Abstract: The disclosure describes a method and system or controlling symptoms of patients suffering from Parkinson's Disease. In some examples, one or more biomarkers indicative of a patient's present symptoms are determined. The biomarkers may be used to control therapy delivered to the patient in a closed-loop manner. In addition, biomarkers may be used as an indication of therapy effectiveness.

Abstract: A blood pump comprises a pump casing having a blood flow inlet and outlet, and an impeller arranged in said pump casing so as to be rotatable. The impeller has blades sized and shaped for conveying blood from the blood flow inlet to the blood flow outlet. The blood pump comprises an outflow cannula having an upstream end portion, a downstream end portion and an intermediate portion. The upstream end portion is connected to the pump casing such that blood is conveyed from the blood flow outlet through the intermediate portion towards the downstream end portion. The downstream end portion has a blood flow outlet through which blood can exit the outflow cannula. At least a portion of the intermediate portion of the outflow cannula has an outer diameter that is larger than an outer diameter of the pump casing.

Abstract: Intravascular devices, systems, and methods are disclosed. In some instances, the intravascular device is a guide wire with electrical conductors printed on a solid core wire. In some instances, the electrical conductors are coupled to conductive bands adjacent a proximal portion of the guide wire. Methods of making, manufacturing, and/or assembling such intravascular devices and associated systems are also provided. In certain aspects, guidewires of the invention include a body having an inner core and an outer layer with one or more embedded conductors. The conductors are exposed at one or more locations along the body and a conductive material can be layered over the exposed locations. A sensor can also be coupled to the body via the conductive material at one of the exposed locations.

Abstract: Presented herein are magnet arrangements for use with encapsulated implantable components. An implantable component comprises an implant body and a plurality of wire loops forming an internal coil that are encapsulated in a biocompatible overmolding. The implantable component also comprises a bone fixture positioned proximate to the plurality of wire loops and an implantable magnet attached to the bone fixture.

Abstract: A skull-implantable electrode assembly for delivering pulses of electric current to a patient's brain, comprising a conductor housed in an insulated conduit and threaded through an electrically-conductive cannulated skull screw. Details of the exterior construction are discussed, as well as electrode arrangements and methods of treating a medical ailment of a patient.

Abstract: Methods and systems of evaluating cardiac pacing in candidate patients for cardiac resynchronization therapy and cardiac resynchronization therapy patients are disclosed. The methods and systems disclosed allow treatments to be personalized to patients by measuring the extent of tissue capture from cardiac pacing under various therapy parameter conditions. Systems and methods of optimizing right ventricle only cardiac pacing are also disclosed.

Abstract: An endoscope captures images of a surgical site for display in a viewing area of a monitor. When a tool is outside the viewing area, a GUI indicates the position of the tool by positioning a symbol in a boundary area around the viewing area so as to indicate the tool position. The distance of the out-of-view tool from the viewing area may be indicated by the size, color, brightness, or blinking or oscillation frequency of the symbol. A distance number may also be displayed on the symbol. The orientation of the shaft or end effector of the tool may be indicated by an orientation indicator superimposed over the symbol, or by the orientation of the symbol itself. When the tool is inside the viewing area, but occluded by an object, the GUI superimposes a ghost tool at its current position and orientation over the occluding object.

Abstract: A device for producing a trabecular fiber within a ventricle of a heart. The device includes a substrate and a first tissue anchor connected to the substrate. The substrate is formed of a non-rigid material.

Abstract: Implantable medical device systems and methods configured to use a detection profile selected from among a plurality of detection profiles to define a detection threshold for identifying cardiac events, in which a close call definition is used to determine which of the plurality of detection profiles is to be chosen. Upon identifying a close call, in which an overdetection nearly occurred but did not actually take place, a relatively less sensitive detection profile is chosen.

Abstract: The invention relates to medicine, namely to cardiac surgery. The object of the invention is to raise the effectiveness of implantation of the HeartMate III left ventricular assist device by minimizing postoperative complications and improving the long-term results of device operation. The HeartMate III left ventricular assist device is implanted in compliance with the phased nature of the procedure. The site of implantation of the outflow cannula is carefully selected. The proposed method of implantation of the HeartMate III left ventricular assist device makes it possible to minimize the surgical causes of device thrombosis and bleeding, to avoid kinking of the outflow graft, to reduce the percentage of development of infection complications of the cable exit region, and thus to improve the long-term results of device operation.

Abstract: Disorders of the eye can be treated by photobiomodulation therapy according to a device designed to direct light into a patient's eye, no matter the configuration of the eye. The device, including a printed circuit board that includes an array of light delivery devices and a heat sink lens, can be placed proximal to the patient's eye. The light delivery devices can be powered to generate light. The light can be directed into the patient's eye regardless of a position of the patient's eye.

Abstract: Methods and systems for obtaining and analyzing electromyography responses of electrodes of an implanted neurostimulation lead for use neurostimulation programming are provided herein. System setups for neural localization and/or programming include a clinician programmer coupleable with a temporary or permanent lead implantable in a patient and at least one pair of EMG sensing electrodes minimally invasively positioned on a skin surface or within the patient. The clinician programmer is configured to determine a plurality of recommended electrode configurations based on thresholds and EMG responses of the plurality of electrodes and rank the electrode configuration according to pre-determined criteria.

Abstract: Catheter and implantable leadless pacing devices, systems, and methods utilizing catheters and implantable leadless pacing devices are disclosed. An example catheter system may include a holding structure extending distally from a tubular member. An implantable device, such as a leadless pacing device, may be located within a cavity of the holding structure. The holding structure may include one or more electrical ports adjacent the proximal end of the holding structure and adjacent or proximal of the proximal end of the implantable device. The electrical ports may provide a conductive pathway extending through the distal structure to allow electrical signals to pass through the distal structure to and/or from the implantable device.

Abstract: A curved laser probe with single-use optic fiber may include a reusable handle, an optic fiber fixture, and a single-use optic fiber. The single-use optic fiber may include an optic fiber having an optic fiber distal end and an optic fiber proximal end. The optic fiber may be disposed in a first transitory connector having a first transitory connector distal end and a first transitory connector proximal end wherein the optic fiber distal end extends a fixed distance from the transitory connector distal end. The optic fiber may be disposed in a second transitory connector having a second transitory connector distal end and a second transitory connector proximal end wherein the optic fiber proximal end extends a fixed distance from the second transitory connector distal end. The first transitory connector may be inserted in the reusable handle and the second transitory connector may be inserted in the optic fiber fixture.

Abstract: The present invention relates to a system (10) for supporting an elderly, frail and/or diseased person (12), in particular a person suffering from Parkinson's disease, wherein the system (10) comprises: a detection unit (14) including (i) a brain activity sensor (20) for detecting a brain activity signal relating to the brain activity of the person (12) and (ii) a motion detection unit (22) for detecting a motion signal relating to a motion of one or more body parts of the person (12); an analysis unit (16) for determining, based on the detected brain activity signal and motion signal, an activity level of the person (12) which is indicative of the motoric and cognitive activity of the person (12); and a feedback unit (18) for providing a feedback to the person (12) if the activity level of the person (12) exceeds a predetermined threshold.

Abstract: A device for performing electrotherapeutic massage on the human head, neck, and shoulders includes an inner core structure, at least four protruding nodules, plural electrical wires, and an outer covering. The inner core structure has a central horizontal accommodating opening for accommodating the neck and plural horizontal cushion openings. The horizontal accommodating opening matches the curvature and alignment of the human cervical spine and the kyphotic curvature of the thoracic vertebrae. Each protruding nodule is made of an electrically conductive fabric and sewn to the wall of the corresponding horizontal cushion opening in order to deliver the electrical nerve stimulation pulses generated by an electrotherapeutic signal generator to the corresponding body portion, thereby relaxing the nerve and muscle groups therein. The electrical wires electrically connect the protruding nodules to the electrotherapeutic signal generator.

Abstract: Systems, devices and methods are disclosed that allow recharging a power source located in an implanted medical device implanted in a patient, the recharging device comprising first and second pairs of electrical coils configured to generate first and second uniform magnetic fields in overlapping first and second cylindrical regions located between the respective pairs of electrical coils.

Abstract: A system for recharging an implantable medical device having a rechargeable battery while the implantable medical device is implanted within a patient includes a recharge energy source configured to be disposed exterior to the patient and a recharging bridge configured to be implanted within the patient. The recharging bridge is configured to facilitate energy transfer from the recharge energy source to the implantable medical device.

Abstract: Target tissue sites for therapy delivery to a patient may be selected based on the patient symptoms or a patient mood state. The therapy delivery may be used to manage a psychiatric disorder of the patient. Selected therapy sites may be weighted based on factors, such as the severity of the patient symptom or mood state or the type of patient symptom or mood state. In some cases, therapy delivery to the patient may be controlled based on the weighting factors. For example, the weighting factors may control the intensity of the therapy delivery or the frequency of the therapy delivery. In some examples, the weighting factors may dynamically change based on the patient's changing symptoms or mood disorders.

Abstract: There is provided an apparatus for monitoring the ingestion of food and/or drink by a subject, the apparatus comprising a control unit that comprises a first obtaining module configured to obtain measurements of one or more physiological characteristics of the subject; a second obtaining module configured to obtain measurements of eddy currents generated in the body of the subject by an externally-applied magnetic field; a setting module configured to set a respective cut-off frequency for one or more filtering stages based on a respective frequency for each of said one or more physiological characteristics; a filtering module configured to filter the measurements of eddy currents using the one or more filtering stages to remove signal components due to the one or more physiological characteristics; and a processing module configured to process the filtered measurements to determine whether food and/or drink is present in the stomach of the subject.