Abstract: A microorganism identification method includes steps of: obtaining a mass spectrum through mass spectrometry of a sample including microorganisms; reading, from the mass spectrum, a mass-to-charge ratio m/z of a peak associated with a marker protein; and identifying which bacterial species of the genus Campylobacter are included in the microorganisms in the sample based on the mass-to-charge ratio m/z. The microorganism identification method is further characterized in that at least one of the following 18 marker proteins is used as the marker protein, S10, L23, S19, L22, L16, L29, S17, L14, L24, S14, L18, L15, L36, S13, S11 (Me), L32, and L7/L12.
Abstract: The invention relates to pesticidal mixtures of Bacillus amyloliquefaciens and cis-jasmone in synergistically effective amounts; methods of application of the pesticidal mixtures for controlling pests; and plant propagation material comprising the pesticidal mixtures.
Type:
Grant
Filed:
November 28, 2016
Date of Patent:
August 3, 2021
Assignee:
BASF SE
Inventors:
Florent Mazuir, Shaun Berry, Eda Reinot, John Hofer, Hendrik Ypema
Abstract: The disclosure relates to Prostaglandin receptor EP2 antagonists, derivatives, compositions, and methods related thereto. In certain embodiments, the disclosure relates to methods of treating or preventing conditions and diseases in which EP2 receptor activation has a physiological role, such as but not limited to, brain injury, inflammatory diseases, neuroinflammation after a seizure, pain, endometriosis, cancer, rheumatoid arthritis, skin inflammation, vascular inflammation, colitis, and neurological disorders by administering a pharmaceutical composition comprising a compound disclosed herein to a subject in need thereof.
Type:
Grant
Filed:
November 15, 2019
Date of Patent:
August 3, 2021
Assignee:
Emory University
Inventors:
Thota Ganesh, Jianxiong Jiang, Raymond Dingledine
Abstract: The present invention relates to a Lactobacillus curvatus strain. In particular, the present invention relates to a composition comprising a Lactobacillus curvatus strain in combination with a further Lactobacillus and the use of the same in the treatment of inflammatory conditions in the oral cavity.
Abstract: Provided herein are methods for the real-time monitoring of an intracellular event or response. In particular, the methods provided herein monitor the conversion of a pro-substrate to a substrate for a protein sensor as a result of an intracellular event or response.
Type:
Grant
Filed:
September 21, 2018
Date of Patent:
July 20, 2021
Assignee:
Promega Corporation
Inventors:
James J. Cali, Sarah Duellman, Jolanta Vidugiriene, Wenhui Zhou
Abstract: The present invention is generally directed to novel fluorophores and their use in imaging methods. In one case, the present invention provides a compound according to the structure shown in FIG. 20A. In another case, the present invention provides a method of imaging one or more cellular structures within one or more cells using a compound of the structure shown in FIG. 20A.
Abstract: Consumption of resistant potato starch results in changes to the gut microbiome in elderly adults, resulting in a healthier gut microbiome profile. Furthermore, consumption of resistant potato starch stimulates an increase in Bifidobacterium abundance in all individuals and also reduces levels of E. coli and Shigella. Furthermore, consumption of MSPrebiotic® increased the relative ratio of butyrate in the elderly and significantly reduced the use of stool softeners in the elderly.
Abstract: The present invention provides, among other things, compositions and methods for CNS delivery of Idursulfase-beta, a human recombinant iduronate-2-sulfatase protein, for effective treatment of Hunter Syndrome. The compositions and methods provided by the present invention effectively reduce symptoms not only in brain and spinal cord but also in peripheral tissues including heart, liver, spleen, lung, and kidney.
Type:
Grant
Filed:
December 21, 2016
Date of Patent:
July 6, 2021
Assignees:
GREEN CROSS CORPORATION, MEDIGENEBIO CORPORATION
Inventors:
Torayuki Okuyama, Thong-Gyu Jin, Han-Yeul Byun, Jin-Wook Seo, Byoung-Ju Lee, Yong-Chul Kim, In-Young Jang, Kyuhyun Lee
Abstract: Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.
Type:
Grant
Filed:
November 9, 2018
Date of Patent:
July 6, 2021
Assignee:
Global Blood Therapeutics, Inc.
Inventors:
Qing Xu, Zhe Li, Stephen L. Gwaltney, II
Abstract: The disclosure relates to compounds of formula (I) useful in the treatment of tauopathies and Alzheimer's disease wherein A, R, W, Q, n, and m are described herein.
Type:
Grant
Filed:
May 15, 2019
Date of Patent:
June 29, 2021
Assignee:
Asceneuron SA
Inventors:
Anna Quattropani, Santosh S. Kulkarni, Awadut Gajendra Giri
Abstract: A microorganism identification method includes steps of: obtaining a mass spectrum through mass spectrometry of a sample including microorganisms; reading, from the mass spectrum, a mass-to-charge ratio m/z of a peak associated with a marker protein; and identifying which bacterial species of the genus Campylobacter are included in the microorganisms in the sample based on the mass-to-charge ratio m/z. The microorganism identification method is further characterized in that at least one of the following 18 marker proteins is used as the marker protein, S10, L23, S19, L22, L16, L29, S17, L14, L24, S14, L18, L15, L36, S13, S11 (Me), L32, and L7/L12.
Abstract: The present disclosure relates to a culturing patch, culturing method, culture test method, culture test device, drug test method, and drug test device, and the culturing patch according to an aspect of the present disclosure includes component required for growth of an object to be cultured, and a mesh structural body provided in a mesh structure forming micro-cavities in which the component required for growth are contained that is configured to come into contact with a reaction region in which the object to be cultured is placed and provide some of the contained component required for growth to the reaction region.
Type:
Grant
Filed:
February 23, 2017
Date of Patent:
June 22, 2021
Inventors:
Dong Young Lee, Chan Yang Lim, Kyung Hwan Kim
Abstract: Compositions and methods for delivering enzymes in enzyme hydrogel formulations are disclosed. More particularly, the present disclosure relates to injectable enzyme hydrogel formulations and delivery of injectable enzyme hydrogel formulations. Also disclosed are methods for GALNS enzyme replacement therapy and lysosomal enzyme replacement therapy.
Type:
Grant
Filed:
November 2, 2018
Date of Patent:
June 15, 2021
Assignee:
Saint Louis University
Inventors:
Adriana M. Montaño, Silviya Petrova Zustiak, Era Jain
Abstract: Methods for increasing the stability of, or protecting, labile components such as ethanolamine, growth factors, vitamins, etc., in compositions such as a cell culture medium. Stability of the labile compound is increased either, by derivatization of the labile compound with chemicals, or by sequestering the labile compound. Sequestering can be done either by encapsulation within a microcapsule, or by the use of sequestering agents. Encapsulation includes the encapsulation of dendrimers complexes of susceptible compounds within the microcapsule, thereby providing the controlled release of the susceptible compound that was protected. These methods may improve and extend storage conditions of compositions comprising the labile compounds, improve shipping and handling of compositions comprising the labile compounds, such as dry media formulations, at room temperature rather than at lower temperatures thereby decreasing shipping costs.
Type:
Grant
Filed:
February 26, 2020
Date of Patent:
June 8, 2021
Assignee:
Life Technologies Corporation
Inventors:
Richard Fike, Bruce Branchaud, Shawn Barrett
Abstract: The present disclosure provides SL and SL derivatives comprising a polar substituent adjacent to the lactone ring. Additionally, the present disclosure provides methods of using the SL and SL derivatives to inhibit the growth of leukemic cancer cells.
Type:
Grant
Filed:
July 26, 2019
Date of Patent:
June 1, 2021
Assignees:
Board of Trustees of the University of Arkansas, BioVentures, LLC, Cornell University, New York Botanical Garden
Inventors:
Monica L. Guzman, Cesar M. Compadre, Paola E. Ordonez, Mariano Martinez, Michael J. Balick, Darin E. Jones, Flavio G. Gaudio
Abstract: This invention relates to, in part, compositions and methods that are useful for, inter alia, the treatment of various diseases, including those linked to binding at a serotonin receptor. The compositions include chiral tetrahydronaphthalen-2-amine derivatives. Accordingly, the present invention provides for compositions and methods that agonize or antagonize one or more serotonin receptors and which find Use in the treatment of various neuropsychiatric diseases or disorders including, without limitation, autism spectrum disorder (ASD) or associated symptoms.
Abstract: The present invention relates to the field of regenerative medicine, and more particularly to the improvement of the in vivo engraftment potential of biological material to be administered to a subject in need thereof.
Type:
Grant
Filed:
June 15, 2016
Date of Patent:
May 25, 2021
Assignees:
INSTITUT PASTEUR, UNIVERSITE PARIS DESCARTES, CENTRE HOSPITALIER SAINTE ANNE PARIS
Inventors:
Fabrice Bruno Chretien, Raphael Gaillard, Pierre Rocheteau
Abstract: Briefly, a sensor for a continuous biological monitor is provided that has a working electrode with an enhanced enzyme layer that in one embodiment is made by mixing an aqueous polyurethane emulsion with an acrylic polyol emulsion to make a base emulsion. An enzyme is added to the base emulsion, which is applied to the working electrode and cured. Optionally, other additives can be added to the base emulsion prior to application, such as hydrophiles, cross linkers, adding imodeoesters, hydroxysuccimide, carboldilite, melamines, epoxies, benzoyl peroxide or dicumyl peroxide.
Abstract: The invention relates to a compound capable of blocking the absorption of heavy metals by plants and a composition containing the same. The compound was extracted from Aegiceras corniculatum. The compound is extracted by enzyme extraction, filtration, concentrating and drying. The compound is derived from natural plants, and no organic solvents are used in the extraction process. The compound and the composition formed by the compound have a certain barrier effect on the absorption of heavy metals by plants.
Type:
Grant
Filed:
November 29, 2019
Date of Patent:
May 11, 2021
Assignee:
SICHUAN HUI TAI AGRICULTURAL TECHNOLOGY CO. LTD.