Patents Examined by Gina C Justice
  • Treating infection by a platelet-targeting microbe using nanoparticles
    Patent number: 11224577
    Abstract: The present invention relates to prevention and/or treatment of infection by a platelet-targeting microbe in a subject. The present invention provides for methods, combinations and pharmaceutical compositions for preventing and/or treating (and/or related uses) infection by a platelet-targeting microbe in a subject, using, inter alia, an effective amount of a nanoparticle comprising a) an inner core comprising a non-cellular material, b) an outer surface comprising a cellular membrane derived from a platelet; and optionally c) an agent for preventing said infection, treating said infection, diagnosing said infection, prognosing said infection and/or monitoring prevention or treatment of said infection. Exemplary platelet-targeting infections include infections by a bacterium, a virus, a fungus and/or a parasite.
    Type: Grant
    Filed: June 7, 2016
    Date of Patent: January 18, 2022
    Assignee: The Regents of the University of California
    Inventors: Liangfang Zhang, Che-Ming Jack Hu, Ronnie H. Fang, Brian T. Luk, Soracha Kun Thamphiwatana
  • Composition containing phytic acid, magnesium and polyphenols for the treatment or prevention of renal lithiasis
    Patent number: 11213535
    Abstract: The present invention is related to a composition comprising phytic acid or a phytate salt, magnesium in the form of salt, hydroxide or oxide and optionally at least one polyphenol. These components may be in isolated form or be part of an enriched plant extract. The invention is also related to the use of this composition for the treatment of renal lithiasis, preferably calcium or calcium oxalate lithiasis, either in the form of a medicament, a nutraceutical or functional food or food supplement.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: January 4, 2022
    Assignee: UNIVERSITAT DE LES ILLES BALEARS
    Inventors: Félix Grases Freixedas, Antonia Costa Bauzá, Rafael María Prieto Almirall, Adrián Rodríguez Rodríguez
  • Cosmetic composition comprising a passionflower extract and edelweiss cells, and uses
    Patent number: 11213479
    Abstract: The present invention relates to a novel cosmetic or dermatological composition for topical or oral use, comprising at least one passionflower extract, at least edelweiss callus cells, and at least one physiologically acceptable support, to a non-therapeutic cosmetic skin treatment process using such a cosmetic composition, and also to the non-therapeutic use of such a cosmetic composition for protecting the skin against environmental attack, preventing, retarding and/or combating the signs of ageing of the skin.
    Type: Grant
    Filed: August 8, 2019
    Date of Patent: January 4, 2022
    Assignee: SOCIETE DE RECHERCHE COSMETIQUE S.A.R.L.
    Inventors: Eve Merinville, Judith Elkaim
  • Compositions of midodrine and methods of using the same
    Patent number: 11202760
    Abstract: This disclosure provides pharmaceutical compositions comprising midodrine, a pharmaceutically acceptable salt thereof, desglymidodrine, a pharmaceutically acceptable salt thereof, or a combination therefore that can be administered to a human subject in need thereof in a supine position. The disclosure also provides pharmaceutical compositions which can be administered once-a-day. This disclosure further provides pharmaceutical compositions comprising an extended release composition and providing a delayed release period between about 30 min to about 12 hours.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: December 21, 2021
    Assignee: XENAMED CORP.
    Inventors: Yogesh Dandiker, Maulik Panchal, Xiao Yu
  • Solid cosmetic composition comprising a fatty acid-based gelling agent and a co-gelling agent
    Patent number: 11197806
    Abstract: A solid state, oil gel composition for keratinous substance, such as skin, contains (a) at least one fatty acid-based gelling agent; (b) at least one polysaccharide fatty acid ester; and (c) at least one oil. An embodiment according to the present invention provides improved storage stability, morphological stability, and application property.
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: December 14, 2021
    Assignee: L'OREAL
    Inventors: Kazuyoshi Tsubata, Chisato Masumoto
  • Composition for enhancing immunity of insects and method thereof
    Patent number: 11178895
    Abstract: Provided is a use of a Macaranga tanarius preparation or extract for manufacturing a composition for enhancing immunity of an insect, particularly a bee. Also provided is a method for enhancing immunity of an insect, particularly a bee. The method comprises administering an effective amount of a composition of the present invention to the insect.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: November 23, 2021
    Assignee: NATUREWISE BIOTECH & MEDICALS CORPORATION
    Inventors: Yu-Cheng Kuo, Chung-Yang Huang, Chia-Chung Hou, Chi-Jung Chen
  • Corticosteroid containing orally disintegrating tablet compositions for eosinophilic esophagitis
    Patent number: 11166961
    Abstract: The present invention is directed to orally administered compositions of topically acting corticosteroids for the treatment of inflammation of the gastrointestinal tracts such as eosinophilic esophagitis. The present invention also provides a method for treating conditions associated with inflammation of the gastrointestinal tract in an individual. The method comprises administering to an individual in need thereof a pharmaceutical composition of the present invention as orally disintegrating tablets comprising a topically active corticosteroid adsorbed onto a pharmaceutically acceptable carrier such as silicified microcrystalline cellulose.
    Type: Grant
    Filed: September 23, 2019
    Date of Patent: November 9, 2021
    Assignee: ELLODI PHARMACEUTICALS, L.P.
    Inventors: Michael A. Gosselin, Jin-Wang Lai, Gopi M. Venkatesh
  • Solid dosage formulations of an orexin receptor antagonist
    Patent number: 11160811
    Abstract: The present invention is directed to a pharmaceutical composition comprising the compound suvorexant, or a pharmaceutically acceptable salt thereof, a concentration-enhancing polymer, and optionally a pharmaceutically acceptable surfactant.
    Type: Grant
    Filed: August 9, 2018
    Date of Patent: November 2, 2021
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Paul A. Harmon, Narayan Variankaval
  • Method for producing an osteoinductive calcium phosphate and products thus obtained
    Patent number: 11147836
    Abstract: The invention relates to a method for producing an osteoinductive calcium phosphate material, the method comprising the steps of providing a sintered calcium phosphate starting material having a surface topography consisting of calcium phosphate grains, subjecting the sintered calcium phosphate starting material to a hydrothermal treatment of between 125-150° C. for a duration sufficient to change calcium phosphate grains on the surface of the starting material into calcium phosphate needles.
    Type: Grant
    Filed: December 23, 2019
    Date of Patent: October 19, 2021
    Assignee: KUROS BIOSCIENCES B.V.
    Inventors: Florence De Groot-Barrere, Vincent Van Miegem, Huipin Yuan, Joost De Bruijn
  • Orodispersible dosage unit containing an estetrol component
    Patent number: 11147771
    Abstract: The invention provides an orodispersible solid pharmaceutical dosage unit having a weight between 30 and 1,000 mg, said dosage unit consisting of: 0.1-25 wt. % of estetrol particles containing at least 80 wt. % of an estetrol component selected from estetrol, estetrol esters and combinations thereof; and 75-99.9 wt. % of one or more pharmaceutically acceptable ingredients; the solid dosage unit comprising at least 100 ?g of the estetrol component; and wherein the solid dosage unit can be obtained by a process comprising wet granulation of estetrol particles having a volume weighted average particle size of 2 ?m to 50 ?m. The solid dosage unit is easy to manufacture and perfectly suited for sublingual, buccal or sublabial administration.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: October 19, 2021
    Assignee: ESTETRA SPRL
    Inventors: Séverine Francine Isabelle Jaspart, Johannes Jan Platteeuw, Denny Johan Marijn Van Den Heuvel
  • Skin care composition and method thereof
    Patent number: 11135147
    Abstract: The disclosed technology relates to a composition comprising: 0.1 to 3 wt % (or 0.5 to 2.5 wt %) of a beta hydroxy acid, 0.05 to 3 wt % (or 0.09 to 2.5 wt %) of an O-substituted ascorbic acid or a derivative thereof, and a cosmetically acceptable medium comprising an aqueous phase, wherein a beta hydroxy acid is present at a higher concentration than O-substituted ascorbic acid or a derivative thereof. The disclosed technology further relates to the use and method of improving skin condition.
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: October 5, 2021
    Assignee: THE BOOTS COMPANY PLC
    Inventors: Jake Thomas Hicks, Paul James Tomlinson
  • Surface-modified effect pigment and nail varnish composition
    Patent number: 11111390
    Abstract: The invention relates to a surface-modified effect pigment comprising particular additives and to the production thereof. The present invention further provides a nail varnish composition comprising a) at least one effect pigment that has been surface-modified with a starting material (additive), where the effect pigment comprises a substrate in platelet form and optionally at least one coating applied to the substrate, b) at least one hydrocarbon resin as binder, and c) at least one solvent or solvent mixture, where the starting material (additive) for surface modification of the effect pigment is at least one compound taken from the group consisting of phosphoric ester-containing, phosphonic ester-containing, phosphonic acid-containing, fatty acid-containing and/or silane-containing compounds or mixtures thereof.
    Type: Grant
    Filed: April 13, 2017
    Date of Patent: September 7, 2021
    Assignee: ECKART GmbH
    Inventors: Christine Schilling, Ulrich Schmidt, Christina Pippinger, Ann-Katrin Gebhard
  • Hypochlorous acid-based eyelid cleansers
    Patent number: 11090236
    Abstract: An antimicrobial eyelid cleanser composition contains: (a) a hypohalous acid; (b) one or more surfactants having a HLB value of 5 to 18; and (c) an aqueous vehicle, the aqueous vehicle comprising: (i) one or more tonicity adjusters; (ii) one or more osmolality adjusters for adjusting an osmolality of the composition; and (iii) one or more pH adjusters for maintaining the pH of the composition at between about 4.5 to about 8.0. The composition can be dispensed in a foam, liquid, spray, mist, gel or lotion form. The composition can facilitate long term eyelid hygiene by removing excess oil, debris and desquamated skin and provide relief for inflammation of the eyes.
    Type: Grant
    Filed: May 1, 2019
    Date of Patent: August 17, 2021
    Assignee: OCUSOFT, INC.
    Inventors: Nat Adkins, Jr., Cynthia Barratt, Thomas Mason, Paramita Sarkar
  • Shear-thinning therapeutic composition, and related methods
    Patent number: 11077051
    Abstract: A shear-thinning therapeutic composition is provided along with methods of making and using the therapeutic composition.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: August 3, 2021
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Xiaochu Ding, Jin Gao, Yadong Wang
  • Compositions and treatments for keratinous materials providing damage protection and sensorial benefits
    Patent number: 11065193
    Abstract: The present invention relates to a cosmetic treatment and processes for treating keratinous materials, in particular for altering the color of hair as in hair coloration, hair color lightening or removal, and treatment of artificially colored hair, wherein the composition can include at least one antioxidant, applied separately or combined or combinable with one or more components of a color altering system in amounts sufficient to confer protection when the treatment composition is applied to keratinous material and thereby enhance and protect one or more sensorial features, and preserve the mechanical properties and native amino acid structure of the keratinous material.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: July 20, 2021
    Assignee: L'OREAL
    Inventors: Andrea Elsen-Wahrer, Jim Singer, Paul Bonvallet, Zhi Pan
  • Topical formulations including lipid microcapsule delivery vehicles and their uses
    Patent number: 11065206
    Abstract: The present invention relates to topical formulations that include lipid microcapsules formed from tocopherol, tocotrienol, or mixtures thereof; a stabilizer/surfactant component; and an aqueous component. The lipid microcapsules may be formed without the use of steroids, preservatives, initiators and/or oils. The topical formulations are capable of delivering transdermal active agent(s) such as vitamin D through the skin and into the bloodstream without the use of skin penetration enhancers. In certain embodiments, the topical formulations also able to deliver topical active agent(s) such as sun-protecting agents to the surface of the skin where they remain, while simultaneously delivering the transdermal active agent(s) through the skin and into the bloodstream.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: July 20, 2021
    Assignee: Avidas Pharmaceuticals, LLC
    Inventor: David Craig Wright
  • Natural product formulations with improved residual insect repellent/deterrent activity
    Patent number: 11064704
    Abstract: Natural products were screened for their insect repellent activity, and carrot seed essential oil gave very high activity in biting repellent/deterrent bioassays. Analysis of the oil revealed the presence of 47 compounds, mainly mono- and sesqui-terpenes. The sesquiterpene, carotol, constituted more than 75% w/w of the oil. In the initial screening, the essential oil gave high biting deterrent activity and high repellent activity comparable to DEET against both Aedes aegypti and Anophies quadrimaculatus species of mosquitoes. The active fraction mainly comprises pure carotol. The essential oil and the pure compound have a potential to be developed and used as effective repellent against mosquitoes.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: July 20, 2021
    Assignee: University of Mississippi
    Inventors: Abbas Ali, Ikhlas A. Khan, Mohamed Mahmoud Radwan
  • Implantable medical devices with increased immune tolerance, and methods for making and implanting
    Patent number: 11058798
    Abstract: The present invention relates to the contacting of one or more surfaces of an implantable medical device with one or more diketopiperazines (DKPs).
    Type: Grant
    Filed: September 19, 2019
    Date of Patent: July 13, 2021
    Assignee: Ampio Pharmaceuticals, Inc.
    Inventor: David Bar-Or
  • Use of potassium hydroxide in the treatment of actinic keratosis
    Patent number: 11045494
    Abstract: An agent in the form of potassium hydroxide (KOH) in a pharmaceutically acceptable composition is used in the dermal treatment of actinic keratosis. The composition may be an aqueous alkaline solution of potassium hydroxide and topically applied to the skin or on the scalp, within the face, the neck, the nose, as well as on the bosom.
    Type: Grant
    Filed: July 10, 2015
    Date of Patent: June 29, 2021
    Assignee: Infectopharm Arzneimittel und Consilium GmbH
    Inventors: Thomas Wimmer, Bertil Wachall, Philip Zoeller, Alessandro Giunta
  • Use of trientine to deliver copper to ischemic tissue
    Patent number: 11033579
    Abstract: Methods of ischemic tissue repair and regeneration through promoting tissue redistribution and reuse of copper by administering a composition comprising a copper chelating tetramine, such as trientine. Methods and compositions for increasing intracellular copper lever and/or inducing repair of an ischemic tissue in an individual. Increased copper level in an ischemic tissue may promote copper-dependent HIF-1 transcriptional activities and tissue repair.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: June 15, 2021
    Assignee: INNOLIFE CO., LTD.
    Inventor: Yujian James Kang