Patents Examined by Gary L. Geist
  • Patent number: 5648518
    Abstract: The invention relates to a process for the production of (meth)acrylic acid esters of polyhydric alcohols by reaction of the reactants with acrylic acid and/or methacrylic acid in the presence of acidic esterification catalysts with addition of sterically hindered phenolic compounds as polymerization inhibitors. The process is characterized in that tocopherols are used as the sterically hindered phenolic compounds and .alpha.-tocopherol is preferably at least partly used. The process is preferably carried out using reaction mixtures which are liquid at room temperature and which are at least substantially free from solvents and/or azeotropic entraining agents; more particularly, the water of condensation formed is removed from the gas phase of the reaction zone.
    Type: Grant
    Filed: August 23, 1991
    Date of Patent: July 15, 1997
    Assignee: Henkel Kommanditgesellschaft auf Aktien
    Inventors: Wolfgang Ritter, Hans-Dieter Sitz, Ludwig Speitkamp
  • Patent number: 5637779
    Abstract: A process for the preparation of vitamin A which comprises condensing ethynyl-.beta.-ionol with the acetal of a C.sub.5 allylic halide in the presence of a catalytic amount of a copper-based catalyst and a base; hydrogenating the condensed compound; eliminating the hydroxyl functional group to obtain retinal; and correcting the retinal obtained.
    Type: Grant
    Filed: February 3, 1995
    Date of Patent: June 10, 1997
    Assignee: Rhone-Poulenc Nutrition Animale
    Inventors: Jean-Erick Ancel, Hugues Bienayme
  • Patent number: 5631302
    Abstract: From a synthesis gas which contains hydrogen and carbon oxides, methanol is produced on copper-containing catalysts under pressures in the range from 20 to 20 bars and at temperatures in the range from 200 to 350.degree. C. The synthesis gas is passed through a first synthesis reactor, which consists of a shaft reactor and contains a fixed bed of a copper-containing catalyst. The reaction in the shaft reactor is carried out adiabatically and without a recycling of synthesis gas. Together with recycle gas, the gas mixture which has not been reacted in the first synthesis reactor is passed through a second synthesis reactor, which contains a copper-containing catalyst, which is disposed in tubes and is indirectly cooled through boiling water. 10 to 30% of the carbon oxides of the synthesis gas are reacted in the shaft reactor to form methanol.
    Type: Grant
    Filed: May 8, 1995
    Date of Patent: May 20, 1997
    Assignee: Metallgesellschaft Aktiengesellschaft
    Inventors: Peter Konig, Hermann Gohna
  • Patent number: 5629446
    Abstract: A process for preparing purified 2,6-naphthalenedicarboxylic acid which comprises hydrolyzing a dialkyl-2,6-naphthalenedicarboxylate with water at a reaction temperature of at least about 450.degree. F. under liquid phase condition, the amount of water present being sufficient to solubilize, at the reaction temperature, at least about 10 percent of the 2,6-naphthalenedicarboxylic acid formed; and a process for purifying 2,6-naphthalenedicarboxylic acid comprising combining impure 2,6-naphthalenedicarboxylic acid with a purification solvent, heating the resulting mixture under liquid phase conditions at a temperature of at least about 500.degree. F. to form a product mixture and thereafter recovering from the product mixture purified 2,6-naphthalenedicarboxylic acid.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: May 13, 1997
    Assignee: Amoco Corporation
    Inventors: Juergen K. Holzhauer, Rusins Albertins, Stephen V. Hoover, David L. Sikkenga
  • Patent number: 5625093
    Abstract: Novel substituted amino acid derivatives are provided which inhibit platelet aggregation and which are useful in pharmaceutical compositions and methods of inhibiting platelet aggregation.
    Type: Grant
    Filed: May 25, 1995
    Date of Patent: April 29, 1997
    Assignee: G. D. Searle & Co.
    Inventor: Thomas E. Rogers
  • Patent number: 5554309
    Abstract: A method for reducing the coefficient of friction and wear at the interface of two ceramic surfaces at temperatures above approximately 600.degree. F. The method comprising the steps of: a) providing a first and second ceramic surface; b) providing a lubricant selected from the group consisting of p-dodecylphenol, C26 and organophosphorus compounds; and c) applying the lubricant to the interface of the first and second ceramic surfaces at temperatures above approximately 600.degree. F. to reduce the coefficient of friction at the interface.
    Type: Grant
    Filed: August 28, 1989
    Date of Patent: September 10, 1996
    Assignee: Aluminum Company of America
    Inventors: Robert W. Bruce, E. Erwin Klaus
  • Patent number: 5518654
    Abstract: A light modulating material is disclosed, comprising a solid, light transmissive, polymeric matrix having dispersed within said matrix droplets of a liquid crystalline composition, wherein said composition is a mixture of at least 2 compounds, at least one of said compounds having general formula (I), where n is 1 or 2, the fluorine substituent(s) may be in any of the available substitution positions and R.sup.1 is C.sub.1-12 alkynyl, hydrogen, R, RO or RCO where R is alkyl or perfluoroalkyl and at least one other of said compounds having general formula (II), where m is 0 or 1 and R.sup.2 is hydrogen or C.sub.1-12 alkyl or alkoxy.
    Type: Grant
    Filed: June 12, 1992
    Date of Patent: May 21, 1996
    Assignee: The Secretary of State for Defence in her Britannic Majesty's Government of the U.K. of Gt. Britain and Northern Ireland
    Inventor: David Coates
  • Patent number: 5518653
    Abstract: Optically active compounds of the formula ##STR1## wherein n stands for the number 0 or 1; Z.sup.1 is a single covalent bond or --CH.sub.2 CH.sub.2 --; Z.sup.2 is a single covalent bond, --CH.sub.2 CH.sub.2 --, --CH.sub.2 O--, --OCH.sub.2 --, --COO-- or --OOC--; rings A.sup.1 and A.sup.2 each independently represent trans-1,4-cyclohexylene or optionally halogen-, cyano- and/or methyl-substituted 1,4-phenylene in which optionally 1 CH group or 2 CH groups is/are replaced by nitrogen; R.sup.2 is a group R.sup.4 or a group of the formula ##STR2## R.sup.4 is cyano, halogen, --OCY.sup.1 F.sub.2, --CY.sup.1 F.sub.2 or an alkyl group in which optionally one >CH--CH< is replaced by >C.dbd.C< and/or optionally one methylene group or two non-adjacent methylene groups is/are replaced by --O--, --COO-- and/or --OOC-- and/or optionally one methylene group is replaced by --CHY.sup.2 --; Y.sup.1 is hydrogen or fluorine; Y.sup.2 is halogen, cyano or methyl; R.sup.1 and R.sup.
    Type: Grant
    Filed: January 12, 1995
    Date of Patent: May 21, 1996
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard Buchecker, Jurg Funfschilling, Martin Schadt
  • Patent number: 5510356
    Abstract: The present invention relates to new bisquinolines useful in the treatment of malaria and to processes for the production thereof. The invention also relates to methods for the treatment of malaria and, in particular, to the treatment of chloroquine-resistant strains of malaria. The compounds of the invention have the following formula: ##STR1## wherein R is a bivalent radical derived from an acyclic or cyclic hydrocarbon by removal of one hydrogen atom from each of two different carbon atoms. R' is hydrogen or lower alkyl (generally containing between about 1 and about 4 carbon atoms). X is hydrogen (--H), fluoro (--F), chloro (--Cl), bromo (--Br), trifluoromethyl (--CF.sub.3), cyano (--CN), or methylsulfoxide (--SOCH.sub.3). In its acyclic form, R generally contains at least two, and no more than about 12, carbon atoms and, preferably, is an unsubstituted straight or branched alkane.
    Type: Grant
    Filed: October 3, 1991
    Date of Patent: April 23, 1996
    Assignee: University of Nebraska Board of Regents
    Inventor: Jonathan L. Vennerstrom
  • Patent number: 5507975
    Abstract: A ferroelectric liquid crystal device having a pair of substrates each provided with voltage applying means, an orientation control layer formed on at least one of the substrates, and a layer of ferroelectric liquid crystal composition disposed between the pair of substrates, the ferroelectric liquid crystal composition comprising at least one compound (a) having an optically active group of the formula (I): ##STR1## at least one compound (b) which is reverse to the compound (a) in the direction of a helical pitch induced in a nematic phase and at least one liquid crystal compound (c) exhibiting a smectic C phase, the liquid crystal composition exhibiting at least a smectic C phase, smectic A phase and nematic phase.
    Type: Grant
    Filed: June 27, 1994
    Date of Patent: April 16, 1996
    Assignee: Sharp Kabushiki Kaisha
    Inventors: Mitsuhiro Koden, Tomoaki Kuratate, Fumiaki Funada, Kazuhiko Sakaguchi, Yutaka Shiomi, Tohru Kitamura
  • Patent number: 5506364
    Abstract: A process for the production of bis(fluoromethyl)ether by contacting formaldehyde with hydrogen fluoride in a reaction/distillation vessel. The reaction/distillation vessel is preferably a reaction/distillation column through which formaldehyde and hydrogen fluoride preferably flow in counter current.The bis(fluoromethyl)ether may be converted to difluoromethane, preferably by heating the bis(fluoromethyl)ether to elevated temperature in the presence of a metal, metal oxide, metal fluoride or metal oxyfluoride catalyst.
    Type: Grant
    Filed: May 5, 1994
    Date of Patent: April 9, 1996
    Assignee: Imperial Chemical Industries PLC
    Inventors: John S. Martin, Thomas A. Ryan, Rachel A. Spooncer
  • Patent number: 5506360
    Abstract: There is provided a process for the manufacture of 2-alkoxymethylacrolein compounds via the reaction of an appropriate alcohol and acrolein in the presence of an acid and a trisubstituted amine to form an intermediate and the subsequent reaction of the intermediate with formaldehyde in the presence of an acid and a disubstituted amine. There is also provided a process for the manufacture of 3-alkoxymethylquinolines from 2-alkoxymethylacrolein.
    Type: Grant
    Filed: November 5, 1993
    Date of Patent: April 9, 1996
    Assignee: American CYanamid Company
    Inventors: Henry L. Strong, David A. Cortes, Zareen Ahmed
  • Patent number: 5492651
    Abstract: Methods are provided for inhibiting the corrosion of iron and iron-containing metals in contact with aqueous systems. Salicylaldoxime is added to cooling water systems to inhibit the corrosion of these metal surfaces.
    Type: Grant
    Filed: July 29, 1993
    Date of Patent: February 20, 1996
    Assignee: Betz Laboratories, Inc.
    Inventor: William J. Yorke
  • Patent number: 5493056
    Abstract: The invention relates to a method for producing tetrakis(pentafluorophenyl)borate derivatives of the formula (C.sub.6 F.sub.5).sub.4 BM which comprises reacting 1 equivalent of pentafluorobenzene with 0.5 to 1.5 equivalents of an organometallic compound RM at -120.degree. to 80.degree. C., in an ether type solvent, a hydrocarbon type solvent or a mixture thereof, to generate pentafluorophenyl alkali metal salt represented by the formula C.sub.6 F.sub.5 M, and then reacting either (1) not less than 3.7 equivalents of said pentafluorophenyl alkali metal salt with 1 equivalent of a boron compound BX.sub.3, or (2) not less than 0.8 equivalents of said pentafluorophenyl alkali metal salt with 1 equivalent of tris(pentafluorophenyl)borane.
    Type: Grant
    Filed: December 22, 1993
    Date of Patent: February 20, 1996
    Assignee: Tosoh Akzo Corporation
    Inventors: Yoshihiko Ikeda, Takeo Yamane, Eiichi Kaji, Kenji Ishimaru
  • Patent number: 5487845
    Abstract: Fluorobenzene derivatives of the formula I, ##STR1## R, A1, A2, S1, 22, L, m, Y, Q are as defined herein.
    Type: Grant
    Filed: April 12, 1994
    Date of Patent: January 30, 1996
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Volker Reiffenrath, Hans A. Kurmeier, Eike Poetsch, Herbert Plach, Ulrich Finkenzeller, Ekkehard Bartmann, Joachim Krause, Bernhard Scheuble
  • Patent number: 5486626
    Abstract: Process for the preparation of 3.beta.-aminocholanic acid derivativesA process for the preparation of 3.beta.-aminocholanic acid derivatives of the formula II ##STR1## wherein R(1), R(2) and R(3) have the meanings given, starting from the corresponding 3.beta.-hydroxycholanic acid esters, is described.
    Type: Grant
    Filed: March 7, 1994
    Date of Patent: January 23, 1996
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Alfons Enhsen, Heiner Glombik, Werner Kramer, Gunther Wess
  • Patent number: 5486274
    Abstract: The use of substituted phthalocyanines for the generation of singlet oxygen in which at least one of the peripheral carbon atoms in the 1-16 positions of the phthalocyanine nucleus (M.sub.k Pc) of Formula (1): ##STR1## wherein: M is selected from H, metal, halometal, oxymetal and hydroxymetal; andk is the inverse of 1/2 of the valency of M; is linked via an oxygen atom to an aromatic radical and the remaining peripheral carbon atoms are unsubstituted or substituted by any combination of atoms or groups and sulphonated derivatives thereof provided that the phthalocyanine absorbs electromagnetic radiation at a wavelength from 650 nm to 800 nm.
    Type: Grant
    Filed: November 17, 1994
    Date of Patent: January 23, 1996
    Assignee: Zeneca, Limited
    Inventors: Dean Thetford, Peter Gregory
  • Patent number: 5486526
    Abstract: The present invention is directed to compounds of the class of piperidyl-imidazole derivative histamine H.sub.3 -receptor antagonists. Such compounds have affinity for histamine H.sub.3 -receptor, and preferably penetrate the blood-brain barrier. The compounds can block the soporific effect of an H.sub.3 -receptor agonist. Illustrative of the compounds of the invention is the molecule 4-(1-cyclohexylvaleroyl-4-piperidyl)-1H-imidazole. These compounds have been found to have utility in treating cognitive disorders and have been found to be useful as appetite suppressants.
    Type: Grant
    Filed: October 29, 1993
    Date of Patent: January 23, 1996
    Assignees: The University of Toledo, Gliatech, Inc.
    Inventors: Graham J. Durant, Amin M. Khan, Clark E. Tedford
  • Patent number: 5486308
    Abstract: A composition for inhibiting corrosion. The composition contains a mixture of a dessicant and a vapor-corrosion inhibitor. The mixture of dessicant and inhibitor is synergistic: the service life of the corrosion inhibitor is signficiantly longer when so used than when used alone or in in the presence of but not physically mixed with the dessicant.
    Type: Grant
    Filed: April 4, 1994
    Date of Patent: January 23, 1996
    Assignee: A+ Corp.
    Inventor: Donald P. Mayeaux
  • Patent number: H1664
    Abstract: A dry-type analytical element for immunoassay utilizing antigen-antibody reaction in which the antigenic component is isolated from the antibody component by incorporating both components in separate layers or separately in a layer using different solvents. The analytical element is excellent in sensitivity and accuracy, and the analytical operation is simple.
    Type: Grant
    Filed: March 8, 1989
    Date of Patent: July 1, 1997
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Yukio Sudo, Nobuhito Masuda