Abstract: A system for detecting the formation of a crack in a metal joint includes an electrochemical electrical current detection device. Carrier material surrounds the metal joint, at least partially, with conductive media having electrolyte therein. An auxiliary electrode is in electrical contact with the carrier material. The placement of the auxiliary electrode in electrical contact with carrier material forms a passive layer on the metal joint. The formation of a crack in the metal joint ruptures the passive layer to generate a current for detection by the electrochemical electrical current detection device.

Abstract: NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof, an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.

Abstract: An olfactory sensing device is presented herein. The device includes a housing with at least one inlet or outlet port to facilitate a flow of air through an interior area. At least one olfactory processing unit (OPU) is disposed within the interior area and includes at least one base, several chemical detection sensors, a potentiostat configured to sense an electrochemical response of an odorant in the flow of air, and a processor. Each of the chemical detection sensors are tuned to detect a particular chemical compound. The OPU is formed in such a way to facilitate an effective flow of air through the interior area such that the sensors are effectively exposed to the chemicals in the air. A main controller is communicative with each of the OPUs and includes its own processor to fuse sensor data from the sensors to generate a chemical profile in the air.

Abstract: An acetone sensor including a substrate, a pair of interdigitated electrodes disposed on the substrate, and a sensing film disposed on the pair of interdigitated electrodes and having electrical conductivity that depends upon a concentration of acetone. A method for detecting acetone includes for each sensor of a plurality of sensors: generating a signal if said sensor is exposed to a sample of acetone having density greater than or equal to an acetone detection threshold of said sensor, wherein the plurality of sensors has a respective plurality of acetone detection limits that span a detection range. A method for forming an acetone sensor includes dissolving a co-polymer and suspending conductive nanoparticles in an organic solvent to form a sensing solution, and coating the solution to form a conductive sensing film disposed on a pair of interdigitated electrodes disposed on a substrate.

Abstract: An analyte sensor includes a microcontroller, a base layer, a conductive layer disposed on the base layer where the conductive layer includes a working electrode configured to provide a current signal in presence of glucose, an interference rejection membrane (“IRM”) layer disposed on the working electrode where the IRM layer is negatively charged, and an enzyme layer disposed on the IRM layer where the enzyme layer includes an enzyme selected to generate a detectable electrical signal upon exposure to the glucose. The microcontroller is configured to process an electrochemical impedance spectroscopy (EIS) parameter to determine a state of the IRM layer.

Abstract: NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof, an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.

Abstract: A gas sensor includes: a sensor element including a sensing part on a side of one end portion thereof; a casing; and a connector disposed in the casing to electrically connect the sensor element to an outside, wherein the casing includes: an outer tube including a main portion in which a reference gas is included and a sealing portion being an end portion having a smaller diameter than the main portion, another end portion of the sensor element protruding to the main portion, a rubber seal member fitted into the sealing portion to seal the outer tube, and a spacer intervening between the seal member and the connector in the outer tube. The spacer includes a concave portion in an end surface on a side having contact with the connector, and has contact with the connector in the end surface except for the concave portion.

Abstract: NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof; an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.

Abstract: Membranes permeable to an analyte may overlay the active sensing region of a sensor to limit the analyte flux and improve the response linearity of the sensor. Temperature variation of the analyte permeability can be problematic in some instances. Polymeric membrane compositions having limited variation in analyte permeability as a function of temperature may comprise: a polymer backbone comprising one or more side chains that comprise a heterocycle; and an amine-free polyether arm appended, via an alkyl spacer or a hydroxy-functionalized alkyl spacer, to the heterocycle of at least a portion of the one or more side chains.

Abstract: Embodiments of the invention provide amperometric analyte sensors having optimized elements such as interference rejection membranes as well as methods for making and using such sensors. The amperometric analyte sensor apparatus comprises: a base layer; a conductive layer disposed on the base layer and comprising a working electrode; an interference rejection membrane disposed on an electroactive surface of the working electrode, wherein the interference rejection membrane comprises poly(vinyl alcohol) (PVA) polymers crosslinked by an acid crosslinker, wherein the crosslinker is a dicarboxylic acid type monomer or a polymer comprising a carboxylic acid group; and an analyte sensing layer. While embodiments of the innovation can be used in a variety of contexts, typical embodiments of the invention include glucose sensors used in the management of diabetes.

Abstract: The present invention relates to a biosensor capable of determining whether the sample addition amount is sufficient. The biosensor at least comprises an insulating substrate, a working electrode and a fill detection electrode. The fill detection electrode is further away from the sample supply port of the biosensor than the working electrode, and the fill detection electrode is not in contact with a sample supply channel. The biosensor of the present invention can determine whether the sample amount added to the biosensor meets detection requirements, which effectively avoids the risk of insufficient sample amount and ensures the accuracy of test results.

Abstract: A reference electrode of an electrochemical sensor includes a substrate having well, a channel, and a conductive element therein. The well extends from a first surface of a substrate towards a second surface of the substrate. The channel is within the substrate. A longitudinal axis of the channel may be substantially perpendicular to a longitudinal axis of the well. The channel has a first end connected to the well and the conductive element is exposed to a second of the channel. The channel and the wells form a flow path of a conductive medium. A valve is coupled to the flow path and configured to control a flow of the conductive medium to the electrically conductive element through the flow path.

Abstract: A potentiostat is an essential piece of analytical equipment for studying electrochemical devices and reactions. As the design of electrochemical devices evolve, applications for systems with multiple working electrodes have become more common. These applications drive a need for low-cost multi-channel potentiostat systems. Embodiments describe herein include a portable, low-cost and scalable system with a modular design that can support 8 to 64 channels at a cost as low as $8 per channel. This design can replace the functionality of commercial potentiostats which cost upwards of $10k for certain applications. Each channel in the multi-channel potentiostat has an independent adjustable voltage source with a built-in ammeter and switch, making the device flexible for various configurations. The multi-channel potentiostat can be designed for low current applications (nA range), but its purpose can change by varying its shunt resistor value.

Abstract: A method for evaluating a capacity of a serum to neutralize a virus is disclosed. The method includes preparing a solution comprising at least one cell, a serum and a virus, placing the solution in contact with an organic electrochemical transistor comprising a source, a drain and a gate electrode, wherein the source and drain electrodes are electrically connected by means of a conductive channel, applying a potential difference between the drain and source electrode, applying a plurality of pulses of a potential difference between the gate and source electrode and measuring a respective plurality of values of pulses of current flowing through the channel; calculating a value of an estimation of a response time of the transistor, and comparing the value of the estimated response time with respect to a threshold value and detecting whether the serum has a neutralising capacity against the at least one virus.

Abstract: A gas sensor includes: a sensor element including a sensing part on one end portion thereof; a casing; and a connector disposed in the casing to electrically connect the sensor element to an outside, wherein the casing includes: an outer tube including a main portion in which a reference gas is included and a sealing portion with a diameter smaller than the main portion so that another end portion of the sensor element protrudes to the main portion; a rubber seal member fitted into the sealing portion; and a spacer intervening between the seal member and the connector, and the spacer is secured by being sandwiched between the connector and the seal member due to friction force acting on a contact surface with the seal member which occurs by that load acts on the spacer from the seal member in accordance with reduction in the diameter by swaging.

Abstract: A device and method for continuously sensing at least one target analyte in a sample fluid. The device 100 includes a plurality of electrochemical aptamer sensors 120, 122, 124, 126; and at least one gating component 132, 134, 136 associated with at least one electrochemical aptamer sensor of the plurality of electrochemical aptamer sensors. The method includes bringing a sample fluid 190 into contact with the device, and determining or measuring a change in an electrical current associated with the at least one electrochemical aptamer sensor to (1) determine the presence of an analyte in the sample fluid, or (2) measure the amount or concentration of an analyte in the sample fluid.

Abstract: A nanopore-based sequencing system includes a plurality of nanopore-based sequencing chips. Each of the nanopore-based sequencing chips comprises a plurality of nanopore sensors. The system comprises at least one flow cell coupled to at least one of the plurality of nanopore-based sequencing chips, wherein the flow cell coupled to the at least one of the plurality of nanopore-based sequencing chips comprises one or more fluidic flow channels that allow a fluid external to the system to flow on top of the nanopore-based sequencing chip and out of the system. The system further comprises a printed circuit board electrically connected to the plurality of nanopore-based sequencing chips.

Abstract: A gas sensor (1) including: a sensor element (21); a tubular casing (81); a lead wire (71); and an elastic member (85) having a terminal passage hole (85h) through which the lead wire passes, the terminal passage hole having two or more annular projecting ridges (85R1-85R2) on an inner surface thereof, the elastic member being placed on a rear-end of the casing and sealing the opening (81e), wherein the casing is reduced in diameter by a crimping portion (81c) so that the projecting ridges contact with an outer surface of the lead wire in an airtight state, and when the elastic member is viewed in a state of being removed from the casing, an inner diameter d1 of a first projecting ridge which is the projecting ridge on a most-front-end side is smallest among inner diameters of all the projecting ridges.

Abstract: An electro-osmotic pump according to an embodiment of the present disclosure includes: a membrane that allows fluid movement; and a first electrode and a second electrode respectively provided on both sides of the membrane. The first electrode and the second electrode are formed of an impermeable substrate material and an electrode material coated thereon and have at least one fluid pathway. The impermeable substrate material is a plate-shaped substrate including at least one of a conducting material, a semiconducing material and a non-conducting material.

Abstract: An automatic pathogen-from-expiration detection system includes a gas pathogen recovery unit, a pathogen concentration unit and a sample detection unit. The method includes making the sample recovered by the gas pathogen recovery unit enter the pathogen concentration unit; in the pathogen concentration unit, gradually biasing the pathogen particles in the sample to the positive electrode side into the concentration channel under the action of the electrode; applying a fluctuating voltage greater than zero to a single sub-positive electrode, and alternating the voltage of the sub-positive electrode adjacent thereto with the fluctuating voltage, so that a varying potential difference is formed between the adjacent sub-positive electrodes, wherein the pathogen particles are gradually enriched in the middle region of the two adjacent sub-positive electrodes, and the concentrated sample is driven to move to the sample detection unit; and immediately detecting the concentrated sample in the sample detection unit.