: March 4, 1986
    Assignee: Conoco Inc.
    Inventor: Jeff T. Fenton
  • Patent number: 4570007
    Abstract: 2-Amino-1-(1,3-dioxolan-4-yl)ethanol compounds of formula (I) ##STR1## wherein R.sup.1 and R.sup.2 are identical or different and can be hydrogen or a lower alkyl group of 1-4 carbon atoms; or when R.sup.2 is an alkyl group of 1-4 carbon atoms, R.sup.1 can also be an alkoxy group of 1-4 carbon atoms; or R.sup.1 and R.sup.2 combined form an alkylene residue of 5 or 6 carbon atoms,are especially suited as intermediates in the production of opacifying compounds useful in X-ray contrast media.
    Type: Grant
    Filed: April 11, 1985
    Date of Patent: February 11, 1986
    Assignee: Shering Aktiengesellschaft
    Inventors: Ulrich Niedballa, Heinz Gries
  • Patent number: 4568686
    Abstract: The invention provides compounds of the formula: ##STR1## wherein each of R.sub.1, R.sub.2 and R.sub.3, which can be the same or different, is hydrogen, chloro, bromo, fluoro, methyl, ethyl, methoxy, amino, hydroxy or nitro; R.sub.4 is hydrogen or alkyl of 1 to 7 carbons atoms; X is ##STR2## (R.sub.5 is hydrogen or hydroxy) and n is 1-4; and their non-toxic pharmaceutically acceptable acid additions salts. These compounds exhibit valuable pharmacological activity and are useful in the treatment of mammals, especially as anti-hypertensive agents. Furthermore, some of the compounds have proved to possess diuretic, .beta.-blocking activity and/or antithrombotic activity. The compounds may be made by a variety of methods and may be incorporated in pharmaceutical compositions also comprising a compatible pharmaceutically acceptable carrier.
    Type: Grant
    Filed: February 11, 1981
    Date of Patent: February 4, 1986
    Assignee: Farmos Yhtyma Oy
    Inventors: Arto J. Karjalainen, Kauko O. A. Kurkela
  • Patent number: 4567197
    Abstract: The invention concerns novel 4-phenyl-1,3-dioxan-5-ylalkenoic acid derivatives of the formula I having cis relative stereochemistry at positions 4 and 5 of the dioxane ring and wherein Ra and Rb are variously hydrogen, alkyl, halogenoalkyl, alkenyl, and optionally substituted aryl or arylalkyl, Rc is hydroxy, alkoxy or alkanesulphonamido, n is 1 or 2, A is ethylene or vinylene, Y is (2-5C)polymethylene optionally substituted by alkyl, and benzene ring B is optionally substituted phenyl, or, when Rc is hydroxy, a salt thereof. The acid derivatives antagonize one or more of the actions of thromboxane A.sub.2 (TXA.sub.2) and are expected to be of value in those disease conditions in which TXA.sub.2 is involved. The invention also provides pharmaceutical compositions containing an acid derivative of formula I, and processes for their chemical production.
    Type: Grant
    Filed: May 6, 1983
    Date of Patent: January 28, 1986
    Assignee: Imperial Chemical Industries PLC
    Inventors: Andrew G. Brewster, Peter W. R. Caulkett
  • Patent number: 4567302
    Abstract: Quaternary ammonium salts exhibiting strong antimicrobial activity are disclosed along with the method of using them as antimicrobial agents. The salts having the formulas I or II: ##STR1## wherein R is C.sub.1-20 alkyl, C.sub.5-7 cycloalkyl or an aralkyl group, R.sup.
    Type: Grant
    Filed: July 20, 1984
    Date of Patent: January 28, 1986
    Inventor: Kallidaikurichi N. Sivaramakrishnan
  • Patent number: 4567282
    Abstract: A method of producing (S)-glyceraldehyde acetonide, which comprises reacting 3,4-O-isopropylidene-L-threonic acid or a salt thereof with hypochlorite ion or hypochlorous acid under an acid condition. Also a method of producing (S)-glyceraldehyde acetonide, which comprises reacting 5,6-O-isopropylidene-L-ascorbic acid or a salt thereof with an oxidizing agent to produce 3,4-O-isopropylidene-L-threonic acid or a salt thereof and then reacting the 3,4-O-isopropylidene-L-threonic acid or a salt thereof with hypochlorite ion or hypochlorous acid under an acid condition.
    Type: Grant
    Filed: October 26, 1984
    Date of Patent: January 28, 1986
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Yukio Mizuno, Keiichi Sugimoto
  • Patent number: 4567254
    Abstract: A method for preparing an N.sup.6,8-disubstituted 3',5'-cyclic adenosine monophosphate or a salt thereof represented by the general formula ##STR1## wherein X denotes a halogen atom or ##STR2## N.sub.3, OH or OR, R being an alkyl or aralkyl group; A.sup..sym. denotes a hydrogen ion, alkali metal ion, ammonium ion or organic ammonium ion; and R.sub.1 denotes an alkyl or aromatic group, which method comprises reacting an 8-substituted 3',5'-cyclic adenosine monophosphate or a salt thereof represented by the general formula (II) ##STR3## wherein X and A.sup.61 are as defined above, with an aldehyde represented by the general formulaR.sub.1 --CHO (III)wherein R.sub.1 is as defined above, to form an imine compound represented by the general formula ##STR4## wherein X, R.sub.1 and A.sup..sym. are as defined above, as an intermediate, and then reducing the imine compound.
    Type: Grant
    Filed: September 19, 1984
    Date of Patent: January 28, 1986
    Assignee: Kikkoman Corporation
    Inventors: Shigehiro Kataoka, Takashi Nakamura, Nobuyuki Yamaji, Seiichi Nasuno
  • Patent number: 4565882
    Abstract: The invention relates to substituted dihydrobenzopyrans carboxylates of the formula: ##STR1## wherein A is a methylene chain having 1-10 carbon atoms, inclusive, optionally substituted by hydroxy;wherein V is:(a) hydrogen;(b) hydroxy;(c) .dbd.O; or(d) R.sub.6 CH.sub.2 O--;wherein R.sub.1 is:(a) --COCH.sub.3 ;(b) --CHOHCH.sub.3 ;(c) --C.sub.2 H.sub.5 ;(d) -hydrogen; or(e) --COOC.sub.2 H.sub.5wherein R.sub.2 is:(a) -hydrogen;(b) -hydroxy; or(c) R.sub.12 CH.sub.2 CO.sub.2 --;wherein R.sub.3, R.sub.4, R.sub.6, R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11 and R.sub.12 each of which may be the same or different, are:(a) hydrogen;(b) lower-alkyl having 1-6 carbon atoms inclusive; or(c) allyl;wherein R.sub.5 is:(a) hydrogen; or(b) R.sub.7 CH.sub.2 C(O)--;wherein R.sub.13 is hydrogen, hydroxy, alkoxy of 1 to 6 carbon atoms inclusive, or --OM wherein M is an alkali metal, alkyl of 1 to 6 carbon atoms, inclusive, or NR.sub.8.sup..sym. R.sub.9 R.sub.10 R.sub.11, or HNR.sub.8.sup..sym. R.sub.9 R.sub.
    Type: Grant
    Filed: January 6, 1984
    Date of Patent: January 21, 1986
    Assignee: G. D. Searle & Co.
    Inventors: Masateru Miyano, Robert L. Shone
  • Patent number: 4565881
    Abstract: Liquid crystal substituted 1,3-dioxanes and mixtures containing the same.The invention relates to liquid crystal substituted 1,3-dioxanes and substances containing the same, for electro-optical arrays for the modulation of incident or transmitted light as well as for the reproduction of figures, symbols and images.The object of the invention is nematic liquid-crystal substances with favorable properties with respect to melting and clear points, stability toward thermal stress, effect of light, chemicals and electric fields as well as loss of color and processes for their production.The object is accomplished by the creation of new nematic liquid-crystal substances.According to the invention, liquid crystal 2,5-disubstituted derivatives of 1,3-dioxane of the general formula ##STR1## are proposed, wherein ##STR2## The new substances may be used in mixtures containing at least one of the substances according to the invention.
    Type: Grant
    Filed: August 6, 1982
    Date of Patent: January 21, 1986
    Assignee: Veb Werk fur Fernsehdektronik im Veb Kombinat Mikroelektronik
    Inventors: Dietrich Demus, Horst Zaschke, Hans-Matthias Vorbrodt, Horst Kresse, Wolfgang Weissflog
  • Patent number: 4564629
    Abstract: N-Acylated N-phenyl-aminotetrahydro-2-furanones of the formula ##STR1## wherein R represents C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy or halogen,R.sub.1 represents C.sub.1 -C.sub.3 -alkyl, C.sub.1 -C.sub.4 -alkoxy or halogen,R.sub.2 represents hydrogen, C.sub.1 -C.sub.3 -alkyl, C.sub.1 -C.sub.4 -alkoxy or halogen,R.sub.3 represents hydrogen or methyl, with the total number of C atoms of the substituents R, R.sub.1, R.sub.2 and R.sub.3 in the phenyl ring not exceeding the number 8,R.sub.4 represents hydrogen or methyl, whileR.sub.5 represents one of the following groups: an alkylthioalkyl or alkoxyalkyl group having 2 to 5 carbon atoms or an alkoxyalkoxymethyl group having a maximum of 6 carbon atoms, a 2-furanyl or 2-tetrahydrofuranyl group optionally substituted by halogen, a 1,2,4-triazolylmethyl group, a 1,2-pyrazolylmethyl group, or a group --CH.sub.2 --OR.sub.6 in which R.sub.6 represents a 5- or 6-membered heterocycle having oxygen as the hetero atom.are valuable fungicidal active substances.
    Type: Grant
    Filed: August 22, 1980
    Date of Patent: January 14, 1986
    Assignee: Ciba-Geigy Corporation
    Inventors: Walter Kunz, Wolfgang Eckhardt, Adolf Hubele
  • Patent number: 4564686
    Abstract: A phosphoric acid diester of the formula: ##STR1## or its salt is produced by reacting .alpha.-tocopherol with a halogenophosphorylating agent and reacting the resulted product with ascorbic acid having protected hydroxy groups in the 5- and 6-positions followed by removing the protected groups. The compound can be employed as prophylactic and therapeutic agents for cataracts and climacteric hazards and also as an ingredient for cosmetics having skin-beautifying action.
    Type: Grant
    Filed: May 30, 1984
    Date of Patent: January 14, 1986
    Assignee: Senju Pharmaceutical Co., Ltd.
    Inventor: Kazumi Ogata
  • Patent number: 4563536
    Abstract: A method for synthesizing trioxane by heating and reacting an aqueous formaldehyde solution in the presence of a heteropolyacid. As the heteropolyacid, there is preferably used one that contains, as a coordinating element or coordinating elements, W, Mo, V or Nb alone or two or more of them.
    Type: Grant
    Filed: September 27, 1982
    Date of Patent: January 7, 1986
    Assignee: Asahi Kasei Kogyo Kabushiki Kaisha
    Inventors: Koichi Yoshida, Toshiyuki Iwaisako, Junzo Masamoto, Katsuhiko Hamanaka, Hajime Komaki
  • Patent number: 4563188
    Abstract: New para-phenylenediamines suitable for use in the oxidative dyeing of hair are described which provide useful "background" green shades. These compounds have the formula: ##STR1## in which n is an integer from 2 to 6 and R denotes an unsubstituted or mono- or poly-hydroxy substituted linear or branched alkylene group containing up to 6 carbon atoms, which alkylene group can optionally contain one or more ether groups.
    Type: Grant
    Filed: April 5, 1979
    Date of Patent: January 7, 1986
    Assignee: L'Oreal
    Inventors: Andree Bugaut, Patrick Andrillon
  • Patent number: 4561882
    Abstract: This invention relates to 3-alkoxy-4-substituted-phenoxy-2,3-unsaturated acid esters, derivatives thereof, and the use of said acid esters and derivatives for the control of weeds.
    Type: Grant
    Filed: April 20, 1983
    Date of Patent: December 31, 1985
    Assignee: Zoecon Corporation
    Inventor: Shy-Fuh Lee
  • Patent number: 4561876
    Abstract: Herbicide antidote compounds having the formula: ##STR1## in which R is haloalkyl wherein halo is chlorine, bromine or iodine and the alkyl group has 1-4 carbon atoms, inclusive;R.sub.1 is selected from the group consisting of hydrogen; lower alkyl having 1-4 carbon atoms, inclusive; alkenyl having 2-4 carbon atoms, inclusive; and phenyl;R.sub.2 is selected from the group consisting of hydrogen and lower alkyl having 1-4 carbon atoms, inclusive;R.sub.3 is selected from the group consisting of hydrogen and lower alkyl having 1-4 carbon atoms, inclusive;R.sub.4 is selected from the group consisting of hydrogen and a nitro group; andeither R.sub.3 is hydrogen or R.sub.4 is hydrogen.
    Type: Grant
    Filed: June 16, 1981
    Date of Patent: December 31, 1985
    Assignee: Stauffer Chemical Co.
    Inventor: Francis H. Walker
  • Patent number: 4562265
    Abstract: A method is provided for producing a di-acetal of sorbitol and an aromatic aldehyde wherein an aqueous solution containing a catalytic amount of a mineral acid and sorbitol is formed. Thereafter, an effective amount of an aromatic aldehyde such as benzaldehyde is incrementally admixed into the homogeneous aqueous admixture containing the sorbitol at a rate sufficient to allow a substantially spontaneous reaction to occur between the D-sorbitol and aromatic aldehyde; thus, forming an aqueous slurry containing crude di-acetal, e.g., dibenzylidene sorbitol. The amount of aromatic aldehyde employed is that amount sufficient to provide a molar ratio of D-sorbitol to aromatic aldehyde of from about 1:0.75 to about 1:1.75. Thereafter, the aqueous slurry is neutralized, and crude di-acetal is removed from the liquid phase and washed with water to remove mono-acetal impurities, e.g., monobenzylidene sorbitol.
    Type: Grant
    Filed: March 28, 1980
    Date of Patent: December 31, 1985
    Assignee: Milliken Research Corporation
    Inventor: Greville Machell
  • Patent number: 4560777
    Abstract: Process for preparing esters of 2-(6'-methoxy-2'-naphtyl)-propionic acid via rearrangement of new ketals of 2-halo-1-(6'-methoxy-2'-naphtyl)-propan-1-one in the presence of a Lewis acid.The esters thus obtained are useful as intermediate products for preparing Naproxen.The process involves the preparation of the following new compounds:ketals of 2-halo-1-(6'-methoxy-2'-naphtyl)-propan-1-oneesters of 2-(5'-bromo-6'-methoxy-2'-naphtyl)-propionic acid1-(5'-bromo-6'-methoxy-2'-naphtyl)-propan-1-one2-halo-(5'-bromo-6'-methoxy-2'-naphtyl)-propan-1-one.
    Type: Grant
    Filed: August 4, 1983
    Date of Patent: December 24, 1985
    Assignee: Blaschim S.p.A.
    Inventors: Claudio Giordano, Aldo Belli, Fulvio Uggeri, Giovanni Villa