Abstract: NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof; an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.

Abstract: The present invention relates to a test apparatus, system, and method of detecting target nucleic acid molecules in a biological fluid test sample through analyzing changes in electrical parameters caused by hybridization of target nucleic acids that are complementary to the at least partially single-stranded nucleic acid template strand portion of the probe. A test disc encloses at least one set of electrically separated electrodes with the probe bridging the electrodes. The test sample, potentially containing a target virus, is introduced into a cartridge well, and the test disc is added to the well under conditions permitting hybridization. Electrical parameters within the circuit are measured to detect the presence and concentration of any hybridization complexes formed. Multiple test disc structures, including a cylindrical configuration and a cone construct, are disclosed.

Abstract: In one embodiment, a sensor is disclosed that includes a first conductive substrate coupled to, and electrically isolated from, a second conductive substrate. The sensor includes a first electrode trace within the first conductive substrate with a plurality of first working electrode openings. The sensor also includes a second electrode trace within the first conductive substrate with a plurality of second working electrode openings. Additionally a first transport material is included that covers the plurality of first working electrode openings and a second transport material that covers the plurality of second working electrode openings. A third transport material covers, and forms a barrier between the first and the second transport material. The sensor additionally includes a counter-reference electrode that is formed on the second conductive substrate.

Abstract: Each of detection instruments (3a, 3b, 3c, 3d . . . ) of which the number is enabled to be increased or decreased includes at least one sensitive membrane sensitive to a substance, generates first data representing the result of detection of the substance corresponding to the sensitive membrane, and includes second data in which the result of the detection of the substance corresponding to the sensitive membrane is associated with the membrane information of the sensitive membrane. An information terminal (2) collects the first data and the second data from each of the detection instruments (3a, 3b, 3c, 3d . . . ), and compares the first data and the second data, to specify an object to be detected.

Abstract: The present invention provides an electrophoresis device with improved abnormality detection capability. The electrophoresis device according to the present invention includes a flow passage with which a phoresis medium is filled, a first and second electrodes disposed at respectively a cathode side and an anode side of the flow passage, a power supply for applying voltage across the first and second electrodes, a pump for feeding the phoresis medium to the flow passage, and a control section. The control section executes operations including filling the flow passage with the phoresis medium, executing electrophoresis of a sample, and applying voltage to the first and second electrodes prior to the sample electrophoresis to determine a state of a current path based on a value of current flowing through the current path. The control section applies voltage to the current path for 20 seconds or longer in the determine step.

Abstract: A biomarker detection apparatus in which a CMOS-based chip is used to generate independent detection signals from a reaction zone that receives a biological sample, where the biological sample is provided to both a test region and positive and negative control regions within the reaction zone. The independent detection signals can be processed together (i.e. as a group of input parameters for an algorithm) to identify the presence of a biomarker (or a plurality of biomarkers) in a biological sample. The use of sample-specific, independently detectable positive and negative controls facilitates improved detection accuracy.

Abstract: Device and method to determine the quality of a meat product comprising an identifying element that identifies said meat product by means of the emission and/or reception of an identifying signal of the meat product, said identifying signal comprises at least predetermined puncture requirements and/or a puncture depth (zi) in the meat product, positioning means configured to displace a head, where said head is disposed at one end of said positioning means, and comprises an insertion element configured to be inserted inside said meat product at a predetermined puncture depth (zi), and measure at least a pH signal in a predetermined measurement point (xi, yi, zi), the puncture point (xi, yi) being predetermined in accordance with a prior analysis of the anatomy of said meat product by means of an artificial vision device that determines the puncture point (xi, yi) in accordance with the predetermined puncture requirements and anatomy of the meat product.

Abstract: Provided are a potentiometric biosensor (100) and a method for detecting urea concentration in a sample. The potentiometric biosensor (100) comprises an indication electrode (23) and a reference electrode (24). A second reaction reagent on the indication electrode (23) comprises a urease but does not comprise an electron transporter. A first reaction reagent on the reference electrode (24) comprises an electron transporter but does not comprise a urease. In the case where no external voltage is applied, after a blood sample has been added, the urease catalyzes the reaction of urea in the sample, thereby causing a potential difference between the indication electrode (23) and the reference electrode (24). Furthermore, the potential difference between the indication electrode (23) and the reference electrode (24) is in a linear relationship with the urea concentration in the sample, and the urea concentration in the sample can be calculated according to such linear relationship.

Abstract: This present invention relates generally to devices, systems, and methods for performing optical and electrochemical assays and, more particularly, to devices and systems having universal channel circuitry configured to perform optical and electrochemical assays, and methods of performing the optical and electrochemical assays using the universal channel circuitry. The universal channel circuitry is circuitry that has electronic switching capabilities such that any contact pin, and thus any sensor contact pad in a testing device, can be connected to one or more channels capable of taking on one or more measurement modes or configurations (e.g., an amperometric measurement mode or a current drive mode).

Abstract: A method of monitoring a concentration of sanitizer in a solution includes providing a device that includes a plurality of sensors. The method continues by executing, via the device, a calibration stage that includes placing the device in sanitizer-free water, wherein the device: determines a temperature of the water; conducts a water analysis; and measures, via at least one sensor, a baseline resistance of the water. Sanitizing compounds are added to the water; and the device executes an operational stage, wherein the device: determines a resistance of the water with the sanitizing compounds; calculates a concentration of the sanitizing compounds in the water, wherein the concentration is based on the temperature of the water, the water analysis, and the baseline resistance; compares the calculated concentration to a predetermined threshold concentration; and activates an indication module of the device based on the comparison of the calculated concentration to the predetermined concentration.

Abstract: The present invention provides a wood-derived ionic conductive cellulose-Cu(II) film and the preparation thereof as well as a wood-derived ionic conductive cellulose-Cu(II) sensor for sensing MPEA analogues. The wood-derived ionic conductive cellulose-Cu(II) film presents with excellent ion conductivity, high transmittance, and mechanical flexibility, transparent and flexible sensors capable of real-time detection of MPEA are demonstrated. More significantly, the wood-derived ionic conductive cellulose-Cu(II) sensor exhibits outstanding selectivity, ultralow theoretical detection limit, and excellent flexibility performance.

Abstract: An electrochemical device for identifying electroactive analytes. The device includes a substrate; a sample region; a counter electrode; a reference electrode; a working electrode disposed in communication with the substrate, and the working electrode may be an electron conducting fiber. Further, the counter electrode, reference electrode, and working electrode are partially disposed in the sample region configured to be exposed to the electroactive analyte. Further yet, a counter electrode channel, reference electrode channel, and working electrode channel are disposed in the substrate configured to: accommodate each of the counter electrode, reference electrode, and working electrode, respectively, for placement in the respective channels.

Abstract: There is presented an electrochemical sensor (100) for sensing an analyte in an associated volume (106), the sensor comprising a first solid element (126), a second solid element (128) being joined to the first solid element, a chamber (110) being placed at least partially between the first solid element and the second solid element, a working electrode (104) in the chamber (110), a reference electrode (108), and wherein one or more analyte permeable openings (122) connect the chamber (110) with the associated volume (106), and wherein the electrochemical sensor (100) further comprises an analyte permeable membrane (124) in said one or more analyte permeable openings, wherein the one or more analyte permeable openings are placed at least partially between the first solid element and the second solid element.

Abstract: NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)+) or derivative thereof; an NAD(P)+-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.

Abstract: The present disclosure provides a biochemical test chip, including an insulating substrate, an electrode unit, a first insulating septum, a reactive layer and a second insulating septum. The electrode unit is located on the insulating substrate. The electrode unit includes a working electrode and a counter electrode. A current density of the counter electrode is greater than a current density of the working electrode. The first insulating septum is located on the electrode unit. The first insulating septum has an opening, which at least partially exposes the electrode unit. The reactive layer is located in the opening and is electrically connected to the electrode unit. The second insulating septum is located on the first insulating septum.

Abstract: Provided is a sensing method of a FET-type sensor using electric charge storage engineering. The sensing method comprises the following steps to improve reactivity and selectivity to a gas to be sensed: (a) applying a preset erase voltage (Erase bias) or program voltage (Program bias) to the control gate according to the type of gas to be sensed to change a threshold voltage of the FET transducer and control the charge at an interface between the passivation layer and the sensing material layer; and (b) in the recovery phase where the gas detection reaction is terminated and the original state is returned, applying a pre-bias greater or less than a read voltage to the control gate according to the type of gas detected, and then applying the read voltage to the drain and the source of the FET transducer to increase the desorption rate of the detected gas.

Abstract: A gas sensor includes a sensor element, a housing, a contact terminal, a second insulator, a lead wire, a sealing member, an inner periphery side cover and an outer periphery side cover. The inner periphery side cover is mounted on an outer periphery at a position on a base end side in an axial direction of the housing. The outer periphery side cover is disposed on the outer periphery side of the inner periphery side cover, forms a substantially cylindrical space with the inner periphery side cover and holds the sealing member on an inner periphery side.

Abstract: A sensor device is provided. The sensor device includes a first substrate, a second substrate, a flow channel and a first reaction group. The second substrate is disposed opposite the first substrate. The flow channel is disposed between the first substrate and the second substrate, and the flow channel includes a fluidic boundary. The first reaction group is disposed on the first substrate and includes a first reaction site, a second reaction site and a third reaction site. The first reaction site is closer to the fluidic boundary than the second reaction site, and a size of the first reaction site is greater than or equal to a size of the second reaction site. The second reaction site is closer to the fluidic boundary than the third reaction site, and the size of the second reaction site is greater than a size of the third reaction site.

Abstract: A nanopore measurement circuit includes a first analog memory configured to store a first electrical value corresponding to a first measurement sample of a nanopore and a second analog memory configured to store a second electrical value corresponding to a second measurement sample of the nanopore. The nanopore measurement circuit also includes a measurement circuitry configured to provide an output indicating a difference between the first electrical value of the first analog memory and the second electrical value of the second analog memory.

Abstract: Example methods, apparatus, systems for droplet actuator fabrication are disclosed. An example non-transitory computer readable medium includes instructions that, when executed, cause at least one processor to at least control movement of a laser to cause the laser to etch an electrode pattern in a first substrate, the electrode pattern including a first set of electrodes, a second set of electrodes, and a third set of electrodes; control a printer driver to cause a hydrophobic material and a dielectric material to be applied to the second set of electrodes and not the first set of electrodes via a printer; control a bonding driver to cause a gap to be defined between the first substrate and a second substrate; and control a dicing driver to cause a portion the first substrate and a portion of the second substrate to be cut into a droplet actuator.