Patents Examined by Francisco C. Prats
  • Patent number: 5866375
    Abstract: Method for the culture of microorganisms of the genera Helicobacter, Campylobacter and Arcobacter, wherein culture media are employed, which comprise, in place of blood or its derivative, cyclodextrins.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: February 2, 1999
    Assignee: Chiron S.p.A.
    Inventors: Natale Figura, Massimo Bugnoli, Roberto Olivieri, Rino Rappuoli
  • Patent number: 5866392
    Abstract: Enzyme exhibiting cellobiose oxidase activity, which enzyme has a relative activity of at least 70% at a pH of about 9 and a temperature of about 50.degree. C. An enzymatic agent comprising cellobiose oxidase and an endoglycanase and/or oxidoreductase. A process of bleaching paper pulp using cellobiose oxidase.
    Type: Grant
    Filed: June 24, 1996
    Date of Patent: February 2, 1999
    Assignee: Novo Nordisk A/S
    Inventors: Charlotte Schou, Martin Schulein, Thomas Vollmond
  • Patent number: 5863771
    Abstract: A saccharide composition comprising maltooligosyl derivatives of turanose and palatinose which can be readily produced, separated, and purified in a relatively-high yield from maltooligosylsucrose by allowing non-reducing saccharide-forming enzymes to act on aqueous solutions containing maltooligosylsucrose. These saccharides are reducing oligosaccharides with a mild and high-quality sweetness and can be used orally and parenterally, as well as being readily metabolized and used by living bodies.
    Type: Grant
    Filed: March 3, 1997
    Date of Patent: January 26, 1999
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Hajime Aga, Takashi Shibuya, Shigeharu Fukuda, Toshio Miyake
  • Patent number: 5847112
    Abstract: Type-specific capsular polysaccharide preparations from Streptococcus pneumoniae, having on average less than about 1000 oligosaccharide repeat units per molecule, polydispersities between 1.0 and 1.4, intrinsic viscosities between 0.6 and 3.0 dL/g, and less than 3% contamination of type-specific polysaccharide by group-specific C-polysaccharide, are produced by a novel process. The novel type specific polysaccharide products are useful in the preparation of vaccines, especially covalent conjugates comprising the novel polysaccharide linked to a T-cell stimulatory carrier protein. Vaccines comprising the novel polysaccharides are useful in the prevention of infection and of diseases associated with infection by Streptococcus pneumoniae.
    Type: Grant
    Filed: November 14, 1997
    Date of Patent: December 8, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Peter J. Kniskern, William J. Miller, Arpi Hagopian, Charlotte C. Ip, John P. Hennessey, Jr., Dennis J. Kubek, Pamela D. Burke
  • Patent number: 5846788
    Abstract: A process for the manufacture of a lignocellulose-based product from a lignocellulosic material comprises treating the lignocellulosic material and a phenolic polysaccharide having substituents containing a phenolic hydroxy group with an enzyme capable of catalyzing the oxidation of phenolic groups in the presence of an oxidizing agent.
    Type: Grant
    Filed: December 3, 1996
    Date of Patent: December 8, 1998
    Assignee: Novo Nordisk A/S
    Inventors: Lars Saaby Pedersen, Claus Felby
  • Patent number: 5846544
    Abstract: The present invention concerns a method and composition for reducing blood sugar levels in diabetic human subjects. Practice of the invention requires ingestion of bilberry fruit and valerian root in timed relation to meals. Neither bilberry fruit nor valerian root alone achieve the lowering and regulation of blood sugar levels achieved by the combination. Practice of the invention requires ingestion of bilberry fruit with valerian root.
    Type: Grant
    Filed: July 11, 1997
    Date of Patent: December 8, 1998
    Inventor: Holly Christine Al-Dahir
  • Patent number: 5846808
    Abstract: Disclosed is a novel amylase which mainly forms maltohexaose and maltoheptaose when reacted with starch, but does not substantially hydrolyze maltohexaose and an oligosaccharide of lower molecular than maltohexaose. The amylase can be prepared from microorganisms of the genus Alcaligenes, and has a relatively-high optimum temperature and thermal stability, as well as a relatively-wide range of optimum pH and pH stability. By using the amylase, saccharide compositions rich in maltohexaose and/or maltoheptaose or those rich on maltohexaitol and/or maltoheptaitol can be readily prepared in an industrial scale, and the saccharide compositions thus obtained can be used in a variety of food products, cosmetics and pharmaceuticals.
    Type: Grant
    Filed: April 28, 1997
    Date of Patent: December 8, 1998
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Masayuki Nakano, Hiroto Chaen, Toshiyuki Sugimoto, Toshio Miyake
  • Patent number: 5846794
    Abstract: A process for the preparation of D-arabitol, characterised in that it comprises the following stages:hydrolysis of a lactose solution,oxidation of the mixture of glucose and galactose thus obtained to a mixture of gluconic and galactonic acids,decarboxylation of this mixture of gluconic and galactonic acids to a mixture of D-arabinose and D-lyxose,catalytic hydrogenation of this mixture of D-arabinose and D-lyxose to D-arabitol.
    Type: Grant
    Filed: May 27, 1997
    Date of Patent: December 8, 1998
    Assignee: Roquette Freres
    Inventors: Didier Delobeau, Didier Moine
  • Patent number: 5843764
    Abstract: A method for enzymatically separating the non-inked cellulose fibers from the inked cellulose fibers in cellulosic materials. The cellulosic material, such as newsprint, is introduced into a first chamber containing a plastic canvas basket. This first chamber is in fluid communication, via plastic tubing, with a second chamber containing cellobiase beads in a plastic canvas basket. Cellulase is then introduced into the first chamber. A programmable pump then controls the flow rate between the two chambers. The action of cellulase and stirring in the first chamber results in the production of a slurry of newsprint pulp in the first chamber. This slurry contains non-inked fibers, inked fibers, and some cellobiose. The inked fibers and cellobiose flow from the first chamber to the second chamber, whereas the non-inked fibers remain in the first chamber because they are too large to pass through the pores of the plastic canvas basket. The resulting non-inked and inked fibers are then recovered.
    Type: Grant
    Filed: January 18, 1995
    Date of Patent: December 1, 1998
    Assignee: Martin Marietta Energy Systems, Inc.
    Inventor: Jonathan Woodward
  • Patent number: 5843922
    Abstract: The invention provides a method for preparation of a bifidobacteria-nourishing medium by subjecting a saccharide-based feedstock containing fructosyl units to flash flow conditions. The resulting shearform matrix is then treated to provide a medium having fructosyl-containing oligosaccharide. Preferably, the shearform matrix is treated by subjecting it to acid thermolysis conditions. Also provided is a method of nourishing mammalian alimentary tract for preferential growth of bifidobacteria. In addition, there is provided a medium for nourishing bifidobacteria and comestible products made therefrom.
    Type: Grant
    Filed: June 11, 1996
    Date of Patent: December 1, 1998
    Assignee: Fuisz Technologies Ltd.
    Inventors: Roy L. Whistler, James N. BeMiller
  • Patent number: 5840861
    Abstract: New A83543 components, including fermentation products A83543K, A835430, A83543P, A83543U, A83543V, A83543W and A83543Y and N-demethyl derivatives, and salts thereof, are useful for the control of insects and mites. The pseudoaglycones of the new A83543 components are useful for the preparation of A83543 components. Methods are provided for making the new A83543 components by culturing of Saccharopolyspora spinosa NRRL 18395, NRRL 18537, NRRL 18538, or NRRL 18539, or NRRL 18743 or NRRL 18719 or NRRL 18823 in suitable culture medium. Insecticidal and ectoparasiticidal compositions containing new A83543 components are also provided.
    Type: Grant
    Filed: February 8, 1995
    Date of Patent: November 24, 1998
    Assignee: DowElanco
    Inventors: Jon S. Mynderse, Mary C. Broughton, Walter M. Nakatsukasa, James A. Mabe, Jan R. Turner, Lawrence Creemer, Mary L. B. Huber, Herbert A. Kirst, James W. Martin
  • Patent number: 5837527
    Abstract: A .beta.-fructofuranosidase with a molecular weight of 49,000.+-.5,000 daltons on SDS-PAGE, an isoelectric point of 4.6.+-.0.5, an optimum pH of about 5.5-6.0, and an optimum temperature of about 50.degree. C. in the presence of calcium ion. The enzyme acts on saccharides with a .beta.-fructofuranosidic linkage and other substances including other saccharides, sugar alcohols, and alcohols to produce fructosyl-transferred saccharides in a relatively high yield.
    Type: Grant
    Filed: September 30, 1997
    Date of Patent: November 17, 1998
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Tetsuya Nakada, Hiroto Chaen, Toshiyuki Sugimoto
  • Patent number: 5834251
    Abstract: The invention is directed to methods of converting high mannose type glycosylation patterns to hybrid or complex type glycosylation patterns.
    Type: Grant
    Filed: December 30, 1994
    Date of Patent: November 10, 1998
    Assignee: Alko Group Ltd.
    Inventors: Marleen Maras, Roland Contreras
  • Patent number: 5834249
    Abstract: A process for production of a desired protein comprising the steps of:a culturing animal cells capable of producing the desired protein in a medium containing trichostatin compounds; andrecovering the desired protein from the culture.
    Type: Grant
    Filed: December 3, 1996
    Date of Patent: November 10, 1998
    Assignee: Suntory Limited
    Inventors: Kazuaki Furukawa, Keijiro Sugimura, Kazuhiro Ohsuye
  • Patent number: 5834257
    Abstract: The present inventions relate to novel .alpha.-agarase which selectively hydrolyzes the 1,3-bond of an oligosaccharide derived from agarose; a process for producing oligosaccharides and/or monosaccharides, characterized by that a .beta.-agarase which acts on both polysaccharides and oligosaccharides derived from agarose and an .alpha.-agarase which acts specifically on oligosaccharides derived from agarose are allowed to react with a substrate which contains agarose or an oligosaccharide derived from agarose; and a process for producing oligosaccharides and/or monosaccharides, characterized by that the above .alpha.-agarase is allowed to react with a substrate which contains an oligosaccharide derived from agarose.
    Type: Grant
    Filed: November 6, 1995
    Date of Patent: November 10, 1998
    Assignee: Japan Tobacco Inc.
    Inventors: Yasushi Sugano, Ichiro Terada, Hisashi Kodama
  • Patent number: 5834301
    Abstract: A method of removing color from wood pulp is disclosed. The method comprises the steps of preparing a wood pulp, treating the wood pulp with the xylanase wherein the xylanase is capable of releasing chromophores from the pulp and extracting the wood pulp to remove chromophores. Also disclosed are substantially purified preparations of xylanase enzymes from bacterial isolates.
    Type: Grant
    Filed: December 18, 1995
    Date of Patent: November 10, 1998
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Thomas W. Jeffries, Anthony C. Grabski, Rajesh N. Patel, Graziano Elegir, George Szakacs
  • Patent number: 5827715
    Abstract: This invention relates to heat resistant maltose phosphorylase having an activity of 80% or more of the one untreated after treated in a buffer of pH 6.0, at one temperature of 50.degree. to 60.degree. C. for 15 minutes, a process for preparation thereof, bacteria used for preparation thereof, and processes for preparation of .beta.-glucose-1-phosphoric and trehalose using the enzyme.By carrying out enzymatic reaction at high reaction temperatures using this enzyme, it is possible to prepare .beta.-glucose-1-phosphoric acid or trehalose industrially advantageously, with lowering of contamination with various germs and shortening of reaction time.
    Type: Grant
    Filed: July 26, 1996
    Date of Patent: October 27, 1998
    Assignee: Showa Sangyo Co., Ltd.
    Inventors: Keiko Ishii, Yasushi Inoue, Tetsuji Tomita
  • Patent number: 5824527
    Abstract: A novel fructosyl amino acid oxidase derived from genus Penicillium, which is active on both of fructosyl lysine and fructosyl valine, a process for producing the enzyme, an assay of an amadori compound using the enzyme, a reagent or a kit containing the enzyme is provided.
    Type: Grant
    Filed: April 11, 1996
    Date of Patent: October 20, 1998
    Assignee: Kyoto Daiichi Kagaku Co., Ltd.
    Inventors: Nobuo Kato, Yasuyoshi Sakai, Yoshiki Tani, Masayuki Yagi, Fumiyo Funatsu
  • Patent number: 5824664
    Abstract: Chronic HIV infection is treated by administering to a subject an organic thiophosphate alone or in combination with another anti-HIV or anti-AIDS drug. The organic thiophosphate is preferably WR 151327, a compound with antioxidant and free radical scavenging activities, or a functional derivative or analogue thereof. WR 151327 suppresses induction of HIV expression in chronically infected cells mediated by cytokines such as TNF.alpha. and GM-CSF. Pharmaceutical compositions comprising at least one organic thiophosphate in combination with one or more anti-HIV or anti-AIDS drugs are also disclosed.
    Type: Grant
    Filed: March 26, 1993
    Date of Patent: October 20, 1998
    Assignees: U.S. Bioscience, Inc., National Institutes of Health, The National Cancer Institute
    Inventors: Philip S. Schein, Thea Kalebic
  • Patent number: 5824521
    Abstract: A saccharide composition containing trehalulose, which is obtainable by allowing a maltose/trehalose converting enzyme to act on a sucrose solution to produce trehalulose, and collecting the resulting trehalulose-containing mixture. Since the enzyme converts sucrose into trehalulose in a relatively high yield and the conversion rate is controllable, a saccharide composition rich in trehalulose is readily obtained on an industrial scale.
    Type: Grant
    Filed: April 9, 1998
    Date of Patent: October 20, 1998
    Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
    Inventors: Tomoyuki Nishimoto, Hiroto Chaen, Shigeharu Fukuda, Toshio Miyake