Patents Examined by Gary Geist
  • Process for making mesna, dimesna and derivatives thereof
    Patent number: 5922902
    Abstract: A process for synthesizing disulfides and sulfhydryl compounds which are useful pharmaceuticals. The process includes a two step, single pot process for preparing disulfides from an alkenyl sulfonate salt. The disulfides are useful as toxicity mitigating agents of chemotherapeutic drugs, such as certain platinum complexes, and as use therapeutic drugs for a variety of conditions in mammals.The two step process involves first the conversion of the starting reagent to a mercaptane sulfonate, then an oxidation to the desired disulfide.
    Type: Grant
    Filed: June 30, 1998
    Date of Patent: July 13, 1999
    Assignee: BioNumerik Pharmaceuticals, Inc.
    Inventor: Kochat Haridas
  • Carbamoyl carboxylic acid amides
    Patent number: 5922899
    Abstract: Carbamoylcarboxamides of the general formula I ##STR1## (R.sup.1 =unsubstituted or substituted alkyl, alkenyl, alkynyl; R.sup.2 =hydrogen, halogen, cyano, nitro, or unsubstituted or substituted alkyl, alkoxy, alkylthio, or an unsubstituted or substituted phenyl group which is bonded via oxygen or sulfur) and compositions comprising them, processes for their preparation, and the use of the compounds I and of the compositions.
    Type: Grant
    Filed: February 17, 1998
    Date of Patent: July 13, 1999
    Assignee: BASF Aktiengesellschaft
    Inventors: Frank Wetterich, Oliver Wagner, Karl Eicken, Klaus Ditrich, Eberhard Ammermann, Gisela Lorenz, Siegfried Strathmann
  • Method for production of sulfide group-containing thiol compound
    Patent number: 5919985
    Abstract: An object is to provide a method for the production of a sulfide group-containing thiol compound which comprises using a solvent capable of effecting the ring-opening addition reaction of an alkylene sulfide to a thiol compound without inducing the alkylene sulfide to polymerize. A method for the production of a sulfide group-containing thiol compound, which comprises effecting the ring-opening addition reaction of an alkylene sulfide represented by the general formula (1): ##STR1## (wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4, which may be identical or different, stand for a hydrogen atom, an alkyl group of 1 to 10 carbon atoms, or an aromatic group of 6 to 15 carbon atoms) to a thiol compound in a solvent of an amide compound or urea substituent-containing compound.
    Type: Grant
    Filed: December 9, 1997
    Date of Patent: July 6, 1999
    Assignees: Nippon Shokubai Co., Ltd., Elf Atochem SA
    Inventors: Hirokazu Itoh, Kazuaki Abe, Takashi Tomita
  • Foam test for double metal cyanide-catalyzed polyols
    Patent number: 5919988
    Abstract: Double metal cyanide-catalyzed polyols are made by an improved process in which a starter is continuously added during polymerization of the epoxide. The process includes a continuously added starter (S.sub.c), and optionally, an initially charged starter (S.sub.i). The continuously added starter comprises at least about 2 equivalent percent of the total starter used. The process enables the use of water and low molecular weight polyol starters in DMC-catalyzed polyol synthesis. In addition, the process gives polyether polyols having reduced levels of high molecular weight polyol tail, which can adversely affect polyurethane foam processing.
    Type: Grant
    Filed: February 9, 1998
    Date of Patent: July 6, 1999
    Assignee: Arco Chemical Technology, L.P.
    Inventors: Jose F. Pazos, Veril C. Jividen
  • Meadowfoam amidopropyl dimethyl amine salts
    Patent number: 5919958
    Abstract: The present invention deals with the composition of matter and the utilization of certain novel amido amine salts of meadowfoam amido propyl dimethyl amine. These materials are useful in personal care applications.
    Type: Grant
    Filed: May 1, 1998
    Date of Patent: July 6, 1999
    Assignee: Fan Tech Ltd
    Inventor: Anthony J. O'Lenick, Jr.
  • Recovery and reuse of amphoteric surfactants from aqueous solutions
    Patent number: 5919980
    Abstract: Improved surfactant recovery for recycle and reuse upon ultrafiltration of a surfactant-containing aqueous solution can be obtained using a betaine or amide oxide amphoteric surfactant in the aqueous cleaner/contaminant solution. The surfactant passes through the ultrafiltration membrane with the water in the permeate in very high amounts while the contaminants and other undesirable components are held back in the retentate.
    Type: Grant
    Filed: March 10, 1997
    Date of Patent: July 6, 1999
    Assignee: Rhodia Inc.
    Inventors: Manilal S. Dahanayake, Yun Brian Yang, Mark E. Ventura
  • Phytosphingosine-based ceramide I analogs
    Patent number: 5919960
    Abstract: The present invention describes phytospringosine-based analogs of ceramides I, as well as cosmetics and pharmaceutical compositions containing these novel compounds and their use.
    Type: Grant
    Filed: April 29, 1996
    Date of Patent: July 6, 1999
    Assignee: Gist-brocades, B.V.
    Inventors: Pieter Gijsbert Weber, Johannes Wilhelmus Jacobus Lambers, Hein Simon Koger, Jan Verweij
  • Catalytic process for the selective oxidation of organic tertiary polyphosphines to phosphine monooxides
    Patent number: 5919984
    Abstract: This invention concerns a process for the selective mono oxidation of organic tertiary polyphosphines to phosphine monooxides. These monooxides are useful as ligands for transition metals in the formation of transition metal catalysts.
    Type: Grant
    Filed: April 17, 1998
    Date of Patent: July 6, 1999
    Inventor: Vladimir Grushin
  • D-homo vitamin D.sub.3 derivatives
    Patent number: 5919986
    Abstract: Compounds of formula I: ##STR1## wherein the dotted carbon-carbon bond in the D-ring is C--C or C.dbd.C; C(R,R) is CH.sub.2 or C.dbd.CH.sub.2,R.sup.1 is H, F or OH,R.sup.2 and R.sup.3 are each independently C.sub.1-4 -alkyl or CF.sub.3, or together with the carbon to which they are bound form C.sub.3-6 -cycloalkyl.are useful in the treatment of vitamin D dependent disorders, such as psoriasis, leukemia; acne and seborrhoic dermatitis; osteoporosis hyperparathyroidism accompanying renal failure; and multiple sclerosis.
    Type: Grant
    Filed: October 13, 1998
    Date of Patent: July 6, 1999
    Assignee: Hoffmann-la Roche Inc.
    Inventors: Pierre Barbier, Franz Bauer, Peter Mohr, Marc Muller, Wolfgang Pirson
  • Process for the preparation of .beta.-caryophyllene alcohol
    Patent number: 5917096
    Abstract: The present invention discloses a new process for the preparation of .beta.-caryophyllene alcohol, in which the sesquiterpene fraction at 110-120.degree. C./6 mmHg in Chinese pinus massoniana oleoresin composition undergoes isomerization in the presence of sulfuric acid as catalyst and the .beta.-caryophyllene alcohol is thus prepared through separation, re-crystallization and purification of the residue from the bottom of the vessel for the preparation of isolongifolene.
    Type: Grant
    Filed: June 16, 1997
    Date of Patent: June 29, 1999
    Assignee: Research Institute of Chemical Processing and Utilization of Forest Products
    Inventor: Hongjun Liu
  • Purification of .alpha.-acids and .beta.-acids
    Patent number: 5917093
    Abstract: Unsaturated organic compounds, in particular .alpha.-acids and .beta.-acids, are purified prior to hydrogenation by mixing them with an adsorbent capable of adsorbing catalyst poisons, preferably activated carbon, and separating the adsorbent containing the catalyst poisons to recover the thus purified unsaturated organic compounds. A significant reduction in the use of hydrogenation catalyst is realized.
    Type: Grant
    Filed: November 13, 1997
    Date of Patent: June 29, 1999
    Assignee: Miller Brewing Company
    Inventors: Patrick L. Ting, Jay R. Refling, Michael A. VanSanford, Henry Goldstein
  • Adsorbent for treatment of oils and/or fats
    Patent number: 5917069
    Abstract: An adsorbent is described based on an inorganic support material with exchangeable mono- and divalent cations, characterized by the fact that the specific surface of the support material is >100 m.sup.2 /g, its cation exchange capacity is>30 mg-equiv/100 g, its pore volume is>0.15 m/g, the pH value of an aqueous suspension of 8 g of support material in 100 mL of H.sub.2 O is<7.5 and that at least 60, preferably at least 70% of the exchangeable mono- and/or divalent cations are exchanged by cations acting as Lewis acids, preferably Al.sup.3 + cations.
    Type: Grant
    Filed: August 15, 1997
    Date of Patent: June 29, 1999
    Assignee: Sud-Chemie AG
    Inventors: Wolfgang Buckl, Hermann Ebert, Helmut Eicke, Norbert Schall, Werner Zschau, Reinhard Hahn
  • Acrolein-releasing emulsion homopolymers
    Patent number: 5917094
    Abstract: Acrolein-releasing emulsion homopolymers release acrolein in aqueous systems. They are produced by adding acrolein, at least 95% by weight pure, to a solution of an alkali hydroxide, with the temperature not exceeding 25.degree. C. during the addition, and then adjusting the pH to 5 to 7 by adding a mineral acid.
    Type: Grant
    Filed: December 16, 1997
    Date of Patent: June 29, 1999
    Assignee: Degussa-Huls Aktiengesellschaft
    Inventors: Peter Werle, Hans Peter Krimmer, Martin Trageser
  • Polyoxyalkylene glycol meadowfoam esters
    Patent number: 5917070
    Abstract: The present invention deals with the composition of matter and the utilization of certain novel polyoxyalkylene glycol esters which are prepared by the reaction of a meadowfoam oil, meadowfoam fatty acid or meadowfoam methyl ester and a polyoxylalkylene glycol as emulsifiers.
    Type: Grant
    Filed: December 26, 1996
    Date of Patent: June 29, 1999
    Assignee: Fan Tech Ltd.
    Inventor: Anthony J. O'Lenick, Jr.
  • Process for producing an omega-functionalized aliphatic carboxylic acid and intermediate products of said process, including 2-oxepanone-7-substituted products
    Patent number: 5917067
    Abstract: A process for producing an omega-functionalized aliphatic carboxylic acid starting from cyclohexanone and omega-functionalized .alpha.-olefins or acrylic esters. The process comprises an addition step, an oxidation step, an isomerization step, and one or more hydrogenation steps. The process allows to use raw materials that are available at low cost and to achieve high selectivity and high yield with industrially simple steps. The process includes the production of new intermediate products, including 2-oxepanone-7-substituted products.
    Type: Grant
    Filed: April 18, 1996
    Date of Patent: June 29, 1999
    Assignee: Industrie Chimiche Caffaro S.P.A.
    Inventors: Livius Cotarca, Paolo Maggioni, Alfonso Nardelli, Stefano Sguassero
  • Metal-ligand complex catalyzed processes
    Patent number: 5917095
    Abstract: This invention relates to a process for separating one or more phosphorus acidic compounds from a reaction product fluid containing said one or more phosphorus acidic compounds, a metal-organophosphorus ligand complex catalyst and optionally free organophosphorus ligand which process comprises (a) treating said reaction product fluid with water sufficient to remove at least some amount of said one or more phosphorus acidic compounds from said reaction product fluid and (b) treating the water which contains phosphorus acidic compounds removed from said reaction product fluid with an acid removal substance sufficient to remove at least some amount of said one or more phosphorus acidic compounds from said water.
    Type: Grant
    Filed: March 11, 1997
    Date of Patent: June 29, 1999
    Assignee: Union Carbide Chemicals & Plastics Technology Corporation
    Inventors: David Robert Bryant, James Clair Nicholson, John Robert Briggs, Diane Lee Packett, John Michael Maher
  • Process for the preparation of N-carboxyalkyl-3-fluoro-4-dialkylaminoanilines
    Patent number: 5917036
    Abstract: A process for the preparation of N-carboxyalkyl-3-fluoro-4-dialkylaminoanilines, which comprises reacting, in a first step, 2-chloro-4,5-difluoronitrobenzene of the formula (I) ##STR1## with a secondary amine of the formula (II) HNR.sup.1 R.sup.2, in which R.sup.1 and R.sup.2, independently of one another, are identical or different and are an alkyl radical having from 1 to 10 carbon atoms or, together with the N atom to which they are bonded, form a ring having from 5 to 7 members, in the presence of a water-soluble amine which forms hydrofluorides and hydrochlorides which are liquid at the reaction temperature and work-up temperature or soluble in the reaction mixture, in the presence or absence of a solvent at -10 to 120.degree. C., reducing, in a second step, the reaction mixture containing the 2-chloro-4-dialkylamino-5-fluoronitrobenzene using hydrogen at from 30 to 150.degree. C.
    Type: Grant
    Filed: March 5, 1998
    Date of Patent: June 29, 1999
    Assignee: Clariant GmbH
    Inventors: Thomas Schach, Hans Schubert
  • Process for producing ether compound
    Patent number: 5914430
    Abstract: Ether compounds, which are useful as solvents, cosmetics, detergents, lubricants, emulsifiers and so on, are produced by reacting (a) a hydroxy compound with a carbonyl compound of (b) a carbonyl compound under hydrogen atmosphere in the presence of a catalyst with ease and at a low cost. The reaction is carried out while removing out produced water by using a dehydrating agent during the reaction; by distilling off the water by azeotropic dehydration and the like; or by blowing gases such as hydrogen gas to flow through the reaction system.
    Type: Grant
    Filed: July 5, 1996
    Date of Patent: June 22, 1999
    Assignee: Kao Corporation
    Inventors: Yasuyuki Fujii, Hisakazu Furugaki, Katsumi Kita, Mitsuru Uno, Eiko Tamura, Hiromasa Matsumoto
  • Stabilizer and stabilizing method for aqueous aliphatic aldehyde solution
    Patent number: 5912389
    Abstract: A stabilizer for an aqueous aliphatic aldehyde solution comprising acetic acid, a halogenated acetic acid or a compound capable of releasing acetic acid or a halogenated acetic acid in water.
    Type: Grant
    Filed: October 14, 1997
    Date of Patent: June 15, 1999
    Assignee: Katayama Chemical, Inc.
    Inventor: Shinichi Matsumoto
  • Method for preparing fatty acid chlorides
    Patent number: 5912371
    Abstract: A method for preparing fatty acid chlorides. The method comprises reacting a silylation product of a fatty acid comprising at 1east 2 aliphatically unsaturated bonds per molecule and a chlorinating agent.
    Type: Grant
    Filed: October 27, 1997
    Date of Patent: June 15, 1999
    Assignee: Dow Corning Toray Silicone Co., Ltd.
    Inventors: Koji Nakanishi, Tadashi Okawa