Patents Examined by Heidi Reese
  • Compounds for the detection of senescent cells
    Patent number: 10947390
    Abstract: The present disclosure relates to de novo synthesized, chemical compounds of the formula (1) or (2) that function as senescent cell detectors wherein R1, R2, R3, R4 and Z are as defined herein. The present invention also relates to processes for the preparation of these compounds, to their use in the detection of senescent cells, to methods of detecting senescence in cells and to kits comprising said compounds. The compounds have the ability to react with lipofuscin, in an analogous manner to the histochemical dye Sudan Black B (SBB).
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: March 16, 2021
    Assignee: THE UNIVERSITY OF MANCHESTER
    Inventors: Vassilis Gorgoulis, Paul Townsend, Panayiotis Marakos, Nikolaos Lougiakis, Nicole Pouli, Nikolaos Kastrinakis
  • Method of preparing ultra-low molecular weight keratin peptide
    Patent number: 10945940
    Abstract: The present disclosure relates to methods of preparing an ultra-low molecular weight keratin peptide and use thereof. In particular, the present disclosure relates to a method of preparing an ultra-low molecular weight keratin peptide using culturing a microorganism having keratinolytic activity in a medium including keratin, ultrafiltration, ion exchange chromatography and gel filtration chromatography, a peptide prepared by the method, and a cosmetic and food composition for preventing or improving skin aging or skin wrinkles including the same. According to the method of preparing a keratin peptide of the present invention, it is possible to eco-friendly biologically treat waste resources and efficiently purify and recover anti-aging functional ultra-low molecular weight keratin peptides.
    Type: Grant
    Filed: October 31, 2016
    Date of Patent: March 16, 2021
    Assignee: KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Dong Woo Lee, Nam Joo Kang, Yong Jik Lee, Hyeon Su Jin, In Hyuk Yeo, Kyeong Seop Song, Jae-Eun Lee
  • Methods and compositions for detecting or measuring caspases or apoptosis
    Patent number: 10941435
    Abstract: Provided herein are compounds, enzyme substrates, compositions, kits, uses, and methods for detecting the presence or absence of a caspase enzyme, measuring the activity of a caspase enzyme, or detecting the presence or absence of apoptosis. The detection or measurement can occur through intracellular cleavage of a compound or enzyme substrate, which can lead to an increase in fluorescence, e.g., in the violet or red channel, through liberation of a nucleic acid binding dye from a peptide, such as liberation of a DNA-binding dye from a negatively charged peptide comprising a sequence recognized and cleaved by a caspase.
    Type: Grant
    Filed: June 21, 2017
    Date of Patent: March 9, 2021
    Assignee: Life Technologies Corporation
    Inventors: Kyle Gee, Wenjun Zhou, Shih-Jung Huang, Monica Tomaszewski
  • Fungal species, compositions derived therefrom, and uses thereof
    Patent number: 10939685
    Abstract: Provided herein are secretory compositions/cocktails derived from a novel, extremophilic fungal species cultured, isolated, characterized and sequenced herein. Said novel, extremophilic fungal species may be exploited to produce a secretory compositions/cocktails which comprise a unique mixture of thermo-tolerant, stable enzymes capable of digesting cellular and genetic material in its surroundings under extreme temperatures. Such secretory compositions/cocktails may be useful as cleaning and sterilization solutions against biofilm, urine, yeast, bacterial, or viral contamination. Other uses include, but are not limited to, urea removal, fertilizer wastewaters, wastewater reclamation for life support systems in space, pH control, source of ammonia and carbon dioxide, starch digestion, biofuel production, as pharmaceuticals, and medical treatments such as wounds, skin disorders, or nail disorders.
    Type: Grant
    Filed: April 5, 2017
    Date of Patent: March 9, 2021
    Assignee: President and Fellows of Harvard College
    Inventors: David A. Sinclair, Kyle S. Landry
  • Microbial system for biosynthesis of natural and engineered products coupled to in situ extraction in supercritical CO
    Patent number: 10941379
    Abstract: Provided herein are methods of producing a bioproduct by culturing a cell in a multiphase reactor that comprises supercritical CO2, near critical CO2, or liquid CO2.
    Type: Grant
    Filed: May 9, 2017
    Date of Patent: March 9, 2021
    Assignee: Massachusetts Institute of Technology
    Inventors: Janelle Renee Thompson, Kyle C. Peet, Adam J. E. Freedman, Kristala Lanett Jones Prather, Jason Thomas Boock, Michael T. Timko
  • Neurotransmitter transport in probiotics
    Patent number: 10941433
    Abstract: The present invention is directed to methods of probiotic selection and use based on the capability of microbial biogenic amine uptake as a method for targeted clinical and veterinary applications, including promoting health and well-being and/or treating therapeutic conditions. The present invention utilizes a microbially-focused approach for the development of drug selection and/or probiotic administration in a variety of diseases and disorders.
    Type: Grant
    Filed: June 15, 2018
    Date of Patent: March 9, 2021
    Assignees: IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC., REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Mark Lyte, David Robert Brown
  • NHE3-binding compounds and methods for inhibiting phosphate transport
    Patent number: 10940146
    Abstract: Provided are NHE3-binding and/or NHE3-modulating agents having activity as phosphate transport inhibitors, including inhibitors of phosphate transport in the gastrointestinal tract and the kidneys, and methods for their use as therapeutic or prophylactic agent.
    Type: Grant
    Filed: March 12, 2019
    Date of Patent: March 9, 2021
    Assignee: Ardelyx, Inc.
    Inventors: Christopher Carreras, Dominique Charmot, Jeffrey W. Jacobs, Eric Labonte, Jason G. Lewis
  • Mobilizing agents and uses therefor
    Patent number: 10933049
    Abstract: The present invention discloses the use of a complement 3a receptor (C3aR) antagonist and a mobilizer of hematopoietic stem cells and/or progenitor cells in methods and compositions for stimulating or enhancing the development, mobilization, proliferation and/or differentiation of a neutrophil-containing leukocyte population that inhibits growth and/or spread of a tumor and for treating or preventing a hyperproliferative cell disorder.
    Type: Grant
    Filed: June 1, 2016
    Date of Patent: March 2, 2021
    Assignee: The University of Queensland
    Inventors: Trent Woodruff, Barbara Rolfe
  • Aie luminogens for visualization and treatment of cancer
    Patent number: 10935552
    Abstract: The present subject matter relates to ATE luminogens for visualization and treatment of cancer, particularly AIE luminogenic probes for cancer cell visualization and discrimination, lysosome-targeting AIEgens for imaging and autophagy visualization, highly fluorescent AIE-active theranostic agents for monitoring drug distribution and having anti-tumor activity to specific cancer cells, probes comprising AIE luminogens for cancer cell imaging and staining, AIE luminogens having clusteroluminogenic features and applications thereof, and methods of preparing thereof.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: March 2, 2021
    Assignee: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Benzhong Tang, Engui Zhao, Chen Gui, Meijuan Jiang, Haiqin Deng, Wai Tung Leung, Zhiming Wang, Yueyue Zhao, Tsz Kin Kwok, Lucia Viglianti, Ni Xie
  • Method and apparatus for applying aggregating sampling to food items
    Patent number: 10935535
    Abstract: Certain aspects of the present disclosure relate to methods and apparatus for microbial sampling of foods. For example, a method may include providing at least one aggregating sampler at one or more sampling locations, and sampling a production lot of produce or other food items such as meat using the at least one aggregating sampler to create one or more samples that makes up a microbial sampling. Certain aspects of the present disclosure relate to methods and apparatus for microbial sampling of foods. For example, an apparatus, such as a microbial aggregating sampler, may include a covering having a microbial sampling material with a pocket formed in the covering to receive an appendage or a tool for handling of the covering.
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: March 2, 2021
    Assignee: Fremonta Corporation
    Inventors: Eric Child Wilhelmsen, Florence Q. Wu, Yongqing Huang, Jason Thomas Hastings
  • Dermatologic composition containing and
    Patent number: 10933103
    Abstract: Disclosed is a composition comprising an effective amount of a mixture of inactivated Escherichia coli and Enterococcus faecalis as well as pharmaceutically acceptable excipients and/or carriers for use in the treatment, supportive treatment or prevention of dermatologic conditions and diseases.
    Type: Grant
    Filed: November 28, 2018
    Date of Patent: March 2, 2021
    Assignee: SymbioGruppe GmbH & Co. KG
    Inventors: Hans-Jorg Muller, Thomas Michael Schmidts, Kurt Zimmermann, Volker Rusch
  • Outpatient modified rapid detoxification for addiction to alcohol and drugs
    Patent number: 10925873
    Abstract: A medicament regimen for outpatient modified rapid detoxification for addiction to alcohol and drugs is disclosed. Patients are seen by trained medical professionals who are recovering addicts and alcoholics. The medicament protocol addresses all of the withdrawal symptoms while allowing the patient to safely sleep through the detoxification.
    Type: Grant
    Filed: November 9, 2018
    Date of Patent: February 23, 2021
    Inventors: David Alan Hall, Terry Lee Yeiter
  • Salts and polymorphs of SCY-078
    Patent number: 10927142
    Abstract: SCY-078 is a glucan synthase inhibitor with antimicrobial activity. Novel salts and polymorph forms of SCY-078 are disclosed herein. The disclosure also relates to pharmaceutical compositions, methods of use, and methods of preparing the novel salts and polymorphs of SCY-078.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: February 23, 2021
    Assignee: SCYNEXIS, INC.
    Inventor: Yi Zhang
  • Compositions for CYP450 phenotyping using saliva samples
    Patent number: 10927398
    Abstract: Disclosed are methods and compositions which may be used in human cytochrome P450 (CYP450) enzyme phenotyping. The methods and compositions typically utilize a mélange of substrates for different CYP450 enzymes which may be administered orally to a patient. Subsequently, the metabolites of the substrates may be detected in the patient's saliva as well as any non-metabolized substrates to calculate a metabolic ratio for any given CYP450 enzyme in order to generate a phenotypic CYP450 enzyme profile for the patient.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: February 23, 2021
    Assignee: Concordia University Inc.
    Inventors: Joseph McGraw, Armin Gerhardt
  • Conjugate of therapeutic enzymes
    Patent number: 10918736
    Abstract: The present invention relates to a conjugate in which an immunoglobulin Fc region is linked to therapeutic enzymes through a non-peptide polymer linkage moiety, and more specifically, to a conjugate in which a non-peptide polymer linkage moiety is specifically linked to an immunoglobulin Fc, a method of preparing the same, and a composition comprising the same.
    Type: Grant
    Filed: January 31, 2017
    Date of Patent: February 16, 2021
    Assignee: HANMI PHARM. CO., LTD
    Inventors: Dae Jin Kim, Jung Kuk Kim, Sung Youb Jung, Se Chang Kwon
  • Magnesium lactate fermentation process
    Patent number: 10920250
    Abstract: A fermentation process for producing magnesium lactate from a carbon source including the steps of: providing a fermentation medium including a fermentable carbon source in a fermentation reactor; fermenting the fermentation medium by a lactic acid producing microorganism in the presence of an alkaline magnesium salt to provide a fermentation broth including magnesium lactate; and recovering solid magnesium lactate from the magnesium lactate containing fermentation broth, wherein during at least 40% of the operating time of the fermentation process, the concentration of solid magnesium lactate in the fermentation broth is maintained in the range of 5-40 vol. %, calculated as solid magnesium lactate crystals on the total of the fermentation broth. The process allows stable operation at high productivity, in combination with efficient product separation.
    Type: Grant
    Filed: April 10, 2017
    Date of Patent: February 16, 2021
    Assignee: PURAC BIOCHEM BV
    Inventors: Aliaksei Kalbasenka, Jeroen Bokhove
  • Fused pentacyclic imidazole derivatives
    Patent number: 10906919
    Abstract: A series of fused pentacyclic imidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. In particular, the present invention is concerned with 6,7-dihydro-7,14-methanobenzimidazo[1,2-b][2,5]benzodiazocin-5(14H)-one derivatives and analogs thereof.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: February 2, 2021
    Assignees: UCB Biopharma SRL, Sanofi
    Inventors: Teresa De Haro Garcia, Michael Deligny, Jag Paul Heer, Joanna Rachel Quincey, Mengyang Xuan, Zhaoning Zhu, Daniel Christopher Brookings, Mark Daniel Calmiano, Yves Evrard, Martin Clive Hutchings, James Andrew Johnson, Sophie Jadot, Jean Keyaerts, Malcolm Mac Coss, Matthew Duncan Selby, Michael Alan Shaw, Dominique Louis Leon Swinnen, Laurent Schio, Yann Foricher, Bruno Filoche-Romme
  • Process for improved fermentation of a microorganism
    Patent number: 10900015
    Abstract: A method for improving biomass production and/or growth rate of a microorganism in a fermentation process is shown, and includes: (i) providing one or more microorganisms; (ii) providing a fermentation substrate suitable for fermenting the one or more microorganisms; (iii) mixing the one or more microorganisms and the fermentation substrate providing a fermentation broth; (iv) adding the fermentation broth to a fermentation tank; (v) injecting at least one gaseous substrate into the fermentation broth; (vi) running the fermentation process for a fermentation period of at least 1 hour; wherein the at least one gaseous substrate comprises one or more greenhouse gases, such as carbon dioxide (CO2).
    Type: Grant
    Filed: November 8, 2016
    Date of Patent: January 26, 2021
    Assignee: UNIBIO A/S
    Inventor: Subir Kumar Nandy
  • Antiviral and antibacteria agents based on quaternary ammonium compound complexed with boric acid and its derivatives
    Patent number: 10899776
    Abstract: The present document describes compounds resulting from the complexation of quaternary ammonium compounds with boric acid and/or its derivatives, and methods of making the same, and methods of using the same for the treatment of pathogenic infections.
    Type: Grant
    Filed: May 13, 2019
    Date of Patent: January 26, 2021
    Assignee: CANH FEED SOLUTIONS CORP.
    Inventors: Tien Canh Le, Giuliano Lafrenière Di Fruscia
  • Multi-functionalized polysaccharide compounds and use thereof for targeting the cation-independent mannose 6-phosphate receptor
    Patent number: 10894803
    Abstract: The subject matter of the present invention is a compound characterized in that it has the general formula (I): in which P1, X, n, A, L and L1 are as defined in Claim 1. The present invention also relates to a process for preparing said compounds (I) and to the use thereof for targeting the cation-independent mannose 6-phosphate receptor (CI-M6PR). The subject matter of the invention is also a conjugate of formula (III): in which P1, X, n, A, L and L?1 are as defined in Claim 6, and the use thereof: —in a method for therapeutic treatment of the human or animal body, in particular chosen from enzyme replacement therapy, photodynamic therapy or cancer treatment, and/or—in a method of diagnosis, in particular of diseases or of ailments associated with an increase or with a decrease in CI-M6PR expression.
    Type: Grant
    Filed: September 15, 2016
    Date of Patent: January 19, 2021
    Assignees: NANOMEDSYN, Centre National de la Recherche Scientifique, Universite de Montpellier
    Inventors: Alain Morere, Afitz Da Silva, Elise Bouffard, Khaled El Cheikh, Jean-Olivier Durand, Marie Maynadier, Ilaria Basile