Patents Examined by Howard C. Lee
  • Decarboxylation process for 2-ketoaldonic acids
    Patent number: 5872247
    Abstract: Catalytic decarboxylation process for 2-ketoaldonic acids by nickel ions characterized in that an aqueous solution of a 2-ketoaldonic acid is put in contact with a resin carrying vinylpyridine groups.The process allows in particular ribulose, xylulose and erythrulose to be easily obtained.
    Type: Grant
    Filed: May 29, 1997
    Date of Patent: February 16, 1999
    Inventors: Guy Fleche, Pierrick Duflot
  • Heparin-like derivatives
    Patent number: 5872110
    Abstract: The invention relates to carbohydrate derivatives having the formula I, ##STR1## wherein R.sup.1 is H or CH.sub.2 OSO.sub.3.sup.-, R.sup.2 and R.sup.3 are independently H, (1-6C)alkyl or SO.sub.3.sup.- ; R.sup.4 is OSO.sub.3.sup.- or NHSO.sub.3.sup.- ; n is 0 or 1; p is 1 or 2; or a pharmaceutically acceptable salt thereof The compounds of the invention have antithrombotic activity and may be used for inhibiting smooth muscle cell proliferation.
    Type: Grant
    Filed: April 30, 1997
    Date of Patent: February 16, 1999
    Assignee: Akzo Nobel N.V. and Sanofi
    Inventors: Constant Adriaan Anton Van Boeckel, Pieter Westerduin
  • Method of preparing biodegradable modified-starch moldable products and films
    Patent number: 5869647
    Abstract: A method of preparing biodegradable moldable products and films includes the steps of preparing biodegradable, hydrophobic, modified starch, and forming a thermoplastic product, comprising the modified starch, and optionally a miscible and biodegradable plasticizer, and/or a compatible filler.
    Type: Grant
    Filed: July 27, 1993
    Date of Patent: February 9, 1999
    Assignee: Evercorn, Inc.
    Inventors: Ramani Narayan, Steven Bloembergen, Amit Lathia
  • 15-hydroxy 6,9-hemiacetal erythromycin compounds
    Patent number: 5854407
    Abstract: Disclosed are (1) a structurally novel 6,9-hemiacetal- erythromycin derivative having a hydroxyl group at at least one of the 14- and 15-positions br a salt thereof, which has an excellent gastrointestinal function promoting effect and is low in toxicity; (2) a process for preparing a 6,9-hemiacetal-erythromycin derivative having a hydroxyl group at at least one of the 14- and 15-positions or a salt thereof, which comprises reacting a 6,9-hemiacetal-erythromycin derivative or a salt thereof with an organism-derived oxidase; and (3) a gastrointestinal function promoting agent containing a 6,9-hemiacetal-erythromycin derivative having a hydroxyl group at at least one of the 14- and 15-positions or a salt thereof.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 29, 1998
    Assignee: Takeda Chemical Corporation
    Inventors: Setsuo Harada, Yasunori Funabashi, Nobuhiro Inatomi, Shigeharu Tanayama, Seiichi Tanida
  • Compounds derived from cyclodextrin
    Patent number: 5854225
    Abstract: The invention relates to cyclodextrin derivatives of formula (I)CD(OH).sub.I (OCOR).sub.m (OR.sub.2).sub.n (1)in which each R.sub.1 independently denotes a C.sub.6 -C.sub.24 alkyl radical or a C.sub.8 -C.sub.24 alkenyl radical, each R.sub.2 independently denotes a C.sub.1 -C.sub.4 alkyl or C.sub.2 -C.sub.4 hydroxyalkyl radical, and I, m and n are statistical values. The invention also relates to a process for the preparation of the compounds of formula (I) and to the use of these compounds in cosmetics.
    Type: Grant
    Filed: November 12, 1996
    Date of Patent: December 29, 1998
    Assignee: L'Oreal
    Inventors: Herve Richard, Madeleine Leduc
  • Oligosaccharide-containing 14 aminosteroid compounds and novel diastereoselective aminosteroid process chemistry
    Patent number: 5849889
    Abstract: The present invention relates to new 14-aminosteroids, pharmaceutical compositions containing the new compounds and methods of treatment for humans or other mammals afflicted with congestive heart failure.
    Type: Grant
    Filed: February 20, 1997
    Date of Patent: December 15, 1998
    Assignee: The Procter & Gamble Company
    Inventors: Paul Michael Dybas, Roland Norman Johnson, Randy Stuart Muth, Song Liu, David Edward Portlock
  • Method of preparing mixed glucosamine salts
    Patent number: 5847107
    Abstract: A method of preparing a therapeutically active crystalline form of glucosamine sulphate which is stable at ambient temperature and humidity and corresponds to the empirical formula: ##STR1## in which M represents a metal selected from the group consisting of Na, K, Ca, Mg,x=1 if y=2, andx=2 if y=1,wherein glucosamine hydrochloride and a sulphate of a metal selected from Na, K, Ca, Mg are reacted in the stoichiometric ratio defined by formula (I), in an aqueous solvent, and the stable crystalline form is precipitated by the addition of a liquid precipitating agent miscible with water.
    Type: Grant
    Filed: August 13, 1997
    Date of Patent: December 8, 1998
    Assignee: Rotta Research B.V. Amsterdam (Swiss Branch)
    Inventors: Maura De Wan, Giuseppe Volpi
  • Method of reducing a schiff base
    Patent number: 5847110
    Abstract: The invention relates to methods of reducing Schiff bases and making chelator conjugates by treating with borane-pyridine complex.
    Type: Grant
    Filed: August 15, 1997
    Date of Patent: December 8, 1998
    Assignee: Biomedical Frontiers, Inc.
    Inventors: Paul R. Dragsten, Gregory J. Hansen
  • Pharmaceutical compositions
    Patent number: 5846951
    Abstract: Polysaccharides comprising at least 5 sialic acid residues per molecule are used to increase the circulation time of an active ingredient, for instance by decreasing the immunogenicity and/or increasing the stability in vivo of pharmaceutically active compounds. The pharmaceutically active compound may be a foreign protein which is covalently bound to the polysaccharide. Alternatively, the active compound may be associated with a drug delivery system (DDS), for instance a macro-molecular DDS or a particulate DDS, such as liposomes. The polysaccharide is usually a bacterial polysaccharide, e.g., a glycolipid or a derivative thereof, for instance polysaccharide B or E. Coli K1, N. meningitidis, Moraxella liquifaciens or Pasteurella aeroginosis, or K92 of E. Coli K92 strain.
    Type: Grant
    Filed: May 1, 1995
    Date of Patent: December 8, 1998
    Assignee: The School of Pharmacy, University of London
    Inventor: Gregory Gregoriadis
  • Anionic glycasuccinamide sufactants and a process for their manufacture
    Patent number: 5844103
    Abstract: The present invention relates to a new class of carbohydrate based nonionic surfactant, i.e., alkyl and alkenyl glycasuccinamide, and a process for their manufacture.
    Type: Grant
    Filed: March 24, 1995
    Date of Patent: December 1, 1998
    Assignee: Lever Brothers Company, Division of Conopco, Inc.
    Inventors: Van Au, Robert Vermeer, Bijan Harichian
  • Anti-endotoxin compounds
    Patent number: 5843918
    Abstract: Disclosed are lipid A analogs useful for the treatment of septic shock and LPS-mediated activation of viral infection.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 1, 1998
    Assignee: Eisai Co., Ltd.
    Inventors: William J. Christ, Lynn D. Hawkins, Tsutomu Kawata, Daniel P. Rossignol, Seiichi Kobayashi, Osamu Asano
  • Method for controlling crystal morphology of inulin
    Patent number: 5840884
    Abstract: A method for controlling and/or modifying the morphology of inulin is provided. Using this method, inulin can be produced having, as desired, a predominately needle-like morphology or a predominately obloid-type morphology. The controlled morphology inulin of the present invention (i.e., needles, obloids, or combinations thereof) can be used in low-fat and/or fat-free viscous food products where the inulin acts as a fat mimetic. By controlling the morphology of inulin used in such food products, better control of organoleptic and physical properties of the food product can be obtained.
    Type: Grant
    Filed: February 27, 1997
    Date of Patent: November 24, 1998
    Assignee: Kraft Foods, Inc.
    Inventors: Daniel G. Lis, Lisa Anne Preston
  • Dextrin ester of fatty acids and use thereof
    Patent number: 5840883
    Abstract: Disclosed are a dextrin ester of fatty acids in which dextrin has an average saccharide polymerization degree of 3 to 150, the fatty acids comprise a straight chain fatty acid having 8 to 22 carbon atoms and at least one fatty acid selected from the group consisting of branched fatty acids having 4 to 26 carbon atoms, unsaturated fatty acids having 6 to 30 carbon atoms and straight chain saturated fatty acids having 6 or less carbon atoms, and the substitution degree of fatty acids per glucose unit is 1.0 to 3.0; and a gelling agent, a composition and a base comprising the ester, the ester being excellent in thixotropic property, moisture retaining property, emulsifiability, adhesion and dispersibility, and therefore suitably used for cosmetics, printing ink, coatings, etc.
    Type: Grant
    Filed: April 2, 1996
    Date of Patent: November 24, 1998
    Assignees: Chiba Flour Milling Co., Ltd., Kose Corporation
    Inventors: Takanao Suzuki, Isaburo Amano, Koji Chiba, Ruka Tofukuji
  • Derivatives of triterpenoid acids and uses thereof.
    Patent number: 5837690
    Abstract: Triterpenoid acid derivatives are described that exhibit dual pharmacophobic activities, specifically selectin ligand and leukotriene biosynthetic inhibitory activities, and that thus have significant applications for the treatment or prevention of certain diseases including cancer and diseases associated with the inflammatory process as well as applications for the diagnosis of disease.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: November 17, 1998
    Assignee: Glycomed Incorporated
    Inventors: Narasinga Rao, Mark Brian Anderson, John Henry Musser
  • Process for the production of arabinitol
    Patent number: 5831078
    Abstract: A method is disclosed for producing a pentitol. The disclosed method more particularly relates to producing arabinitol from hexoses, e.g. galactose and/or glucose, and/or fructose, or lactose hydrolysate, or invert sugar, or starch hydrolysates. The hexose is oxidatively decarboxylated to a C.sub.5 -aldonic acid which is thereafter catalytically hydrogenated to obtain the desired arabinitol.
    Type: Grant
    Filed: July 23, 1997
    Date of Patent: November 3, 1998
    Assignee: Cerestar Holding B.V.
    Inventors: Myriam Elseviers, Hilde Odile Jozefine Lemmens, Sonia Marianne Jeannine Coomans, Harald Wilhelm Walter Roper
  • Glycosylhydrazines, preparation, immobilization and reactions of: glycoprotein analysis and O-glycan removal
    Patent number: 5831077
    Abstract: The present invention consists in methods of preparing sugar derivatives either in isolation or from glycopeptides or glycoproteins. The methods comprise producing sugar hydrazones, sugar pyrazoles, glycosylpyrazones, azoglycan dyes and hydrazoglycan dyes. The present invention also relates to the removal of O-glycans from glycopeptides or glycoproteins, immobilizing reducing sugars onto solid supports and methods to obtain sugars from a glycopeptide or glycoprotein comprising subjecting the glycopeptide or glycoprotein to solid phase Edman degradation followed by separating and characterizing the sugars.
    Type: Grant
    Filed: September 23, 1996
    Date of Patent: November 3, 1998
    Inventors: John William Redmond, Nicolle Hannah Packer, Andrew Arthur Gooley, Keith Leslie Williams, Michael Batley, Warren Charles Kerr, Anthony Pisano, Helen Joan Tweeddale, Catherine Anne Cooper
  • Process for preparation of glycosides
    Patent number: 5831044
    Abstract: A process for making glycosides having enhance color properties comprising the steps of: (a) reacting a reducing saccharide with excess fatty alcohol to obtain a glycoside reaction mixture; (b) adding an effective amount of an unsaturated aliphatic carboxylic acid, including hydroxy-substituted derivatives thereof and their salt, to the glycoside reaction mixture; and (c) evaporating excess fatty alcohol from the glycoside reaction mixture to form a glycoside mixture.
    Type: Grant
    Filed: February 5, 1996
    Date of Patent: November 3, 1998
    Assignee: Henkel Corporation
    Inventors: Patrick M. McCurry, Jr., John Frederick Hessel
  • Synthesis of galactosylhydroxylysine
    Patent number: 5824786
    Abstract: Galactosylhydroxylysine is a terminal degradation product of the bone matrix which thus serves as biochemical marker of bone resorption. A method of synthesizing galactosylhydroxylysine is provided. Antibodies against this synthetically prepared galactosylhydroxylysine conjugated to protein carriers were raised to establish methods to measure galactosylhydroxylysine in biological fluids. The antibodies of the invention recognize native galactosylhydroxylysine and are, for example, useful in the measurement of galactosylhydroxylysine as a biochemical marker of bone resorption in biological fluids. Testing of human serum or adolescent urine resulted in dose-dependent increases in signal intensity using the method of the invention.
    Type: Grant
    Filed: August 30, 1996
    Date of Patent: October 20, 1998
    Assignee: INCSTAR Corporation
    Inventors: Chaim Manor, Jia Wei, Gordon D. MacFarlane
  • Sunscreen agents from natural sources
    Patent number: 5824312
    Abstract: Photoabsorptive compounds are disclosed which comprise a purified extract of a plant or plant part, wherein said plant is indigenous to an arid region of the world, especially where said arid region is located between 35.degree. north latitude and 35.degree. south latitude. The photoabsorptive compounds in many cases are capable of absorbing solar radiation from about 190 nm to about 500 nm, comprising ultraviolet A, ultraviolet B, and high energy visible light. In particular embodiments, the plant part is pollen, and the plant is mesquite, Prosopis juliflora; Mexican palo verde, Parkinsonia aculeata; blue palo verde, Cercidium floridum; or foothills palo verde, Cercidium microphyllum.
    Type: Grant
    Filed: December 15, 1995
    Date of Patent: October 20, 1998
    Assignee: ImaRx Pharmaceutical Corp.
    Inventors: Evan C. Unger, Thomas P. Mc Creery
  • R-T-E cereal with psyllium
    Patent number: RE36067
    Abstract: Disclosed are ready-to-eat cereals containing high levels of psyllium husk and methods for their preparation. The cereals contain about 2% to 37% psyllium, about 20% to 80% of a starchy cereal component, and about 5% to 15% insoluble fiber. The weight ratio of soluble to insoluble fiber ranges from about 1 to 5:1. The total fructose content is less than about 5%. The minimum soluble fiber content is 3 g/oz.
    Type: Grant
    Filed: October 18, 1995
    Date of Patent: January 26, 1999
    Assignee: Kellogg Company
    Inventors: Mitchell L. Ringe, James R. Stoll