Abstract: This invention concerns a process to provide high purity alkylene carbonate though use of multiple distillations wherein the unused fractions are recycled to the reactor. The high purity alkylene carbonate may be further purified by use of carbon to produce electrochromic or photochromic grade alkylene carbonate by reducing its UV absorbance.
Type:
Grant
Filed:
March 9, 2000
Date of Patent:
May 7, 2002
Assignee:
Huntsman Petrochemical Corporation
Inventors:
James R. Machac, Jr., Edward T. Marquis, Ronald L. Savage, Susan A. Woodrum, John R. Sanderson
Abstract: The present application describes a process for preparing compounds of the indole type of the formula
in which A is a hydrocarbon radical which, together with the carbons to which it is attached, forms a substituted or unsubstituted mono- or polycyclic aromatic system which may contain one or more heteroatoms from the group consisting of N, O and S, and
R1, R2 independently of one another are H, a saturated, linear or branched aliphatic C1-C20-hydrocarbon radical, an unsaturated, linear or branched aliphatic C2-C20-hydrocarbon radical, a saturated or unsaturated, unsubstituted or alkyl-substituted cycloaliphatic C3-C20-hydrocarbon radical or an aromatic C5-C20-hydrocarbon radical, where these radicals may contain in their molecular skeleton one or more heteroatoms from the group consisting of the halogens, N, P, O, S, Si, Sn and B and may be substituted or unsubstituted, by cyclization of alkynylaminoaromatics of the formula
in which R1 and R2 are as defined in formula (I)
Abstract: A promoted multi-metal oxide catalyst is useful for the vapor phase oxidation of an alkane, or a mixture of an alkane and an alkene, to an unsaturated carboxylic acid and for the vapor phase ammoxidation of an alkane, or a mixture of an alkane and an alkene, to an unsaturated nitrile.
Abstract: The present invention relates to novel hydantoin compounds represented by formula (I) which shows an inhibitory activity against farnesyl transferase, and thus can be used as an anti-cancer agent, or pharmaceutically acceptable salts thereof, in which R1, R2, R3 and R4 are as defined in the present application. The present invention also relates to a process for preparation of the compound of formula (I), and to an anti-cancer composition comprising the compound of formula (I) as an active ingredient.
Type:
Grant
Filed:
March 30, 2000
Date of Patent:
May 7, 2002
Assignee:
LG Chemical Ltd.
Inventors:
Jin Ho Lee, Jong Sung Koh, Jong Hyun Kim, Hyun Il Lee, Won Hee Jung, Seong Gu Ro, You Seong Shin, Sang Woong Kim, Ki Won Park, Tae Hwan Kwak, Kyung Duk Moon, Hyun Ho Chung
Abstract: Phosphoramidates and phosphinic amides and related compounds are provided. Also provided are methods that use the compounds for modulating the activity of the endothelin family of peptides are provided. In particular, compounds having formula:
in which A, B, R1 and R2 are as described are provided. Also provided are methods for treating endothelin-mediated disorders by administering effective amounts of one or more of these compounds or prodrugs thereof. Methods for elucidating the physiological and pathophysiological roles of endothelin, as well as isolating endothelin receptors are also provided.
Abstract: Norlabdane oxide, which is a well known fragrance material having ambergris-type odors, is prepared from 12-acetoxy-norlabdane oxide by a hydrogenation reaction.
Abstract: Described are compounds of formula I
wherein at least one of the bonds in the five-membered ring is a double bond; B is any alpha or beta amino acid connected to the ring with an amide or peptide bond; or a salt thereof with a pharmaceutically acceptable acid or base. Pharmaceutical compositions containing these compounds are also described. These compounds are useful for treating type II diabetes.
Type:
Grant
Filed:
January 23, 2001
Date of Patent:
April 30, 2002
Assignee:
Novo Nordisk A/S
Inventors:
Anders Kanstrup, Jane Marie Lundbeck, Lise Brown Christiansen
Abstract: A compound of the formula (I):
or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
Type:
Grant
Filed:
November 17, 2000
Date of Patent:
April 30, 2002
Assignee:
Abbott Laboratories
Inventors:
Martin Winn, Steven A. Boyd, Charles W. Hutchins, Hwan-Soo Jae, Andrew S. Tasker, Thomas W. von Geldern, Jeffrey A. Kester, Bryan K. Sorensen, Bruce G. Szczepankiewicz, Kenneth J. Henry, Gang Liu, Steven J. Wittenberger, Steven A. King
Abstract: A method and catalyst system for economically producing aromatic carbonates from aromatic hydroxy compounds. In one embodiment, the present invention provides a method of carbonylating aromatic hydroxy compounds by contacting at least one aromatic hydroxy compound with oxygen and carbon monoxide in the presence of a carbonylation catalyst system that includes a catalytic amount of a combination of inorganic co-catalysts containing manganese and nickel; manganese and iron; manganese and chromium; manganese and cerium; manganese and europium; manganese, cerium, and europium; manganese, iron, and europium; or manganese and thorium. In various alternative embodiments, the carbonylation catalyst system can include an effective amount of a palladium source and an effective amount of a halide composition. Further alternative embodiments can include catalytic amounts of various other inorganic co-catalyst combinations.
Type:
Grant
Filed:
September 15, 2000
Date of Patent:
April 30, 2002
Assignee:
General Electric Company
Inventors:
James Lawrence Spivack, Donald Wayne Whisenhunt, Jr., James Norman Cawse, Bruce Fletcher Johnson, Grigorii Lev Soloveichik, John Yaw Ofori, Eric James Pressman
Abstract: A process for preparing 1H-indole-3-glyoxamides useful for inhibiting SPLA2 and novel intermediates useful in the preparation of such compounds.
Type:
Grant
Filed:
March 19, 2001
Date of Patent:
April 30, 2002
Assignee:
Eli Lilly and Company
Inventors:
Benjamin Alan Anderson, Nancy Kay Harn, Richard Duane Miller, Edward Francis Plocharczyk
Abstract: Hydrocyanation reactions employing multidentate phosphite ligands and multidentate phosphite ligands are disclosed. The ligands have phenyl containing substituents attached to the ortho position of the terminal phenol group and/or attached to the ortho position of the bridging group. Catalyst compositions havng such ligands achieve 97% or greater distribution in hydrocyanation.
Abstract: Compounds of the formula I
and disulfides thereof and salts thereof are important intermediate products for the preparation of compounds having a microbicidal and plant-immunizing action, of the formula III
In the compounds of the formulae I and III:
X is halogen,
n is 0, 1, 2 or 3;
Z is CN, CO—A or CS—A,
A is hydrogen, halogen, OR1, SR2 and N(R3)R4;
R1 to R4 are hydrogen, a substituted or unsubstituted, open-chain, saturated or unsaturated hydrocarbon radical containing not more than 8 carbon atoms, a substituted or unsubstituted cyclic, saturated or unsaturated hydrocarbon radical containing not more than 10 carbon atoms, substituted or unsubstituted benzyl or phenethyl, a substituted or unsubstituted alkanoyl group containing not more than 8 carbon atoms, a substituted or unsubstituted benzoyl group or a substituted or unsubstituted heterocyclyl radical; or
R3 and R4, together with the nitrogen atom to which they are bonded, are a 5- or 6-membered, subs
Abstract: 4-substituted cyclohexanes substituted in the 1-position with quinazoline either directly or through a C1-C4alkyl, C1-C4alkenyl, C1-C4alkynyl, C1-C4alkoxy, amino, aminoC1-C4alkyl, hydroxyC1-C4alkyl, carbonyl, cycloC3-C6alkyl or aminocarbonyl chain are effective as NMDA NR2B antagonists useful for relieving pain.
Type:
Grant
Filed:
May 21, 2001
Date of Patent:
April 30, 2002
Assignee:
Merck & Co., Inc.
Inventors:
Wayne Thompson, David A. Claremon, Peter M. Munson, John A. McCauley
Abstract: A method and catalyst system for producing aromatic carbonates from aromatic hydroxy compounds. In one embodiment, the method includes the step of contacting at least one aromatic hydroxy compound with oxygen and carbon monoxide in the presence of a carbonylation catalyst system having an effective amount of a manganese source in the absence of a Group VIII B metal source. In various alternative embodiments, the carbonylation catalyst system can include at least one inorganic co-catalyst, as well as a halide composition and/or a base.
Type:
Grant
Filed:
November 27, 2000
Date of Patent:
April 30, 2002
Assignee:
General Electric Company
Inventors:
Ben Purushotam Patel, Grigorii Lev Soloveichik, Donald Wayne Whisenhunt, Jr., Kirill Vladimirovich Shalyaev
Abstract: Reactive dyestuffs of the formula (I)
wherein
R1 denotes H or unsubstituted or substituted C1-C4-alkyl,
R2 denotes C1-C4-alkyl,
X denotes F, Cl or Br,
Z denotes —CH═CH2 or —CH2CH2—OSO3H,
R15 denotes H, C1-C4-alkyl, C1-C4-alkoxy, Cl, Br, acylamino, amino carbonylamino, C1-C4-alkylsulphonylamino or arylsulphonylamino and
R18 denotes H, C1-C4-alkyl, C1-C4-alkoxy, OH or SO3H. The invention also relates to a process for the preparation of the reactive dyestuff and their use of dyeing fibre materials containing OH groups and NH groups.
Type:
Grant
Filed:
October 26, 1999
Date of Patent:
April 23, 2002
Assignee:
DyStar Textilfarben GmbH & Co. Deutschland KG
Abstract: Novel compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory disease and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.
Type:
Grant
Filed:
December 7, 2000
Date of Patent:
April 23, 2002
Assignee:
ICOS Corporation
Inventors:
Timothy J. Martins, Kerry W. Fowler, Joshua Odingo, Laurence E. Burgess, Stephen T. Schlachter
Abstract: Photoprotective, topically applicable sunscreen/cosmetic compositions well suited for the UV-photoprotection of human skin and/or hair, comprise an effective UV-photoprotecting amount of at least one novel benz-x-azole-substituted silane or siloxane having the formula (1) or (2):
A—SiR′1R′2R′3 (2)
in which A is a radical having the structural formula (I):
Abstract:
The invention relates to compounds of formula (I), wherein the symbols have the meanings indicated in the specification. The inventive compounds exhibit dramatic antiarrhythmic proprieties and contain a cardioprotective compound. They can preventively inhibit or strongly reduce pathophysiologic processes upon occurrence of ischemic injuries, especially ischemic cardiac arrhythmia. Said compounds also exhibit a strong inhibiting effect on cellular proliferation.
Type:
Grant
Filed:
January 17, 2001
Date of Patent:
April 16, 2002
Assignee:
Aventis Pharma Deutschland GmbH
Inventors:
Heinz-Werner Kleemann, Hans Jochen Lang, Jan-Robert Schwark, Andreas Weichert, Stefan Petry
Abstract: The present invention provides 5-carboxanilido-2,4-bis-trifluoromethylthiazoles and their compositions. The compounds and compositions are effective for controlling fungal diseases on plants. They are particularly effective for controlling rice blast.
Abstract: &bgr;-sheet mimetics and methods relating to the same are disclosed. The &bgr;-sheet mimetics have utility as protease and kinase inhibitors, as well as inhibitors of transcription factors and protein-protein binding interactions. Methods of the invention include administration of a &bgr;-sheet mimetic, or use of the same for the manufacture of a medicament for treatment of a variety of conditions associated with the targeted protease, kinase, transcription factor and/or protein-protein binding interaction.
Type:
Grant
Filed:
February 9, 2000
Date of Patent:
April 16, 2002
Assignee:
Molecumetics Ltd.
Inventors:
Maher N. Qabar, Michael K. McMillan, Michael S. Kahn, John E. Tulinsky, Cyprian O. Ogbu, Jessymol Mathew