Abstract: Provided herein are improved compositions and methods for enzyme replacement therapy using modified human cystathionine beta synthase (CBS) in the treatment of homocystinuria and related diseases and disorders.
Type:
Grant
Filed:
January 9, 2019
Date of Patent:
August 4, 2020
Assignee:
THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
Inventors:
Jan P. Kraus, Tomas Majtan, Erez Bublil
Abstract: The present invention relates to a liquid detergent composition comprising a novel protease, more in particular a novel and subtilase variant with increased stability, a method for (dish) washing using said liquid detergent composition and a use of said liquid composition in a (dish) washing process.
Type:
Grant
Filed:
November 4, 2016
Date of Patent:
August 4, 2020
Assignee:
Conopco, Inc.
Inventors:
Vincent Charles Mole, Gleb Urevich Priimov, Alastair Richard Sanderson, Matthew Peter Wright
Abstract: The invention provides a recombinant microbial host cell capable of converting a raw material comprising a fermentable carbon substrate to o-aminobenzoate biologically. The invention further provides a method for producing aniline, comprising the steps of: a) producing o-aminobenzoate by fermentation of a raw material comprising at least one fermentable carbon substrate using the recombinant microbial host cell of the capable of converting said raw material comprising at least one fermentable carbon substrate to o-aminobenzoate biologically, wherein said o-aminobenzoate comprises anthranilate anion, b) converting said o-aminobenzoate from said anthranilate anion to anthranilic acid by acid protonation, c) recovering said anthranilic acid by precipitation or by dissolving in an organic solvent, and d) converting said anthranilic acid to aniline by thermal decarboxylation in an organic solvent.
Type:
Grant
Filed:
February 19, 2015
Date of Patent:
August 4, 2020
Assignee:
Covestro Deutschland AG
Inventors:
Gernot Jaeger, Jorgen Magnus, Amgad Salah Moussa, Guenter Olf, Giulio Lolli, Swantje Behnken, Jung-Won Youn, Mohammad Yalfani, Georg Sprenger
Abstract: A method for treating dyed textile, comprises contacting the dyed textile with a pectolytic enxyme, wherein the said method is not applied during the abrasion stage when the dyed textile is a denim fabric.
Abstract: The present invention relates to a recombinant yeast cell comprising a gene encoding a protein exhibiting lactyl-CoA synthase activity and a gene encoding a protein exhibiting lactyl-CoA polymerase activity, said recombinant cell having the ability of producing polylactic acid (PLA), and the uses thereof.
Type:
Grant
Filed:
December 15, 2016
Date of Patent:
July 21, 2020
Assignees:
CARBIOS, INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, A'ALIMENTATION ET L'ENVIRONNEMENT, INSTITUT NATIONAL DES SCIENCES APPLIQUEES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Inventors:
Simon Dusseaux, Sophie Lajus, Vinciane Borsenberger, Jonathan Verbeke, Florence Bordes, Alain Marty, Jean-Marc Nicaud, Athanasios Beopoulos
Abstract: The invention is directed to compositions and methods for the manufacture of pigmented solids structures for which can be used for construction and/or decoration. Manufacturing comprises fixing one or more pigments to an aggregate material such as crushed rock, stone or sand. The pigmented aggregate is incubated with urease or urease producing microorganisms, an amount of a nitrogen source such as urea, and an amount of calcium source such as calcium chloride forming calcite bridges between particles of aggregate. The resulting solid has a hardness and colorfastness for most any construction material. Using selected aggregate and pigment, the process also provides for the manufacture of simulated-stone materials such as clay or granite bricks or blocks, marble counter-tops, and more. The invention is also directed to composition containing microorganisms and pigment as kits that can be added to most any aggregate materials.
Type:
Grant
Filed:
March 10, 2017
Date of Patent:
July 21, 2020
Assignee:
BioMason, Inc.
Inventors:
Thomas A. Hill, Steven W. McAllister, J. Michael Dosier, Ginger K. Dosier
Abstract: Presented herein are polymerase enzymes for improved incorporation of nucleotide analogues, in particular nucleotides which are modified at the 3? sugar hydroxyl, as well as methods and kits using the same.
Type:
Grant
Filed:
November 28, 2018
Date of Patent:
June 30, 2020
Assignee:
Illumina, Inc.
Inventors:
Erin Bomati, Michael Previte, Matthew William Kellinger, Cheng-Yao Chen, Molly He
Abstract: The present invention describes a recombinant yeast cell functionally expressing one or more heterologous nucleic acid sequences encoding for ribulose-1,5-phosphate carboxylase/oxygenase (EC4.1.1.39; Rubisco), and optionally one or more molecular chaperones for Rubisco, and one or more phosphoribulokinase (EC2.7.1.19; PRK), wherein the phosphoribulokinase is under control of a promoter (the “PRK promoter”) that enables higher expression under anaerobic conditions than under aerobic conditions.
Type:
Grant
Filed:
June 13, 2017
Date of Patent:
June 23, 2020
Assignee:
DSM IP ASSETS B.V.
Inventors:
Ioannis Papapetridis, Antonius Jeroen Adriaan Van Maris, Jacobus Thomas Pronk, Paulus Petrus De Waal, Niels Lauret, Maarten Dirk Verhoeven, Jozef Petrus Johannes Schmitz
Abstract: Disclosed herein are methods and compositions for generating a single-stranded break in a target sequence, which facilitates targeted integration of one or more exogenous sequences.
Abstract: A Myrmecridium flexuosum NUK-21, a novel lactose oxidase isolated from the Myrmecridium flexuosum NUK-21 and a method for conversion of lactose into lactobionic acid (LBA) by the novel lactose oxidase are disclosed herein. The Myrmecridium flexuosum NUK-21 produces high yields of the novel lactose oxidase and the novel lactose oxidase has higher reactivity and specificity of converting lactose into lactobionic acid.
Abstract: The disclosure relates to fatty diols and recombinant microorganisms for producing them. More particularly, the disclosure relates to recombinant microorganisms engineered to produce fatty diols via fermentation. Further encompassed is a process that uses the microorganisms to produce fatty diols from a simple carbon source.
Type:
Grant
Filed:
July 17, 2015
Date of Patent:
June 9, 2020
Assignee:
GENOMATICA, INC.
Inventors:
Andreas W. Schirmer, Noah Helman, Haibo Wang, Zhihao Hu, Vikranth Arlagadda, Alma Itzel Ramos-Solis, Elizabeth Clarke
Abstract: Disclosed herein are CRISPR/Cas9-based gene activation systems that include a fusion protein of a Cas9 protein and a protein having histone acetyltransferase activity, and methods of using said systems.
Abstract: The present invention relates to detergent compositions comprising a protease, an alpha-amylase and a surfactant, and methods and uses of the same (for example, in automatic dish washing and laundry).
Abstract: The present invention provides a non-naturally occurring microbe capable of growing in a medium comprising methanol, comprising a heterologous polynucleotide encoding a heterologous methanol dehydrogenase (MDH) derived from a Corynebacterium organism (Cor), wherein the MDH is expressed in the microbe, and wherein the MDH exhibits a Km of no more than 3 mM for methanol. Also provided are uses of the non-naturally occurring microbe for oxidizing methanol and producing a metabolite as well as the preparation of the non-naturally occurring microbe.
Type:
Grant
Filed:
January 13, 2017
Date of Patent:
May 5, 2020
Assignee:
University of Delaware
Inventors:
Eleftherios T. Papoutsakis, William Brian Whitaker, Robert Kyle Bennett
Abstract: The present invention relates to a recombinant microorganism having the ability to produce poly(lactate-co-glycolate) and its copolymers from xylose, and more particularly to a recombinant microorganism having the ability to produce poly(lactate-co-glycolate) and its copolymers without having to supply a glycolate precursor from an external source, and a method of producing a poly(lactate-co-glycolate) copolymers using the same.
Type:
Grant
Filed:
December 13, 2016
Date of Patent:
May 5, 2020
Assignee:
KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventors:
Sang Yup Lee, So Young Choi, Si Jae Park
Abstract: The present invention relates to pullulanase variants comprising substitutions of the parent pullulanase at one or more positions corresponding to positions 393, 143, 150, 243, 244, 345, 346, 368, 370, 373, 381, 382, 385, 387, 402, 429, 430, 431, 432, 456, 486, 492, 610, 624, 631, 632, 665 and 699 of the polypeptide of SEQ ID NO: 3. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
Abstract: The invention relates to the production of one or more terpenoids through microbial engineering, and relates to the manufacture of products comprising terpenoids.
Type:
Grant
Filed:
July 10, 2018
Date of Patent:
April 28, 2020
Assignees:
Massachusetts Institute of Technology, National University of Singapore
Inventors:
Parayil K. Ajikumar, Gregory Stephanopoulos, Heng Phon Too