Patents Examined by Francisco C. Prats
  • Patent number: 7132254
    Abstract: The present invention relates to a method of detecting phycocyanin algae or bacteria in water from reflected light, and also includes devices for the measurement, calculation and transmission of data relating to that method.
    Type: Grant
    Filed: January 22, 2004
    Date of Patent: November 7, 2006
    Assignee: Bowling Green State University
    Inventor: Robert Vincent
  • Patent number: 7097968
    Abstract: This invention relates generally to the field of homocysteine detection. In particular, the invention provides a method for determining homocysteine presence or concentration in samples, which method comprises: contacting a sample containing or suspected of containing Hcy with a Hcy co-substrate and a Hcy converting enzyme in a Hcy conversion reaction to form a Hcy conversion product and a Hcy co-substrate conversion product; and assessing the Hcy co-substrate conversion product to determine the presence, absence and/or amount of the Hcy in the sample. A kit for assaying homocysteine based on the same principle is also provided.
    Type: Grant
    Filed: March 15, 2004
    Date of Patent: August 29, 2006
    Assignee: General Atomics
    Inventors: Chong-Sheng Yuan, Abhijit Datta, Chao Dou
  • Patent number: 7097831
    Abstract: The invention relates to foodstuff and animal feed which contain resistant starch on the basis of water-insoluble linear ?-1,4-D-glucans. The invention also related to the utilization of resistant starch on the basis of water-insoluble linear ?-1,4-D-glucans as medicaments.
    Type: Grant
    Filed: November 30, 1999
    Date of Patent: August 29, 2006
    Assignee: Südzucker Aktiengesellschaft Mannheim/Ochsenfurt
    Inventors: Holger Bengs, Anette Brunner
  • Patent number: 7094528
    Abstract: A diagnostic test kit for detecting the presence or quantity of an enzyme or enzyme inhibitor is provided. The diagnostic kit utilizes reactive complexes to facilitate the detection of the enzyme or enzyme inhibitor. The reactive complexes include a substrate joined (e.g., covalently bonded, physically adsorbed, etc.) to a reporter and magnetic substance. In one embodiment, for example, a peptide, protein, or glycoprotein substrate is joined to a reporter (e.g., dyed latex particle) and magnetic particle. In this embodiment, the substrate provides a cleavage target for a proteolytic enzyme. Specifically, upon contacting the reactive complexes, the proteolytic enzyme cleaves the substrate and releases the reporter and/or magnetic particle. The signal exhibited by the released reporters may then be used to indicate the presence or quantity of an enzyme or enzyme inhibitor within the test sample.
    Type: Grant
    Filed: June 30, 2004
    Date of Patent: August 22, 2006
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Xuedong Song, Shu-Ping Yang, Rosann Marie Matthews Kaylor
  • Patent number: 7091001
    Abstract: A process of preparation of non-bitter high arginine peptide from groundnut, which has an arginine to lysine ratio of at least 5 and a yield of 17–20%.
    Type: Grant
    Filed: July 30, 2004
    Date of Patent: August 15, 2006
    Assignee: Council of Scientific & Industrial Research
    Inventors: Cheruppanpullil Radha, Karadka Govindaraju, Thirumakudalu Chikkaraja Sindhu Kanya, Purnima Kaul Tiku, Sridevi Annapurna Singh, Lalitha Ramakrishna Gowda, Bhagya Swamylingappa, Appu Rao Gopala Rao Appu Rao, Vishveshwariah Prakash, Pallavur Rajagopalan Ramasarma
  • Patent number: 7090857
    Abstract: The present invention relates to antigenic preparations comprising polysaccharides and/or glycopeptides preparable from keratinophilic fungi as well as yeasts, process for the preparation of these antigenic preparations, their use as pharmaceutical substances as well as their use as vaccines, including but not limited to, the prophylaxis and treatment of allergy, as well as for modulating the immune response.
    Type: Grant
    Filed: March 22, 2002
    Date of Patent: August 15, 2006
    Assignee: Boehringer Ingelheim Vetmedica GmbH
    Inventors: Dieter Farnow, Joachim Karle, Igor D. Poliakov, Ludmilla G. Ivanova
  • Patent number: 7083961
    Abstract: The invention provides a crystalline complex containing T. foetus IMPDH in complex with inosine monophosphate (IMP), the complex specified by disclosed atomic coordinates. Also provided are crystalline complexes of containing T. foetus IMPDH with both inosine monophosphate (IMP) and mycophenolic acid, with both xanthosine monophosphate (XMP) and mycophenolic acid, with both xanthosine monophosphate (XMP) and nicotinic adenine dinucleotide (NAD), with ribovirin (1-?-D-ribofuranosyl-1,2,4-triazole-3-carboxamide, and with both ribovirin and mycophenolic acid, each complex specified by disclosed atomic coordinates. Also provided by the invention are the atomic coordinates for these complexes. Further provided by the invention are methods for identifying modulations of IMPDH that employ the atomic coordinates of the invention.
    Type: Grant
    Filed: September 15, 2003
    Date of Patent: August 1, 2006
    Assignee: Regents of the University of California
    Inventors: Hartmut Luecke, Glen Prosise
  • Patent number: 7070964
    Abstract: The present invention provides bioconversion methods for making epothilone analogs. These analogs differ from the starting material by the addition of one or more hydroxyl groups or by the addition of an epoxide. These compounds, in turn, can be further modified by chemical synthesis.
    Type: Grant
    Filed: November 14, 2002
    Date of Patent: July 4, 2006
    Assignee: Kosan Biosciences Incorporated
    Inventors: Li Tang, Brian Metcalf, Leonard Katz, Gary Ashley
  • Patent number: 7041485
    Abstract: The invention relates to a method for preparing free polyunsaturated fatty acids and their oxidation metabolites, wherein, successively, the production of polyunsaturated fatty acids and of their oxidation metabolites is stimulated, in a red alga, by the action of an elicitor which is peptide, lipid or saccharide in nature, and then the polyunsaturated fatty acids produced and also their oxidation metabolites are extracted.
    Type: Grant
    Filed: July 30, 2003
    Date of Patent: May 9, 2006
    Assignee: Laboratoires Goemer S.A.
    Inventors: Kamal Bouarab, Jean-Pierre Salaun, Jean-Claude Yvin, Philippe Potin
  • Patent number: 7029883
    Abstract: A method for producing a purified Auricularia auricula Polysaccharide (AP) extract of Auricularia auricula (AA). A hydrated predetermined amount of AA is filtered and extracted, producing a first pre-extract. A plurality of additional hydrated predetermined amounts of AA is separately filtered and extracted to produce a plurality of additional pre-extracts. The pre-extracts are combined to form a first extract. The first extract is concentrated and suspended, forming a precipitate. The precipitate is purified to form a first filtrate, and repurified to form a second filtrate. The first and second filtrates are combined to form a first combined filtrate, which is concentrated, purified and dried to form a concentrated extract. The concentrated extract is purified to form a third filtrate, and repurified to form a fourth filtrate.
    Type: Grant
    Filed: June 4, 2002
    Date of Patent: April 18, 2006
    Assignee: Eastmedicine Limited
    Inventor: Sun Sun Chan
  • Patent number: 7026111
    Abstract: The ability to efficiently determine the state of enzyme expression in cells has long been desired as material to the diagnosis of disease. This invention relates to cytoenzymology, and more particularly to improved reagents for use in cell-based assays, especially those using fluorogenic substrates.
    Type: Grant
    Filed: October 15, 2001
    Date of Patent: April 11, 2006
    Assignee: Beckman Coulter, Inc.
    Inventors: Adrian Clausell, Jirong Gu, M. Parameswara Reddy
  • Patent number: 7018806
    Abstract: A method for identifying an endocrine disrupter using a cell line having aromatase activity, particularly, a human granulosa-like tumor cell line; and a kit for carrying out the method is disclosed.
    Type: Grant
    Filed: August 31, 2004
    Date of Patent: March 28, 2006
    Assignee: Otsuka Pharmaceutical Co., Ltd.
    Inventors: Hajime Nawata, Toshihiko Yanase
  • Patent number: 7005282
    Abstract: Disclosed is an ionic liquid-coated enzyme, wherein the ionic liquid is an organic salt which presents as a liquid phase at a temperature of about 150° C. or below. The ionic liquid-coated enzyme according to the present invention remarkably improves enzyme functions, such as enantioselectivity and stability, when the enzyme which may be lipase is coated with an ionic liquid. Further, even in the case of when the ionic liquid-coated enzyme is reused, the enantiomeric excess, enantioselectivity, and activity are not degenerated. The coated enzyme is usable as a catalyst for providing a chiral intermediate required in the synthesis of chiral pesticides, medicines, natural chemicals, and so on.
    Type: Grant
    Filed: January 13, 2003
    Date of Patent: February 28, 2006
    Assignee: POSCO and POSTECH Foundation
    Inventors: Mahn-Joo Kim, Jae Kwan Lee
  • Patent number: 6977142
    Abstract: Methods for performing an end-point assay of protein disulfide isomerase activity. The method may be based on the enzyme-catalyzed reduction of insulin in the presence of dithiothreitol; measuring the aggregation of reduced insulin chains at 650 nm; and using hydrogen peroxide as a stop reagent.
    Type: Grant
    Filed: September 23, 2003
    Date of Patent: December 20, 2005
    Assignee: AGY Therapeutics, Inc.
    Inventors: Shu-Gui Huang, Donna Oksenberg, Roman Urfer
  • Patent number: 6797496
    Abstract: A lactosyl glycoside or an N-acetyllactosaminyl glycoside useful as foods, functional food materials, medicines, and reagents is provided with high yield and inexpensively by using a transfer reaction represented by the following formula in the presence of an enzyme having an activity of cleaving a &bgr;1,4 glucosyl bond: LacA-X+Y→LacA-Y+X, wherein LacA represents lactose or N-acetyllactosaminide; X represents hydrogen (H), a saccharide, a glycoconjugate, or a phenolic compound; and Y represents a compound having an alcoholic hydroxyl group or a phenolic hydroxyl group.
    Type: Grant
    Filed: July 18, 2002
    Date of Patent: September 28, 2004
    Assignee: Showa Sangyo Co., Ltd.
    Inventors: Nozomu Yasutake, Shinsuke Miyoshi, Taiichi Usui, Takeomi Murata, Kazuhide Totani
  • Patent number: 6743607
    Abstract: Compositions and methods for making complex carbohydrates in a bacterial production cell are disclosed. The complex carbohydrates that can be made include oligosaccharides and polysaccharides of bacterial or mammalian origin.
    Type: Grant
    Filed: November 16, 2001
    Date of Patent: June 1, 2004
    Assignees: The Regents of the University of California, The University of Iowa Research Foundation
    Inventors: Michael A. Apicella, Bradford W. Gibson, Nancy J. Phillips
  • Patent number: 6733987
    Abstract: An object of the present invention is to provide a method which comprises adhering a biological sample to a film, cutting out a target area of the sample, and then peeling off the film to collect the fragment which was cut out, wherein the operability is good and a cutting sharpness in cutting by a laser beam is good. The present invention provides a method for cutting a biological sample by light irradiation, which comprises locating the biological sample and a colored film having a thickness of 3 to 6 &mgr;m onto one side of a support, and irradiating the biological sample with a light beam, thereby cutting out a target area of the biological sample.
    Type: Grant
    Filed: October 26, 2001
    Date of Patent: May 11, 2004
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Masashi Ogawa, Masatoshi Takahashi, Kazuko Hanai, Hiroshi Arakatsu
  • Patent number: 5919673
    Abstract: A process for the enzymatic synthase of sulfate esters is disclosed in which intermediate phosphorylated adenosine compounds are recycled to minimize enzyme inhibition. Exemplary enzymes include ATP sulfurylase, APS kinase and a sulfotransferase.
    Type: Grant
    Filed: March 22, 1995
    Date of Patent: July 6, 1999
    Assignee: The Scripps Research Institute
    Inventors: Chi-Huey Wong, Chun-Hung Lin, Gwo-Jenn Shen
  • Patent number: 5900372
    Abstract: Method for the culture of microorganisms of the genera Helicobacter, Campylobacter and Arcobacter, wherein culture media are employed, which comprise, in place of blood or its derivative, cyclodextrins, methylcellulose or mixtures thereof.
    Type: Grant
    Filed: August 24, 1994
    Date of Patent: May 4, 1999
    Assignee: Chiron S.p.A.
    Inventors: Natale Figura, Massimo Bugnoli, Roberto Olivieri, Rino Rappuoli
  • Patent number: 5874261
    Abstract: A reiterative method for obtaining the glycosyltransferases useful for glycosyltransferase-catalyzed synthesis of a saccharide composition by serially bonding preselected saccharide units onto an immobilized acceptor moiety which is one member selected from the group consisting of proteins, glycoproteins, lipids, glycolipids and carbohydrates.
    Type: Grant
    Filed: December 20, 1991
    Date of Patent: February 23, 1999
    Assignee: The Trustees of The University of Pennsylvania
    Inventor: Stephen Roth