Patents Examined by Francisco C. Prats
  • Pyrimidine nucleoside derivatives having anti-tumor activity, their preparation and use
    Patent number: 5691319
    Abstract: Compounds of formula (I): ##STR1## wherein: R.sup.1, R.sup.2 and R.sup.3 are independently selected from the group consisting of hydrogen atoms, optionally substituted alkanoyl groups and alkenylcarbonyl groups, PROVIDED THAT at least one of R.sup.1, R.sup.2 and R.sup.3 represents an unsubstituted alkanoyl group having from 5 to 24 carbon atoms, said substituted alkanoyl group or said alkenylcarbonyl group; and one of R.sup.4 and R.sup.5 represents a hydrogen atom and the other represents a cyano group; have valuable anti-tumor activity.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: November 25, 1997
    Assignee: Sankyo Company, Limited
    Inventors: Masakatsu Kaneko, Hitoshi Hotoda, Tomoyuki Shibata, Tomowo Kobayashi, Yoshihiro Mitsuhashi, Akira Matsuda, Takuma Sasaki
  • Astaxanthin-producing yeast cells, methods for their preparation and their use
    Patent number: 5679567
    Abstract: An isolated pure culture of a strain of Phaffia rhodozyma which produces astaxanthin in an mount of at least 600 .mu.g per g Phaffia rhodozyma dry matter, as determined by HPLC analysis.
    Type: Grant
    Filed: October 13, 1994
    Date of Patent: October 21, 1997
    Assignee: Gist-brocades, B.V.
    Inventors: Bent Flen.o slashed., Ib Christensen, Robert Larsen, Steffen Radich Johansen, Eric A. Johnson
  • Method of crystallizing trehalose without using organic solvent
    Patent number: 5677442
    Abstract: Disclosed are novel non-reducing saccharide-forming enzyme, and its preparation and uses. The enzyme is obtainable from the culture of microorganisms such as Rhizobium sp. M-11 (FERM BP 4130) and Arthrobacter sp. Q36 (FERM BP-4316), and capable of forming non-reducing saccharides having a trehalose structure when allowed to act on reducing partial starch hydrolysates. Glucoamylase and .alpha.-glucosidase readily yield trehalose when allowed to act on the non-reducing saccharides. These non-reducing saccharides and trehalose are extensively useful in food products, cosmetics and pharmaceuticals. Also disclosed is a method of crystallizing trehalose from a 65 to 90% aqueous solution in the absence of organic solvent.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 14, 1997
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Kazuhiko Maruta, Michio Kubota, Toshiyuki Sugimoto, Toshio Miyake
  • Method for producing uridine diphosphate N-acetylgluosamine
    Patent number: 5674715
    Abstract: A method for producing uridine diphosphate N-acetylglucosamine comprising culturing osmo-tolerant yeasts in aerobic conditions in a medium having inorganic salt concentration of about 2-8%.
    Type: Grant
    Filed: May 5, 1995
    Date of Patent: October 7, 1997
    Assignee: Tomita Pharmaceutical Co., Ltd.
    Inventors: Minoru Tomita, Hisao Mukai
  • Modifying nucleotide analogues
    Patent number: 5670346
    Abstract: Fluorescently labelled dideoxynucleoside triphosphates are widely used as chain-terminators in Sanger dideoxy sequencing operations. But these unincorporated dye-terminators migrate in an electrophoresis gel and obscure the desired sequence ladder. This invention provides a method and a kit for modifying the unincorporated dye-terminators, e.g. by removal of a 5'-triphosphate group by chemical or enzymatic means e.g. by use of a phosphatase enzyme.
    Type: Grant
    Filed: March 7, 1995
    Date of Patent: September 23, 1997
    Assignee: Amersham International plc
    Inventors: Michael Alan Reeve, Philip Steven Robinson
  • A83543 compounds and process for production thereof
    Patent number: 5670364
    Abstract: New A83543 components, including fermentation products A83543K, A835430, A83543P, A83543U, A83543V, A83543W and A83543Y and N-demethyl derivatives, and salts thereof, are useful for the control of insects and mites. The pseudoaglycones of the new A83543 components are useful for the preparation of A83543 components. Methods are provided for making the new A83543 components by culturing of Saccharopolyspora spinosa NRRL 18395, NRRL 18537, NRRL 18538, or NRRL 18539, or NRRL 18743 or NRRL 18719 or NRRL 18823 in suitable culture medium. Insecticidal and ectoparasiticidal compositions containing new A83543 components are also provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 23, 1997
    Assignee: DowElanco
    Inventors: Jon S. Mynderse, James A. Mabe, Jan R. Turner, Mary L. B. Huber, Mary C. Broughton, Walter M. Nakatsukasa, Lawrence Creemer, Herbert A. Kirst, James W. Martin
  • A83543 compounds and process for production thereof
    Patent number: 5670486
    Abstract: New A83543 components, including fermentation products A83543K, A83543O, A83543P, A83543U, A83543V, A83543W and A83543Y and N-demethyl derivatives, and salts thereof, are useful for the control of insects and mites. The pseudoaglycones of the new A83543 components are useful for the preparation of A83543 components. Methods are provided for making the new A83543 components by culturing of Saccharopolyspora spinosa NRRL 18395, NRRL 18537, NRRL 18538, or NRRL 18539, or NRRL 18743 or NRRL 18719 or NRRL 18823 in suitable culture medium. Insecticidal and ectoparasiticidal compositions containing new A83543 components are also provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 23, 1997
    Assignee: DowElanco
    Inventors: Jon S. Mynderse, James A. Mabe, Jan R. Turner, Mary L. B. Huber, Mary C. Broughton, Walter M. Nakatsukasa, Lawrence Creemer, Herbert A. Kirst, James W. Martin
  • Method for preparing N-acetylneuraminic acid
    Patent number: 5665574
    Abstract: A method for preparing N-acetylneuraminic acid characterized in reacting N-acetylglucosamine with pyruvic acid in an alkaline condition by the action of N-acetylneuraminic acid lyase.
    Type: Grant
    Filed: September 14, 1995
    Date of Patent: September 9, 1997
    Assignee: Marukin Shoyu Co., Ltd.
    Inventors: Yoji Tsukada, Yasuhiro Ohta
  • Compositions for the prevention and treatment of viral-induced tumors
    Patent number: 5662903
    Abstract: Prophylactic and therapeutic agents for the prevention and treatment of viral-induced tumors and, in particular, compositions derived from an Aspergillus fermentation extract, and the use thereof, either directly or to prepare a medicament, for the prevention and treatment of viral-induced tumors in mammals. Such tumors include papilloma-induced tumors. The composition is topically administered.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: September 2, 1997
    Assignee: Genencor International, Inc.
    Inventors: Ernest W. Boyer, Robert L. Charles
  • Compositions for the prevention and treatment of viral-induced tumors
    Patent number: 5662902
    Abstract: Prophylactic and therapeutic agents for the prevention and treatment of viral-induced tumors and, in particular, compositions derived from an Aspergillus fermentation extract, and the use thereof, either directly or to prepare a medicament, for the prevention and treatment of viral-induced tumors in mammals. Such tumors include papilloma-induced tumors. The composition is topically administered.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: September 2, 1997
    Assignee: Genencor International, Inc.
    Inventors: Ernest W. Boyer, Robert L. Charles
  • Xylanase process for producing the same method for the treatment of pulp and production of xylo-oligosaccharides
    Patent number: 5658765
    Abstract: Disclosed are novel xylanases, a process for producing the enzyme, a microorganism capable of producing the enzyme, a method for the treatment of pulp with the xylanase enzyme, and a process for producing xylose or xylo-oligosaccharide using the enzyme.
    Type: Grant
    Filed: September 6, 1995
    Date of Patent: August 19, 1997
    Assignee: Novo Nordisk A/S
    Inventors: Yoshitaka Noguchi, Kazuko Ikeda, Eiko Masatsuji, Masahiko Seko
  • Pseudomonas aeruginosa and its use in a process for the biotechnological preparation of L-rhamnose
    Patent number: 5658793
    Abstract: Bacterial strains are capable of the formation of rhamnolipids, which they generate in the culture solution. If bacteria of the type Pseudomonas aeruginosa are employed for the fermentation, these microorganisms synthesize rhamnolipids in a concentration of 70-120 g/l of culture solution. The L-rhamnose can be recovered directly from the culture solution by hydrolysis of the rhamnolipids, i.e. without a complicated separation of the cell material and without isolation of the rhamnolipids before hydrolysis.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: August 19, 1997
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Carlo Giani, Dieter Wullbrandt, Reinhardt Rothert, Johannes Meiwes
  • Compositions for inhibiting restenosis
    Patent number: 5658894
    Abstract: Polyionic derivatives of cyclodextrins and methods for preparing these derivatives are provided in which a polyionic derivative of cyclodextrin is combined with a growth factor, preferably a heparin binding growth factor. These compositions are of low solubility and are applied directly to the location of a wound. By virtue of the low solubility, the compositions remain in place at the site of application and slowly release growth factor. In an alternative embodiment, the cyclodextrin derivatives are administered in the absence of growth factor and are used to absorb growth factor present in the body at the location of the wound in order to prevent overstimulation of the wound response.
    Type: Grant
    Filed: November 23, 1994
    Date of Patent: August 19, 1997
    Assignee: The Trustees of the University of Pennsylvania
    Inventor: Paul B. Weisz
  • Mutant of Geotrichum candidum which produces novel enzyme system to selectively hydrolyze triglycerides
    Patent number: 5654181
    Abstract: A mutant fungal strain, namely G. candidum NRRL Y-552, mutant known as Henkel 9-2-3-9 produces a lipase called "UNLipase" providing a selectivity of 25:1 for oleic acid over palmitic acid by the assay procedure employed. UNLipase has a temperature range of operation of between 0 and 40 degrees Celsius (and no activity over 55 degrees Celsius). The optimum pH ranges are between 7.5 and 8.5. Magnesium cations increase activity, whereas calcium cations are inhibitory. The molecular weight of the protein appears to be 65 kDa by size exclusion chromatography. UNLipase shows a high degree of selectivity for hydrolysis, esterification and transesterification.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: August 5, 1997
    Assignee: Henkel Corporation
    Inventors: Dean A. Oester, Allen L. Hall, Stephen J. Vesper
  • .alpha.-glycosyl hesperidin, and its preparation and uses
    Patent number: 5652124
    Abstract: .alpha.-Glycosyl hesperidin, a novel hesperidin derivative wherein equimolar or more D-glucose residues are bound to hesperidin via the .alpha.-bond, is formed by a saccharide-transferring enzyme in a liquid containing hesperidin and .alpha.-glucosyl saccharide. The .alpha.-glycosyl hesperidin is easily recovered from the reaction mixture with a synthetic macroporous resin. .alpha.-Glycosyl hesperidin is superior in water-solubility, substantially tasteless and odorless, free of toxicity, and readily hydrolyzable in vivo into hesperidin and D-glucose to exhibit the physiological activity inherent to hesperidin. Thus, .alpha.-glycosyl hesperidin is favorably usable in vitamin P-enriching agents, foods, beverages, tobaccos, foods, pet foods, pharmaceuticals for susceptive diseases, cosmetics and plastics.
    Type: Grant
    Filed: July 12, 1995
    Date of Patent: July 29, 1997
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Hiromi Hijiya, Toshio Miyake
  • Process and bacterial cultures for the preparation of perillyl compounds
    Patent number: 5652137
    Abstract: A process for the preparation of monoterpene compounds (such as perillyl alcohol, aldehyde and .alpha.-terpineol) from limonene is described. The process uses Bacillus stearothermophilus which is effective at high temperatures (55.degree. to 70.degree. C.).
    Type: Grant
    Filed: September 5, 1995
    Date of Patent: July 29, 1997
    Assignee: Board of Trustees operating Michigan State University
    Inventors: Hae Choon Chang, Patrick J. Oriel
  • Device and process for isolating nucleic acids from cell suspension
    Patent number: 5652141
    Abstract: A device and a process for isolating nucleic acids by lysing intact cells and removing nucleic acids emerging from the lysed cells by the following steps:a) the cells are immobilized in a porous matrix, with the size of matrix voids being in the range of the type of cell to be lysed;b) the cells are lysed;c) the nucleic acids are fixated on the matrix surface, and subsequentlyd) are eluted.
    Type: Grant
    Filed: May 16, 1995
    Date of Patent: July 29, 1997
    Assignee: Oiagen GmbH
    Inventors: Karsten Henco, Metin Colpan, Petra Feuser
  • Strains of Phaffia rhodozyma containing high levels of astaxanthin and low levels of 3-hydroxy-3',4'-didehydro-.beta., .PSI.-caroten-4-one (HDCO)
    Patent number: 5648261
    Abstract: The present invention provides Phaffia rhodozyma strains having increased levels of astaxantin and a low percentage of 3-hydroxy-3',4'-didehydro-.beta.,.psi.-caroten-4-one (HDCO). Such strains are obtained by a combination of mutagenesis and selection. The invention further provides a method for obtaining such strains. The invention also provides astaxanthin obtained from a mutagenized strain of Phaffia rhodozyma characterized in that it contains a decreased relative amount of HDCO.
    Type: Grant
    Filed: October 12, 1993
    Date of Patent: July 15, 1997
    Assignee: Gist-brocades, N.V.
    Inventors: Lex De Boer, Bart Van Hell, Andreas Jacobus Johanna Krouwer
  • Collagen-based viscoelastic solution for visco-surgery
    Patent number: 5631243
    Abstract: The present invention relates to a method of treating a patient with visco-surgery, particularly ocular visco-surgery, utilizing a collagen-based viscoelastic solution having a reversibly high viscosity. The invention also relates to collagen-based viscoelastic solutions which further include mucopolysaccarides or growth factors.
    Type: Grant
    Filed: December 28, 1994
    Date of Patent: May 20, 1997
    Assignee: Collagenesis Inc.
    Inventors: Charles D. Kelman, Dale P. DeVore
  • Galactosyl and mannosyl cyclodextrins
    Patent number: 5623071
    Abstract: A cyclodextrin having a galactosyl group which is bonded to a 6-hydroxyl group of a glucosyl group of the cyclodextrin via an .alpha.-bond or a .beta.-bond; a cyclodextrin having a mannosyl group which is bonded to a 6-hydroxyl group of the cyclodextrin via an .alpha.-bond.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: April 22, 1997
    Assignees: Ensuiko Sugar Refining Co., Ltd., Sumio Kitahata
    Inventors: Sumio Kitahata, Koji Hara, Koki Fujita, Nobuhiro Kuwahara, Kyoko Koizumi