Patents Examined by Heidi Reese
  • Burkholderia and applications thereof
    Patent number: 11001866
    Abstract: A strain of Burkholderia is Burkholderia glathei ECU0712, with an accession number of CGMCC NO. 14464. With the strain or its extract as the biocatalyst, thioether is catalyzed to be oxidized asymmetrically to chiral sulfoxide, with significant advantages that the obtained product has a high optical purity, and benefits of a simple reaction system, short preparation time of the catalyst and a high yield of the product.
    Type: Grant
    Filed: October 25, 2017
    Date of Patent: May 11, 2021
    Assignees: JIANGSU AOSAIKANG PHARMACEUTICAL CO., LTD., EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Huilei Yu, Qian Zhao, Yan Zhang, Jiang Pan, Jianhe Xu
  • Biological disinfection or sterilization indicator
    Patent number: 11001799
    Abstract: A biological indicator for testing the efficacy of sterilization or disinfection processes of closed environments or confined spaces, the biological indicator comprising a carrier; biological material supported on or embedded in the carrier; and a carrier container comprising a body and a cap. The carrier is fixed within an inner space of the cap, the cap being able to be placed in an open position completely exposing the carrier and the biological material to the closed environment or confined space to be disinfected. A method for determine the efficacy of a process of sterilization or disinfection of closed environments or confined spaces, preferably by means of an enzyme and a fluorescence compound, using said biological indicator.
    Type: Grant
    Filed: October 18, 2018
    Date of Patent: May 11, 2021
    Assignee: TERRAGENE LLC
    Inventors: Esteban Lombardía, Adrián Jesús Rovetto
  • Orally administered composition to lower serum methionine levels and method of use
    Patent number: 11001826
    Abstract: A composition and method for lowing serum and plasma levels of methionine by oral administration. The composition includes a recombinant methioninase enzyme and a cofactor (pyridoxal-L-phosphate). Methods of use describe methods for treatment of cancer, including malignant melanoma, by oral administration of the methioninase composition. Methods for chronic suppressive therapy of melanoma and other cancers are described. Because reduction of plasma methionine levels is effective in treating other conditions, including diabetes and conditions associated with aging, the use of the methods described herein includes treatment of these and other conditions.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: May 11, 2021
    Assignee: ANTICANCER, INC.
    Inventors: Qinghong Han, Shukuan Li, Yuying Tan, Kei Kawaguchi, Robert M. Hoffman, Sant Chawla
  • Enzymatic replacement therapy and antisense therapy for pompe disease
    Patent number: 10993995
    Abstract: The present invention is direct to the treatment of Pompe disease by administration of an enzyme or nucleic acid encoding for said enzyme suitable for Enzyme Replacement Therapy for Pompe disease in combination with the administration of an antisense oligomeric compound that modulates the splicing of acid alpha-glucosidase (GAA) gene.
    Type: Grant
    Filed: December 7, 2015
    Date of Patent: May 4, 2021
    Assignee: Erasmus University Medical Center Rotterdam
    Inventors: Erik van der Wal, Atze Jacobus Bergsma, Wilhelmus Wenceslaus Matthias Pijnappel, Antje Tjitske van der Ploeg, Arnoldus Reuser
  • Gluconobacter cerinus plus hanseniaspora osmophila for controlling fungal infections in plants and fruits
    Patent number: 10993444
    Abstract: The present invention relates to a biological product useful for the control of fungal diseases in plants comprising bacteria of Gluconobacter genus and yeast of Hanseniaspora genus. It also includes a method for preparing the aforementioned biological product and uses thereof to treat, prevent, control or cure fungal diseases in plants.
    Type: Grant
    Filed: November 24, 2016
    Date of Patent: May 4, 2021
    Assignee: PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO
    Inventors: Ximena Alejandra Besoain Canales, Fabiola Francisca Cadiz Morales, Eduardo Salgado Varas
  • Microbial pesticidal composition and production thereof
    Patent number: 10986842
    Abstract: The present invention relates to a process for harvesting biomass of a bacterium, and/or a lipoprotein produced by a bacterium, which exhibit antifungal and antibacterial activity against various phytopathogenic agents.
    Type: Grant
    Filed: November 10, 2016
    Date of Patent: April 27, 2021
    Assignee: CHR. HANSEN A/S
    Inventors: Hans Bisgaard-Frantzen, Michelle Madsen, Line Thorsen, Jakob Worm
  • PRMT5 inhibitors and uses thereof
    Patent number: 10980794
    Abstract: Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described.
    Type: Grant
    Filed: July 8, 2019
    Date of Patent: April 20, 2021
    Assignee: Epizyme, Inc.
    Inventors: Kenneth W. Duncan, Richard Chesworth, Paula Ann Boriack-Sjodin, Michael John Munchhof, Lei Jin
  • Method for treating obesity, diabetes, cardiovascular and kidney diseases by regulating GPR30/GPER activity
    Patent number: 10980785
    Abstract: The current invention is in the field of molecular biology/pharmacology and provides methods of using compounds that modulate the effects of GPR30/GPER for treating obesity and diabetes (preferably agonists) as well as disease states and/or conditions that result from excessive formation of reactive oxygen species (preferably antagonists). These compounds may function as agonists and/or antagonists of the disclosed estrogen receptor and/or modulate the expression/upregulation of nox and nox-associated reactive oxygen species (ROS).
    Type: Grant
    Filed: September 20, 2019
    Date of Patent: April 20, 2021
    Assignee: UNM Rainforest Innovations
    Inventors: Eric R. Prossnitz, Geetanjali Sharma, Matthias Barton, Matthias R. Meyer
  • Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor
    Patent number: 10981914
    Abstract: Compounds having a structure according to formula (I), (II), or (III) where R1, R2, R3, R5 X1, X2, and X3 are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.
    Type: Grant
    Filed: September 23, 2019
    Date of Patent: April 20, 2021
    Assignee: Bristol-Myers Squibb Companay
    Inventors: Ian S. Young, Sanjeev Gangwar, Shoshana L. Posy, Yam B. Poudel, Prasanna Sivaprakasam
  • Process of laundering fabrics using a water-soluble unit dose article
    Patent number: 10982176
    Abstract: Described herein is a process of laundering fabrics using a household care composition, which delivers active agents onto fabric or hard surfaces while modifying the pH of the wash liquor to greater than 8.
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: April 20, 2021
    Assignee: The Procter & Gamble Company
    Inventors: Mark Robert Sivik, Frank William Denome, Philip Frank Souter
  • Process for producing a polyacrylamide solution with increased viscosity
    Patent number: 10975177
    Abstract: The present invention relates to a method for producing a polyacrylamide solution having increased viscosity. In particular, the present invention is related to the separation of a biocatalyst from an aqueous acrylamide solution prepared utilizing the biocatalyst prior to polymerization of the aqueous acrylamide solution to polyacrylamide. A polyacrylamide solution having increased viscosity is well suited to be used in tertiary oil recovery. Accordingly, the present application provides means and methods to crucially improve the quality of polyacrylamide solutions for use in tertiary oil recovery.
    Type: Grant
    Filed: March 29, 2017
    Date of Patent: April 13, 2021
    Inventors: Bjoern Langlotz, Linda Garella, Michael Guenter Braun, Juergen Daeuwel
  • Biological conversion and product recovery processes
    Patent number: 10968465
    Abstract: The invention provides a process for reducing bio-catalytic oxidation of a product in a post-production stream. More particularly the invention provides a process for reducing bio-catalytic oxidation of an alcohol in a product stream, the product stream comprising an alcohol product, dissolved carbon dioxide, and at least one enzyme capable of oxidizing the alcohol. The invention finds applicability in fermentation processes, wherein a C1-fixing microorganism utilizes a C1-containing substrate to produce a fermentation product.
    Type: Grant
    Filed: June 13, 2018
    Date of Patent: April 6, 2021
    Assignee: LANZATECH, INC.
    Inventors: Michael James Harry Mawdsley, Michael Emerson Martin, Kathleen Frances Smart, Rachel Jane Brenc
  • Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists
    Patent number: 10968246
    Abstract: The invention relates to non-systemic TGR5 agonist useful in the treatment of chemotherapy-induced diarrhea, diabetes, Type II diabetes, gestational diabetes, impaired fasting glucose, impaired glucose tolerance, insulin resistance, hyperglycemia, obesity, metabolic syndrome, ulcerative colitis, Crohn's disease, disorders associated with parenteral nutrition especially during short bowel syndrome, and irritable bowel syndrome (IBS), and other TGR5 associated diseases and disorders, having the Formula: where R1, R2, R2?, R3, R4, X1, X2, X3, X4, Q, and n are described herein.
    Type: Grant
    Filed: June 28, 2019
    Date of Patent: April 6, 2021
    Assignee: Ardelyx, Inc.
    Inventors: Jason G. Lewis, Michael Robert Leadbetter, Jeremy Caldwell, Dean Dragoli, Noah Bell, Jeffrey W. Jacobs, Patricia Finn, Rakesh Jain, Tao Chen, Matthew Siegel
  • Regulation of feed efficiency and methane production in ruminating animals
    Patent number: 10961559
    Abstract: A method of determining the feed efficiency and methane production of a ruminating animal comprising analyzing the number and/or diversity of a bacterial taxon of a microbiome of the animal or of a gene content of said microbiome, wherein a number and/or diversity of said taxon below a predetermined level is indicative of an animal having a high feed efficiency and low methane production, or a number of genes below a predetermined level is indicative of an animal having a high feed efficiency and low methane production.
    Type: Grant
    Filed: November 3, 2016
    Date of Patent: March 30, 2021
    Assignee: The State of Israel Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center)
    Inventor: Itzhak Mizrahi
  • Anti-obesity microbiota compositions and preparation methods and uses thereof
    Patent number: 10960030
    Abstract: The present invention relates to microbiota compositions and their preparation methods and uses. Particularly, the present invention provides microbiota compositions collected from a dual-specificity phosphatase 6 (dusp6) deficient mammal, which is effective in altering a relative abundance of gut microbiota and also useful in reducing body weight, fat mass, and/or size of adipocytes and increasing oxygen consumption and/or energy expenditure and thus can be used to treat or prevent obesity or its associated disorders or conditions in a subject in need.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: March 30, 2021
    Assignee: NATIONAL HEALTH RESEARCH INSTITUTES
    Inventors: Cheng-Yuan Kao, Jhen-Wei Ruan
  • Process for recovering alcohols in a fermenter
    Patent number: 10961489
    Abstract: The present invention concerns a process for recovering fermentation products present in a fermentation mash produced in a bioreactor (9), comprising a step a) in which a gas stream (15) is sent into the fermentation mash under pressure in order to entrain at least a portion of the products and produce a gas stream (16) which is enriched in fermentation products. The process comprises a step h) for storage of the fermentation gases and the gas stream which is sent to the step a) is constituted by the stored fermentation gases.
    Type: Grant
    Filed: May 17, 2017
    Date of Patent: March 30, 2021
    Assignee: IFP Energies nouvelles
    Inventors: Vincent Coupard, Helena Gonzalez Penas, Eszter Toth, Mehdi Le Moel
  • Donezil pamoate, method of preparation and use thereof
    Patent number: 10952958
    Abstract: The composition containing a pamoate salt of donepezil, the method of preparation and the use thereof are disclosed.
    Type: Grant
    Filed: October 31, 2019
    Date of Patent: March 23, 2021
    Inventor: Zi-Qiang Gu
  • Glaucoma treatment
    Patent number: 10946076
    Abstract: Disclosed herein are methods of treatment for an intraocular pressure (IOP)-associated condition in a subject, that include administering to the subject an effective amount of a tissue plasminogen activator (tPA) therapeutic agent. In one embodiment, the IOP-associated condition is glaucoma. The administration of a tPA therapeutic agent can be an extended administration intended to cause a reduction in IOP in the subject for a period of at least one day to a year or more, relative to IOP levels in the subject prior to administration of the tPA therapeutic agent. The tPA therapeutic agent can be, for example, tPA, a tPA derivative, a small molecule direct or indirect tPA agonist, or a gene therapy vector.
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: March 16, 2021
    Assignees: The Research Foundation for The State University of New York, Icahn School of Medicine at Mount Sinai
    Inventors: Ioannis Danias, Oscar A. Candia, Rosana Gerometta
  • Pseudomonas strains and consortia thereof for use in protection against plant diseases
    Patent number: 10945439
    Abstract: The present invention relates Pseudomonas strains and consortia thereof that are useful in protecting plants against microbial plant diseases caused by pathogens such as Ralstonia, Clavibacter, Erwinia, Curtobacterium, Fusarium, Phytophthora and Helminthosporium. The Pseudomonas strains were selected on the basis of their antagonistic abilities against plant pathogens such as production of antimicrobial compounds, direct inhibition of growth of plant pathogens, competition of carbon or nitrogen sources and endophytic features such as anaerobic growth on nitrate as electron acceptor and growth on arabinose as carbon source. The invention further relates to compositions comprising the strains or consortia of the invention, preferably lyophilized compositions, and to methods wherein they are used in protecting a wide variety of plants against a wide variety of microbial plant diseases.
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: March 16, 2021
    Assignee: Wim de Laat Consultancy B.V.
    Inventors: Wilhelmus Theodorus Antonius Maria de Laat, Erwin Suir, Ap de Haan, Joyce Josephine Elisabeth Arnouts
  • Method for producing methane from carbon dioxide by co-culture
    Patent number: 10947564
    Abstract: A method for producing methane by biological conversion of carbon dioxide is performed using a symbiosis between one or more methane-generating bacteria and: (i) one or more hetero-autotrophic cyanobacteria and/or microalgae, or (ii) one or more sulfobacteria and/or acetobacteria, wherein the hetero-autotrophic cyanobacteria and/or microalgae, or the sulfobacteria and/or acetobacteria, produce the molecular hydrogen required for the conversion of carbon dioxide into methane performed by the methane-generating bacteria.
    Type: Grant
    Filed: November 15, 2016
    Date of Patent: March 16, 2021
    Assignee: BIOREWEAL S.R.L.
    Inventor: Riccardo Reverso