Abstract: The invention is concerned with novel dithioketal derivatives of 1-(2-aryl-2-oxoethyl)-1H-imidazoles and sulfones and sulfoxides derived therefrom, said compounds being useful as antimicrobial agents.
Type:
Grant
Filed:
September 28, 1984
Date of Patent:
June 18, 1985
Assignee:
Janssen Pharmaceutica N.V.
Inventors:
Jan Heeres, Leo J. J. Backx, Joseph H. Mostmans
Abstract: A process for direct fluorination of etherified or unetherified hydroxy group-bearing aromatic compounds, which comprises reacting an etherified or unetherified hydroxy group-bearing aromatic compound with fluorine gas to give the corresponding etherified or unetherified hydroxy group and at least one fluorine atom-bearing aromatic compound.
Abstract: The invention relates to watersoluble derivatives of non-steroidal anti-inflammatory drugs and also to therapeutic compositions containing these derivatives.
Abstract: Novel malondialdehyde tetraalkylacetals and the preparation of malondialdehyde tetraalkylacetals by reacting alkyl formates, oxiranes and alkyl vinyl ethers in the presence of a halide of boron, antimony(V), iron(III), tin(II or IV) and/or zinc.The malondialdehyde tetraalkylacetals obtainable by the process of the invention are valuable starting materials for the preparation of dyes, pest control agents and pharmaceuticals.
Type:
Grant
Filed:
October 29, 1982
Date of Patent:
May 21, 1985
Assignee:
BASF Aktiengesellschaft
Inventors:
Heinz Eckhardt, Klaus Halbritter, Wolfgang Rohr
Abstract: Antibiotic acmimycin of the formula ##STR1## is active against Gram positive and Gram negative bacteria. It is produced by culturing the microorganism Streptomyces sp. AC4559 FERM P-6445, and isolating the above compound from the cultured medium.
Abstract: 1-R.sub.1 -3-amino-5-(3-R'-4-R"-phenyl)-6-R-2(1H)-pyridinones or salts thereof, which are useful as cardiotonics, where R.sub.1 is hydrogen, lower-alkyl, or lower-hydroxyalkyl, R is hydrogen or lower-alkyl, and, R' and R" are each hydrogen, hydroxy or amino at least one of R' or R" being other than hydrogen, are prepared by reacting the corresponding 3-carbamyl compound with a reagent capable of converting carbamyl to amino or by first reacting the corresponding 3-carbamyl compound where R' and R" are each hydrogen, nitro or lower-alkoxy at least one of R' and R" being other than hydrogen with a reagent capable of converting carbamyl to amino and then reacting the resulting 3-amino compound where R' and/or R" are/is lower-alkoxy and/or nitro with a reagent capable of converting lower-alkoxy to hydroxy and/or with a reagent capable of converting nitro to amino. Preparation of the corresponding 3-carbamyl and 3-cyano compounds is shown, the latter including cardiotonically active novel 1-R.sub.
Type:
Grant
Filed:
March 5, 1982
Date of Patent:
May 7, 1985
Assignee:
Sterling Drug Inc.
Inventors:
George Y. Lesher, Chester J. Opalka, Jr., Donald F. Page
Abstract: Polyhydroxyl non-ionic surface active agents, for use in a cosmetic composition such as hair dye or shampoo composition is prepared by condensing glycidol on a polyhydroxyl fatty chain reactant in the presence of an acid catalyst at a temperature of 50.degree.-120.degree. C.
Abstract: This invention relates to 6,11-dihydro-11-oxo-dibenz[b,e]oxepin derivatives of the formula ##STR1## where Y is alkyl, alkoxy, halogen or trifluoromethyl, n is 0, 1, 2 or 3; R is ##STR2## where Hal is a halogen; ##STR3## where n is 0, 1, 2 or 3; p is 1 or 2; q is 0, 1, or 2; R.sup.1 to R.sup.7 are the same or different and are hydrogen and alkyl and R.sup.8 is hydrogen, alkyl and phenyl; and R.sup.9 is alkyl and the pharmaceutically acceptable acid addition salts thereof.
Abstract: Rearrangement of allyl acetals to ketene acetals is disclosed. The rearrangement is accomplished by mixing the allyl acetal with a solution of an alkali metal lower alkyl in a water-soluble primary amine. After several hours contact with the allyl acetal with the solution ketene acetal formed during the contact is separated from the reaction mixture.
Type:
Grant
Filed:
December 1, 1982
Date of Patent:
April 23, 1985
Assignee:
SRI International
Inventors:
Steven Y. Ng, Donald W. Penhale, Jorge Heller
Abstract: Trioxane and other acetals are purified by contacting with an alkali metal superoxide, then isolated in a purified form. Optionally, a phase transfer catalyst can be utilized in the purification. Recovered acetals are sufficiently pure for polymerization to high molecular weight.
Abstract: A process for producing 3,3,7-trimethyl-2,9-dioxatricyclo[3.3.1.0.sup.4,7 ]nonane useful as an insect pheromone and having the formula, ##STR1## which comprises reducing 1,5,5-trimethyl-7-endo-tert-butyldimethylsilyloxy-4-oxabicyclo[4.2.0]octan -3-one with diisobutylaluminum hydride, and treating with an acid, after desilylation.
Abstract: Cyclic oligomers are extracted from liquid polyethers, especially polymers of epihalohydrin, by contacting the polyethers with a hydrocarbon solvent containing 3 to 8 carbon atoms while agitating the polyethers.
Abstract: A process for selectively controlling or interfering with the effect or function of foreign nucleic acid in the presence of otherwise normal living cells which comprises determining the base sequence for the nucleic acid and binding the nucleic acid with an appropriately prepared nonionic oligonucleoside alkyl or arylphosphonate analogue which is complementary to the indicated sequence of the foreign nucleic acid.
Abstract: Esters of monoacetals of pentaerythritol. The monoacetals result from the reaction of a 4-hydroxyphenylpropionaldehyde and pentaerythritol, and the further reaction of this monoacetal with either of two particular acid chlorides yields the esters of the invention. These esters are useful, in small proportions, to stabilize polymer compositions, especially olefin polymers.
Type:
Grant
Filed:
September 9, 1982
Date of Patent:
March 26, 1985
Assignee:
Borg-Warner Chemicals, Inc.
Inventors:
Ingenuin Hechenbleikner, William P. Enlow
Abstract: A compound represented by the formula ##STR1## wherein R.sup.1 represents a lower alkyl group, a phenyl group or a benzyl group, or the two R.sup.1 groups together represent a group of the formula --CH.sub.2 --.sub.n in which n is an integer of 4 to 7; R.sup.2 represents a hydrogen atom, an alkyl group, or a substituted or unsubstituted aralkyl group; and Z represents a hydrogen atom, a lower alkyl group or a substituted or unsubstituted benzyl group;and a process for production thereof. The compounds of this invention are useful as intermediates for the synthesis of various biologically active substances, such as various antibiotics, particularly .beta.-lactam antibiotic derivatives, thienamycin, antibiotic PS-5 and their analogous substances.
Abstract: Disclosed herein is a novel 2,3-dialkoxypropyl glyceryl ether and the preparation process for it. The above diglycerin dialkyl ether is readily prepared with high yield and purity by reacting its corresponding glycidyl ether with a protected glycerin to form a 1,3-dioxolan compound, followed by etherifying the thus formed 1,3-dioxolan compound into a dialkyl ether dioxolan compound, and then hydrolyzing the resultant dialkyl ether dioxolan compound. This diglycerin dialkyl ether is useful as an emulsifier, cleaner etc., and is preferably used as a component of cosmetic compositions. A cosmetic composition comprising the above 2,3-dialkoxypropyl glyceryl ether is also disclosed.
Abstract: The invention relates to new phosphorylating agents, a process for producing said compounds and their use in a process for the phosphorylation of organic hydroxyl compounds to obtain intermediate products useful for the production of polynucleotides. The phosphorylation is achieved without side reactions at the purine- or pyrimidine bases.
Type:
Grant
Filed:
May 10, 1982
Date of Patent:
March 5, 1985
Assignee:
Internationale Octrooi Maatschappij "Octropa" BV
Inventors:
Jacobus H. Van Boom, Gijsbert A. Van Den Marel, Constant A. A. Van Boeckel